Anti-Tau Antibodies that Block Tau Aggregate Seeding In Vitro Markedly Decrease Pathology and Improve Cognition In Vivo
Yanamandra, Kiran, Kfoury, Najla, Jiang, Hong, Mahan, Thomas E., Ma, Shengmei, Maloney, Susan E., Wozniak, David F., Diamond, Marc I., Holtzman, David M.
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Published in Neuron (Cambridge, Mass.) (16.10.2013)
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The sleep-wake cycle regulates brain interstitial fluid tau in mice and CSF tau in humans
Holth, Jerrah K, Fritschi, Sarah K, Wang, Chanung, Pedersen, Nigel P, Cirrito, John R, Mahan, Thomas E, Finn, Mary Beth, Manis, Melissa, Geerling, Joel C, Fuller, Patrick M, Lucey, Brendan P, Holtzman, David M
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Published in Science (American Association for the Advancement of Science) (22.02.2019)
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TREM2-mediated early microglial response limits diffusion and toxicity of amyloid plaques
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Published in The Journal of experimental medicine (02.05.2016)
Published in The Journal of experimental medicine (02.05.2016)
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Proteopathic tau seeding predicts tauopathy in vivo
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Published in Proceedings of the National Academy of Sciences - PNAS (14.10.2014)
Published in Proceedings of the National Academy of Sciences - PNAS (14.10.2014)
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Neuronal activity regulates extracellular tau in vivo
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Published in The Journal of experimental medicine (10.03.2014)
Published in The Journal of experimental medicine (10.03.2014)
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ApoE facilitates the microglial response to amyloid plaque pathology
Ulrich, Jason D, Ulland, Tyler K, Mahan, Thomas E, Nyström, Sofie, Nilsson, K Peter, Song, Wilbur M, Zhou, Yingyue, Reinartz, Mariska, Choi, Seulah, Jiang, Hong, Stewart, Floy R, Anderson, Elise, Wang, Yaming, Colonna, Marco, Holtzman, David M
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Published in The Journal of experimental medicine (02.04.2018)
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Selective reduction of astrocyte apoE3 and apoE4 strongly reduces Aβ accumulation and plaque-related pathology in a mouse model of amyloidosis
Mahan, Thomas E, Wang, Chao, Bao, Xin, Choudhury, Ankit, Ulrich, Jason D, Holtzman, David M
Published in Molecular neurodegeneration (02.02.2022)
Published in Molecular neurodegeneration (02.02.2022)
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Potential role of orexin and sleep modulation in the pathogenesis of Alzheimer's disease
Roh, Jee Hoon, Jiang, Hong, Finn, Mary Beth, Stewart, Floy R, Mahan, Thomas E, Cirrito, John R, Heda, Ashish, Snider, B Joy, Li, Mingjie, Yanagisawa, Masashi, de Lecea, Luis, Holtzman, David M
Published in The Journal of experimental medicine (15.12.2014)
Published in The Journal of experimental medicine (15.12.2014)
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High‐affinity interactions and signal transduction between Aβ oligomers and TREM2
Lessard, Christian B, Malnik, Samuel L, Zhou, Yingyue, Ladd, Thomas B, Cruz, Pedro E, Ran, Yong, Mahan, Thomas E, Chakrabaty, Paramita, Holtzman, David M, Ulrich, Jason D, Colonna, Marco, Golde, Todd E
Published in EMBO molecular medicine (01.11.2018)
Published in EMBO molecular medicine (01.11.2018)
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Lack of hepatic apoE does not influence early Aβ deposition: observations from a new APOE knock-in model
Huynh, Tien-Phat V, Wang, Chao, Tran, Ainsley C, Tabor, G Travis, Mahan, Thomas E, Francis, Caroline M, Finn, Mary Beth, Spellman, Rebecca, Manis, Melissa, Tanzi, Rudolph E, Ulrich, Jason D, Holtzman, David M
Published in Molecular neurodegeneration (17.10.2019)
Published in Molecular neurodegeneration (17.10.2019)
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Analysis of in vivo turnover of tau in a mouse model of tauopathy
Yamada, Kaoru, Patel, Tirth K, Hochgräfe, Katja, Mahan, Thomas E, Jiang, Hong, Stewart, Floy R, Mandelkow, Eva-Maria, Holtzman, David M
Published in Molecular neurodegeneration (26.10.2015)
Published in Molecular neurodegeneration (26.10.2015)
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Altered sleep and EEG power in the P301S Tau transgenic mouse model
Holth, Jerrah K., Mahan, Thomas E., Robinson, Grace O., Rocha, Andreia, Holtzman, David M.
Published in Annals of clinical and translational neurology (01.03.2017)
Published in Annals of clinical and translational neurology (01.03.2017)
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In vivo measurement of apolipoprotein E from the brain interstitial fluid using microdialysis
Ulrich, Jason D, Burchett, Jack M, Restivo, Jessica L, Schuler, Dorothy R, Verghese, Philip B, Mahan, Thomas E, Landreth, Gary E, Castellano, Joseph M, Jiang, Hong, Cirrito, John R, Holtzman, David M
Published in Molecular neurodegeneration (19.04.2013)
Published in Molecular neurodegeneration (19.04.2013)
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Anti-Tau Antibodies that Block Tau Aggregate Seeding In Vitro Markedly Decrease Pathology and Improve Cognition In Vivo
Yanamandra, Kiran, Kfoury, Najla, Jiang, Hong, Mahan, Thomas E., Ma, Shengmei, Maloney, Susan E., Wozniak, David F., Diamond, Marc I., Holtzman, David M.
Published in Neuron (Cambridge, Mass.) (18.12.2013)
Published in Neuron (Cambridge, Mass.) (18.12.2013)
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Age-Dependent Effects of apoE Reduction Using Antisense Oligonucleotides in a Model of β-amyloidosis
Huynh, Tien-Phat V., Liao, Fan, Francis, Caroline M., Robinson, Grace O., Serrano, Javier Remolina, Jiang, Hong, Roh, Joseph, Finn, Mary Beth, Sullivan, Patrick M., Esparza, Thomas J., Stewart, Floy R., Mahan, Thomas E., Ulrich, Jason D., Cole, Tracy, Holtzman, David M.
Published in Neuron (Cambridge, Mass.) (06.12.2017)
Published in Neuron (Cambridge, Mass.) (06.12.2017)
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C9orf72 deficiency promotes microglial-mediated synaptic loss in aging and amyloid accumulation
Lall, Deepti, Lorenzini, Ileana, Mota, Thomas A., Bell, Shaughn, Mahan, Thomas E., Ulrich, Jason D., Davtyan, Hayk, Rexach, Jessica E., Muhammad, A.K.M. Ghulam, Shelest, Oksana, Landeros, Jesse, Vazquez, Michael, Kim, Junwon, Ghaffari, Layla, O’Rourke, Jacqueline Gire, Geschwind, Daniel H., Blurton-Jones, Mathew, Holtzman, David M., Sattler, Rita, Baloh, Robert H.
Published in Neuron (Cambridge, Mass.) (21.07.2021)
Published in Neuron (Cambridge, Mass.) (21.07.2021)
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Altered microglial response to Aβ plaques in APPPS1-21 mice heterozygous for TREM2
Ulrich, Jason D, Finn, Mary Beth, Wang, Yaming, Shen, Alice, Mahan, Thomas E, Jiang, Hong, Stewart, Floy R, Piccio, Laura, Colonna, Marco, Holtzman, David M
Published in Molecular neurodegeneration (03.06.2014)
Published in Molecular neurodegeneration (03.06.2014)
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Hyperglycemia modulates extracellular amyloid-β concentrations and neuronal activity in vivo
Macauley, Shannon L, Stanley, Molly, Caesar, Emily E, Yamada, Steven A, Raichle, Marcus E, Perez, Ronaldo, Mahan, Thomas E, Sutphen, Courtney L, Holtzman, David M
Published in The Journal of clinical investigation (01.06.2015)
Published in The Journal of clinical investigation (01.06.2015)
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Anti-ApoE antibody given after plaque onset decreases Aβ accumulation and improves brain function in a mouse model of Aβ amyloidosis
Liao, Fan, Hori, Yukiko, Hudry, Eloise, Bauer, Adam Q, Jiang, Hong, Mahan, Thomas E, Lefton, Katheryn B, Zhang, Tony J, Dearborn, Joshua T, Kim, Jungsu, Culver, Joseph P, Betensky, Rebecca, Wozniak, David F, Hyman, Bradley T, Holtzman, David M
Published in The Journal of neuroscience (21.05.2014)
Published in The Journal of neuroscience (21.05.2014)
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