Purification and Cloning of Aggrecanase-1: A Member of the ADAMTS Family of Proteins
Tortorella, M. D., Burn, T. C., Pratta, M. A., Abbaszade, I., Hollis, J. M., Liu, R., Rosenfeld, S. A., Copeland, R. A., Decicco, C. P., Wynn, R., Rockwell, A., Yang, F., Duke, J. L., Solomon, K., George, H., Bruckner, R., Nagase, H., Itoh, Y., Ellis, D. M., Ross, H., Wiswall, B. H., Murphy, K., Hillman, M. C., Hollis, G. F., Newton, R. C., Magolda, R. L., Trzaskos, J. M., Arner, E. C.
Published in Science (American Association for the Advancement of Science) (04.06.1999)
Published in Science (American Association for the Advancement of Science) (04.06.1999)
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Identification of a Novel Inhibitor of Mitogen-activated Protein Kinase Kinase
Favata, M F, Horiuchi, K Y, Manos, E J, Daulerio, A J, Stradley, D A, Feeser, W S, Van Dyk, D E, Pitts, W J, Earl, R A, Hobbs, F, Copeland, R A, Magolda, R L, Scherle, P A, Trzaskos, J M
Published in The Journal of biological chemistry (17.07.1998)
Published in The Journal of biological chemistry (17.07.1998)
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Design, Synthesis, and Structure−Activity Relationships of Macrocyclic Hydroxamic Acids That Inhibit Tumor Necrosis Factor α Release in Vitro and in Vivo
Xue, Chu-Biao, Voss, Matthew E, Nelson, David J, Duan, James J.-W, Cherney, Robert J, Jacobson, Irina C, He, Xiaohua, Roderick, John, Chen, Lihua, Corbett, Ronald L, Wang, Li, Meyer, Dayton T, Kennedy, Kenneth, DeGrado, William F, Hardman, Karl D, Teleha, Christopher A, Jaffee, Bruce D, Liu, Rui-Qin, Copeland, Robert A, Covington, Maryanne B, Christ, David D, Trzaskos, James M, Newton, Robert C, Magolda, Ronald L, Wexler, Ruth R, Decicco, Carl P
Published in Journal of medicinal chemistry (02.08.2001)
Published in Journal of medicinal chemistry (02.08.2001)
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Preclinical characterization of WAY‐211612: a dual 5‐HT uptake inhibitor and 5‐HT 1A receptor antagonist and potential novel antidepressant
Beyer, CE, Lin, Q, Platt, B, Malberg, J, Hornby, G, Sullivan, KM, Smith, DL, Lock, T, Mitchell, PJ, Hatzenbuhler, NT, Evrard, DA, Harrison, BL, Magolda, R, Pangalos, MN, Schechter, LE, Rosenzweig‐Lipson, S, Andree, TH
Published in British journal of pharmacology (01.05.2009)
Published in British journal of pharmacology (01.05.2009)
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Cloning and Characterization of ADAMTS11 , an Aggrecanase from the ADAMTS Family
Abbaszade, Ilgar, Liu, Rui-Qin, Yang, Fude, Rosenfeld, Stuart A., Ross, O. Harold, Link, John R., Ellis, Dawn M., Tortorella, Micky D., Pratta, Michael A., Hollis, Jeannine M., Wynn, Richard, Duke, Jodie L., George, Henry J., Hillman, Milton C., Murphy, Kathleen, Wiswall, Barbara H., Copeland, Robert A., Decicco, Carl P., Bruckner, Robert, Nagase, Hideaki, Itoh, Yoshifumi, Newton, Robert C., Magolda, Ronald L., Trzaskos, James M., Hollis, Gregory F., Arner, Elizabeth C., Burn, Timothy C.
Published in The Journal of biological chemistry (13.08.1999)
Published in The Journal of biological chemistry (13.08.1999)
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Design and synthesis of a series of (2R)-N(4)-hydroxy-2-(3-hydroxybenzyl)-N(1)- [(1S,2R)-2-hydroxy-2,3-dihydro-1H-inden-1-yl]butanediamide derivatives as potent, selective, and orally bioavailable aggrecanase inhibitors
Yao, W, Wasserman, Z R, Chao, M, Reddy, G, Shi, E, Liu, R Q, Covington, M B, Arner, E C, Pratta, M A, Tortorella, M, Magolda, R L, Newton, R, Qian, M, Ribadeneira, M D, Christ, D, Wexler, R R, Decicco, C P
Published in Journal of medicinal chemistry (11.10.2001)
Published in Journal of medicinal chemistry (11.10.2001)
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Preclinical characterization of WAY‐211612: a dual 5‐HT uptake inhibitor and 5‐HT1A receptor antagonist and potential novel antidepressant
Beyer, CE, Lin, Q, Platt, B, Malberg, J, Hornby, G, Sullivan, KM, Smith, DL, Lock, T, Mitchell, PJ, Hatzenbuhler, NT, Evrard, DA, Harrison, BL, Magolda, R, Pangalos, MN, Schechter, LE, Rosenzweig‐Lipson, S, Andree, TH
Published in British journal of pharmacology (01.05.2009)
Published in British journal of pharmacology (01.05.2009)
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Discovery of Macrocyclic Hydroxamic Acids Containing Biphenylmethyl Derivatives at P1‘, a Series of Selective TNF-α Converting Enzyme Inhibitors with Potent Cellular Activity in the Inhibition of TNF-α Release
Xue, Chu-Biao, He, Xiaohua, Corbett, Ronald L, Roderick, John, Wasserman, Zelda R, Liu, Rui-Qin, Jaffee, Bruce D, Covington, Maryanne B, Qian, Mingxin, Trzaskos, James M, Newton, Robert C, Magolda, Ronald L, Wexler, Ruth R, Decicco, Carl P
Published in Journal of medicinal chemistry (11.10.2001)
Published in Journal of medicinal chemistry (11.10.2001)
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Inhibition of Mitogen-Activated Protein Kinase Kinase Blocks T Cell Proliferation But Does Not Induce or Prevent Anergy
DeSilva, Dimuthu R, Jones, Elizabeth A, Favata, Margaret F, Jaffee, Bruce D, Magolda, Ronald L, Trzaskos, James M, Scherle, Peggy A
Published in The Journal of immunology (1950) (01.05.1998)
Published in The Journal of immunology (1950) (01.05.1998)
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MEK inhibitors: The chemistry and biological activity of U0126, its analogs, and cyclization products
Duncia, John V., Santella, Joseph B., Higley, C.Anne, Pitts, William J., Wityak, John, Frietze, William E., Rankin, F.Wayne, Sun, Jung-Hui, Earl, Richard A., Tabaka, A.Christine, Teleha, Christopher A., Blom, Karl F., Favata, Margaret F., Manos, Elizabeth J., Daulerio, Andrea J., Stradley, Deborah A., Horiuchi, Kurumi, Copeland, Robert A., Scherle, Peggy A., Trzaskos, James M., Magolda, Ronald L., Trainor, George L., Wexler, Ruth R., Hobbs, Frank W., Olson, Richard E.
Published in Bioorganic & medicinal chemistry letters (20.10.1998)
Published in Bioorganic & medicinal chemistry letters (20.10.1998)
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Lanosterol 14 alpha-methyl demethylase. Isolation and characterization of the third metabolically generated oxidative demethylation intermediate
Fischer, R T, Trzaskos, J M, Magolda, R L, Ko, S S, Brosz, C S, Larsen, B
Published in The Journal of biological chemistry (05.04.1991)
Published in The Journal of biological chemistry (05.04.1991)
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Structure-based design and synthesis of a series of hydroxamic acids with a quaternary-hydroxy group in P1 as inhibitors of matrix metalloproteinases
Jacobson, Irina C., Reddy, Prabhakar G., Wasserman, Zelda R., Hardman, Karl D., Covington, Maryanne B., Arner, Elizabeth C., Copeland, Robert A., Decicco, Carl P., Magolda, Ronald L.
Published in Bioorganic & medicinal chemistry letters (07.04.1998)
Published in Bioorganic & medicinal chemistry letters (07.04.1998)
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Heteroatom- and carbon-linked biphenyl analogs of Brequinar as immunosuppressive agents
Batt, Douglas G., Petraitis, Joseph J., Sherk, Susan R., Copeland, Robert A., Dowling, Randine L., Taylor, Tracy L., Jones, Elizabeth A., Magolda, Ronald L., Jaffee, Bruce D.
Published in Bioorganic & medicinal chemistry letters (07.07.1998)
Published in Bioorganic & medicinal chemistry letters (07.07.1998)
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Terphenyl cyclooxygenase-2 (COX-2) inhibitors: Optimization of the central ring and o-biphenyl analogs
Pinto, Donald J.P., Batt, Douglas G., Pitts, William J., Petraitis, Joseph J., Orwat, Michael J., Wang, Shuaige, Jetter, James W., Sherk, Susan R., Houghton, Gregory C., Copeland, Robert A., Covington, Maryanne B., Trzaskos, James M., Magolda, Ronald L.
Published in Bioorganic & medicinal chemistry letters (05.04.1999)
Published in Bioorganic & medicinal chemistry letters (05.04.1999)
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Modulation of 3-hydroxy-3-methylglutaryl-CoA reductase by 15 alpha-fluorolanost-7-en-3 beta-ol. A mechanism-based inhibitor of cholesterol biosynthesis
Trzaskos, J.M., Magolda, R.L., Favata, M.F., Fischer, R.T., Johnson, P.R., Chen, H.W., Ko, S.S., Leonard, D.A., Gaylor, J.L.
Published in The Journal of biological chemistry (25.10.1993)
Published in The Journal of biological chemistry (25.10.1993)
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Total synthesis of ionophore antibiotic X-14547A
Nicolaou, K. C, Papahatjis, D. P, Claremon, D. A, Magolda, R. L, Dolle, R. E
Published in Journal of organic chemistry (01.05.1985)
Published in Journal of organic chemistry (01.05.1985)
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Inhibition of MAP Kinase Kinase (MEK) Results in an Anti-inflammatory Response in Vivo
Jaffee, Bruce D., Manos, Elizabeth J., Collins, Robert J., Czerniak, Phillip M., Favata, Margaret F., Magolda, Ronald L., Scherle, Peggy A., Trzaskos, James M.
Published in Biochemical and biophysical research communications (16.02.2000)
Published in Biochemical and biophysical research communications (16.02.2000)
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Aggrecanase: A Target for the Design of Inhibitors of Cartilage Degradation
ARNER, ELIZABETH C., PRATTA, MICHAEL A., DECICCO, CARL P., XUE, CHU-BIAO, NEWTON, ROBERT C., TRZASKOS, JAMES M., MAGOLDA, RONALD L., TORTERELLA, MICKY D.
Published in Annals of the New York Academy of Sciences (01.06.1999)
Published in Annals of the New York Academy of Sciences (01.06.1999)
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