Retooling a Blood-Based Biomarker: Phase I Assessment of the High-Affinity CA19-9 Antibody HuMab-5B1 for Immuno-PET Imaging of Pancreatic Cancer
Lohrmann, Christian, O'Reilly, Eileen M, O'Donoghue, Joseph A, Pandit-Taskar, Neeta, Carrasquillo, Jorge A, Lyashchenko, Serge K, Ruan, Shutian, Teng, Rebecca, Scholz, Wolfgang, Maffuid, Paul W, Lewis, Jason S, Weber, Wolfgang A
Published in Clinical cancer research (01.12.2019)
Published in Clinical cancer research (01.12.2019)
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Abstract CT026: Phase I trial of HuMab-5B1 (MVT-5873), a novel monoclonal antibody targeting sLea, in patients with advanced pancreatic cancer and other CA19-9 positive malignancies
O’Reilly, Eileen M., Bauer, Todd M., Infante, Jeffrey, Gutheil, John C., Klein, Pamela, Yu, Kenneth H., Lowery, Maeve A., Livingston, Phil, Martin, Pricilla, Scholz, Wolfgang, Maffuid, Paul W.
Published in Cancer research (Chicago, Ill.) (15.07.2016)
Published in Cancer research (Chicago, Ill.) (15.07.2016)
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Abstract LB-002: A fully human antibody binds Tn and sTn carbohydrate antigens specifically on serine residues, without need for polypeptide interaction
Rainey, G Jonah, Sawada, Ritsuko, Ostrowski, Jacek, Kahn, Ayesha, Marinkovic-Petrovic, Aleksandra, Mudd, Kevin, Scholz, Wolfgang, Maffuid, Paul W.
Published in Cancer research (Chicago, Ill.) (01.07.2018)
Published in Cancer research (Chicago, Ill.) (01.07.2018)
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Abstract A73: Antitumor activity of MVT-5873, a monoclonal antibody targeting sialyl Lewisa, alone and in combination with gemcitabine/nab-paclitaxel in a BxPC3 human pancreatic cancer xenograft model
Ragupathi, Govind, Wu, Xiaohong, Livingston, Philip, Scholz, Wolfgang, Kearns, Christine, Maffuid, Paul
Published in Cancer research (Chicago, Ill.) (15.12.2016)
Published in Cancer research (Chicago, Ill.) (15.12.2016)
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Abstract LB196: SPR965, a PI3K/mTORC1/C2 inhibitor for treatment of chordoma
Dugar, Sundeep, Sen, Somdutta, Maffuid, Paul, Freed, Dan, Sommer, Josh, Anderson, Edward, Hickey, Anthony
Published in Cancer research (Chicago, Ill.) (15.06.2022)
Published in Cancer research (Chicago, Ill.) (15.06.2022)
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Abstract B104: A therapeutic antibody candidate against the broadly expressed Tn and STn carbohydrate cancer antigens
Rainey, G Jonah, Sawada, Ritsuko, Jun, Toni, Marinkovic-Petrovic, Aleksandra, Kahn, Ayesha, Scholz, Wolfgang, Maffuid, Paul W.
Published in Molecular cancer therapeutics (01.01.2018)
Published in Molecular cancer therapeutics (01.01.2018)
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Abstract B44: Optimization and IND enabling investigations of MVT-2163 (89Zr-DFO-5B1) leading to First-in-Human readiness
Houghton, Jacob L., Lyashchenko, Serge K., Sawada, Ritsuko, Zanzonico, Pat, Rudge, Scott, Scholz, Wolfgang W., Maffuid, Paul, Lewis, Jason S.
Published in Cancer research (Chicago, Ill.) (15.12.2016)
Published in Cancer research (Chicago, Ill.) (15.12.2016)
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Abstract A062: Using CA19-9 as a translational biomarker for sLea targeted agents MVT-5873 and MVT-1075 in cancer
Jun, H. Toni, Lohrmann, Christian, Allaj, Viola, Scholz, Wolfgang, Rainey, G. Jonah, Weber, Wolfgang A., Lewis, Jason S., Poirier, John, Maffuid, Paul W.
Published in Molecular cancer therapeutics (01.01.2018)
Published in Molecular cancer therapeutics (01.01.2018)
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Abstract 5204: Preclinical development of MVT-1075 as radioimmunotherapy for pancreatic cancer and other CA19-9 positive malignancies
Houghton, Jacob L., Lanning, Ryan, Abdel-atti, Dayla, Jun, Toni, Kearns, Christine M., Schlosser, Michael, Scholz, Wolfgang, Lewis, Jason S., Maffuid, Paul W.
Published in Cancer research (Chicago, Ill.) (01.07.2017)
Published in Cancer research (Chicago, Ill.) (01.07.2017)
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Abstract 3036: PEGylated hyaluronidase increases tumor uptake of 89Zr-DFO-HuMab-5B1 (MVT-2163) in a CA19-9 positive hyaluronan-accumulating pancreatic cancer model
Rainey, Jonah, Maffuid, Paul, Scholz, Wolfgang W., Ostrowski, Jack, Jun, H Toni, Resnick, Paul, Li, Xiaoming, Bahn, Jesse D., Zimmerman, Susan, Chen, Kelly, Blouw, Barbara, Thompson, Curtis B., Maneval, Daniel C., Kang, David W.
Published in Cancer research (Chicago, Ill.) (01.07.2018)
Published in Cancer research (Chicago, Ill.) (01.07.2018)
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Abstract CT140: Phase I dose escalation study of 177Lu-HuMab-5B1 (MVT-1075) in combination with MVT-5873 as radioimmunotherapy (RIT) in subjects with relapsed / refractory pancreatic cancer or other CA19-9+ malignancies
O'Reilly, Eileen A., Lohrmann, Christian, O'Donoghue, Joseph A., Borazanci, Erkut, Estrella, Hayley, Teng, Rebecca, Melink, Terri, Dorr, Kirsten, Kearns, Christine, Peterson, Marvin, Ostrowski, Jack, Gutheil, John, Maffuid, Paul W., Lewis, Jason S., Weber, Wolfgang
Published in Cancer research (Chicago, Ill.) (01.07.2018)
Published in Cancer research (Chicago, Ill.) (01.07.2018)
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HuMab-5B1 (MVT-5873), a mAb targeting sLe a , in combination with first-line gemcitabine plus nab-paclitaxel (gem/nab-P) for patients with pancreatic cancer (PDAC) and other CA19-9 positive malignancies
O'Reilly, Eileen Mary, Borazanci, Erkut Hasan, Yu, Kenneth H., Varghese, Anna M., Estrella, Hayley, Kamins, David, Melink, Teresa, Dorr, Kirsten, Maffuid, Paul, Gutheil, John, Wang, Judy Sing-Zan, Bauer, Todd Michael
Published in Journal of clinical oncology (20.05.2018)
Published in Journal of clinical oncology (20.05.2018)
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First-in-Human Study of ^sup 89^Zr-DFO-HuMab-5B1 (MVT-2163) PET/CT imaging with and without HuMab-5B1 (MVT-5873) in patients with pancreatic cancer and other CA 19-9 positive malignancies
Lohrmann, Christian, O'Reilly, Eileen, ODonoghue, Joseph, Yu, Kenneth H, Pandit-Taskar, Neeta, Lyashchenko, Serge, Ruan, Shutian, Wu, Jiong, DeNoble, Phillip, Carrasquillo, Jorge, Schmidtlein, Charles, Teng, Rebecca, Lowery, Maeve A, Varghese, Anna, Estrella, Hayley, Scholz, Wolfgang, Maffuid, Paul, Lewis, Jason, Weber, Wolfgang
Published in The Journal of nuclear medicine (1978) (01.05.2017)
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Published in The Journal of nuclear medicine (1978) (01.05.2017)
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Biodistribution and radiation rose estimates for ^sup 89^Zr-DFO-HuMab-5B1 (MVT-2163) in CA19-9 positive cancer: first-in-man results
O'Donoghue, Joseph, Lohrmann, Christian, O'Reilly, Eileen, Yu, Kenneth, Lowery, Maeve, Lyashchenko, Serge, Pandit-Taskar, Neeta, Ruan, Shutian, Wu, Lilly, Teng, Rebecca, Schmidtlein, Charles, Carrasquillo, Jorge, Scholz, Wolfgang, Maffuid, Paul, Lewis, Jason, Weber, Wolfgang
Published in The Journal of nuclear medicine (1978) (01.05.2017)
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Published in The Journal of nuclear medicine (1978) (01.05.2017)
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Abstract LB-B25: Preliminary phase I data comparing HuMab-5B1 (MVT-5873), a monoclonal antibody targeting sLea, as a single agent and in combination with first line nab-paclitaxel and gemcitabine in patients with CA19-9 positive pancreatic cancer
O'Reilly, Eileen Mary, Wang, Judy Sing-Zan, Yu, Kenneth H., Lowery, Maeve Aine, Varghese, Anna M., Bendell, Johanna C., Borazanci, Erkut Hasan, Estrella, Hayley, Fowler, Kimberly, Hoskins, Mariella, Bussen, Stephanie, Melink, Teresa J., Kearns, Christine M., Jun, H Toni, Maffuid, Paul W., Gutheil, John C., Bauer, Todd Michael
Published in Molecular cancer therapeutics (01.01.2018)
Published in Molecular cancer therapeutics (01.01.2018)
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Journal Article
Single agent HuMab-5B1 (MVT-5873), a monoclonal antibody targeting sLe a , in patients with pancreatic cancer and other CA19-9 positive malignancies
O'Reilly, Eileen Mary, Wang, Judy Sing-Zan, Yu, Kenneth H., Lowery, Maeve Aine, Varghese, Anna M., Bendell, Johanna C., Borazanci, Erkut Hasan, Estrella, Hayley, Fowler, Kimberly, Hoskin, Mariella, Jun, H. Toni, Melink, Teresa J., Maffuid, Paul, Klein, Pamela, Gutheil, John, Bauer, Todd Michael
Published in Journal of clinical oncology (20.05.2017)
Published in Journal of clinical oncology (20.05.2017)
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Journal Article