Antithrombotic Effects of the Novel Small-Molecule Factor XIa Inhibitor Milvexian in a Rabbit Arteriovenous Shunt Model of Venous Thrombosis
Wang, Xinkang, Li, Qiu, Du, Fuyong, Shukla, Neetu, Nawrocki, Andrea R., Chintala, Madhu
Published in TH open : companion journal to thrombosis and haemostasis (01.04.2023)
Published in TH open : companion journal to thrombosis and haemostasis (01.04.2023)
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Journal Article
Basic and Translational Research on Proteinase-Activated Receptors: Antagonism of the Proteinase-Activated Receptor 1 for Thrombin, a Novel Approach to Antiplatelet Therapy for Atherothrombotic Disease
Chintala, Madhu, Shimizu, Kenji, Ogawa, Masami, Yamaguchi, Hiroya, Doi, Masaki, Jensen, Peder
Published in Journal of Pharmacological Sciences (2008)
Published in Journal of Pharmacological Sciences (2008)
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Discovery of Potent Orally Active Thrombin Receptor (Protease Activated Receptor 1) Antagonists as Novel Antithrombotic Agents
Chackalamannil, Samuel, Xia, Yan, Greenlee, William J, Clasby, Martin, Doller, Darìo, Tsai, Hsingan, Asberom, Theodros, Czarniecki, Michael, Ahn, Ho-Sam, Boykow, George, Foster, Carolyn, Agans-Fantuzzi, Jacqueline, Bryant, Matthew, Lau, Janice, Chintala, Madhu
Published in Journal of medicinal chemistry (22.09.2005)
Published in Journal of medicinal chemistry (22.09.2005)
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Journal Article
Cardiac Expression of Factor X Mediates Cardiac Hypertrophy and Fibrosis in Pressure Overload
Guo, Xinji, Kolpakov, Mikhail A, Hooshdaran, Bahman, Schappell, William, Wang, Tao, Eguchi, Satoru, Elliott, Katherine J, Tilley, Douglas G, Rao, A Koneti, Andrade-Gordon, Patricia, Bunce, Matthew, Madhu, Chintala, Houser, Steven R, Sabri, Abdelkarim
Published in JACC. Basic to translational science (01.01.2020)
Published in JACC. Basic to translational science (01.01.2020)
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Journal Article
Inhibition of Protease-activated Receptor 1 Ameliorates Intestinal Radiation Mucositis in a Preclinical Rat Model
Wang, Junru, MD, PhD, Kulkarni, Ashwini, MS, Chintala, Madhu, PhD, Fink, Louis M., MD, Hauer-Jensen, Martin, MD, PhD
Published in International journal of radiation oncology, biology, physics (01.01.2013)
Published in International journal of radiation oncology, biology, physics (01.01.2013)
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RETRACTED: Cardiac Expression of Factor X Mediates Cardiac Hypertrophy and Fibrosis in Pressure Overload
Guo, Xinji, Kolpakov, Mikhail A., Hooshdaran, Bahman, Schappell, William, Wang, Tao, Eguchi, Satoru, Elliott, Katherine J., Tilley, Douglas G., Rao, A. Koneti, Andrade-Gordon, Patricia, Bunce, Matthew, Madhu, Chintala, Houser, Steven R., Sabri, Abdelkarim
Published in JACC. Basic to translational science (01.01.2020)
Published in JACC. Basic to translational science (01.01.2020)
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Journal Article
Discovery of SCH 900271, a Potent Nicotinic Acid Receptor Agonist for the Treatment of Dyslipidemia
Palani, Anandan, Rao, Ashwin U, Chen, Xiao, Huang, Xianhai, Su, Jing, Tang, Haiqun, Huang, Ying, Qin, Jun, Xiao, Dong, Degrado, Sylvia, Sofolarides, Michael, Zhu, Xiaohong, Liu, Zhidan, McKittrick, Brian, Zhou, Wei, Aslanian, Robert, Greenlee, William J, Senior, Mary, Cheewatrakoolpong, Boonlert, Zhang, Hongtao, Farley, Constance, Cook, John, Kurowski, Stan, Li, Qiu, van Heek, Margaret, Wang, Gangfeng, Hsieh, Yunsheng, Li, Fangbiao, Greenfeder, Scott, Chintala, Madhu
Published in ACS medicinal chemistry letters (12.01.2012)
Published in ACS medicinal chemistry letters (12.01.2012)
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Metabolism-Based Identification of a Potent Thrombin Receptor Antagonist
Clasby, Martin C, Chackalamannil, Samuel, Czarniecki, Michael, Doller, Dario, Eagen, Keith, Greenlee, William, Kao, Grace, Lin, Yan, Tsai, Hsingan, Xia, Yan, Ahn, Ho-Sam, Agans-Fantuzzi, Jacqueline, Boykow, George, Chintala, Madhu, Foster, Carolyn, Smith-Torhan, April, Alton, Kevin, Bryant, Matthew, Hsieh, Yunsheng, Lau, Janice, Palamanda, Jairam
Published in Journal of medicinal chemistry (11.01.2007)
Published in Journal of medicinal chemistry (11.01.2007)
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Molecular identification and characterization of the platelet ADP receptor targeted by thienopyridine antithrombotic drugs
Foster, C J, Prosser, D M, Agans, J M, Zhai, Y, Smith, M D, Lachowicz, J E, Zhang, F L, Gustafson, E, Monsma, Jr, F J, Wiekowski, M T, Abbondanzo, S J, Cook, D N, Bayne, M L, Lira, S A, Chintala, M S
Published in The Journal of clinical investigation (15.06.2001)
Published in The Journal of clinical investigation (15.06.2001)
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Himbacine derived thrombin receptor antagonists: Discovery of a new tricyclic core
Clasby, Martin C., Chackalamannil, Samuel, Czarniecki, Michael, Doller, Darío, Eagen, Keith, Greenlee, William J., Lin, Yan, Tagat, Jayaram R., Tsai, Hsingan, Xia, Yan, Ahn, Ho-Sam, Agans-Fantuzzi, Jacqueline, Boykow, George, Chintala, Madhu, Hsieh, Yunsheng, McPhail, Andrew T.
Published in Bioorganic & medicinal chemistry letters (01.07.2007)
Published in Bioorganic & medicinal chemistry letters (01.07.2007)
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Journal Article
The anticoagulant effects of milvexian, a novel small molecule FXIa inhibitor, are neutralized by aPCC and rFVIIa in human plasma and whole blood in vitro
Bunce, Matthew, Devine, Zheng Huang, Chintala, Madhu
Published in Research and practice in thrombosis and haemostasis (01.10.2024)
Published in Research and practice in thrombosis and haemostasis (01.10.2024)
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Journal Article
Evidence for the Presence of a Proteinase-Activated Receptor Distinct From the Thrombin Receptor in Vascular Endothelial Cells
Hwa, Joyce J, Ghibaudi, Lorraine, Williams, Patricia, Chintala, Madhu, Zhang, Rumin, Chatterjee, Meeta, Sybertz, Edmund
Published in Circulation research (01.04.1996)
Published in Circulation research (01.04.1996)
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Translational PK/PD and model-informed development of JNJ-67842125, a F ab reversal agent for JNJ-64179375, a long-acting thrombin inhibitor
Ayyar, Vivaswath S, Jaiprasart, Pharavee, Geist, Brian, Huang Devine, Zheng, Case, Martin, Hazra, Anasuya, Hsu, Chyi-Hung, Chintala, Madhu, Wang, Weirong
Published in British journal of pharmacology (01.10.2021)
Published in British journal of pharmacology (01.10.2021)
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