A Simple Orthogonal Approach to Poly(phenylenevinylene) Dendrimers
Deb, Shirshendu K, Maddux, Todd M, Yu, Luping
Published in Journal of the American Chemical Society (24.09.1997)
Published in Journal of the American Chemical Society (24.09.1997)
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Journal Article
Stepwise Synthesis of Substituted Oligo(phenylenevinylene) via an Orthogonal Approach
Maddux, Todd, Li, Wenjie, Yu, Luping
Published in Journal of the American Chemical Society (29.01.1997)
Published in Journal of the American Chemical Society (29.01.1997)
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Journal Article
Design, Synthesis, and Biological Evaluation of 3-[4-(2-Hydroxyethyl)piperazin-1-yl]-7-(6-methoxypyridin-3-yl)-1-(2-propoxyethyl)pyrido[3,4-b]pyrazin-2(1H)-one, a Potent, Orally Active, Brain Penetrant Inhibitor of Phosphodiesterase 5 (PDE5)
Hughes, Robert O, Rogier, D. Joseph, Jacobsen, E. Jon, Walker, John K, MacInnes, Alan, Bond, Brian R, Zhang, Lena L, Yu, Ying, Zheng, Yi, Rumsey, Jeanne M, Walgren, Jennie L, Curtiss, Sandra W, Fobian, Yvette M, Heasley, Steven E, Cubbage, Jerry W, Moon, Joseph B, Brown, David L, Acker, Brad A, Maddux, Todd M, Tollefson, Mike B, Mischke, Brent V, Owen, Dafydd R, Freskos, John N, Molyneaux, John M, Benson, Alan G, Blevis-Bal, Rhadika M
Published in Journal of medicinal chemistry (25.03.2010)
Published in Journal of medicinal chemistry (25.03.2010)
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Journal Article
Investigation of aminopyridiopyrazinones as PDE5 inhibitors: Evaluation of modifications to the central ring system
Hughes, Robert O., Walker, John K., Cubbage, Jerry W., Fobian, Yvette M., Rogier, D. Joseph, Heasley, Steve E., Blevis-Bal, Rhadika M., Benson, Alan G., Owen, Dafydd R., Jacobsen, E. Jon, Freskos, John N., Molyneaux, John M., Brown, David L., Stallings, William C., Acker, Brad A., Maddux, Todd M., Tollefson, Mike B., Williams, Jennifer M., Moon, Joseph B., Mischke, Brent V., Rumsey, Jeanne M., Zheng, Yi, MacInnes, Alan, Bond, Brian R., Yu, Ying
Published in Bioorganic & medicinal chemistry letters (01.08.2009)
Published in Bioorganic & medicinal chemistry letters (01.08.2009)
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Identification, synthesis and SAR of amino substituted pyrido[3,2b]pyrazinones as potent and selective PDE5 inhibitors
Owen, Dafydd R., Walker, John K., Jon Jacobsen, E., Freskos, John N., Hughes, Robert O., Brown, David L., Bell, Andrew S., Brown, David G., Phillips, Christopher, Mischke, Brent V., Molyneaux, John M., Fobian, Yvette M., Heasley, Steve E., Moon, Joseph B., Stallings, William C., Joseph Rogier, D., Fox, David N.A., Palmer, Michael J., Ringer, Tracy, Rodriquez-Lens, Margarita, Cubbage, Jerry W., Blevis-Bal, Radhika M., Benson, Alan G., Acker, Brad A., Maddux, Todd M., Tollefson, Michael B., Bond, Brian R., MacInnes, Alan, Yu, Yung
Published in Bioorganic & medicinal chemistry letters (01.08.2009)
Published in Bioorganic & medicinal chemistry letters (01.08.2009)
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Journal Article
Optimization of the aminopyridopyrazinones class of PDE5 inhibitors: Discovery of 3-[( trans-4-hydroxycyclohexyl)amino]-7-(6-methoxypyridin-3-yl)-1-(2-propoxyethyl)pyrido[3,4- b]pyrazin-2(1 H)-one
Hughes, Robert O., Walker, John K., Joseph Rogier, D., Heasley, Steve E., Blevis-Bal, Rhadika M., Benson, Alan G., Jon Jacobsen, E., Cubbage, Jerry W., Fobian, Yvette M., Owen, Dafydd R., Freskos, John N., Molyneaux, John M., Brown, David L., Acker, Brad A., Maddux, Todd M., Tollefson, Mike B., Moon, Joseph B., Mischke, Brent V., Rumsey, Jeanne M., Zheng, Yi, MacInnes, Alan, Bond, Brian R., Yu, Ying
Published in Bioorganic & medicinal chemistry letters (01.09.2009)
Published in Bioorganic & medicinal chemistry letters (01.09.2009)
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Journal Article
면역조정성 아잘라이드
RESPONDEK TOMASZ, MADDUX TODD M, HOT IMELDA, EWIN RICHARD A, COX MARK R
Year of Publication 30.04.2024
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Year of Publication 30.04.2024
Patent
In Pursuit of an Allosteric Human Tropomyosin Kinase A (hTrkA) Inhibitor for Chronic Pain
Subramanian, Govindan, Duclos, Brian, Johnson, Paul D, Williams, Tracey, Ross, Jason T, Bowen, Scott J, Zhu, Yaqi, White, Julie A, Hedke, Carolyn, Huczek, Dennis, Collard, Wendy, Javens, Christopher, Vairagoundar, Rajendran, Respondek, Tomasz, Zachary, Theresa, Maddux, Todd, Cox, Mark R, Kamerling, Steven, Gonzales, Andrea J
Published in ACS medicinal chemistry letters (11.11.2021)
Published in ACS medicinal chemistry letters (11.11.2021)
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면역조절성 유레아 아잘라이드
RESPONDEK TOMASZ, STUK TIMOTHY L, MADDUX TODD M, EWIN RICHARD ANDREW, KYNE GRAHAM M, VAIRAGOUNDAR RAJENDRAN, COX MARK R, JOHNSON PAUL D
Year of Publication 25.11.2022
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Year of Publication 25.11.2022
Patent
내부기생충성 뎁시펩타이드
RESPONDEK TOMASZ, EWIN RICHARD ANDREW, MADDUX TODD, KYNE GRAHAM M, VAIRAGOUNDAR RAJENDRAN, SHEEHAN SUSAN M. K, JOHNSON PAUL D, BEDORE MATTHEW W, CURTIS MICHAEL P
Year of Publication 13.01.2021
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Year of Publication 13.01.2021
Patent
Investigation of the pyrazinones as PDE5 inhibitors: Evaluation of regioisomeric projections into the solvent region
Hughes, Robert O., Maddux, Todd, Joseph Rogier, D., Lu, Sharon, Walker, John K., Jon Jacobsen, E., Rumsey, Jeanne M., Zheng, Yi, MacInnes, Alan, Bond, Brian R., Han, Seungil
Published in Bioorganic & medicinal chemistry letters (01.11.2011)
Published in Bioorganic & medicinal chemistry letters (01.11.2011)
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IMMUNOMODULATING AZALIDES
EWIN, Richard, HOT, Imelda, COX, Mark, RESPONDEK, Tomasz, MADDUX, Todd
Year of Publication 21.03.2024
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Year of Publication 21.03.2024
Patent
IMMUNOMODULATING AZALIDES
EWIN, Richard, HOT, Imelda, COX, Mark, RESPONDEK, Tomasz, MADDUX, Todd
Year of Publication 16.03.2023
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Year of Publication 16.03.2023
Patent