Distinct Regulation of Th17 and Th1 Cell Differentiation by Glutaminase-Dependent Metabolism
Johnson, Marc O., Wolf, Melissa M., Madden, Matthew Z., Andrejeva, Gabriela, Sugiura, Ayaka, Contreras, Diana C., Maseda, Damian, Liberti, Maria V., Paz, Katelyn, Kishton, Rigel J., Johnson, Matthew E., de Cubas, Aguirre A., Wu, Pingsheng, Li, Gongbo, Zhang, Yongliang, Newcomb, Dawn C., Wells, Andrew D., Restifo, Nicholas P., Rathmell, W. Kimryn, Locasale, Jason W., Davila, Marco L., Blazar, Bruce R., Rathmell, Jeffrey C.
Published in Cell (13.12.2018)
Published in Cell (13.12.2018)
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SAMHD1 Promotes DNA End Resection to Facilitate DNA Repair by Homologous Recombination
Daddacha, Waaqo, Koyen, Allyson E., Bastien, Amanda J., Head, PamelaSara E., Dhere, Vishal R., Nabeta, Geraldine N., Connolly, Erin C., Werner, Erica, Madden, Matthew Z., Daly, Michele B., Minten, Elizabeth V., Whelan, Donna R., Schlafstein, Ashley J., Zhang, Hui, Anand, Roopesh, Doronio, Christine, Withers, Allison E., Shepard, Caitlin, Sundaram, Ranjini K., Deng, Xingming, Dynan, William S., Wang, Ya, Bindra, Ranjit S., Cejka, Petr, Rothenberg, Eli, Doetsch, Paul W., Kim, Baek, Yu, David S.
Published in Cell reports (Cambridge) (22.08.2017)
Published in Cell reports (Cambridge) (22.08.2017)
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EZH2 has a non-catalytic and PRC2-independent role in stabilizing DDB2 to promote nucleotide excision repair
Koyen, Allyson E., Madden, Matthew Z., Park, Dongkyoo, Minten, Elizabeth V., Kapoor-Vazirani, Priya, Werner, Erica, Pfister, Neil T., Haji-Seyed-Javadi, Ramona, Zhang, Hui, Xu, Jie, Deng, Nikita, Duong, Duc M., Pecen, Turner J., Frazier, Zoë, Nagel, Zachary D., Lazaro, Jean-Bernard, Mouw, Kent W., Seyfried, Nicholas T., Moreno, Carlos S., Owonikoko, Taofeek K., Deng, Xingming, Yu, David S.
Published in Oncogene (18.06.2020)
Published in Oncogene (18.06.2020)
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ATRIP Deacetylation by SIRT2 Drives ATR Checkpoint Activation by Promoting Binding to RPA-ssDNA
Zhang, Hui, Head, PamelaSara E., Daddacha, Waaqo, Park, Seong-Hoon, Li, Xingzhe, Pan, Yunfeng, Madden, Matthew Z., Duong, Duc M., Xie, Maohua, Yu, Bing, Warren, Matthew D., Liu, Elaine A., Dhere, Vishal R., Li, Chunyang, Pradilla, Ivan, Torres, Mylin A., Wang, Ya, Dynan, William S., Doetsch, Paul W., Deng, Xingming, Seyfried, Nicholas T., Gius, David, Yu, David S.
Published in Cell reports (Cambridge) (16.02.2016)
Published in Cell reports (Cambridge) (16.02.2016)
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Stimulating TAM-mediated anti-tumor immunity with mannose-decorated nanoparticles in ovarian cancer
Glass, Evan B, Hoover, Alyssa A, Bullock, Kennady K, Madden, Matthew Z, Reinfeld, Bradley I, Harris, Whitney, Parker, Dominique, Hufnagel, Demetra H, Crispens, Marta A, Khabele, Dineo, Rathmell, W Kimryn, Rathmell, Jeffrey C, Wilson, Andrew J, Giorgio, Todd D, Yull, Fiona E
Published in BMC cancer (06.05.2022)
Published in BMC cancer (06.05.2022)
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Cell-programmed nutrient partitioning in the tumour microenvironment
Reinfeld, Bradley I., Madden, Matthew Z., Wolf, Melissa M., Chytil, Anna, Bader, Jackie E., Patterson, Andrew R., Sugiura, Ayaka, Cohen, Allison S., Ali, Ahmed, Do, Brian T., Muir, Alexander, Lewis, Caroline A., Hongo, Rachel A., Young, Kirsten L., Brown, Rachel E., Todd, Vera M., Huffstater, Tessa, Abraham, Abin, O’Neil, Richard T., Wilson, Matthew H., Xin, Fuxue, Tantawy, M. Noor, Merryman, W. David, Johnson, Rachelle W., Williams, Christopher S., Mason, Emily F., Mason, Frank M., Beckermann, Katherine E., Vander Heiden, Matthew G., Manning, H. Charles, Rathmell, Jeffrey C., Rathmell, W. Kimryn
Published in Nature (London) (13.05.2021)
Published in Nature (London) (13.05.2021)
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Single-cell analysis by mass cytometry reveals metabolic states of early-activated CD8+ T cells during the primary immune response
Levine, Lauren S., Hiam-Galvez, Kamir J., Marquez, Diana M., Tenvooren, Iliana, Madden, Matthew Z., Contreras, Diana C., Dahunsi, Debolanle O., Irish, Jonathan M., Oluwole, Olalekan O., Rathmell, Jeffrey C., Spitzer, Matthew H.
Published in Immunity (Cambridge, Mass.) (13.04.2021)
Published in Immunity (Cambridge, Mass.) (13.04.2021)
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MTHFD2 is a metabolic checkpoint controlling effector and regulatory T cell fate and function
Sugiura, Ayaka, Andrejeva, Gabriela, Voss, Kelsey, Heintzman, Darren R., Xu, Xincheng, Madden, Matthew Z., Ye, Xiang, Beier, Katherine L., Chowdhury, Nowrin U., Wolf, Melissa M., Young, Arissa C., Greenwood, Dalton L., Sewell, Allison E., Shahi, Shailesh K., Freedman, Samantha N., Cameron, Alanna M., Foerch, Patrik, Bourne, Tim, Garcia-Canaveras, Juan C., Karijolich, John, Newcomb, Dawn C., Mangalam, Ashutosh K., Rabinowitz, Joshua D., Rathmell, Jeffrey C.
Published in Immunity (Cambridge, Mass.) (11.01.2022)
Published in Immunity (Cambridge, Mass.) (11.01.2022)
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Leptin Augments Antitumor Immunity in Obesity by Repolarizing Tumor-Associated Macrophages
Dudzinski, Stephanie O, Bader, Jackie E, Beckermann, Kathryn E, Young, Kirsten L, Hongo, Rachel, Madden, Matthew Z, Abraham, Abin, Reinfeld, Bradley I, Ye, Xiang, MacIver, Nancie J, Giorgio, Todd D, Rathmell, Jeffrey C
Published in The Journal of immunology (1950) (15.12.2021)
Published in The Journal of immunology (1950) (15.12.2021)
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Macrophages Promote Aortic Valve Cell Calcification and Alter STAT3 Splicing
Raddatz, Michael A, Huffstater, Tessa, Bersi, Matthew R, Reinfeld, Bradley I, Madden, Matthew Z, Booton, Sabrina E, Rathmell, W Kimryn, Rathmell, Jeffrey C, Lindman, Brian R, Madhur, Meena S, Merryman, W David
Published in Arteriosclerosis, thrombosis, and vascular biology (01.06.2020)
Published in Arteriosclerosis, thrombosis, and vascular biology (01.06.2020)
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Differential Effects of Glutamine Inhibition Strategies on Antitumor CD8 T Cells
Madden, Matthew Z, Ye, Xiang, Chi, Channing, Fisher, Emilie L, Wolf, Melissa M, Needle, Gabriel A, Bader, Jackie E, Patterson, Andrew R, Reinfeld, Bradley I, Landis, Madelyn D, Hathaway, Emma S, Muka, Jason E, O'Neil, Richard T, Karijolich, John, Philip, Mary, Rathmell, Jeffrey C
Published in The Journal of immunology (1950) (15.08.2023)
Published in The Journal of immunology (1950) (15.08.2023)
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Obesity induces PD-1 on macrophages to suppress anti-tumour immunity
Bader, Jackie E., Wolf, Melissa M., Lupica-Tondo, Gian Luca, Madden, Matthew Z., Reinfeld, Bradley I., Arner, Emily N., Hathaway, Emma S., Steiner, KayLee K., Needle, Gabriel A., Hatem, Zaid, Landis, Madelyn D., Faneuff, Eden E., Blackman, Amondrea, Wolf, Elysa M., Cottam, Matthew A., Ye, Xiang, Bates, Madison E., Smart, Kyra, Wang, Wenjun, Pinheiro, Laura V., Christofides, Anthos, Smith, DuPreez, Boussiotis, Vassiliki A., Haake, Scott M., Beckermann, Kathryn E., Wellen, Kathryn E., Reinhart-King, Cynthia A., Serezani, C. Henrique, Lee, Cheng-Han, Aubrey, Christa, Chen, Heidi, Rathmell, W. Kimryn, Hasty, Alyssa H., Rathmell, Jeffrey C.
Published in Nature (London) (27.06.2024)
Published in Nature (London) (27.06.2024)
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Journal Article
Author Correction: Obesity induces PD-1 on macrophages to suppress anti-tumour immunity
Bader, Jackie E., Wolf, Melissa M., Lupica-Tondo, Gian Luca, Madden, Matthew Z., Reinfeld, Bradley I., Arner, Emily N., Hathaway, Emma S., Steiner, KayLee K., Needle, Gabriel A., Hatem, Zaid, Landis, Madelyn D., Faneuff, Eden E., Blackman, Amondrea, Wolf, Elysa M., Cottam, Matthew A., Ye, Xiang, Bates, Madison E., Smart, Kyra, Wang, Wenjun, Pinheiro, Laura V., Christofides, Anthos, Smith, DuPreez, Boussiotis, Vassiliki A., Haake, Scott M., Beckermann, Kathryn E., Wellen, Kathryn E., Reinhart-King, Cynthia A., Serezani, C. Henrique, Lee, Cheng-Han, Aubrey, Christa, Chen, Heidi, Rathmell, W. Kimryn, Hasty, Alyssa H., Rathmell, Jeffrey C.
Published in Nature (London) (25.07.2024)
Published in Nature (London) (25.07.2024)
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Targeting In Vivo Metabolic Vulnerabilities of Th2 and Th17 Cells Reduces Airway Inflammation
Healey, Diana C Contreras, Cephus, Jacqueline Y, Barone, Sierra M, Chowdhury, Nowrin U, Dahunsi, Debolanle O, Madden, Matthew Z, Ye, Xiang, Yu, Xuemei, Olszewski, Kellen, Young, Kirsten, Gerriets, Valerie A, Siska, Peter J, Dworski, Ryszard, Hemler, Jonathan, Locasale, Jason W, Poyurovsky, Masha V, Peebles, Jr, R Stokes, Irish, Jonathan M, Newcomb, Dawn C, Rathmell, Jeffrey C
Published in The Journal of immunology (1950) (15.03.2021)
Published in The Journal of immunology (1950) (15.03.2021)
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VHL loss reprograms the immune landscape to promote an inflammatory myeloid microenvironment in renal tumorigenesis
Wolf, Melissa M, Madden, Matthew Z, Arner, Emily N, Bader, Jackie E, Ye, Xiang, Vlach, Logan, Tigue, Megan L, Landis, Madelyn D, Jonker, Patrick B, Hatem, Zaid, Steiner, KayLee K, Gaines, Dakim K, Reinfeld, Bradley I, Hathaway, Emma S, Xin, Fuxue, Tantawy, M Noor, Haake, Scott M, Jonasch, Eric, Muir, Alexander, Weiss, Vivian L, Beckermann, Kathryn E, Rathmell, W Kimryn, Rathmell, Jeffrey C
Published in The Journal of clinical investigation (15.04.2024)
Published in The Journal of clinical investigation (15.04.2024)
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STING-activating nanoparticles normalize the vascular-immune interface to potentiate cancer immunotherapy
Wang-Bishop, Lihong, Kimmel, Blaise R, Ngwa, Verra M, Madden, Matthew Z, Baljon, Jessalyn J, Florian, David C, Hanna, Ann, Pastora, Lucinda E, Sheehy, Taylor L, Kwiatkowski, Alexander J, Wehbe, Mohamed, Wen, Xiaona, Becker, Kyle W, Garland, Kyle M, Schulman, Jacob A, Shae, Daniel, Edwards, Deanna, Wolf, Melissa M, Delapp, Rossane, Christov, Plamen P, Beckermann, Kathryn E, Balko, Justin M, Rathmell, W Kimryn, Rathmell, Jeffrey C, Chen, Jin, Wilson, John T
Published in Science immunology (12.05.2023)
Published in Science immunology (12.05.2023)
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A gemcitabine sensitivity screen identifies a role for NEK9 in the replication stress response
Smith, Scott C, Petrova, Aleksandra V, Madden, Matthew Z, Wang, Hongyan, Pan, Yunfeng, Warren, Matthew D, Hardy, Claire W, Liang, Dong, Liu, Elaine A, Robinson, M Hope, Rudra, Soumon, Wang, Jie, Ehdaivand, Shahrzad, Torres, Mylin A, Wang, Ya, Yu, David S
Published in Nucleic acids research (13.10.2014)
Published in Nucleic acids research (13.10.2014)
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CHD7 Expression Predicts Survival Outcomes in Patients with Resected Pancreatic Cancer
COLBERT, Lauren E, PETROVA, Aleksandra V, SAKA, Burcu, HALL, William A, SHELTON, Joseph W, GANDHI, Khanjan, PAULY, Rini, KOWALSKI, Jeanne, KOOBY, David A, EL-RAYES, Bassel F, STALEY, Charles A, ADSAY, N. Volkan, FISHER, Sarah B, CURRAN, Walter J, LANDRY, Jerome C, MAITHEL, Shishir K, YU, David S, PANTAZIDES, Brooke G, MADDEN, Matthew Z, HARDY, Claire W, WARREN, Matthew D, YUNFENG PAN, NAGARAJU, Ganji P, LIU, Elaine A
Published in Cancer research (Chicago, Ill.) (15.05.2014)
Published in Cancer research (Chicago, Ill.) (15.05.2014)
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Androgen signaling restricts glutaminolysis to drive sex-specific Th17 metabolism in allergic airway inflammation
Chowdhury, Nowrin U, Cephus, Jacqueline-Yvonne, Henriquez Pilier, Emely, Wolf, Melissa M, Madden, Matthew Z, Kuehnle, Shelby N, McKernan, Kaitlin E, Jennings, Erin Q, Arner, Emily N, Heintzman, Darren R, Chi, Channing, Sugiura, Ayaka, Stier, Matthew T, Voss, Kelsey, Ye, Xiang, Scales, Kennedi L, Krystofiak, Evan S, Gandhi, Vivek D, Guzy, Robert D, Cahill, Katherine N, Sperling, Anne I, Peebles, Jr, R Stokes, Rathmell, Jeffrey C, Newcomb, Dawn C
Published in The Journal of clinical investigation (01.10.2024)
Published in The Journal of clinical investigation (01.10.2024)
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