The Mechanism of Cellulose Hydrolysis by a Two-Step, Retaining Cellobiohydrolase Elucidated by Structural and Transition Path Sampling Studies
Knott, Brandon C, Haddad Momeni, Majid, Crowley, Michael F, Mackenzie, Lloyd F, Götz, Andreas W, Sandgren, Mats, Withers, Stephen G, Ståhlberg, Jerry, Beckham, Gregg T
Published in Journal of the American Chemical Society (08.01.2014)
Published in Journal of the American Chemical Society (08.01.2014)
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Journal Article
AQX‐1125, small molecule SHIP1 activator inhibits bleomycin‐induced pulmonary fibrosis
Cross, Jennifer, Stenton, Grant R, Harwig, Curtis, Szabo, Csaba, Genovese, Tiziana, Di Paola, Rosanna, Esposito, Emanuale, Cuzzocrea, Salvatore, Mackenzie, Lloyd F
Published in British journal of pharmacology (01.09.2017)
Published in British journal of pharmacology (01.09.2017)
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Journal Article
Characterization of AQX-1125, a small-molecule SHIP1 activator: Part 1. Effects on inflammatory cell activation and chemotaxis in vitro and pharmacokinetic characterization in vivo
Stenton, Grant R, Mackenzie, Lloyd F, Tam, Patrick, Cross, Jennifer L, Harwig, Curtis, Raymond, Jeffrey, Toews, Judy, Wu, Joyce, Ogden, Nancy, MacRury, Thomas, Szabo, Csaba
Published in British journal of pharmacology (01.03.2013)
Published in British journal of pharmacology (01.03.2013)
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Journal Article
Characterization of AQX-1125, a small-molecule SHIP1 activator: Part 2. Efficacy studies in allergic and pulmonary inflammation models in vivo
Stenton, Grant R, Mackenzie, Lloyd F, Tam, Patrick, Cross, Jennifer L, Harwig, Curtis, Raymond, Jeffrey, Toews, Judy, Chernoff, David, MacRury, Thomas, Szabo, Csaba
Published in British journal of pharmacology (01.03.2013)
Published in British journal of pharmacology (01.03.2013)
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Journal Article
Crystal structure of the family 7 endoglucanase I (Cel7B) from Humicola insolens at 2.2 A resolution and identification of the catalytic nucleophile by trapping of the covalent glycosyl-enzyme intermediate
MacKenzie, L F, Sulzenbacher, G, Divne, C, Jones, T A, Wöldike, H F, Schülein, M, Withers, S G, Davies, G J
Published in Biochemical journal (15.10.1998)
Published in Biochemical journal (15.10.1998)
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Journal Article
The Crystal Structure of a 2-Fluorocellotriosyl Complex of the Streptomyces lividans Endoglucanase CelB2 at 1.2 Å Resolution
Sulzenbacher, Gerlind, Mackenzie, Lloyd F, Wilson, Keith S, Withers, Stephen G, Dupont, Claude, Davies, Gideon J
Published in Biochemistry (Easton) (13.04.1999)
Published in Biochemistry (Easton) (13.04.1999)
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Journal Article
Glycosynthases: Mutant Glycosidases for Oligosaccharide Synthesis
Mackenzie, Lloyd F, Wang, Qingping, Warren, R. Antony J, Withers, Stephen G
Published in Journal of the American Chemical Society (10.06.1998)
Published in Journal of the American Chemical Society (10.06.1998)
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Journal Article
Synthesis of SHIP1-Activating Analogs of the Sponge Meroterpenoid Pelorol
Meimetis, Labros G., Nodwell, Matt, Yang, Lu, Wang, Xiaoxia, Wu, Joyce, Harwig, Curtis, Stenton, Grant R., Mackenzie, Lloyd F., MacRury, Thomas, Patrick, Brian O., Ming-Lum, Andrew, Ong, Christopher J., Krystal, Gerald, Mui, Alice L. -F., Andersen, Raymond J.
Published in European journal of organic chemistry (01.09.2012)
Published in European journal of organic chemistry (01.09.2012)
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Journal Article
Characterization of AQX‐1125, a small‐molecule SHIP1 activator
Stenton, Grant R, Mackenzie, Lloyd F, Tam, Patrick, Cross, Jennifer L, Harwig, Curtis, Raymond, Jeffrey, Toews, Judy, Wu, Joyce, Ogden, Nancy, MacRury, Thomas, Szabo, Csaba
Published in British journal of pharmacology (01.03.2013)
Published in British journal of pharmacology (01.03.2013)
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Journal Article
Characterization of AQX‐1125, a small‐molecule SHIP1 activator
Stenton, Grant R, Mackenzie, Lloyd F, Tam, Patrick, Cross, Jennifer L, Harwig, Curtis, Raymond, Jeffrey, Toews, Judy, Chernoff, David, MacRury, Thomas, Szabo, Csaba
Published in British journal of pharmacology (01.03.2013)
Published in British journal of pharmacology (01.03.2013)
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Journal Article
SHIP1 SHIP1 MODULATORS AND METHODS RELATED THERETO
RAYMOND JEFFERY R, BOGUCKI DAVID, MACKENZIE LLOYD F, MACRURY THOMAS B, HARWIG CURTIS, PETTIGREW JEREMY D
Year of Publication 05.08.2022
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Year of Publication 05.08.2022
Patent
SHIP1 SHIP1 MODULATORS AND METHODS RELATED THERETO
RAYMOND JEFFERY R, BOGUCKI DAVID, MACKENZIE LLOYD F, MACRURY THOMAS B, HARWIG CURTIS, PETTIGREW JEREMY D
Year of Publication 06.10.2021
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Year of Publication 06.10.2021
Patent
SHIP1 MODULATORS AND METHODS RELATED THERETO
RAYMOND JEFFERY R, BOGUCKI DAVID, MACKENZIE LLOYD F, HARWIG CURTIS, PETTIGREW JEREMY D
Year of Publication 23.11.2015
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Year of Publication 23.11.2015
Patent
SHIP1 MODULATORS AND METHODS RELATED THERETO
RAYMOND JEFFERY R, BOGUCKI DAVID, MACKENZIE LLOYD F, MACRURY THOMAS B, HARWIG CURTIS, PETTIGREW JEREMY D
Year of Publication 16.11.2015
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Year of Publication 16.11.2015
Patent
SHIP1 MODULATORS AND METHODS RELATED THERETO
RAYMOND JEFFERY R, BOGUCKI DAVID, MACKENZIE LLOYD F, MACRURY THOMAS B, HARWIG CURTIS, KHLEBNIKOV VLADIMIR, SHAN RUDONG, PETTIGREW JEREMY D
Year of Publication 22.09.2015
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Year of Publication 22.09.2015
Patent
MP39-13 AN OPEN-LABEL, TWO-PART, SEQUENTIAL DOSE STUDY ASSESSING THE ABSOLUTE BIOAVAILABILITY, MASS BALANCE, AND RECOVERY FOR [14C]-ROSIPTOR (AQX-1125) IN HEALTHY SUBJECTS
Tam, Patrick, Scholl, Dorothea, Toews, Judy, Harwig, Curtis, Mackenzie, Lloyd F
Published in The Journal of urology (01.04.2018)
Published in The Journal of urology (01.04.2018)
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Journal Article
Preclinical Evaluation of a Novel SHIP1 Phosphatase Activator for Inhibition of PI3K Signaling in Malignant B Cells
Lemm, Elizabeth A, Valle-Argos, Beatriz, Smith, Lindsay D, Richter, Johanna, Gebreselassie, Yohannes, Carter, Matthew J, Karolova, Jana, Svaton, Michael, Helman, Karel, Weston-Bell, Nicola J, Karydis, Laura, Williamson, Chris T, Lenz, Georg, Pettigrew, Jeremy, Harwig, Curtis, Stevenson, Freda K, Cragg, Mark, Forconi, Francesco, Steele, Andrew J, Cross, Jennifer, Mackenzie, Lloyd, Klener, Pavel, Packham, Graham
Published in Clinical cancer research (01.04.2020)
Published in Clinical cancer research (01.04.2020)
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Journal Article
The cellulose-binding domains from Cellulomonas fimi β-1,4-glucanase CenC bind nitroxide spin-labeled cellooligosaccharides in multiple orientations
Johnson, Philip E., Brun, Emmanuel, MacKenzie, Lloyd F., Withers, Stephen G., McIntosh, Lawrence P.
Published in Journal of molecular biology (02.04.1999)
Published in Journal of molecular biology (02.04.1999)
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Journal Article
Enzymatic synthesis of disaccharides using Agrobacterium sp. β-glucosidase
Prade, Heiko, Mackenzie, Lloyd F., Withers, Stephen G.
Published in Carbohydrate research (01.12.1997)
Published in Carbohydrate research (01.12.1997)
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