novel, small molecule inhibitor of Hsc70/Hsp70 potentiates Hsp90 inhibitor induced apoptosis in HCT116 colon carcinoma cells
Massey, Andrew J, Williamson, Douglas S, Browne, Helen, Murray, James B, Dokurno, Pawel, Shaw, Terry, Macias, Alba T, Daniels, Zoe, Geoffroy, Stephanie, Dopson, Melanie, Lavan, Paul, Matassova, Natalia, Francis, Geraint L, Graham, Christopher J, Parsons, Rachel, Wang, Yikang, Padfield, Antony, Comer, Mike, Drysdale, Martin J, Wood, Mike
Published in Cancer chemotherapy and pharmacology (01.08.2010)
Published in Cancer chemotherapy and pharmacology (01.08.2010)
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Journal Article
Characterization of ATP-independent ERK inhibitors identified through in silico analysis of the active ERK2 structure
Chen, Fengming, Hancock, Chad N., Macias, Alba T., Joh, Joseph, Still, Kimberly, Zhong, Shijun, MacKerell, Alexander D., Shapiro, Paul
Published in Bioorganic & medicinal chemistry letters (15.12.2006)
Published in Bioorganic & medicinal chemistry letters (15.12.2006)
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Journal Article
Novel Adenosine-Derived Inhibitors of 70 kDa Heat Shock Protein, Discovered Through Structure-Based Design
Williamson, Douglas S, Borgognoni, Jenifer, Clay, Alexandra, Daniels, Zoe, Dokurno, Pawel, Drysdale, Martin J, Foloppe, Nicolas, Francis, Geraint L, Graham, Christopher J, Howes, Rob, Macias, Alba T, Murray, James B, Parsons, Rachel, Shaw, Terry, Surgenor, Allan E, Terry, Lindsey, Wang, Yikang, Wood, Mike, Massey, Andrew J
Published in Journal of medicinal chemistry (26.03.2009)
Published in Journal of medicinal chemistry (26.03.2009)
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Journal Article
Adenosine-Derived Inhibitors of 78 kDa Glucose Regulated Protein (Grp78) ATPase: Insights into Isoform Selectivity
Macias, Alba T, Williamson, Douglas S, Allen, Nicola, Borgognoni, Jenifer, Clay, Alexandra, Daniels, Zoe, Dokurno, Pawel, Drysdale, Martin J, Francis, Geraint L, Graham, Christopher J, Howes, Rob, Matassova, Natalia, Murray, James B, Parsons, Rachel, Shaw, Terry, Surgenor, Allan E, Terry, Lindsey, Wang, Yikang, Wood, Mike, Massey, Andrew J
Published in Journal of medicinal chemistry (23.06.2011)
Published in Journal of medicinal chemistry (23.06.2011)
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Journal Article
A covalent fragment-based strategy targeting a novel cysteine to inhibit activity of mutant EGFR kinase
Kuki, Naoki, Walmsley, David L, Kanai, Kazuo, Takechi, Sho, Yoshida, Masao, Murakami, Ryo, Takano, Kohei, Tominaga, Yuichi, Takahashi, Mizuki, Ito, Shuichiro, Nakao, Naoki, Angove, Hayley, Baker, Lisa M, Carter, Edward, Dokurno, Pawel, Le Strat, Loic, Macias, Alba T, Molyneaux, Carrie-Anne, Murray, James B, Surgenor, Allan E, Hamada, Tomoaki, Hubbard, Roderick E
Published in MedChemComm (13.12.2023)
Published in MedChemComm (13.12.2023)
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Journal Article
Application of Off-Rate Screening in the Identification of Novel Pan-Isoform Inhibitors of Pyruvate Dehydrogenase Kinase
Brough, Paul A, Baker, Lisa, Bedford, Simon, Brown, Kirsten, Chavda, Seema, Chell, Victoria, D’Alessandro, Jalanie, Davies, Nicholas G. M, Davis, Ben, Le Strat, Loic, Macias, Alba T, Maddox, Daniel, Mahon, Patrick C, Massey, Andrew J, Matassova, Natalia, McKenna, Sean, Meissner, Johannes W. G, Moore, Jonathan D, Murray, James B, Northfield, Christopher J, Parry, Charles, Parsons, Rachel, Roughley, Stephen D, Shaw, Terry, Simmonite, Heather, Stokes, Stephen, Surgenor, Allan, Stefaniak, Emma, Robertson, Alan, Wang, Yikang, Webb, Paul, Whitehead, Neil, Wood, Mike
Published in Journal of medicinal chemistry (23.03.2017)
Published in Journal of medicinal chemistry (23.03.2017)
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Journal Article
CH/π interactions involving aromatic amino acids: Refinement of the CHARMM tryptophan force field
Macias, Alba T., MacKerell, Alexander D.
Published in Journal of computational chemistry (15.11.2005)
Published in Journal of computational chemistry (15.11.2005)
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Journal Article
Fatty acid amide hydrolase inhibitors. Surprising selectivity of chiral azetidine ureas
Hart, Terance, Macias, Alba T., Benwell, Karen, Brooks, Teresa, D’Alessandro, Jalanie, Dokurno, Pawel, Francis, Geraint, Gibbons, Ben, Haymes, Timothy, Kennett, Guy, Lightowler, Sean, Mansell, Howard, Matassova, Natalia, Misra, Anil, Padfield, Anthony, Parsons, Rachel, Pratt, Robert, Robertson, Alan, Walls, Steven, Wong, Melanie, Roughley, Stephen
Published in Bioorganic & medicinal chemistry letters (01.08.2009)
Published in Bioorganic & medicinal chemistry letters (01.08.2009)
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Journal Article
Fatty acid amide hydrolase inhibitors. 3: Tetra-substituted azetidine ureas with in vivo activity
Roughley, Stephen D., Browne, Helen, Macias, Alba T., Benwell, Karen, Brooks, Teresa, D’Alessandro, Jalanie, Daniels, Zoe, Dugdale, Sarah, Francis, Geraint, Gibbons, Ben, Hart, Terance, Haymes, Timothy, Kennett, Guy, Lightowler, Sean, Matassova, Natalia, Mansell, Howard, Merrett, Angela, Misra, Anil, Padfield, Anthony, Parsons, Rachel, Pratt, Robert, Robertson, Alan, Simmonite, Heather, Tan, Kiri, Walls, Steven B., Wong, Melanie
Published in Bioorganic & medicinal chemistry letters (15.01.2012)
Published in Bioorganic & medicinal chemistry letters (15.01.2012)
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Journal Article
Lead Validation and SAR Development via Chemical Similarity Searching; Application to Compounds Targeting the pY+3 Site of the SH2 Domain of p56lck
Macias, Alba T, Mia, Md. Younus, Xia, Guanjun, Hayashi, Jun, MacKerell, Alexander D
Published in Journal of chemical information and modeling (01.11.2005)
Published in Journal of chemical information and modeling (01.11.2005)
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Journal Article
3-Chloropropanoic acid (UMB66): a ligand for the gamma-hydroxybutyric acid receptor lacking a 4-hydroxyl group
Macias, Alba T, Hernandez, R.Jason, Mehta, Ashok K, MacKerell, Alexander D, Ticku, Maharaj K, Coop, Andrew
Published in Bioorganic & medicinal chemistry (01.04.2004)
Published in Bioorganic & medicinal chemistry (01.04.2004)
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Journal Article
Computational Studies of Inclusion Phenomena and Synthesis of a Novel and Selective Molecular Receptor for 1,4-Disubstituted Benzenes and 4,4‘-Disubstituted Biphenyls
Macias, Alba T, Kumar, Kaipenchery A, Marchand, Alan P, Evanseck, Jeffrey D
Published in Journal of organic chemistry (07.04.2000)
Published in Journal of organic chemistry (07.04.2000)
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Journal Article
Abstract A212: A novel, small molecule inhibitor of Hsc70/Hsp70 potentiates Hsp90 inhibitor-induced apoptosis in HCT116 colon carcinoma cells
Massey, Andrew J., Borgognoni, Jennifer, Browne, Helen, Daniels, Zoe, Dokurno, Pawel, Drysdale, Martin J., Francis, Geraint L., Graham, Christopher J., Macias, Alba T., Matassova, Natalia, Murray, James B., Parsons, Rachel, Shaw, Terry, Wang, Yikang, Wood, Mike, Williamson, Douglas
Published in Molecular cancer therapeutics (10.12.2009)
Published in Molecular cancer therapeutics (10.12.2009)
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Journal Article
Lead Validation and SAR Development via Chemical Similarity Searching; Application to Compounds Targeting the pY+3 Site of the SH2 Domain of p56 lck
Macias, Alba T., Mia, Md. Younus, Xia, Guanjun, Hayashi, Jun, MacKerell, Alexander D.
Published in Journal of chemical information and modeling (01.11.2005)
Published in Journal of chemical information and modeling (01.11.2005)
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Journal Article
AMINO-PYRIMIDONYL DERIVATIVES, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
WEBER CHARLOTTA, MOLNAR BALAZS, DAVIES NICHOLAS, KISS ARPAD, MACIAS ALBA, IVANSCHITZ LISA, KOTSCHY ANDRAS, SELLIER EMILIE, DEMARLES DIDIER, GENESTE OLIVIER, VASAS ATTILA, MURRAY JAMES BROOKE, FIUMANA ANDREA
Year of Publication 12.02.2021
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Year of Publication 12.02.2021
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