Preclinical Safety Evaluation of AAV2-sFLT01— A Gene Therapy for Age-related Macular Degeneration
MacLachlan, Timothy K, Lukason, Michael, Collins, Margaret, Munger, Robert, Isenberger, Elisabete, Rogers, Cindy, Malatos, Shana, DuFresne, Elizabeth, Morris, James, Calcedo, Roberto, Veres, Gabor, Scaria, Abraham, Andrews, Laura, Wadsworth, Samuel
Published in Molecular therapy (01.02.2011)
Published in Molecular therapy (01.02.2011)
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Journal Article
The Bespoke Gene Therapy Consortium: facilitating development of AAV gene therapies for rare diseases
Brooks, P J, Miller, Timothy M, Revah, Frédéric, Suh, Junghae, Garrison, Bradley R, Starke, Lawrence C, MacLachlan, Timothy K, Neilan, Edward G, Raychaudhuri, Gopa, Kassim, Sadik H, Dehdashti, Jean, Rutter, Joni L
Published in Nature reviews. Drug discovery (01.03.2024)
Published in Nature reviews. Drug discovery (01.03.2024)
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Classic and evolving approaches to evaluating cross reactivity of mAb and mAb-like molecules – A survey of industry 2008–2019
MacLachlan, Timothy K., Price, Shari, Cavagnaro, Joy, Andrews, Laura, Blanset, Diann, Cosenza, Mary Ellen, Dempster, Maggie, Galbreath, Elizabeth, Giusti, Anna Maria, Heinz-Taheny, Kathleen Marie, Fleurance, Renaud, Sutter, Esther, Leach, Michael W.
Published in Regulatory toxicology and pharmacology (01.04.2021)
Published in Regulatory toxicology and pharmacology (01.04.2021)
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Challenges and opportunities for the future of monoclonal antibody development: Improving safety assessment and reducing animal use
Sewell, Fiona, Chapman, Kathryn, Couch, Jessica, Dempster, Maggie, Heidel, Shawn, Loberg, Lise, Maier, Curtis, Maclachlan, Timothy K, Todd, Marque, van der Laan, Jan Willem
Published in mAbs (04.07.2017)
Published in mAbs (04.07.2017)
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Journal Article
Industry experiences with immune-mediated findings in biotherapeutic nonclinical toxicology studies
MacLachlan, Timothy K., Kronenberg, Sven, Marshall, Nikki, Andrews, Laura, Berens, Shawn Jay, Brouta, Frederic, Fogal, Birgit, Freebern, Wendy, Herzyk, Danuta, Kamperschroer, Cris, Kiessling, Andrea, Schneidkraut, Marlowe, Maier, Curtis
Published in Regulatory toxicology and pharmacology (01.02.2021)
Published in Regulatory toxicology and pharmacology (01.02.2021)
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Journal Article
Inhibition of Choroidal Neovascularization in a Nonhuman Primate Model by Intravitreal Administration of an AAV2 Vector Expressing a Novel Anti-VEGF Molecule
Lukason, Michael, DuFresne, Elizabeth, Rubin, Hillard, Pechan, Peter, Li, Qiuhong, Kim, Ivana, Kiss, Szilard, Flaxel, Christina, Collins, Margaret, Miller, Joan, Hauswirth, William, MacLachlan, Timothy, Wadsworth, Samuel, Scaria, Abraham
Published in Molecular therapy (01.02.2011)
Published in Molecular therapy (01.02.2011)
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Journal Article
Inflammation and immunogenicity limit the utility of the rabbit as a nonclinical species for ocular biologic therapeutics
de Zafra, Christina L.Zuch, Sasseville, Vito G., Matsumoto, Steven, Freichel, Christian, Milton, Mark, MacLachlan, Timothy K., Farman, Cindy, Raymond, Iona, Gupta, Swati, Newton, Ronald, Atzpodien, Elke-Astrid, Thackaberry, Evan A.
Published in Regulatory toxicology and pharmacology (01.06.2017)
Published in Regulatory toxicology and pharmacology (01.06.2017)
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Journal Article
Nonclinical Safety Evaluation of scAAV8- RLBP1 for Treatment of RLBP1 Retinitis Pigmentosa
MacLachlan, Timothy K, Milton, Mark N, Turner, Oliver, Tukov, Francis, Choi, Vivian W, Penraat, Jan, Delmotte, Marie-Hélène, Michaut, Lydia, Jaffee, Bruce D, Bigelow, Chad E
Published in Molecular therapy. Methods & clinical development (16.03.2018)
Published in Molecular therapy. Methods & clinical development (16.03.2018)
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Journal Article
Apoptotic Threshold is Lowered by p53 Transactivation of Caspase-6
MacLachlan, Timothy K., El-Deiry, Wafik S.
Published in Proceedings of the National Academy of Sciences - PNAS (09.07.2002)
Published in Proceedings of the National Academy of Sciences - PNAS (09.07.2002)
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Journal Article
Storm forecasting: additional lessons from the CD28 superagonist TGN1412 trial
Horvath, Christopher, Andrews, Laura, Baumann, Andreas, Black, Lauren, Blanset, Diann, Cavagnaro, Joy, Hastings, Kenneth L, Hutto, David L, MacLachlan, Timothy K, Milton, Mark, Reynolds, Theresa, Roberts, Stan, Rogge, Mark, Sims, Jennifer, Treacy, George, Warner, Garvin, Green, James D
Published in Nature reviews. Immunology (01.10.2012)
Published in Nature reviews. Immunology (01.10.2012)
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Journal Article
Nonclinical Evaluation of GMA161-An Antihuman CD16 (FcγRIII) Monoclonal Antibody for Treatment of Autoimmune Disorders in CD16 Transgenic Mice
Flaherty, Meghan M., MacLachlan, Timothy K., Troutt, Misty, Magee, Tomas, Tuaillon, Nadine, Johnson, Syd, Stein, Kathryn E., Bonvini, Ezio, Garman, Richard, Andrews, Laura
Published in Toxicological sciences (2012)
Published in Toxicological sciences (2012)
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Nonclinical Studies that Support Viral Vector-Delivered Gene Therapies: An EFPIA Gene Therapy Working Group Perspective
Bolt, Michael W., Whiteley, Laurence O., Lynch, Jessica L., Lauritzen, Brian, Fernández de Henestrosa, Antonio R., MacLachlan, Timothy, Ulrich, Peter, Philip, Binu K., Mahalingaiah, Prathap Kumar, Fuller, Claudette L., Compton, David R.
Published in Molecular therapy. Methods & clinical development (11.12.2020)
Published in Molecular therapy. Methods & clinical development (11.12.2020)
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Journal Article
Corrigendum to “Inflammation and immunogenicity limit the utility of the rabbit as a nonclinical species for ocular biologic therapeutics” [Regul. Toxicol. Pharmacol. (2017) 221–230]
de Zafra, Christina L.Zuch, Sasseville, Vito G., Matsumoto, Steven, Freichel, Christian, Milton, Mark, MacLachlan, Timothy K., Farman, Cindy, Raymond, Iona, Gupta, Swati, Newton, Ronald, Atzpodien, Elke-Astrid, Thackaberry, Evan A.
Published in Regulatory toxicology and pharmacology (01.08.2017)
Published in Regulatory toxicology and pharmacology (01.08.2017)
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Journal Article
Storm forecasting: additional lessons from the CD28 superagonist TGN1412 trial: 1
Horvath, Christopher, Andrews, Laura, Baumann, Andreas, Black, Lauren, Blanset, Diann, Cavagnaro, Joy, Hastings, Kenneth L, Hutto, David L, Maclachlan, Timothy K, Milton, Mark, Reynolds, Theresa, Roberts, Stan, Rogge, Mark, Sims, Jennifer, Treacy, George, Warner, Garvin, Green, James D
Published in Nature reviews. Immunology (01.10.2012)
Published in Nature reviews. Immunology (01.10.2012)
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Journal Article
Insulin-like growth factor factor binding protein-2 is a novel mediator of p53 inhibition of insulin-like growth factor signaling
Grimberg, Adda, Coleman, Carrie M, Shi, Zonggao, Burns, Timothy F, MacLachlan, Timothy K, Wang, Wenge, El-Deiry, Wafik S
Published in Cancer biology & therapy (01.10.2006)
Published in Cancer biology & therapy (01.10.2006)
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Journal Article
BRCA1 Transcriptionally Regulates Damaged DNA Binding Protein (DDB2) In the DNA Repair Response Following UV-Irradiation
Takimoto, Rishu, MacLachlan, Timothy K., Dicker, David T., Niitsu, Yoshiro, Mori, Toshio, El-Deiry, Wafik S.
Published in Cancer biology & therapy (07.03.2002)
Published in Cancer biology & therapy (07.03.2002)
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Journal Article
Not reinventing the wheel: applying the 3Rs concepts to viral vector gene therapy biodistribution studies
MacLachlan, Timothy K, McIntyre, Maritza, Mitrophanous, Kyriacos, Miskin, James, Jolly, Douglas J, Cavagnaro, Joy A
Published in Human gene therapy. Clinical development (01.03.2013)
Published in Human gene therapy. Clinical development (01.03.2013)
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