Structural plasticity of KIR2DL2 and KIR2DL3 enables altered docking geometries atop HLA-C
Moradi, Shoeib, Stankovic, Sanda, O'Connor, Geraldine M, Pymm, Phillip, MacLachlan, Bruce J, Faoro, Camilla, Retière, Christelle, Sullivan, Lucy C, Saunders, Philippa M, Widjaja, Jacqueline, Cox-Livingstone, Shea, Rossjohn, Jamie, Brooks, Andrew G, Vivian, Julian P
Published in Nature communications (12.04.2021)
Published in Nature communications (12.04.2021)
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Structural definition of HLA class II-presented SARS-CoV-2 epitopes reveals a mechanism to escape pre-existing CD4+ T cell immunity
Chen, Yuan, Mason, Georgina H., Scourfield, D. Oliver, Greenshields-Watson, Alexander, Haigh, Tracey A., Sewell, Andrew K., Long, Heather M., Gallimore, Awen M., Rizkallah, Pierre, MacLachlan, Bruce J., Godkin, Andrew
Published in Cell reports (Cambridge) (29.08.2023)
Published in Cell reports (Cambridge) (29.08.2023)
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The Role of the HLA Class I α2 Helix in Determining Ligand Hierarchy for the Killer Cell Ig-like Receptor 3DL1
Saunders, Philippa M, MacLachlan, Bruce J, Widjaja, Jacqueline, Wong, Shu Cheng, Oates, Clare V L, Rossjohn, Jamie, Vivian, Julian P, Brooks, Andrew G
Published in The Journal of immunology (1950) (15.02.2021)
Published in The Journal of immunology (1950) (15.02.2021)
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CD4+ T Cells Recognize Conserved Influenza A Epitopes through Shared Patterns of V-Gene Usage and Complementary Biochemical Features
Greenshields-Watson, Alexander, Attaf, Meriem, MacLachlan, Bruce J., Whalley, Thomas, Rius, Cristina, Wall, Aaron, Lloyd, Angharad, Hughes, Hywel, Strange, Kathryn E., Mason, Georgina H., Schauenburg, Andrea J., Hulin-Curtis, Sarah L., Geary, James, Chen, Yuan, Lauder, Sarah N., Smart, Kathryn, Vijaykrishna, Dhanasekaran, Grau, Miguel L., Shugay, Mikhail, Andrews, Robert, Dolton, Garry, Rizkallah, Pierre J., Gallimore, Awen M., Sewell, Andrew K., Godkin, Andrew J., Cole, David K.
Published in Cell reports (Cambridge) (14.07.2020)
Published in Cell reports (Cambridge) (14.07.2020)
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In Silico and Structural Analyses Demonstrate That Intrinsic Protein Motions Guide T Cell Receptor Complementarity Determining Region Loop Flexibility
Holland, Christopher J, MacLachlan, Bruce J, Bianchi, Valentina, Hesketh, Sophie J, Morgan, Richard, Vickery, Owen, Bulek, Anna M, Fuller, Anna, Godkin, Andrew, Sewell, Andrew K, Rizkallah, Pierre J, Wells, Stephen, Cole, David K
Published in Frontiers in immunology (11.04.2018)
Published in Frontiers in immunology (11.04.2018)
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Molecular Rules Underpinning Enhanced Affinity Binding of Human T Cell Receptors Engineered for Immunotherapy
Crean, Rory M., MacLachlan, Bruce J., Madura, Florian, Whalley, Thomas, Rizkallah, Pierre J., Holland, Christopher J., McMurran, Catriona, Harper, Stephen, Godkin, Andrew, Sewell, Andrew K., Pudney, Christopher R., van der Kamp, Marc W., Cole, David K.
Published in Molecular therapy. Oncolytics (25.09.2020)
Published in Molecular therapy. Oncolytics (25.09.2020)
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The Structural Basis for Recognition of Human Leukocyte Antigen Class I Molecules by the Pan-HLA Antibody W6/32
Pymm, Phillip, Saunders, Philippa M., Anand, Sushma, MacLachlan, Bruce J., Faoro, Camilla, Hitchen, Corinne, Rossjohn, Jamie, Brooks, Andrew G., Vivian, Julian P.
Published in The Journal of immunology (1950) (15.09.2024)
Published in The Journal of immunology (1950) (15.09.2024)
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Molecular characterization of HLA class II binding to the LAG‐3 T cell co‐inhibitory receptor
MacLachlan, Bruce J., Mason, Georgina H., Greenshields‐Watson, Alexander, Triebel, Frederic, Gallimore, Awen, Cole, David K., Godkin, Andrew
Published in European journal of immunology (01.02.2021)
Published in European journal of immunology (01.02.2021)
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A pocket guide on how to structure SARS-CoV-2 drugs and therapies
Littler, Dene R, MacLachlan, Bruce J, Watson, Gabrielle M, Vivian, Julian P, Gully, Benjamin S
Published in Biochemical Society transactions (18.12.2020)
Published in Biochemical Society transactions (18.12.2020)
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The molecular basis of how buried human leukocyte antigen polymorphism modulates natural killer cell function
Saunders, Philippa M., MacLachlan, Bruce J., Pymm, Phillip, Illing, Patricia T., Deng, Yuanchen, Wong, Shu Cheng, Oates, Clare V. L., Purcell, Anthony W., Rossjohn, Jamie, Vivian, Julian P., Brooks, Andrew G.
Published in Proceedings of the National Academy of Sciences - PNAS (26.05.2020)
Published in Proceedings of the National Academy of Sciences - PNAS (26.05.2020)
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Human leukocyte antigen (HLA) class II peptide flanking residues tune the immunogenicity of a human tumor-derived epitope
MacLachlan, Bruce J., Dolton, Garry, Papakyriakou, Athanasios, Greenshields-Watson, Alexander, Mason, Georgina H., Schauenburg, Andrea, Besneux, Matthieu, Szomolay, Barbara, Elliott, Tim, Sewell, Andrew K., Gallimore, Awen, Rizkallah, Pierre, Cole, David K., Godkin, Andrew
Published in The Journal of biological chemistry (27.12.2019)
Published in The Journal of biological chemistry (27.12.2019)
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A targeted single mutation in influenza A virus universal epitope transforms immunogenicity and protective immunity via CD4+ T cell activation
Hulin-Curtis, Sarah, Geary, James K., MacLachlan, Bruce J., Altmann, Danny M., Baillon, Laury, Cole, David K., Greenshields-Watson, Alex, Hesketh, Sophie J., Humphreys, Ian R., Jones, Ian M., Lauder, Sarah N., Mason, Georgina H., Smart, Kathryn, Scourfield, D. Oliver, Scott, Jake, Sukhova, Ksenia, Stanton, Richard J., Wall, Aaron, Rizkallah, Pierre J., Barclay, Wendy S., Gallimore, Awen, Godkin, Andrew
Published in Cell reports (Cambridge) (25.06.2024)
Published in Cell reports (Cambridge) (25.06.2024)
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The nature of the human T cell response to the cancer antigen 5T4 is determined by the balance of regulatory and inflammatory T cells of the same antigen-specificity: implications for vaccine design
Besneux, Matthieu, Greenshields-Watson, Alexander, Scurr, Martin J., MacLachlan, Bruce J., Christian, Adam, Davies, Michael M., Hargest, Rachel, Phillips, Simon, Godkin, Andrew, Gallimore, Awen
Published in Cancer Immunology, Immunotherapy (01.02.2019)
Published in Cancer Immunology, Immunotherapy (01.02.2019)
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Using X-ray Crystallography, Biophysics, and Functional Assays to Determine the Mechanisms Governing T-cell Receptor Recognition of Cancer Antigens
MacLachlan, Bruce J, Greenshields-Watson, Alexander, Mason, Georgina H, Schauenburg, Andrea J, Bianchi, Valentina, Rizkallah, Pierre J, Sewell, Andrew K, Fuller, Anna, Cole, David K
Published in Journal of visualized experiments (06.02.2017)
Published in Journal of visualized experiments (06.02.2017)
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Using X-ray Crystallography, Biophysics, and Functional Assays to Determine the Mechanisms Governing T-cell Receptor Recognition of Cancer Antigens
MacLachlan, Bruce J., Greenshields-Watson, Alexander, Mason, Georgina H, Schauenburg, Andrea J, Bianchi, Valentina, Rizkallah, Pierre J, Sewell, Andrew K, Fuller, Anna, Cole, David K
Published in Journal of visualized experiments (06.02.2017)
Published in Journal of visualized experiments (06.02.2017)
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