Regulation of Transforming Growth Factor-β1-driven Lung Fibrosis by Galectin-3
MACKINNON, Alison C, GIBBONS, Michael A, SETHI, Tariq, FARNWORTH, Sarah L, LEFFLER, Hakon, NILSSON, Uif J, DELAINE, Tamara, JOHN SIMPSON, A, FORBES, Stuart J, HIRANI, Nik, GAULDIE, Jack
Published in American journal of respiratory and critical care medicine (01.03.2012)
Published in American journal of respiratory and critical care medicine (01.03.2012)
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Target inhibition of galectin-3 by inhaled TD139 in patients with idiopathic pulmonary fibrosis
Hirani, Nikhil, MacKinnon, Alison C, Nicol, Lisa, Ford, Paul, Schambye, Hans, Pedersen, Anders, Nilsson, Ulf J, Leffler, Hakon, Sethi, Tariq, Tantawi, Susan, Gravelle, Lise, Slack, Robert J, Mills, Ross, Karmakar, Utsa, Humphries, Duncan, Zetterberg, Fredrik, Keeling, Lucy, Paul, Lyn, Molyneaux, Philip L, Li, Feng, Funston, Wendy, Forrest, Ian A, Simpson, A John, Gibbons, Michael A, Maher, Toby M
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Published in The European respiratory journal (01.05.2021)
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CD133+ Cancer Stem-like Cells in Small Cell Lung Cancer Are Highly Tumorigenic and Chemoresistant but Sensitive to a Novel Neuropeptide Antagonist
SARVI, Sana, MACKINNON, Alison C, AVLONITIS, Nicolaos, BRADLEY, Mark, RINTOUL, Robert C, RASSL, Doris M, WEI WANG, FORBES, Stuart J, GREGORY, Christopher D, SETHI, Tariq
Published in Cancer research (Chicago, Ill.) (01.03.2014)
Published in Cancer research (Chicago, Ill.) (01.03.2014)
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Alternatively activated macrophages promote resolution of necrosis following acute liver injury
Starkey Lewis, Philip, Campana, Lara, Aleksieva, Niya, Cartwright, Jennifer Ann, Mackinnon, Alison, O'Duibhir, Eoghan, Kendall, Timothy, Vermeren, Matthieu, Thomson, Adrian, Gadd, Victoria, Dwyer, Benjamin, Aird, Rhona, Man, Tak-Yung, Rossi, Adriano Giorgio, Forrester, Lesley, Park, B. Kevin, Forbes, Stuart John
Published in Journal of hepatology (01.08.2020)
Published in Journal of hepatology (01.08.2020)
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An Orally Active Galectin-3 Antagonist Inhibits Lung Adenocarcinoma Growth and Augments Response to PD-L1 Blockade
Vuong, Lynda, Kouverianou, Eleni, Rooney, Claire M, McHugh, Brian J, Howie, Sarah E M, Gregory, Christopher D, Forbes, Stuart J, Henderson, Neil C, Zetterberg, Fredrik R, Nilsson, Ulf J, Leffler, Hakon, Ford, Paul, Pedersen, Anders, Gravelle, Lise, Tantawi, Susan, Schambye, Hans, Sethi, Tariq, MacKinnon, Alison C
Published in Cancer research (Chicago, Ill.) (01.04.2019)
Published in Cancer research (Chicago, Ill.) (01.04.2019)
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Regulation of Alternative Macrophage Activation by Galectin-3
MacKinnon, Alison C, Farnworth, Sarah L, Hodkinson, Philip S, Henderson, Neil C, Atkinson, Kirsten M, Leffler, Hakon, Nilsson, Ulf J, Haslett, Christopher, Forbes, Stuart J, Sethi, Tariq
Published in The Journal of immunology (1950) (15.02.2008)
Published in The Journal of immunology (1950) (15.02.2008)
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CSF1 Restores Innate Immunity After Liver Injury in Mice and Serum Levels Indicate Outcomes of Patients With Acute Liver Failure
Stutchfield, Benjamin M, Antoine, Daniel J, Mackinnon, Alison C, Gow, Deborah J, Bain, Calum C, Hawley, Catherine A, Hughes, Michael J, Francis, Benjamin, Wojtacha, Davina, Man, Tak Y, Dear, James W, Devey, Luke R, Mowat, Alan M, Pollard, Jeffrey W, Park, B. Kevin, Jenkins, Stephen J, Simpson, Kenneth J, Hume, David A, Wigmore, Stephen J, Forbes, Stuart J
Published in Gastroenterology (New York, N.Y. 1943) (01.12.2015)
Published in Gastroenterology (New York, N.Y. 1943) (01.12.2015)
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Galectin-3 Expression and Secretion Links Macrophages to the Promotion of Renal Fibrosis
Henderson, Neil C, Mackinnon, Alison C, Farnworth, Sarah L, Kipari, Tiina, Haslett, Christopher, Iredale, John P, Liu, Fu-Tong, Hughes, Jeremy, Sethi, Tariq
Published in The American journal of pathology (01.02.2008)
Published in The American journal of pathology (01.02.2008)
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Resistance to anti-PD-1/anti-PD-L1: galectin-3 inhibition with GB1211 reverses galectin-3-induced blockade of pembrolizumab and atezolizumab binding to PD-1/PD-L1
Mabbitt, Joseph, Holyer, Ian D., Roper, James A., Nilsson, Ulf J., Zetterberg, Fredrik R., Vuong, Lynda, Mackinnon, Alison C., Pedersen, Anders, Slack, Robert J.
Published in Frontiers in immunology (28.08.2023)
Published in Frontiers in immunology (28.08.2023)
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Discovery of the Selective and Orally Available Galectin‑1 Inhibitor GB1908 as a Potential Treatment for Lung Cancer
Zetterberg, Fredrik R., Peterson, Kristoffer, Nilsson, Ulf J., Andréasson Dahlgren, Kajsa, Diehl, Carl, Holyer, Ian, Håkansson, Maria, Khabut, Areej, Kahl-Knutson, Barbro, Leffler, Hakon, MacKinnon, Alison C., Roper, James A., Slack, Robert J., Zarrizi, Reihaneh, Pedersen, Anders
Published in Journal of medicinal chemistry (13.06.2024)
Published in Journal of medicinal chemistry (13.06.2024)
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A Selective Galactose–Coumarin-Derived Galectin‑3 Inhibitor Demonstrates Involvement of Galectin-3-glycan Interactions in a Pulmonary Fibrosis Model
Rajput, Vishal K, MacKinnon, Alison, Mandal, Santanu, Collins, Patrick, Blanchard, Helen, Leffler, Hakon, Sethi, Tariq, Schambye, Hans, Mukhopadhyay, Balaram, Nilsson, Ulf J
Published in Journal of medicinal chemistry (08.09.2016)
Published in Journal of medicinal chemistry (08.09.2016)
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Galectin-3 Regulates Myofibroblast Activation and Hepatic Fibrosis
Henderson, Neil C., Mackinnon, Alison C., Farnworth, Sarah L., Poirier, Francoise, Russo, Francesco P., Iredale, John P., Haslett, Christopher, Simpson, Kenneth J., Sethi, Tariq
Published in Proceedings of the National Academy of Sciences - PNAS (28.03.2006)
Published in Proceedings of the National Academy of Sciences - PNAS (28.03.2006)
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An Inhaled Galectin-3 Inhibitor in COVID-19 Pneumonitis: A Phase Ib/IIa Randomized Controlled Clinical Trial (DEFINE)
Gaughan, Erin E, Quinn, Tom M, Mills, Andrew, Bruce, Annya M, Antonelli, Jean, MacKinnon, Alison C, Aslanis, Vassilios, Li, Feng, O'Connor, Richard, Boz, Cecilia, Mills, Ross, Emanuel, Philip, Burgess, Matthew, Rinaldi, Giulia, Valanciute, Asta, Mills, Bethany, Scholefield, Emma, Hardisty, Gareth, Findlay, Emily Gwyer, Parker, Richard A, Norrie, John, Dear, James W, Akram, Ahsan R, Koch, Oliver, Templeton, Kate, Dockrell, David H, Walsh, Timothy S, Partridge, Stephen, Humphries, Duncan, Wang-Jairaj, Jie, Slack, Robert J, Schambye, Hans, Phung, De, Gravelle, Lise, Lindmark, Bertil, Shankar-Hari, Manu, Hirani, Nikhil, Sethi, Tariq, Dhaliwal, Kevin
Published in American journal of respiratory and critical care medicine (15.01.2023)
Published in American journal of respiratory and critical care medicine (15.01.2023)
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Safety and pharmacokinetics of GB1211, an oral galectin-3 inhibitor: a single- and multiple-dose first-in-human study in healthy participants
Aslanis, Vassilios, Slack, Robert J., MacKinnon, Alison C., McClinton, Catherine, Tantawi, Susan, Gravelle, Lise, Nilsson, Ulf J., Leffler, Hakon, Brooks, Ashley, Khindri, Sanjeev K., Marshall, Richard P., Pedersen, Anders, Schambye, Hans, Zetterberg, Fredrik
Published in Cancer chemotherapy and pharmacology (01.03.2023)
Published in Cancer chemotherapy and pharmacology (01.03.2023)
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Defining the mechanism of galectin-3–mediated TGF-β1 activation and its role in lung fibrosis
Calver, Jessica F., Parmar, Nimesh R., Harris, Gemma, Lithgo, Ryan M., Stylianou, Panayiota, Zetterberg, Fredrik R., Gooptu, Bibek, Mackinnon, Alison C., Carr, Stephen B., Borthwick, Lee A., Scott, David J., Stewart, Iain D., Slack, Robert J., Jenkins, R. Gisli, John, Alison E.
Published in The Journal of biological chemistry (01.06.2024)
Published in The Journal of biological chemistry (01.06.2024)
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Inhibition of galectin-3 reduces atherosclerosis in apolipoprotein E-deficient mice
MacKinnon, Alison C, Liu, Xiaojun, Hadoke, Patrick Wf, Miller, Mark R, Newby, David E, Sethi, Tariq
Published in Glycobiology (Oxford) (01.06.2013)
Published in Glycobiology (Oxford) (01.06.2013)
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Galectin-3 inhibitor GB0139 protects against acute lung injury by inhibiting neutrophil recruitment and activation
Humphries, Duncan C., Mills, Ross, Boz, Cecilia, McHugh, Brian J., Hirani, Nikhil, Rossi, Adriano G., Pedersen, Anders, Schambye, Hans T., Slack, Robert J., Leffler, Hakon, Nilsson, Ulf J., Wang, Wei, Sethi, Tariq, Mackinnon, Alison C.
Published in Frontiers in pharmacology (08.08.2022)
Published in Frontiers in pharmacology (08.08.2022)
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Proteinase activated receptor 1 mediated fibrosis in a mouse model of liver injury: a role for bone marrow derived macrophages
Kallis, Yiannis N, Scotton, Christopher J, Mackinnon, Alison C, Goldin, Robert D, Wright, Nicholas A, Iredale, John P, Chambers, Rachel C, Forbes, Stuart J
Published in PloS one (27.01.2014)
Published in PloS one (27.01.2014)
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Chemical Modulation of in Vivo Macrophage Function with Subpopulation-Specific Fluorescent Prodrug Conjugates
Fernandez, Antonio, Vermeren, Matthieu, Humphries, Duncan, Subiros-Funosas, Ramon, Barth, Nicole, Campana, Lara, MacKinnon, Alison, Feng, Yi, Vendrell, Marc
Published in ACS central science (27.09.2017)
Published in ACS central science (27.09.2017)
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