A Conserved Mito-Cytosolic Translational Balance Links Two Longevity Pathways
Molenaars, Marte, Janssens, Georges E., Williams, Evan G., Jongejan, Aldo, Lan, Jiayi, Rabot, Sylvie, Joly, Fatima, Moerland, Perry D., Schomakers, Bauke V., Lezzerini, Marco, Liu, Yasmine J., McCormick, Mark A., Kennedy, Brian K., van Weeghel, Michel, van Kampen, Antoine H.C., Aebersold, Ruedi, MacInnes, Alyson W., Houtkooper, Riekelt H.
Published in Cell metabolism (03.03.2020)
Published in Cell metabolism (03.03.2020)
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Glycine promotes longevity in Caenorhabditis elegans in a methionine cycle-dependent fashion
Liu, Yasmine J, Janssens, Georges E, McIntyre, Rebecca L, Molenaars, Marte, Kamble, Rashmi, Gao, Arwen W, Jongejan, Aldo, Weeghel, Michel van, MacInnes, Alyson W, Houtkooper, Riekelt H
Published in PLoS genetics (07.03.2019)
Published in PLoS genetics (07.03.2019)
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Extensive localization of long noncoding RNAs to the cytosol and mono- and polyribosomal complexes
van Heesch, Sebastiaan, van Iterson, Maarten, Jacobi, Jetse, Boymans, Sander, Essers, Paul B, de Bruijn, Ewart, Hao, Wensi, MacInnes, Alyson W, Cuppen, Edwin, Simonis, Marieke
Published in Genome biology (07.01.2014)
Published in Genome biology (07.01.2014)
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A Long Noncoding RNA on the Ribosome Is Required for Lifespan Extension
Essers, Paul B., Nonnekens, Julie, Goos, Yvonne J., Betist, Marco C., Viester, Marjon D., Mossink, Britt, Lansu, Nico, Korswagen, Hendrik C., Jelier, Rob, Brenkman, Arjan B., MacInnes, Alyson W.
Published in Cell reports (Cambridge) (20.01.2015)
Published in Cell reports (Cambridge) (20.01.2015)
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Reduced ech-6 expression attenuates fat-induced lifespan shortening in C. elegans
Liu, Yasmine J., Gao, Arwen W., Smith, Reuben L., Janssens, Georges E., Panneman, Daan M., Jongejan, Aldo, van Weeghel, Michel, Vaz, Frédéric M., Silvestrini, Melissa J., Lapierre, Louis R., MacInnes, Alyson W., Houtkooper, Riekelt H.
Published in Scientific reports (01.03.2022)
Published in Scientific reports (01.03.2022)
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Ribosomal protein mutations induce autophagy through S6 kinase inhibition of the insulin pathway
Heijnen, Harry F, van Wijk, Richard, Pereboom, Tamara C, Goos, Yvonne J, Seinen, Cor W, van Oirschot, Brigitte A, van Dooren, Rowie, Gastou, Marc, Giles, Rachel H, van Solinge, Wouter, Kuijpers, Taco W, Gazda, Hanna T, Bierings, Marc B, Da Costa, Lydie, MacInnes, Alyson W
Published in PLoS genetics (01.05.2014)
Published in PLoS genetics (01.05.2014)
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Recurring mutations in RPL15 are linked to hydrops fetalis and treatment independence in Diamond-Blackfan anemia
Wlodarski, Marcin W, Da Costa, Lydie, O'Donohue, Marie-Françoise, Gastou, Marc, Karboul, Narjesse, Montel-Lehry, Nathalie, Hainmann, Ina, Danda, Dominika, Szvetnik, Amina, Pastor, Victor, Paolini, Nahuel, di Summa, Franca M, Tamary, Hannah, Quider, Abed Abu, Aspesi, Anna, Houtkooper, Riekelt H, Leblanc, Thierry, Niemeyer, Charlotte M, Gleizes, Pierre-Emmanuel, MacInnes, Alyson W
Published in Haematologica (Roma) (01.06.2018)
Published in Haematologica (Roma) (01.06.2018)
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Insulin/IGF‐1‐mediated longevity is marked by reduced protein metabolism
Stout, Gerdine J, Stigter, Edwin C A, Essers, Paul B, Mulder, Klaas W, Kolkman, Annemieke, Snijders, Dorien S, van den Broek, Niels J F, Betist, Marco C, Korswagen, Hendrik C, MacInnes, Alyson W, Brenkman, Arjan B
Published in Molecular systems biology (02.07.2013)
Published in Molecular systems biology (02.07.2013)
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Ribosomal Protein Mutations Result in Constitutive p53 Protein Degradation through Impairment of the AKT Pathway
Antunes, Ana T, Goos, Yvonne J, Pereboom, Tamara C, Hermkens, Dorien, Wlodarski, Marcin W, Da Costa, Lydie, MacInnes, Alyson W
Published in PLoS genetics (01.07.2015)
Published in PLoS genetics (01.07.2015)
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Aging-regulated PNUTS maintains endothelial barrier function via SEMA3B suppression
Lozano-Vidal, Noelia, Stanicek, Laura, Bink, Diewertje I., Juni, Rio P., Hooglugt, Aukie, Kremer, Veerle, Phelp, Philippa, van Bergen, Anke, MacInnes, Alyson W., Dimmeler, Stefanie, Boon, Reinier A.
Published in Communications biology (07.05.2024)
Published in Communications biology (07.05.2024)
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Translation of branched-chain aminotransferase-1 transcripts is impaired in cells haploinsufficient for ribosomal protein genes
Pereboom, Tamara C, Bondt, Albert, Pallaki, Paschalina, Klasson, Tim D, Goos, Yvonne J, Essers, Paul B, Groot Koerkamp, Marian J.A, Gazda, Hanna T, Holstege, Frank C.P, Costa, Lydie Da, MacInnes, Alyson W
Published in Experimental hematology (01.05.2014)
Published in Experimental hematology (01.05.2014)
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Mitochondrial translation and dynamics synergistically extend lifespan in C. elegans through HLH-30
Liu, Yasmine J, McIntyre, Rebecca L, Janssens, Georges E, Williams, Evan G, Lan, Jiayi, van Weeghel, Michel, Schomakers, Bauke, van der Veen, Henk, van der Wel, Nicole N, Yao, Pallas, Mair, William B, Aebersold, Ruedi, MacInnes, Alyson W, Houtkooper, Riekelt H
Published in The Journal of cell biology (01.06.2020)
Published in The Journal of cell biology (01.06.2020)
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HEATR3 variants impair nuclear import of uL18 (RPL5) and drive Diamond-Blackfan anemia
O'Donohue, Marie-Françoise, Da Costa, Lydie, Lezzerini, Marco, Unal, Sule, Joret, Clément, Bartels, Marije, Brilstra, Eva, Scheijde-Vermeulen, Marijn, Wacheul, Ludivine, De Keersmaecker, Kim, Vereecke, Stijn, Labarque, Veerle, Saby, Manon, Lefevre, Sophie D., Platon, Jessica, Montel-Lehry, Nathalie, Laugero, Nathalie, Lacazette, Eric, van Gassen, Koen, Houtkooper, Riekelt H., Simsek-Kiper, Pelin Ozlem, Leblanc, Thierry, Yarali, Nese, Cetinkaya, Arda, Akarsu, Nurten A., Gleizes, Pierre-Emmanuel, Lafontaine, Denis L.J., MacInnes, Alyson W.
Published in Blood (26.05.2022)
Published in Blood (26.05.2022)
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Molecular approaches to diagnose Diamond-Blackfan anemia: The EuroDBA experience
Da Costa, Lydie, O'Donohue, Marie-Françoise, van Dooijeweert, Birgit, Albrecht, Katarzyna, Unal, Sule, Ramenghi, Ugo, Leblanc, Thierry, Dianzani, Irma, Tamary, Hannah, Bartels, Marije, Gleizes, Pierre-Emmanuel, Wlodarski, Marcin, MacInnes, Alyson W.
Published in European journal of medical genetics (01.11.2018)
Published in European journal of medical genetics (01.11.2018)
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A Ribosomopathy Reveals Decoding Defective Ribosomes Driving Human Dysmorphism
Paolini, Nahuel A., Attwood, Martin, Sondalle, Samuel B., Vieira, Carolina Marques dos Santos, van Adrichem, Anita M., di Summa, Franca M., O’Donohue, Marie-Françoise, Gleizes, Pierre-Emmanuel, Rachuri, Swaksha, Briggs, Joseph W., Fischer, Roman, Ratcliffe, Peter J., Wlodarski, Marcin W., Houtkooper, Riekelt H., von Lindern, Marieke, Kuijpers, Taco W., Dinman, Jonathan D., Baserga, Susan J., Cockman, Matthew E., MacInnes, Alyson W.
Published in American journal of human genetics (02.03.2017)
Published in American journal of human genetics (02.03.2017)
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Ribosomal protein gene RPL9 variants can differentially impair ribosome function and cellular metabolism
Lezzerini, Marco, Penzo, Marianna, O’Donohue, Marie-Françoise, Marques dos Santos Vieira, Carolina, Saby, Manon, Elfrink, Hyung L, Diets, Illja J, Hesse, Anne-Marie, Couté, Yohann, Gastou, Marc, Nin-Velez, Alexandra, Nikkels, Peter G J, Olson, Alexandra N, Zonneveld-Huijssoon, Evelien, Jongmans, Marjolijn C J, Zhang, GuangJun, van Weeghel, Michel, Houtkooper, Riekelt H, Wlodarski, Marcin W, Kuiper, Roland P, Bierings, Marc B, van der Werff ten Bosch, Jutte, Leblanc, Thierry, Montanaro, Lorenzo, Dinman, Jonathan D, Da Costa, Lydie, Gleizes, Pierre-Emmanuel, MacInnes, Alyson W
Published in Nucleic acids research (24.01.2020)
Published in Nucleic acids research (24.01.2020)
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Journal Article
HNRNPR Variants that Impair Homeobox Gene Expression Drive Developmental Disorders in Humans
Duijkers, Floor A., McDonald, Andrew, Janssens, Georges E., Lezzerini, Marco, Jongejan, Aldo, van Koningsbruggen, Silvana, Leeuwenburgh-Pronk, Wendela G., Wlodarski, Marcin W., Moutton, Sébastien, Tran-Mau-Them, Frédéric, Thauvin-Robinet, Christel, Faivre, Laurence, Monaghan, Kristin G., Smol, Thomas, Boute-Benejean, Odile, Ladda, Roger L., Sell, Susan L., Bruel, Ange-Line, Houtkooper, Riekelt H., MacInnes, Alyson W.
Published in American journal of human genetics (06.06.2019)
Published in American journal of human genetics (06.06.2019)
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