Search Results - "Märki, Hans-Peter" :: K.UTB vyhledávací portál | TBU Library Retrieval Portal

Discovery of 3‑Pyridyl Isoindolin-1-one Derivatives as Potent, Selective, and Orally Active Aldosterone Synthase (CYP11B2) Inhibitors

Discovery of 3‑Pyridyl Isoindolin-1-one Derivatives as Potent, Selective, and Orally Active Aldosterone Synthase (CYP11B2) Inhibitors

by Liu, Yongfu, Wu, Jun, Zhou, Mingwei, Chen, Wenming, Li, Dongbo, Wang, Zhanguo, Hornsperger, Benoit, Aebi, Johannes D, Märki, Hans-Peter, Kuhn, Bernd, Wang, Lisha, Kuglstatter, Andreas, Benz, Jörg, Müller, Stephan, Hochstrasser, Remo, Ottaviani, Giorgio, Xin, Jian, Kirchner, Stephan, Mohr, Susanne, Verry, Philippe, Riboulet, William, Shen, Hong C, Mayweg, Alexander V, Amrein, Kurt, Tan, Xuefei
Published in Journal of medicinal chemistry (09.07.2020)

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Discovery of 4‑Aryl-5,6,7,8-tetrahydroisoquinolines as Potent, Selective, and Orally Active Aldosterone Synthase (CYP11B2) Inhibitors: In Vivo Evaluation in Rodents and Cynomolgus Monkeys

Discovery of 4‑Aryl-5,6,7,8-tetrahydroisoquinolines as Potent, Selective, and Orally Active Aldosterone Synthase (CYP11B2) Inhibitors: In Vivo Evaluation in Rodents and Cynomolgus Monkeys

by Martin, Rainer E, Aebi, Johannes D, Hornsperger, Benoit, Krebs, Hans-Jakob, Kuhn, Bernd, Kuglstatter, Andreas, Alker, André M, Märki, Hans Peter, Müller, Stephan, Burger, Dominique, Ottaviani, Giorgio, Riboulet, William, Verry, Philippe, Tan, Xuefei, Amrein, Kurt, Mayweg, Alexander V
Published in Journal of medicinal chemistry (22.10.2015)

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Synthesis of annulated pyridines as inhibitors of aldosterone synthase (CYP11B2)

Synthesis of annulated pyridines as inhibitors of aldosterone synthase (CYP11B2)

by Martin, Rainer E., Lehmann, Johannes, Alzieu, Thibaut, Lenz, Mario, Corrales, Marjorie A. Carnero, Aebi, Johannes D., Marki, Hans Peter, Kuhn, Bernd, Amrein, Kurt, Mayweg, Alexander V., Britton, Robert
Published in Organic & biomolecular chemistry (01.01.2016)

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Aleglitazar, a new, potent, and balanced dual PPARα/γ agonist for the treatment of type II diabetes

Aleglitazar, a new, potent, and balanced dual PPARα/γ agonist for the treatment of type II diabetes

by Bénardeau, Agnes, Benz, Jörg, Binggeli, Alfred, Blum, Denise, Boehringer, Markus, Grether, Uwe, Hilpert, Hans, Kuhn, Bernd, Märki, Hans Peter, Meyer, Markus, Püntener, Kurt, Raab, Susanne, Ruf, Armin, Schlatter, Daniel, Mohr, Peter
Published in Bioorganic & medicinal chemistry letters (01.05.2009)

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A Novel Partial Agonist of Peroxisome Proliferator-Activated Receptor-γ (PPARγ) Recruits PPARγ-Coactivator-1α, Prevents Triglyceride Accumulation, and Potentiates Insulin Signaling in Vitro

A Novel Partial Agonist of Peroxisome Proliferator-Activated Receptor-γ (PPARγ) Recruits PPARγ-Coactivator-1α, Prevents Triglyceride Accumulation, and Potentiates Insulin Signaling in Vitro

by Burgermeister, Elke, Schnoebelen, Astride, Flament, Angele, Benz, Jörg, Stihle, Martine, Gsell, Bernard, Rufer, Arne, Ruf, Armin, Kuhn, Bernd, Märki, Hans Peter, Mizrahi, Jacques, Sebokova, Elena, Niesor, Eric, Meyer, Markus
Published in Molecular endocrinology (Baltimore, Md.) (01.04.2006)

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Development of a New Class of Inhibitors for the Malarial Aspartic Protease Plasmepsin II Based on a Central 7-Azabicyclo[2.2.1]heptane Scaffold

Development of a New Class of Inhibitors for the Malarial Aspartic Protease Plasmepsin II Based on a Central 7-Azabicyclo[2.2.1]heptane Scaffold

by Carcache, David A., Hörtner, Simone R., Seiler, Paul, Diederich, François, Dorn, Arnulf, Märki, Hans Peter, Binkert, Christoph, Bur, Daniel
Published in Helvetica chimica acta (01.06.2003)

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A New Class of Inhibitors for the Malarial Aspartic Protease Plasmepsin II Based on a Central 11-Azatricyclo[6.2.1.02,7]undeca-2,4,6-triene Scaffold

A New Class of Inhibitors for the Malarial Aspartic Protease Plasmepsin II Based on a Central 11-Azatricyclo[6.2.1.02,7]undeca-2,4,6-triene Scaffold

by Carcache, David A., Hörtner, Simone R., Bertogg, Andreas, Diederich, François, Dorn, Arnulf, Märki, Hans Peter, Binkert, Christoph, Bur, Daniel
Published in Helvetica chimica acta (01.06.2003)

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Challenges and Rewards in Medicinal Chemistry Targeting Cardiovascular and Metabolic Diseases

Challenges and Rewards in Medicinal Chemistry Targeting Cardiovascular and Metabolic Diseases

by Neidhart, Werner, Ackermann, Jean, Amrein, Kurt, Conte, Aurelia, Hunziker, Daniel, Kuhn, Bernd, Märki, Hans Peter, Nettekoven, Matthias, Ruf, Armin, Schulz-Gasch, Tanja, Mayweg, Alexander V
Published in Chimia (01.01.2015)

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Channels and Transporters

Channels and Transporters

by Raimund Dutzler, Beat Ernst, Matthias A. Hediger, Dietrich Keppler, Peter Mohr, Werner Neidhart, Hans Peter Märki
Published in Chimia (01.09.2010)

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Frontiers in Medicinal Chemistry – Joint German-Swiss Meeting on Medicinal Chemistry: Berlin, Germany, March 18–21, 2007

Frontiers in Medicinal Chemistry – Joint German-Swiss Meeting on Medicinal Chemistry: Berlin, Germany, March 18–21, 2007

by Werner Neidhart, Peter Mohr, Hans Peter Märki
Published in Chimia (01.09.2007)

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Substituted piperidines - highly potent renin inhibitors due to induced fit adaptation of the active site

Substituted piperidines - highly potent renin inhibitors due to induced fit adaptation of the active site

by Vieira, Eric, Binggeli, Alfred, Breu, Volker, Bur, Daniel, Fischli, Walter, Güller, Rolf, Hirth, Georges, Märki, Hans Peter, Müller, Marcel, Oefner, Christian, Scalone, Michelangelo, Stadler, Heinz, Wihelm, Maurice, Wostl, Wolfgang
Published in Bioorganic & medicinal chemistry letters (17.05.1999)

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De Novo Design, Synthesis, and In Vitro Evaluation of a New Class of Nonpeptidic Inhibitors of the Malarial Enzyme Plasmepsin II

De Novo Design, Synthesis, and In Vitro Evaluation of a New Class of Nonpeptidic Inhibitors of the Malarial Enzyme Plasmepsin II

by Carcache, David A., Hörtner, Simone R., Bertogg, Andreas, Binkert, Christoph, Bur, Daniel, Märki, Hans Peter, Dorn, Arnulf, Diederich, François
Published in Chembiochem : a European journal of chemical biology (04.11.2002)

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Imaging in Biomedical Research: Mini-Symposium of the Division for Medicinal Chemistry (DMC) of the Swiss Chemical Society (SCS), at the Department of Chemistry, University of Basel, May 18, 2006

Imaging in Biomedical Research: Mini-Symposium of the Division for Medicinal Chemistry (DMC) of the Swiss Chemical Society (SCS), at the Department of Chemistry, University of Basel, May 18, 2006

by Gerd Folkers, Alumit Ishai, Markus Rudin, Pius August Schubiger, Matthias Bräutigam, Hanns Möhler, Hans Peter Märki
Published in Chimia (01.11.2006)

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Oxidosqualene Cyclase (OSC) Inhibitors for the Treatment of Dyslipidemia

Oxidosqualene Cyclase (OSC) Inhibitors for the Treatment of Dyslipidemia

by Henrietta Dehmlow, Ralf Thoma, Armin Ruf, Narendra Panday, Elisabeth Von Der Mark, Olivier Morand, Hans Peter Märki, Manfred Kansy, Peter Hartman, Philippe Coassolo, Alexander Chucholowski, Denise Blum-Kaelin, Johannes Aebi, Jean Ackermann, Tanja Schulz-Gasch
Published in Chimia (01.03.2005)

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Enhancing Drug Discovery and Development through the Integration of Medicinal Chemistry, Chemical Biology, and Academia-Industry Partnerships: Insights from Roche's Endocannabinoid System Projects

Enhancing Drug Discovery and Development through the Integration of Medicinal Chemistry, Chemical Biology, and Academia-Industry Partnerships: Insights from Roche's Endocannabinoid System Projects

by Aebi, Johannes, Atz, Kenneth, Ametamey, Simon M, Benz, Jörg, Blaising, Julie, Butini, Stefania, Campiani, Giuseppe, Carreira, Erick M, Collin, Ludovic, De Lago, Eva, Gazzi, Thais, Gertsch, Jürg, Gobbi, Luca, Guba, Wolfgang, Fernández-Ruiz, Javier, Fingerle, Jürgen, Haider, Ahmed, He, Yingfang, Heitman, Laura H, Honer, Michael, Hunziker, Daniel, Kuhn, Bernd, Maccarrone, Mauro, Märki, Hans Peter, Martin, Rainer E, Mohr, Peter, Mu, Linjing, Nazaré, Marc, Nippa, David F, Oddi, Sergio, O'Hara, Fionn, Pacher, Pal, Romero, Julian, Röver, Stephan, Rufer, Arne C, Schibli, Roger, Schneider, Gisbert, Stepan, Antonia F, Sykes, David A, Ullmer, Christoph, Van der Stelt, Mario, Veprintsev, Dmitry B, Wittwer, Matthias B, Grether, Uwe
Published in Chimia (21.08.2024)

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Synthesis of annulated pyridines as inhibitors of aldosterone synthase (CYP11B2)Electronic supplementary information (ESI) available: Experimental details and characterization data. See DOI: 10.1039/c6ob00848h

Synthesis of annulated pyridines as inhibitors of aldosterone synthase (CYP11B2)Electronic supplementary information (ESI) available: Experimental details and characterization data. See DOI: 10.1039/c6ob00848h

by Martin, Rainer E, Lehmann, Johannes, Alzieu, Thibaut, Lenz, Mario, Carnero Corrales, Marjorie A, Aebi, Johannes D, Märki, Hans Peter, Kuhn, Bernd, Amrein, Kurt, Mayweg, Alexander V, Britton, Robert
Year of Publication 22.06.2016

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Structure-based design of indole propionic acids as novel PPARα/γ co-agonists

Structure-based design of indole propionic acids as novel PPARα/γ co-agonists

by Kuhn, Bernd, Hilpert, Hans, Benz, Jörg, Binggeli, Alfred, Grether, Uwe, Humm, Roland, Märki, Hans Peter, Meyer, Markus, Mohr, Peter
Published in Bioorganic & medicinal chemistry letters (01.08.2006)

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Challenges and Rewards in Medicinal Chemistry Targeting Cardiovascular and Metabolic Diseases

Challenges and Rewards in Medicinal Chemistry Targeting Cardiovascular and Metabolic Diseases

by Neidhart, Werner, Ackermann, Jean, Amrein, Kurt, Conte, Aurelia, Hunziker, Daniel, Kuhn, Bernd, Märki, Hans Peter, Nettekoven, Matthias, Ruf, Armin, Schulz-Gasch, Tanja, Mayweg, Alexander V
Published in Chimia (19.08.2015)

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Frontiers in Medicinal Chemistry – Joint German-Swiss Meeting on Medicinal Chemistry: Heidelberg, Germany, March 15–18, 2009

Frontiers in Medicinal Chemistry – Joint German-Swiss Meeting on Medicinal Chemistry: Heidelberg, Germany, March 15–18, 2009

by Werner Neidhart, Hans Peter Märki, Peter Mohr
Published in Chimia (01.09.2009)

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Design and Biological Evaluation of Novel, Balanced Dual PPARα/γ Agonists

Design and Biological Evaluation of Novel, Balanced Dual PPARα/γ Agonists

by Grether, Uwe, Bénardeau, Agnes, Benz, Jörg, Binggeli, Alfred, Blum, Denise, Hilpert, Hans, Kuhn, Bernd, Märki, Hans Peter, Meyer, Markus, Mohr, Peter, Püntener, Kurt, Raab, Susanne, Ruf, Armin, Schlatter, Daniel
Published in ChemMedChem (08.06.2009)

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