Potent quinoxaline-Based inhibitors of PDGF receptor tyrosine kinase activity. Part 2: the synthesis and biological activities of RPR127963 an orally bioavailable inhibitor
He, Wei, Myers, Michael R., Hanney, Barbara, Spada, Alfred P., Bilder, Glenda, Galzcinski, Helen, Amin, Dilip, Needle, Saul, Page, Ken, Jayyosi, Zaid, Perrone, Mark H.
Published in Bioorganic & medicinal chemistry letters (15.09.2003)
Published in Bioorganic & medicinal chemistry letters (15.09.2003)
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Journal Article
Potent quinoxaline-Based inhibitors of PDGF receptor tyrosine kinase activity. Part 1: SAR Exploration and Effective Bioisosteric Replacement of a phenyl substituent
Myers, Michael R., He, Wei, Hanney, Barbara, Setzer, Natalie, Maguire, Martin P., Zulli, Allison, Bilder, Glenda, Galzcinski, Helen, Amin, Dilip, Needle, Saul, Spada, Alfred P.
Published in Bioorganic & medicinal chemistry letters (15.09.2003)
Published in Bioorganic & medicinal chemistry letters (15.09.2003)
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Journal Article
Benzimidazoles and isosteric compounds as potent and selective factor Xa inhibitors
WEI HE, HANNEY, Barbara, MYERS, Michael R, CONDON, Stephen, BECKER, Michael R, SPADA, Alfred P, BURNS, Christopher, BROWN, Karen, COLUSSI, Dennis, CHU, Valeria
Published in Bioorganic & medicinal chemistry letters (25.03.2002)
Published in Bioorganic & medicinal chemistry letters (25.03.2002)
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Journal Article
Nonbenzamidine compounds as selective factor xa inhibitors
He, Wei, Hanney, Barbara, Myers, Michael R, Spada, Alfred P, Brown, Karen, Colussi, Dennis, Chu, Valeria
Published in Bioorganic & medicinal chemistry letters (07.08.2000)
Published in Bioorganic & medicinal chemistry letters (07.08.2000)
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Journal Article
Potent quinoxaline-based inhibitors of PDGF receptor tyrosine kinase activity. Part 2: The synthesis and biological activities of RPR127963 an orally bioavailable inhibitor: Recent advances in the design of kinase inhibitors as novel therapeutic agents
WEI HE, MYERS, Michael R, PERRONE, Mark H, HANNEY, Barbara, SPADA, Alfred P, BILDER, Glenda, GALZCINSKI, Helen, AMIN, Dilip, NEEDLE, Saul, PAGE, Ken, JAYYOSI, Zaid
Published in Bioorganic & medicinal chemistry letters (2003)
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Published in Bioorganic & medicinal chemistry letters (2003)
Journal Article
Potent quinoxaline-based inhibitors of PDGF receptor tyrosine kinase activity. Part 1: SAR exploration and effective bioisosteric replacement of a phenyl substituent: Recent advances in the design of kinase inhibitors as novel therapeutic agents
MYERS, Michael R, WEI HE, SPADA, Alfred P, HANNEY, Barbara, SETZER, Natalie, MAGUIRE, Martin P, ZULLI, Allison, BILDER, Glenda, GALZCINSKI, Helen, AMIN, Dilip, NEEDLE, Saul
Published in Bioorganic & medicinal chemistry letters (2003)
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Published in Bioorganic & medicinal chemistry letters (2003)
Journal Article
The synthesis and SAR of new 4-(N-alkyl-N-phenyl)amino-6,7-dimethoxyquinazolines and 4-(N-alkyl-N-phenyl)amino-pyrazolo[3,4-d]pyrimidines, inhibitors of CSF-1R tyrosine kinase activity
MYERS, M. R, SETZER, N. N, FRANKS, C. F, MITCHELL, K. J, SPADA, A. P, PERSONS, P. E, LY, C. Q, MAGUIRE, M. P, ZULLI, A. L, CHENEY, D. L, ZILBERSTEIN, A, JOHNSON, S. E
Published in Bioorganic & medicinal chemistry letters (18.02.1997)
Published in Bioorganic & medicinal chemistry letters (18.02.1997)
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Journal Article
The synthesis and SAR of new 4-( N-alkyl- N-phenyl)amino-6,7-dimethoxyquinazolines and 4-( N-alkyl- N-phenyl)aminopyrazolo[3,4- d]pyrimidines, inhibitors of CSF-1R tyrosine kinase activity
Myers, Michael R., Setzer, Natalie N., Spada, Alfred.P., Persons, Paul E., Ly, Cuong Q., Maguire, Martin P., Zulli, Allison L., Cheney, Daniel L., Zilberstein, Asher, Johnson, Susan E., Franks, Carol F., Mitchell, Karen J.
Published in Bioorganic & medicinal chemistry letters (18.02.1997)
Published in Bioorganic & medicinal chemistry letters (18.02.1997)
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Journal Article
The preparation and sar of 4-(anilino), 4-(phenoxy), and 4-(thiophenoxy)-quinazolines: Inhibitors of p56 lck and EGF-R tyrosine kinase activity
Myers, Michael R., Setzer, Natalie N., Spada, Alfred.P., Zulli, Allison L., Hsu, Chin-Yi J., Zilberstein, Asher, Johnson, Susan E., Hook, Linda E., Jacoski, Mary V.
Published in Bioorganic & medicinal chemistry letters (1997)
Published in Bioorganic & medicinal chemistry letters (1997)
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Journal Article
The preparation and SAR of 4-(anilino), 4-(phenoxy), and 4-(thiophenoxy)-quinazolines : Inhibitors of p56lck and EGF-R tyrosine kinase activity
MYERS, M. R, SETZER, N. N, SPADA, A. P, ZULLI, A. L, HSU, C.-Y. J, ZILBERSTEIN, A, JOHNSON, S. E, HOOK, L. E, JACOSKI, M. V
Published in Bioorganic & medicinal chemistry letters (01.02.1997)
Published in Bioorganic & medicinal chemistry letters (01.02.1997)
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Journal Article