Discovery of Tropifexor (LJN452), a Highly Potent Non-bile Acid FXR Agonist for the Treatment of Cholestatic Liver Diseases and Nonalcoholic Steatohepatitis (NASH)
Tully, David C, Rucker, Paul V, Chianelli, Donatella, Williams, Jennifer, Vidal, Agnès, Alper, Phil B, Mutnick, Daniel, Bursulaya, Badry, Schmeits, James, Wu, Xiangdong, Bao, Dingjiu, Zoll, Jocelyn, Kim, Young, Groessl, Todd, McNamara, Peter, Seidel, H. Martin, Molteni, Valentina, Liu, Bo, Phimister, Andrew, Joseph, Sean B, Laffitte, Bryan
Published in Journal of medicinal chemistry (28.12.2017)
Published in Journal of medicinal chemistry (28.12.2017)
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Journal Article
Total Synthesis of the Lycopodium Alkaloid (+)-Serratezomine A
Chandra, Aroop, Pigza, Julie A, Han, Jeong-Seok, Mutnick, Daniel, Johnston, Jeffrey N
Published in Journal of the American Chemical Society (18.03.2009)
Published in Journal of the American Chemical Society (18.03.2009)
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Journal Article
Discovery and biological evaluation of benzo[ a]carbazole-based small molecule agonists of the thrombopoietin (Tpo) receptor
Alper, Phil B., Marsilje, Thomas H., Mutnick, Daniel, Lu, Wenshuo, Chatterjee, Arnab, Roberts, Michael J., He, Yun, Karanewsky, Donald S., Chow, Donald, Lao, Jianmin, Gerken, Andrea, Tuntland, Tove, Liu, Bo, Chang, Jonathan, Gordon, Perry, Martin Seidel, H., Tian, Shin-Shay
Published in Bioorganic & medicinal chemistry (01.10.2008)
Published in Bioorganic & medicinal chemistry (01.10.2008)
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Journal Article
Topoisomerase Inhibitors Addressing Fluoroquinolone Resistance in Gram-Negative Bacteria
Skepper, Colin K, Armstrong, Duncan, Balibar, Carl J, Bauer, Daniel, Bellamacina, Cornelia, Benton, Bret M, Bussiere, Dirksen, De Pascale, Gianfranco, De Vicente, Javier, Dean, Charles R, Dhumale, Bhavesh, Fisher, L. Mark, Fuller, John, Fulsunder, Mangesh, Holder, Lauren M, Hu, Cheng, Kantariya, Bhavin, Lapointe, Guillaume, Leeds, Jennifer A, Li, Xiaolin, Lu, Peichao, Lvov, Anatoli, Ma, Sylvia, Madhavan, Shravanthi, Malekar, Swapnil, McKenney, David, Mergo, Wosenu, Metzger, Louis, Moser, Heinz E, Mutnick, Daniel, Noeske, Jonas, Osborne, Colin, Patel, Ashish, Patel, Darshit, Patel, Tushar, Prajapati, Krunal, Prosen, Katherine R, Reck, Folkert, Richie, Daryl L, Rico, Alice, Sanderson, Mark R, Satasia, Shailesh, Sawyer, William S, Selvarajah, Jogitha, Shah, Nirav, Shanghavi, Kartik, Shu, Wei, Thompson, Katherine V, Traebert, Martin, Vala, Anand, Vala, Lakhan, Veselkov, Dennis A, Vo, Jason, Wang, Michael, Widya, Marcella, Williams, Sarah L, Xu, Yongjin, Yue, Qin, Zang, Richard, Zhou, Bo, Rivkin, Alexey
Published in Journal of medicinal chemistry (23.07.2020)
Published in Journal of medicinal chemistry (23.07.2020)
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Journal Article
Discovery of potent, orally bioavailable in vivo efficacious antagonists of the TLR7/8 pathway
Alper, Phil B., Deane, Jonathan, Betschart, Claudia, Buffet, David, Collignon Zipfel, Géraldine, Gordon, Perry, Hampton, Janice, Hawtin, Stuart, Ibanez, Maureen, Jiang, Tao, Junt, Tobias, Knoepfel, Thomas, Liu, Bo, Maginnis, Jillian, McKeever, Una, Michellys, Pierre-Yves, Mutnick, Daniel, Nayak, Bishnu, Niwa, Satoru, Richmond, Wendy, Rush, James S., Syka, Peter, Zhang, Yi, Zhu, Xuefeng
Published in Bioorganic & medicinal chemistry letters (01.09.2020)
Published in Bioorganic & medicinal chemistry letters (01.09.2020)
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Journal Article
Discovery of the TLR7/8 Antagonist MHV370 for Treatment of Systemic Autoimmune Diseases
Alper, Phil, Betschart, Claudia, André, Cédric, Boulay, Thomas, Cheng, Dai, Deane, Jonathan, Faller, Michael, Feifel, Roland, Glatthar, Ralf, Han, Dong, Hemmig, Rene, Jiang, Tao, Knoepfel, Thomas, Maginnis, Jillian, Mutnick, Daniel, Pei, Wei, Ruzzante, Giulia, Syka, Peter, Zhang, Guobao, Zhang, Yi, Zink, Florence, Zipfel, Géraldine, Hawtin, Stuart, Junt, Tobias, Michellys, Pierre-Yves
Published in ACS medicinal chemistry letters (10.08.2023)
Published in ACS medicinal chemistry letters (10.08.2023)
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Journal Article
Total Synthesis of the Lycopodium Alkaloid Serratezomine A Using Free Radical-Mediated Vinyl Amination to Prepare a β‑Stannyl Enamine Linchpin
Pigza, Julie A, Han, Jeong-Seok, Chandra, Aroop, Mutnick, Daniel, Pink, Maren, Johnston, Jeffrey N
Published in Journal of organic chemistry (01.02.2013)
Published in Journal of organic chemistry (01.02.2013)
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Journal Article
COMPOUNDS AND COMPOSITIONS AS INHIBITORS OF ENDOSOMAL TOLL-LIKE RECEPTORS
MUTNICK DANIEL, PEI WEI, MICHELLYS PIERRE YVES, SYKA PETER, DEANE JONATHAN, JIANG TAO, ZHANG YI, KNOEPFEL THOMAS, ZHANG GUOBAO, ALPER PHILLIP, JIANG SONGCHUN
Year of Publication 24.06.2021
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Year of Publication 24.06.2021
Patent
Novel tricyclic pyrazolopyrimidines as potent and selective GPR119 agonists
Azimioara, Mihai, Alper, Phil, Cow, Christopher, Mutnick, Daniel, Nikulin, Victor, Lelais, Gerald, Mecom, John, McNeill, Matthew, Michellys, Pierre-Yves, Wang, Zhiliang, Reding, Esther, Paliotti, Michael, Li, Jing, Bao, Dingjiu, Zoll, Jocelyn, Kim, Young, Zimmerman, Matthew, Groessl, Todd, Tuntland, Tove, Joseph, Sean B., McNamara, Peter, Seidel, H. Martin, Epple, Robert
Published in Bioorganic & medicinal chemistry letters (01.12.2014)
Published in Bioorganic & medicinal chemistry letters (01.12.2014)
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Journal Article
Discovery of structurally novel, potent and orally efficacious GPR119 agonists
Alper, Phil, Azimioara, Mihai, Cow, Christopher, Mutnick, Daniel, Nikulin, Victor, Michellys, Pierre-Yves, Wang, Zhiliang, Reding, Esther, Paliotti, Michael, Li, Jing, Bao, Dingjiu, Zoll, Jocelyn, Kim, Young, Zimmerman, Matthew, Groessel, Todd, Tuntland, Tove, Joseph, Sean B., McNamara, Peter, Seidel, H. Martin, Epple, Robert
Published in Bioorganic & medicinal chemistry letters (15.05.2014)
Published in Bioorganic & medicinal chemistry letters (15.05.2014)
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Journal Article
엔도솜 톨-유사 수용체의 억제제로서의 화합물 및 조성물
MUTNICK DANIEL, PEI WEI, MICHELLYS PIERRE YVES, SYKA PETER, DEANE JONATHAN, JIANG TAO, ZHANG YI, KNOEPFEL THOMAS, ZHANG GUOBAO, ALPER PHILLIP, JIANG SONGCHUN
Year of Publication 15.04.2019
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Year of Publication 15.04.2019
Patent
The First Azacyclopentenyl Carbinyl Radical Isomerizations (ACCRI): Independent Use of Steric and Electronic (Polarization) Effects as Gating Elements
Viswanathan, Rajesh, Mutnick, Daniel, Johnston, Jeffrey N
Published in Journal of the American Chemical Society (18.06.2003)
Published in Journal of the American Chemical Society (18.06.2003)
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Journal Article
COMPOSITIONS AND METHODS FOR MODULATING FXR
MUTNICK DANIEL, ALPER PHILLIP B, CHIANELLI DONATELLA, RUCKER PAUL VINCENT, TULLY DAVID C
Year of Publication 07.10.2013
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Year of Publication 07.10.2013
Patent
Optimization of small molecule agonists of the thrombopoietin (Tpo) receptor derived from a benzo[ a]carbazole hit scaffold
Marsilje, Thomas H., Alper, Phil B., Lu, Wenshuo, Mutnick, Daniel, Michellys, Pierre-Yves, He, Yun, Karanewsky, Donald S., Chow, Donald, Gerken, Andrea, Lao, Jianmin, Kim, Min-Ju, Seidel, H. Martin, Tian, Shin-Shay
Published in Bioorganic & medicinal chemistry (01.10.2008)
Published in Bioorganic & medicinal chemistry (01.10.2008)
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Journal Article
Arylaminoethyl carbamates as a novel series of potent and selective cathepsin S inhibitors
Tully, David C., Liu, Hong, Chatterjee, Arnab K., Alper, Phil B., Williams, Jennifer A., Roberts, Michael J., Mutnick, Daniel, Woodmansee, David H., Hollenbeck, Thomas, Gordon, Perry, Chang, Jonathan, Tuntland, Tove, Tumanut, Christine, Li, Jun, Harris, Jennifer L., Karanewsky, Donald S.
Published in Bioorganic & medicinal chemistry letters (01.10.2006)
Published in Bioorganic & medicinal chemistry letters (01.10.2006)
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Journal Article
COMPOUNDS AND COMPOSITIONS AS MODULATORS OF GPR119 ACTIVITY
MUTNICK DANIEL, EPPLE ROBERT, MICHELLYS PIERRE YVES, COW CHRISTOPHER, ALPER PHILLIP
Year of Publication 16.11.2010
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Year of Publication 16.11.2010
Patent
COMPOUNDS AND COMPOSITIONS AS MODULATORS OF GPR119 ACTIVITY
MUTNICK DANIEL, EPPLE ROBERT, LELAIS GERALD, AZIMIOARA MIHAI, COW CHRISTOPHER, JIANG SONGCHUN, WU BAOGEN
Year of Publication 27.10.2010
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Year of Publication 27.10.2010
Patent
COMPOUNDS AND COMPOSITIONS AS MODULATORS OF GPR119 ACTIVITY
MUTNICK DANIEL, EPPLE ROBERT, LELAIS GERALD, AZIMIOARA MIHAI, MICHELLYS PIERRE YVES, WESTCOTT BAKER LUCAS, COW CHRISTOPHER, ALPER PHILLIP, JIANG SONGCHUN, NIKULIN VICTOR
Year of Publication 26.05.2010
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Year of Publication 26.05.2010
Patent
COMPOUNDS AND COMPOSITIONS AS INHIBITORS OF ENDOSOMAL TOLL-LIKE RECEPTORS
ALPER, Phillip, SYKA, Peter, KNOEPFEL, Thomas, JIANG, Songchun, JIANG, Tao, PEI, Wei, DEANE, Jonathan, MICHELLYS, Pierre-Yves, MUTNICK, Daniel, ZHANG, Guobao, ZHANG, Yi
Year of Publication 16.12.2022
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Year of Publication 16.12.2022
Patent
COMPOUNDS AND COMPOSITIONS AS INHIBITORS OF ENDOSOMAL TOLL-LIKE RECEPTORS
ALPER, Phillip, SYKA, Peter, KNOEPFEL, Thomas, JIANG, Songchun, JIANG, Tao, PEI, Wei, DEANE, Jonathan, MICHELLYS, Pierre-Yves, MUTNICK, Daniel, ZHANG, Guobao, ZHANG, Yi
Year of Publication 21.09.2022
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Year of Publication 21.09.2022
Patent