Synthesis, Molecular Editing, and Biological Assessment of the Potent Cytotoxin Leiodermatolide
Mailhol, Damien, Willwacher, Jens, Kausch-Busies, Nina, Rubitski, Elizabeth E, Sobol, Zhanna, Schuler, Maik, Lam, My-Hanh, Musto, Sylvia, Loganzo, Frank, Maderna, Andreas, Fürstner, Alois
Published in Journal of the American Chemical Society (05.11.2014)
Published in Journal of the American Chemical Society (05.11.2014)
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Journal Article
Multivalent peptidic linker enables identification of preferred sites of conjugation for a potent thialanstatin antibody drug conjugate
Puthenveetil, Sujiet, He, Haiyin, Loganzo, Frank, Musto, Sylvia, Teske, Jesse, Green, Michael, Tan, Xingzhi, Hosselet, Christine, Lucas, Judy, Tumey, L Nathan, Sapra, Puja, Subramanyam, Chakrapani, O'Donnell, Christopher J, Graziani, Edmund I
Published in PloS one (30.05.2017)
Published in PloS one (30.05.2017)
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Journal Article
Natural Product Bis-Intercalator Depsipeptides as a New Class of Payloads for Antibody–Drug Conjugates
Ratnayake, Anokha S, Chang, Li-ping, Tumey, L. Nathan, Loganzo, Frank, Chemler, Joseph A, Wagenaar, Melissa, Musto, Sylvia, Li, Fengping, Janso, Jeffrey E, Ballard, T. Eric, Rago, Brian, Steele, Greg L, Ding, WeiDong, Feng, Xidong, Hosselet, Christine, Buklan, Vlad, Lucas, Judy, Koehn, Frank E, O’Donnell, Christopher J, Graziani, Edmund I
Published in Bioconjugate chemistry (16.01.2019)
Published in Bioconjugate chemistry (16.01.2019)
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Journal Article
Paclitaxel-resistant cells have a mutation in the paclitaxel-binding region of β-tubulin (Asp26Glu) and less stable microtubules
Hari, Malathi, Loganzo, Frank, Annable, Tami, Tan, Xingzhi, Musto, Sylvia, Morilla, Daniel B, Nettles, James H, Snyder, James P, Greenberger, Lee M
Published in Molecular cancer therapeutics (01.02.2006)
Published in Molecular cancer therapeutics (01.02.2006)
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Journal Article
MAC-321, a novel taxane with greater efficacy than paclitaxel and docetaxel in vitro and in vivo
Sampath, Deepak, Discafani, Carolyn M, Loganzo, Frank, Beyer, Carl, Liu, Hao, Tan, Xingzhi, Musto, Sylvia, Annable, Tami, Gallagher, Patricia, Rios, Carol, Greenberger, Lee M
Published in Molecular cancer therapeutics (01.09.2003)
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Published in Molecular cancer therapeutics (01.09.2003)
Journal Article
Cells resistant to HTI-286 do not overexpress P-glycoprotein but have reduced drug accumulation and a point mutation in α-tubulin
Loganzo, Frank, Hari, Malathi, Annable, Tami, Tan, Xingzhi, Morilla, Daniel B, Musto, Sylvia, Zask, Arie, Kaplan, Joshua, Minnick, Jr, Albert A, May, Michael K, Ayral-Kaloustian, Semiramis, Poruchynsky, Marianne S, Fojo, Tito, Greenberger, Lee M
Published in Molecular cancer therapeutics (01.10.2004)
Published in Molecular cancer therapeutics (01.10.2004)
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Journal Article
Tumor cells chronically treated with a trastuzumab-maytansinoid antibody-drug conjugate develop varied resistance mechanisms but respond to alternate treatments
Loganzo, Frank, Tan, Xingzhi, Sung, Matthew, Jin, Guixian, Myers, Jeremy S, Melamud, Eugene, Wang, Fang, Diesl, Veronica, Follettie, Maximillian T, Musto, Sylvia, Lam, My-Hanh, Hu, William, Charati, Manoj B, Khandke, Kiran, Kim, Kenny Sung Kyoo, Cinque, Mike, Lucas, Judy, Graziani, Edmund, Maderna, Andreas, O'Donnell, Christopher J, Arndt, Kim T, Gerber, Hans-Peter
Published in Molecular cancer therapeutics (01.04.2015)
Published in Molecular cancer therapeutics (01.04.2015)
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Journal Article
Development of Solid-Phase Site-Specific Conjugation and Its Application toward Generation of Dual Labeled Antibody and Fab Drug Conjugates
Puthenveetil, Sujiet, Musto, Sylvia, Loganzo, Frank, Tumey, L. Nathan, O’Donnell, Christopher J, Graziani, Edmund
Published in Bioconjugate chemistry (20.04.2016)
Published in Bioconjugate chemistry (20.04.2016)
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Journal Article
Discovery of Cytotoxic Dolastatin 10 Analogues with N‑Terminal Modifications
Maderna, Andreas, Doroski, Matthew, Subramanyam, Chakrapani, Porte, Alexander, Leverett, Carolyn A, Vetelino, Beth C, Chen, Zecheng, Risley, Hud, Parris, Kevin, Pandit, Jayvardhan, Varghese, Alison H, Shanker, Suman, Song, Cynthia, Sukuru, Sai Chetan K, Farley, Kathleen A, Wagenaar, Melissa M, Shapiro, Michael J, Musto, Sylvia, Lam, My-Hanh, Loganzo, Frank, O’Donnell, Christopher J
Published in Journal of medicinal chemistry (26.12.2014)
Published in Journal of medicinal chemistry (26.12.2014)
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Journal Article
Natural Product Splicing Inhibitors: A New Class of Antibody–Drug Conjugate (ADC) Payloads
Puthenveetil, Sujiet, Loganzo, Frank, He, Haiyin, Dirico, Ken, Green, Michael, Teske, Jesse, Musto, Sylvia, Clark, Tracey, Rago, Brian, Koehn, Frank, Veneziale, Robert, Falahaptisheh, Hadi, Han, Xiaogang, Barletta, Frank, Lucas, Judy, Subramanyam, Chakrapani, O’Donnell, Christopher J, Tumey, L. Nathan, Sapra, Puja, Gerber, Hans Peter, Ma, Dangshe, Graziani, Edmund I
Published in Bioconjugate chemistry (17.08.2016)
Published in Bioconjugate chemistry (17.08.2016)
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Journal Article
Site Selection: a Case Study in the Identification of Optimal Cysteine Engineered Antibody Drug Conjugates
Tumey, L. Nathan, Li, Fengping, Rago, Brian, Han, Xiaogang, Loganzo, Frank, Musto, Sylvia, Graziani, Edmund I., Puthenveetil, Sujiet, Casavant, Jeffrey, Marquette, Kimberly, Clark, Tracey, Bikker, Jack, Bennett, Eric M., Barletta, Frank, Piche-Nicholas, Nicole, Tam, Amy, O’Donnell, Christopher J., Gerber, Hans Peter, Tchistiakova, Lioudmila
Published in The AAPS journal (01.07.2017)
Published in The AAPS journal (01.07.2017)
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Journal Article
Novel PIKK inhibitor antibody-drug conjugates: Synthesis and anti-tumor activity
Zhou, Dahui, Casavant, Jeffrey, Graziani, Edmund I., He, Haiyin, Janso, Jeffrey, Loganzo, Frank, Musto, Sylvia, Tumey, Nathan, O'Donnell, Christopher J., Dushin, Russell
Published in Bioorganic & medicinal chemistry letters (01.04.2019)
Published in Bioorganic & medicinal chemistry letters (01.04.2019)
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Journal Article
Optimization of Tubulysin Antibody–Drug Conjugates: A Case Study in Addressing ADC Metabolism
Tumey, L. Nathan, Leverett, Carolyn A, Vetelino, Beth, Li, Fengping, Rago, Brian, Han, Xiaogang, Loganzo, Frank, Musto, Sylvia, Bai, Guoyun, Sukuru, Sai Chetan K, Graziani, Edmund I, Puthenveetil, Sujiet, Casavant, Jeffrey, Ratnayake, Anokha, Marquette, Kimberly, Hudson, Sarah, Doppalapudi, Venkata Ramana, Stock, Joseph, Tchistiakova, Lioudmila, Bessire, Andrew J, Clark, Tracey, Lucas, Judy, Hosselet, Christine, O’Donnell, Christopher J, Subramanyam, Chakrapani
Published in ACS medicinal chemistry letters (10.11.2016)
Published in ACS medicinal chemistry letters (10.11.2016)
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Journal Article
Establishing in vitro–in vivo correlation for antibody drug conjugate efficacy: a PK/PD modeling approach
Shah, Dhaval K., Loganzo, Frank, Haddish-Berhane, Nahor, Musto, Sylvia, Wald, Hallie S., Barletta, Frank, Lucas, Judy, Clark, Tracey, Hansel, Steve, Betts, Alison
Published in Journal of pharmacokinetics and pharmacodynamics (01.04.2018)
Published in Journal of pharmacokinetics and pharmacodynamics (01.04.2018)
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Journal Article
Design, Synthesis, and Cytotoxic Evaluation of Novel Tubulysin Analogues as ADC Payloads
Leverett, Carolyn A, Sukuru, Sai Chetan K, Vetelino, Beth C, Musto, Sylvia, Parris, Kevin, Pandit, Jayvardhan, Loganzo, Frank, Varghese, Alison H, Bai, Guoyun, Liu, Bin, Liu, Dingguo, Hudson, Sarah, Doppalapudi, Venkata Ramana, Stock, Joseph, O’Donnell, Christopher J, Subramanyam, Chakrapani
Published in ACS medicinal chemistry letters (10.11.2016)
Published in ACS medicinal chemistry letters (10.11.2016)
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Journal Article
Abstract 1830: Antibody-drug conjugates with modified linker-payloads overcome resistance to a trastuzumab-maytansinoid conjugate in multiple cultured tumor cell models
Tan, Xingzhi, Lu, Bingwen, Jin, Guixian, Wang, Fang, Myers, Jeremy, Musto, Sylvia, Lam, My-Hanh, Hu, William, Khandke, Kiran, Arndt, Kim, Gerber, Hans-Peter, Loganzo, Frank
Published in Cancer research (Chicago, Ill.) (01.10.2014)
Published in Cancer research (Chicago, Ill.) (01.10.2014)
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Journal Article
New cytotoxic benzosuberene analogs. Synthesis, molecular modeling and biological evaluation
Chen, Zecheng, Maderna, Andreas, Sukuru, Sai Chetan K., Wagenaar, Melissa, O’Donnell, Christopher J., Lam, My-Hanh, Musto, Sylvia, Loganzo, Frank
Published in Bioorganic & medicinal chemistry letters (15.12.2013)
Published in Bioorganic & medicinal chemistry letters (15.12.2013)
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Journal Article
Abstract 4837: Extracellular proteolytic cleavage of peptide-linked antibody-drug conjugates promotes bystander killing of cancer cells
Lam, My-Hanh, Lucas, Judy, Maderna, Andreas, Wald, Hallie, Wojciechowicz, Megan, Dushin, Russell, Peano, Bryan, Wang, Fang, Myers, Jeremy, Tan, Xingzhi, Musto, Sylvia, Charati, Manoj, Gerber, Hans-Peter, Loganzo, Frank
Published in Cancer research (Chicago, Ill.) (01.10.2014)
Published in Cancer research (Chicago, Ill.) (01.10.2014)
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