Functional analysis of Hsp70 inhibitors
Schlecht, Rainer, Scholz, Sebastian R, Dahmen, Heike, Wegener, Ansgar, Sirrenberg, Christian, Musil, Djordje, Bomke, Joerg, Eggenweiler, Hans-Michael, Mayer, Matthias P, Bukau, Bernd
Published in PloS one (12.11.2013)
Published in PloS one (12.11.2013)
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Journal Article
Estimation of Protein–Ligand Unbinding Kinetics Using Non-Equilibrium Targeted Molecular Dynamics Simulations
Wolf, Steffen, Amaral, Marta, Lowinski, Maryse, Vallée, Francois, Musil, Djordje, Güldenhaupt, Jörn, Dreyer, Matthias K, Bomke, Jörg, Frech, Matthias, Schlitter, Jürgen, Gerwert, Klaus
Published in Journal of chemical information and modeling (23.12.2019)
Published in Journal of chemical information and modeling (23.12.2019)
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Journal Article
Structure-Based Optimization of Potent, Selective, and Orally Bioavailable CDK8 Inhibitors Discovered by High-Throughput Screening
Czodrowski, Paul, Mallinger, Aurélie, Wienke, Dirk, Esdar, Christina, Pöschke, Oliver, Busch, Michael, Rohdich, Felix, Eccles, Suzanne A, Ortiz-Ruiz, Maria-Jesus, Schneider, Richard, Raynaud, Florence I, Clarke, Paul A, Musil, Djordje, Schwarz, Daniel, Dale, Trevor, Urbahns, Klaus, Blagg, Julian, Schiemann, Kai
Published in Journal of medicinal chemistry (27.10.2016)
Published in Journal of medicinal chemistry (27.10.2016)
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Journal Article
Discovery of Potent, Selective, and Orally Bioavailable Small-Molecule Modulators of the Mediator Complex-Associated Kinases CDK8 and CDK19
Mallinger, Aurélie, Schiemann, Kai, Rink, Christian, Stieber, Frank, Calderini, Michel, Crumpler, Simon, Stubbs, Mark, Adeniji-Popoola, Olajumoke, Poeschke, Oliver, Busch, Michael, Czodrowski, Paul, Musil, Djordje, Schwarz, Daniel, Ortiz-Ruiz, Maria-Jesus, Schneider, Richard, Thai, Ching, Valenti, Melanie, de Haven Brandon, Alexis, Burke, Rosemary, Workman, Paul, Dale, Trevor, Wienke, Dirk, Clarke, Paul A, Esdar, Christina, Raynaud, Florence I, Eccles, Suzanne A, Rohdich, Felix, Blagg, Julian
Published in Journal of medicinal chemistry (11.02.2016)
Published in Journal of medicinal chemistry (11.02.2016)
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Journal Article
Selection of Fragments for Kinase Inhibitor Design: Decoration Is Key
Czodrowski, Paul, Hölzemann, Günter, Barnickel, Gerhard, Greiner, Hartmut, Musil, Djordje
Published in Journal of medicinal chemistry (08.01.2015)
Published in Journal of medicinal chemistry (08.01.2015)
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Journal Article
Structural and Biophysical Characterization of the Syk Activation Switch
Grädler, Ulrich, Schwarz, Daniel, Dresing, Verena, Musil, Djordje, Bomke, Jörg, Frech, Matthias, Greiner, Hartmut, Jäkel, Stefan, Rysiok, Thomas, Müller-Pompalla, Dirk, Wegener, Ansgar
Published in Journal of molecular biology (23.01.2013)
Published in Journal of molecular biology (23.01.2013)
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Journal Article
Fragment-Based Discovery of New Highly Substituted 1H‑Pyrrolo[2,3‑b]- and 3H‑Imidazolo[4,5‑b]‑Pyridines as Focal Adhesion Kinase Inhibitors
Heinrich, Timo, Seenisamy, Jeyaprakashnarayanan, Emmanuvel, Lourdusamy, Kulkarni, Santosh S, Bomke, Jörg, Rohdich, Felix, Greiner, Hartmut, Esdar, Christina, Krier, Mireille, Grädler, Ulrich, Musil, Djordje
Published in Journal of medicinal chemistry (14.02.2013)
Published in Journal of medicinal chemistry (14.02.2013)
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Journal Article
Identification and characterization of M6903, an antagonistic anti-TIM-3 monoclonal antibody
Zhang, Dong, Jiang, Feng, Zaynagetdinov, Rinat, Huang, Hui, Sood, Vanita D., Wang, Hong, Zhao, Xinyan, Jenkins, Molly H., Ji, Qingyong, Wang, Youbin, Nannemann, David P., Musil, Djordje, Wesolowski, John, Paoletti, Andrea, Bartholomew, Tin, Derner, Melissa G., An, Qi, Iffland, Christel, Halle, Joern-Peter
Published in Oncoimmunology (01.01.2020)
Published in Oncoimmunology (01.01.2020)
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Journal Article
Discovery of potent and selective CDK8 inhibitors from an HSP90 pharmacophore
Schiemann, Kai, Mallinger, Aurélie, Wienke, Dirk, Esdar, Christina, Poeschke, Oliver, Busch, Michael, Rohdich, Felix, Eccles, Suzanne A., Schneider, Richard, Raynaud, Florence I., Czodrowski, Paul, Musil, Djordje, Schwarz, Daniel, Urbahns, Klaus, Blagg, Julian
Published in Bioorganic & medicinal chemistry letters (01.03.2016)
Published in Bioorganic & medicinal chemistry letters (01.03.2016)
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Journal Article
A selective chemical probe for exploring the role of CDK8 and CDK19 in human disease
Dale, Trevor, Clarke, Paul A, Esdar, Christina, Waalboer, Dennis, Adeniji-Popoola, Olajumoke, Ortiz-Ruiz, Maria-Jesus, Mallinger, Aurélie, Samant, Rahul S, Czodrowski, Paul, Musil, Djordje, Schwarz, Daniel, Schneider, Klaus, Stubbs, Mark, Ewan, Ken, Fraser, Elizabeth, TePoele, Robert, Court, Will, Box, Gary, Valenti, Melanie, de Haven Brandon, Alexis, Gowan, Sharon, Rohdich, Felix, Raynaud, Florence, Schneider, Richard, Poeschke, Oliver, Blaukat, Andree, Workman, Paul, Schiemann, Kai, Eccles, Suzanne A, Wienke, Dirk, Blagg, Julian
Published in Nature chemical biology (26.10.2015)
Published in Nature chemical biology (26.10.2015)
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Journal Article
Correction: Functional Analysis of Hsp70 Inhibitors
Schlecht, Rainer, Scholz, Sebastian R., Dahmen, Heike, Wegener, Ansgar, Sirrenberg, Christian, Musil, Djordje, Bomke, Joerg, Eggenweiler, Hans-Michael, Mayer, Matthias P., Bukau, Bernd
Published in PloS one (19.12.2013)
Published in PloS one (19.12.2013)
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Journal Article
Synthesis of Novel Thrombin Inhibitors. Use of Ring-Closing Metathesis Reactions for Synthesis of P2 Cyclopentene- and Cyclohexenedicarboxylic Acid Derivatives
Thorstensson, Fredrik, Kvarnström, Ingemar, Musil, Djordje, Nilsson, Ingemar, Samuelsson, Bertil
Published in Journal of medicinal chemistry (27.03.2003)
Published in Journal of medicinal chemistry (27.03.2003)
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Journal Article
Synthesis and SAR of Thrombin Inhibitors Incorporating a Novel 4-Amino-Morpholinone Scaffold: Analysis of X-ray Crystal Structure of Enzyme Inhibitor Complex
Nilsson, Jonas W, Kvarnström, Ingemar, Musil, Djordje, Nilsson, Ingemar, Samulesson, Bertil
Published in Journal of medicinal chemistry (11.09.2003)
Published in Journal of medicinal chemistry (11.09.2003)
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Journal Article
Estimation of Drug-Target Residence Times by τ‑Random Acceleration Molecular Dynamics Simulations
Kokh, Daria B, Amaral, Marta, Bomke, Joerg, Grädler, Ulrich, Musil, Djordje, Buchstaller, Hans-Peter, Dreyer, Matthias K, Frech, Matthias, Lowinski, Maryse, Vallee, Francois, Bianciotto, Marc, Rak, Alexey, Wade, Rebecca C
Published in Journal of chemical theory and computation (10.07.2018)
Published in Journal of chemical theory and computation (10.07.2018)
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Journal Article
Large-Scale Assessment of Binding Free Energy Calculations in Active Drug Discovery Projects
Schindler, Christina E. M, Baumann, Hannah, Blum, Andreas, Böse, Dietrich, Buchstaller, Hans-Peter, Burgdorf, Lars, Cappel, Daniel, Chekler, Eugene, Czodrowski, Paul, Dorsch, Dieter, Eguida, Merveille K. I, Follows, Bruce, Fuchß, Thomas, Grädler, Ulrich, Gunera, Jakub, Johnson, Theresa, Jorand Lebrun, Catherine, Karra, Srinivasa, Klein, Markus, Knehans, Tim, Koetzner, Lisa, Krier, Mireille, Leiendecker, Matthias, Leuthner, Birgitta, Li, Liwei, Mochalkin, Igor, Musil, Djordje, Neagu, Constantin, Rippmann, Friedrich, Schiemann, Kai, Schulz, Robert, Steinbrecher, Thomas, Tanzer, Eva-Maria, Unzue Lopez, Andrea, Viacava Follis, Ariele, Wegener, Ansgar, Kuhn, Daniel
Published in Journal of chemical information and modeling (23.11.2020)
Published in Journal of chemical information and modeling (23.11.2020)
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Journal Article
Predicting Residence Time and Drug Unbinding Pathway through Scaled Molecular Dynamics
Schuetz, Doris A, Bernetti, Mattia, Bertazzo, Martina, Musil, Djordje, Eggenweiler, Hans-Michael, Recanatini, Maurizio, Masetti, Matteo, Ecker, Gerhard F, Cavalli, Andrea
Published in Journal of chemical information and modeling (28.01.2019)
Published in Journal of chemical information and modeling (28.01.2019)
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Journal Article
Discovery and Optimization of 2‑Arylquinazolin-4-ones into a Potent and Selective Tankyrase Inhibitor Modulating Wnt Pathway Activity
Buchstaller, Hans-Peter, Anlauf, Uwe, Dorsch, Dieter, Kuhn, Daniel, Lehmann, Martin, Leuthner, Birgitta, Musil, Djordje, Radtki, Daniela, Ritzert, Claudio, Rohdich, Felix, Schneider, Richard, Esdar, Christina
Published in Journal of medicinal chemistry (12.09.2019)
Published in Journal of medicinal chemistry (12.09.2019)
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Journal Article
Structure-kinetic relationship reveals the mechanism of selectivity of FAK inhibitors over PYK2
Berger, Benedict-Tilman, Amaral, Marta, Kokh, Daria B., Nunes-Alves, Ariane, Musil, Djordje, Heinrich, Timo, Schröder, Martin, Neil, Rebecca, Wang, Jing, Navratilova, Iva, Bomke, Joerg, Elkins, Jonathan M., Müller, Susanne, Frech, Matthias, Wade, Rebecca C., Knapp, Stefan
Published in Cell chemical biology (20.05.2021)
Published in Cell chemical biology (20.05.2021)
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Journal Article
Discovery of M5049: A Novel Selective Toll-Like Receptor 7/8 Inhibitor for Treatment of Autoimmunity
Vlach, Jaromir, Bender, Andrew T, Przetak, Melinda, Pereira, Albertina, Deshpande, Aditee, Johnson, Theresa L, Reissig, Sonja, Tzvetkov, Evgeni, Musil, Djordje, Morse, Noune Tahmassian, Haselmayer, Philipp, Zimmerli, Simone C, Okitsu, Shinji L, Walsky, Robert L, Sherer, Brian
Published in The Journal of pharmacology and experimental therapeutics (01.03.2021)
Published in The Journal of pharmacology and experimental therapeutics (01.03.2021)
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Journal Article
Ligand‐Induced Conformational Changes in HSP90 Monitored Time Resolved and Label Free—Towards a Conformational Activity Screening for Drug Discovery
Güldenhaupt, Jörn, Amaral, Marta, Kötting, Carsten, Schartner, Jonas, Musil, Djordje, Frech, Matthias, Gerwert, Klaus
Published in Angewandte Chemie International Edition (26.07.2018)
Published in Angewandte Chemie International Edition (26.07.2018)
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Journal Article