Cryo-EM of full-length α-synuclein reveals fibril polymorphs with a common structural kernel
Li, Binsen, Ge, Peng, Murray, Kevin A., Sheth, Phorum, Zhang, Meng, Nair, Gayatri, Sawaya, Michael R., Shin, Woo Shik, Boyer, David R., Ye, Shulin, Eisenberg, David S., Zhou, Z. Hong, Jiang, Lin
Published in Nature communications (06.09.2018)
Published in Nature communications (06.09.2018)
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Journal Article
Structure-based discovery of small molecules that disaggregate Alzheimer’s disease tissue derived tau fibrils in vitro
Seidler, Paul M., Murray, Kevin A., Boyer, David R., Ge, Peng, Sawaya, Michael R., Hu, Carolyn J., Cheng, Xinyi, Abskharon, Romany, Pan, Hope, DeTure, Michael A., Williams, Christopher K., Dickson, Dennis W., Vinters, Harry V., Eisenberg, David S.
Published in Nature communications (16.09.2022)
Published in Nature communications (16.09.2022)
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Journal Article
Structure-based inhibitors halt prion-like seeding by Alzheimer’s disease–and tauopathy–derived brain tissue samples
Seidler, Paul Matthew, Boyer, David R., Murray, Kevin A., Yang, Tianxiao P., Bentzel, Megan, Sawaya, Michael R., Rosenberg, Gregory, Cascio, Duilio, Williams, Christopher Kazu, Newell, Kathy L., Ghetti, Bernardino, DeTure, Michael A., Dickson, Dennis W., Vinters, Harry V., Eisenberg, David S.
Published in The Journal of biological chemistry (01.11.2019)
Published in The Journal of biological chemistry (01.11.2019)
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Journal Article
Structure-based inhibitors of amyloid beta core suggest a common interface with tau
Griner, Sarah L, Seidler, Paul, Bowler, Jeannette, Murray, Kevin A, Yang, Tianxiao Peter, Sahay, Shruti, Sawaya, Michael R, Cascio, Duilio, Rodriguez, Jose A, Philipp, Stephan, Sosna, Justyna, Glabe, Charles G, Gonen, Tamir, Eisenberg, David S
Published in eLife (15.10.2019)
Published in eLife (15.10.2019)
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Journal Article
Amyloid β-protein oligomers promote the uptake of tau fibril seeds potentiating intracellular tau aggregation
Shin, Woo Shik, Di, Jing, Cao, Qin, Li, Binsen, Seidler, Paul M, Murray, Kevin A, Bitan, Gal, Jiang, Lin
Published in Alzheimer's research & therapy (18.10.2019)
Published in Alzheimer's research & therapy (18.10.2019)
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Journal Article
Inhibition of synucleinopathic seeding by rationally designed inhibitors
Sangwan, Smriti, Sahay, Shruti, Murray, Kevin A, Morgan, Sophie, Guenther, Elizabeth L, Jiang, Lin, Williams, Christopher K, Vinters, Harry V, Goedert, Michel, Eisenberg, David S
Published in eLife (02.01.2020)
Published in eLife (02.01.2020)
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Journal Article
Atomic structures of corkscrew‐forming segments of SOD1 reveal varied oligomer conformations
Sangwan, Smriti, Sawaya, Michael R., Murray, Kevin A., Hughes, Michael P., Eisenberg, David S.
Published in Protein science (01.07.2018)
Published in Protein science (01.07.2018)
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Journal Article
Low complexity domains of the nucleocapsid protein of SARS-CoV-2 form amyloid fibrils
Tayeb-Fligelman, Einav, Bowler, Jeannette T., Tai, Christen E., Sawaya, Michael R., Jiang, Yi Xiao, Garcia, Gustavo, Griner, Sarah L., Cheng, Xinyi, Salwinski, Lukasz, Lutter, Liisa, Seidler, Paul M., Lu, Jiahui, Rosenberg, Gregory M., Hou, Ke, Abskharon, Romany, Pan, Hope, Zee, Chih-Te, Boyer, David R., Li, Yan, Anderson, Daniel H., Murray, Kevin A., Falcon, Genesis, Cascio, Duilio, Saelices, Lorena, Damoiseaux, Robert, Arumugaswami, Vaithilingaraja, Guo, Feng, Eisenberg, David S.
Published in Nature communications (25.04.2023)
Published in Nature communications (25.04.2023)
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Journal Article
Different Amyloid-β Self-Assemblies Have Distinct Effects on Intracellular Tau Aggregation
Shin, Woo Shik, Di, Jing, Murray, Kevin A, Sun, Chuanqi, Li, Binsen, Bitan, Gal, Jiang, Lin
Published in Frontiers in molecular neuroscience (08.11.2019)
Published in Frontiers in molecular neuroscience (08.11.2019)
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Journal Article
Correction to: Amyloid β-protein oligomers promote the uptake of tau fibril seeds potentiating intracellular tau aggregation
Shin, Woo Shik, Di, Jing, Cao, Qin, Li, Binsen, Seidler, Paul M, Murray, Kevin A, Bitan, Gal, Jiang, Lin
Published in Alzheimer's research & therapy (19.04.2021)
Published in Alzheimer's research & therapy (19.04.2021)
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Journal Article
Cryo-EM structures of hIAPP fibrils seeded by patient-extracted fibrils reveal new polymorphs and conserved fibril cores
Cao, Qin, Boyer, David R., Sawaya, Michael R., Abskharon, Romany, Saelices, Lorena, Nguyen, Binh A., Lu, Jiahui, Murray, Kevin A., Kandeel, Fouad, Eisenberg, David S.
Published in Nature structural & molecular biology (01.09.2021)
Published in Nature structural & molecular biology (01.09.2021)
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Journal Article
De novo designed protein inhibitors of amyloid aggregation and seeding
Murray, Kevin A, Hu, Carolyn J, Griner, Sarah L, Pan, Hope, Bowler, Jeannette T, Abskharon, Romany, Rosenberg, Gregory M, Cheng, Xinyi, Seidler, Paul M, Eisenberg, David S
Published in Proceedings of the National Academy of Sciences - PNAS (23.08.2022)
Published in Proceedings of the National Academy of Sciences - PNAS (23.08.2022)
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Journal Article
Extended β-Strands Contribute to Reversible Amyloid Formation
Murray, Kevin A, Evans, Declan, Hughes, Michael P, Sawaya, Michael R, Hu, Carolyn J, Houk, Kendall N, Eisenberg, David
Published in ACS nano (22.02.2022)
Published in ACS nano (22.02.2022)
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Journal Article
Small molecules disaggregate alpha-synuclein and prevent seeding from patient brain-derived fibrils
Murray, Kevin A, Hu, Carolyn J, Pan, Hope, Lu, Jiahui, Abskharon, Romany, Bowler, Jeannette T, Rosenberg, Gregory M, Williams, Christopher K, Elezi, Gazmend, Balbirnie, Melinda, Faull, Kym F, Vinters, Harry V, Seidler, Paul M, Eisenberg, David S
Published in Proceedings of the National Academy of Sciences - PNAS (14.02.2023)
Published in Proceedings of the National Academy of Sciences - PNAS (14.02.2023)
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Journal Article
Identifying amyloid-related diseases by mapping mutations in low-complexity protein domains to pathologies
Murray, Kevin A., Hughes, Michael P., Hu, Carolyn J., Sawaya, Michael R., Salwinski, Lukasz, Pan, Hope, French, Samuel W., Seidler, Paul M., Eisenberg, David S.
Published in Nature structural & molecular biology (01.06.2022)
Published in Nature structural & molecular biology (01.06.2022)
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Journal Article
Inhibiting amyloid-β cytotoxicity through its interaction with the cell surface receptor LilrB2 by structure-based design
Cao, Qin, Shin, Woo Shik, Chan, Henry, Vuong, Celine K., Dubois, Bethany, Li, Binsen, Murray, Kevin A., Sawaya, Michael R., Feigon, Juli, Black, Douglas L., Eisenberg, David S., Jiang, Lin
Published in Nature chemistry (01.12.2018)
Published in Nature chemistry (01.12.2018)
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Journal Article
Structure-based design of nanobodies that inhibit seeding of Alzheimer's patient-extracted tau fibrils
Abskharon, Romany, Pan, Hope, Sawaya, Michael R, Seidler, Paul M, Olivares, Eileen J, Chen, Yu, Murray, Kevin A, Zhang, Jeffrey, Lantz, Carter, Bentzel, Megan, Boyer, David R, Cascio, Duilio, Nguyen, Binh A, Hou, Ke, Cheng, Xinyi, Pardon, Els, Williams, Christopher K, Nana, Alissa L, Vinters, Harry V, Spina, Salvatore, Grinberg, Lea T, Seeley, William W, Steyaert, Jan, Glabe, Charles G, Ogorzalek Loo, Rachel R, Loo, Joseph A, Eisenberg, David S
Published in Proceedings of the National Academy of Sciences - PNAS (10.10.2023)
Published in Proceedings of the National Academy of Sciences - PNAS (10.10.2023)
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