Antibody-Mediated Delivery of Chimeric BRD4 Degraders. Part 2: Improvement of In Vitro Antiproliferation Activity and In Vivo Antitumor Efficacy
Dragovich, Peter S, Pillow, Thomas H, Blake, Robert A, Sadowsky, Jack D, Adaligil, Emel, Adhikari, Pragya, Chen, Jinhua, Corr, Nicholas, dela Cruz-Chuh, Josefa, Del Rosario, Geoffrey, Fullerton, Aaron, Hartman, Steven J, Jiang, Fan, Kaufman, Susan, Kleinheinz, Tracy, Kozak, Katherine R, Liu, Liling, Lu, Ying, Mulvihill, Melinda M, Murray, Jeremy M, O’Donohue, Aimee, Rowntree, Rebecca K, Sawyer, William S, Staben, Leanna R, Wai, John, Wang, Jian, Wei, BinQing, Wei, Wentao, Xu, Zijin, Yao, Hui, Yu, Shang-Fan, Zhang, Donglu, Zhang, Hongyan, Zhang, Shenhua, Zhao, Yongxin, Zhou, Hao, Zhu, Xiaoyu
Published in Journal of medicinal chemistry (11.03.2021)
Published in Journal of medicinal chemistry (11.03.2021)
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Journal Article
Molecular basis for negative regulation of the glucagon receptor
Koth, Christopher M., Murray, Jeremy M., Mukund, Susmith, Madjidi, Azadeh, Minn, Alexandra, Clarke, Holly J., Wong, Terence, Chiang, Vicki, Luis, Elizabeth, Estevez, Alberto, Rondon, Jesus, Zhang, Yingnan, Hötzel, Isidro, Allan, Bernard B.
Published in Proceedings of the National Academy of Sciences - PNAS (04.09.2012)
Published in Proceedings of the National Academy of Sciences - PNAS (04.09.2012)
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Journal Article
Conformational stabilization of ubiquitin yields potent and selective inhibitors of USP7
Zhang, Yingnan, Zhou, Lijuan, Rouge, Lionel, Phillips, Aaron H, Lam, Cynthia, Liu, Peter, Sandoval, Wendy, Helgason, Elizabeth, Murray, Jeremy M, Wertz, Ingrid E, Corn, Jacob E
Published in Nature chemical biology (01.01.2013)
Published in Nature chemical biology (01.01.2013)
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Journal Article
Conformational dynamics control ubiquitin-deubiquitinase interactions and influence in vivo signaling
Phillips, Aaron H, Zhang, Yingnan, Cunningham, Christian N, Zhou, Lijuan, Forrest, William F, Liu, Peter S, Steffek, Micah, Lee, James, Tam, Christine, Helgason, Elizabeth, Murray, Jeremy M, Kirkpatrick, Donald S, Fairbrother, Wayne J, Corn, Jacob E
Published in Proceedings of the National Academy of Sciences - PNAS (09.07.2013)
Published in Proceedings of the National Academy of Sciences - PNAS (09.07.2013)
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Journal Article
Discovery of Small-Molecule Inhibitors of Ubiquitin Specific Protease 7 (USP7) Using Integrated NMR and in Silico Techniques
Di Lello, Paola, Pastor, Richard, Murray, Jeremy M, Blake, Robert A, Cohen, Frederick, Crawford, Terry D, Drobnick, Joy, Drummond, Jason, Kategaya, Lorna, Kleinheinz, Tracy, Maurer, Till, Rougé, Lionel, Zhao, Xianrui, Wertz, Ingrid, Ndubaku, Chudi, Tsui, Vickie
Published in Journal of medicinal chemistry (28.12.2017)
Published in Journal of medicinal chemistry (28.12.2017)
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Journal Article
Structural insights into lipoprotein N-acylation by Escherichia coli apolipoprotein N-acyltransferase
Noland, Cameron L., Kattke, Michele D., Diao, Jingyu, Gloor, Susan L., Pantua, Homer, Reichelt, Mike, Katakam, Anand K., Yan, Donghong, Kang, Jing, Zilberleyb, Inna, Xu, Min, Kapadia, Sharookh B., Murray, Jeremy M.
Published in Proceedings of the National Academy of Sciences - PNAS (25.07.2017)
Published in Proceedings of the National Academy of Sciences - PNAS (25.07.2017)
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Journal Article
Potent and Highly Selective Benzimidazole Inhibitors of PI3-Kinase Delta
Murray, Jeremy M, Sweeney, Zachary K, Chan, Bryan K, Balazs, Mercedesz, Bradley, Erin, Castanedo, Georgette, Chabot, Christine, Chantry, David, Flagella, Michael, Goldstein, David M, Kondru, Rama, Lesnick, John, Li, Jun, Lucas, Matthew C, Nonomiya, Jim, Pang, Jodie, Price, Stephen, Salphati, Laurent, Safina, Brian, Savy, Pascal P. A, Seward, Eileen M, Ultsch, Mark, Sutherlin, Daniel P
Published in Journal of medicinal chemistry (13.09.2012)
Published in Journal of medicinal chemistry (13.09.2012)
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Journal Article
Catalytic Mechanism of the Quinoenzyme Amine Oxidase from Escherichia coli: Exploring the Reductive Half-Reaction
Wilmot, Carrie M, Murray, Jeremy M, Alton, Gordon, Parsons, Mark R, Convery, Maire A, Blakeley, Veronica, Corner, Adam S, Palcic, Monica M, Knowles, Peter F, McPherson, Michael J, Phillips, Simon E. V
Published in Biochemistry (Easton) (18.02.1997)
Published in Biochemistry (Easton) (18.02.1997)
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Journal Article
Design of Selective Benzoxazepin PI3Kδ Inhibitors Through Control of Dihedral Angles
Safina, Brian S, Elliott, Richard L, Forrest, Andrew K, Heald, Robert A, Murray, Jeremy M, Nonomiya, Jim, Pang, Jodie, Salphati, Laurent, Seward, Eileen M, Staben, Steven T, Ultsch, Mark, Wei, Binqing, Yang, Wenqian, Sutherlin, Daniel P
Published in ACS medicinal chemistry letters (14.09.2017)
Published in ACS medicinal chemistry letters (14.09.2017)
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Journal Article
Discovery and Optimization of C-2 Methyl Imidazopyrrolopyridines as Potent and Orally Bioavailable JAK1 Inhibitors with Selectivity over JAK2
Zak, Mark, Mendonca, Rohan, Balazs, Mercedesz, Barrett, Kathy, Bergeron, Philippe, Blair, Wade S, Chang, Christine, Deshmukh, Gauri, DeVoss, Jason, Dragovich, Peter S, Eigenbrot, Charles, Ghilardi, Nico, Gibbons, Paul, Gradl, Stefan, Hamman, Chris, Hanan, Emily J, Harstad, Eric, Hewitt, Peter R, Hurley, Christopher A, Jin, Tian, Johnson, Adam, Johnson, Tony, Kenny, Jane R, Koehler, Michael F. T, Bir Kohli, Pawan, Kulagowski, Janusz J, Labadie, Sharada, Liao, Jiangpeng, Liimatta, Marya, Lin, Zhonghua, Lupardus, Patrick J, Maxey, Robert J, Murray, Jeremy M, Pulk, Rebecca, Rodriguez, Madeleine, Savage, Scott, Shia, Steven, Steffek, Micah, Ubhayakar, Savita, Ultsch, Mark, van Abbema, Anne, Ward, Stuart I, Xiao, Ling, Xiao, Yisong
Published in Journal of medicinal chemistry (12.07.2012)
Published in Journal of medicinal chemistry (12.07.2012)
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Journal Article
Identification of GNE-293, a potent and selective PI3Kδ inhibitor: Navigating in vitro genotoxicity while improving potency and selectivity
Safina, Brian S., Sweeney, Zachary K., Li, Jun, Chan, Bryan K., Bisconte, Angelina, Carrera, Diane, Castanedo, Georgette, Flagella, Michael, Heald, Robert, Lewis, Cristina, Murray, Jeremy M., Nonomiya, Jim, Pang, Jodie, Price, Steve, Reif, Karin, Salphati, Laurent, Seward, Eileen M., Wei, Binqing, Sutherlin, Daniel P.
Published in Bioorganic & medicinal chemistry letters (01.09.2013)
Published in Bioorganic & medicinal chemistry letters (01.09.2013)
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Journal Article
Targeting the purinome
Murray, Jeremy M, Bussiere, Dirksen E
Published in Methods in molecular biology (Clifton, N.J.) (01.01.2009)
Published in Methods in molecular biology (Clifton, N.J.) (01.01.2009)
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Journal Article
Structure-based design of thienobenzoxepin inhibitors of PI3-kinase
Staben, Steven T, Siu, Michael, Goldsmith, Richard, Olivero, Alan G, Do, Steven, Burdick, Daniel J, Heffron, Timothy P, Dotson, Jenna, Sutherlin, Daniel P, Zhu, Bing-Yan, Tsui, Vickie, Le, Hoa, Lee, Leslie, Lesnick, John, Lewis, Cristina, Murray, Jeremy M, Nonomiya, Jim, Pang, Jodie, Prior, Wei Wei, Salphati, Laurent, Rouge, Lionel, Sampath, Deepak, Sideris, Steve, Wiesmann, Christian, Wu, Ping
Published in Bioorganic & medicinal chemistry letters (01.07.2011)
Published in Bioorganic & medicinal chemistry letters (01.07.2011)
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Journal Article
Structure-based discovery of C-2 substituted imidazo-pyrrolopyridine JAK1 inhibitors with improved selectivity over JAK2
Labadie, Sharada, Dragovich, Peter S., Barrett, Kathy, Blair, Wade S., Bergeron, Philippe, Chang, Christine, Deshmukh, Gauri, Eigenbrot, Charles, Ghilardi, Nico, Gibbons, Paul, Hurley, Christopher A., Johnson, Adam, Kenny, Jane R., Kohli, Pawan Bir, Kulagowski, Janusz J., Liimatta, Marya, Lupardus, Patrick J., Mendonca, Rohan, Murray, Jeremy M., Pulk, Rebecca, Shia, Steven, Steffek, Micah, Ubhayakar, Savita, Ultsch, Mark, van Abbema, Anne, Ward, Stuart, Zak, Mark
Published in Bioorganic & medicinal chemistry letters (15.12.2012)
Published in Bioorganic & medicinal chemistry letters (15.12.2012)
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Journal Article
Conformational stabilization of ubiquitin yields potent and selective inhibitors of USP7
Zhang, Yingnan, Zhou, Lijuan, Rouge, Lionel, Phillips, Aaron H, Lam, Cynthia, Liu, Peter, Sandoval, Wendy, Helgason, Elizabeth, Murray, Jeremy M, Wertz, Ingrid E, Corn, Jacob E
Published in Nature chemical biology (01.03.2013)
Published in Nature chemical biology (01.03.2013)
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Journal Article
Structure-based optimization of pyrazolo-pyrimidine and -pyridine inhibitors of PI3-kinase
Staben, Steven T., Heffron, Timothy P., Sutherlin, Daniel P., Bhat, Seema R., Castanedo, Georgette M., Chuckowree, Irina S., Dotson, Jenna, Folkes, Adrian J., Friedman, Lori S., Lee, Leslie, Lesnick, John, Lewis, Cristina, Murray, Jeremy M., Nonomiya, Jim, Olivero, Alan G., Plise, Emile, Pang, Jodie, Prior, Wei Wei, Salphati, Laurent, Rouge, Lionel, Sampath, Deepak, Tsui, Vickie, Wan, Nan Chi, Wang, Shumei, Weismann, Christian, Wu, Ping, Zhu, Bing-Yan
Published in Bioorganic & medicinal chemistry letters (15.10.2010)
Published in Bioorganic & medicinal chemistry letters (15.10.2010)
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Journal Article
Discovery of 2-pyrimidyl-5-amidothiophenes as potent inhibitors for AKT: Synthesis and SAR studies
Lin, Xiaodong, Murray, Jeremy M., Rico, Alice C., Wang, Michael X., Chu, Daniel T., Zhou, Yasheen, Rosario, Merci Del, Kaufman, Susan, Ma, Sylvia, Fang, Eric, Crawford, Kenneth, Jefferson, A.B.
Published in Bioorganic & medicinal chemistry letters (15.08.2006)
Published in Bioorganic & medicinal chemistry letters (15.08.2006)
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Journal Article
The Active Site Base Controls Cofactor Reactivity in Escherichia coli Amine Oxidase: X-ray Crystallographic Studies with Mutational Variants
Murray, Jeremy M, Saysell, Colin G, Wilmot, Carrie M, Tambyrajah, Winston S, Jaeger, Joachim, Knowles, Peter F, Phillips, Simon E. V, McPherson, Michael J
Published in Biochemistry (Easton) (29.06.1999)
Published in Biochemistry (Easton) (29.06.1999)
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