MicroRNA-132-mediated loss of p120RasGAP activates the endothelium to facilitate pathological angiogenesis
Cheresh, David A, Anand, Sudarshan, Majeti, Bharat K, Acevedo, Lisette M, Murphy, Eric A, Mukthavaram, Rajesh, Scheppke, Lea, Huang, Miller, Shields, David J, Lindquist, Jeffrey N, Lapinski, Philip E, King, Philip D, Weis, Sara M
Published in Nature medicine (01.08.2010)
Published in Nature medicine (01.08.2010)
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Journal Article
Nanoparticle-mediated drug delivery to tumor vasculature suppresses metastasis
Murphy, Eric A, Majeti, Bharat K, Barnes, Leo A, Makale, Milan, Weis, Sara M, Lutu-Fuga, Kimberly, Wrasidlo, Wolfgang, Cheresh, David A
Published in Proceedings of the National Academy of Sciences - PNAS (08.07.2008)
Published in Proceedings of the National Academy of Sciences - PNAS (08.07.2008)
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Journal Article
Notch promotes vascular maturation by inducing integrin-mediated smooth muscle cell adhesion to the endothelial basement membrane
Scheppke, Lea, Murphy, Eric A., Zarpellon, Alessandro, Hofmann, Jennifer J., Merkulova, Alona, Shields, David J., Weis, Sara M., Byzova, Tatiana V., Ruggeri, Zaverio M., Iruela-Arispe, M. Luisa, Cheresh, David A.
Published in Blood (01.03.2012)
Published in Blood (01.03.2012)
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Journal Article
EGFR-mediated carcinoma cell metastasis mediated by integrin αvβ5 depends on activation of c-Src and cleavage of MUC1
Lau, Steven K M, Shields, David J, Murphy, Eric A, Desgrosellier, Jay S, Anand, Sudarshan, Huang, Miller, Kato, Shumei, Lim, Ssang-Taek, Weis, Sara M, Stupack, Dwayne G, Schlaepfer, David D, Cheresh, David A
Published in PloS one (07.05.2012)
Published in PloS one (07.05.2012)
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Journal Article
RBBP9: A tumor-associated serine hydrolase activity required for pancreatic neoplasia
Shields, David J, Niessen, Sherry, Murphy, Eric A, Mielgo, Ainhoa, Desgrosellier, Jay S, Lau, Steven K.M, Barnes, Leo A, Lesperance, Jacqueline, Bouvet, Michael, Tarin, David, Cravatt, Benjamin F, Cheresh, David A
Published in Proceedings of the National Academy of Sciences - PNAS (02.02.2010)
Published in Proceedings of the National Academy of Sciences - PNAS (02.02.2010)
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Journal Article
Disruption of angiogenesis and tumor growth with an orally active drug that stabilizes the inactive state of PDGFRβ/B-RAF
Murphy, Eric A, Shields, David J, Stoletov, Konstantin, Dneprovskaia, Elena, McElroy, Michele, Greenberg, Joshua I, Lindquist, Jeff, Acevedo, Lisette M, Anand, Sudarshan, Majeti, Bharat Kumar, Tsigelny, Igor, Saldanha, Adrian, Walsh, Breda, Hoffman, Robert M, Bouvet, Michael, Klemke, Richard L, Vogt, Peter K, Arnold, Lee, Wrasidlo, Wolfgang, Cheresh, David A
Published in Proceedings of the National Academy of Sciences - PNAS (02.03.2010)
Published in Proceedings of the National Academy of Sciences - PNAS (02.03.2010)
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Journal Article
Discovery of KIN-3248, An Irreversible, Next Generation FGFR Inhibitor for the Treatment of Advanced Tumors Harboring FGFR2 and/or FGFR3 Gene Alterations
Tyhonas, John S., Arnold, Lee D., Cox, Jason M., Franovic, Aleksandra, Gardiner, Elisabeth, Grandinetti, Kathryn, Kania, Robert, Kanouni, Toufike, Lardy, Matthew, Li, Chun, Martin, Eric S., Miller, Nichol, Mohan, Adithi, Murphy, Eric A., Perez, Michelle, Soroceanu, Liliana, Timple, Noel, Uryu, Sean, Womble, Scott, Kaldor, Stephen W.
Published in Journal of medicinal chemistry (08.02.2024)
Published in Journal of medicinal chemistry (08.02.2024)
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Journal Article
The Discovery of Exarafenib (KIN-2787): Overcoming the Challenges of Pan-RAF Kinase Inhibition
Chen, Young K., Kanouni, Toufike, Arnold, Lee D., Cox, Jason M., Gardiner, Elisabeth, Grandinetti, Kathryn, Jiang, Ping, Kaldor, Stephen W., Lee, Catherine, Li, Chun, Martin, Eric S., Miller, Nichol, Murphy, Eric A., Timple, Noel, Tyhonas, John S., Vassar, Angie, Wang, Tim S., Williams, Richard, Yuan, Ding, Kania, Robert S.
Published in Journal of medicinal chemistry (08.02.2024)
Published in Journal of medicinal chemistry (08.02.2024)
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Journal Article
Targeted nanogels: a versatile platform for drug delivery to tumors
Murphy, Eric A, Majeti, Bharat K, Mukthavaram, Rajesh, Acevedo, Lisette M, Barnes, Leo A, Cheresh, David A
Published in Molecular cancer therapeutics (01.06.2011)
Published in Molecular cancer therapeutics (01.06.2011)
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Journal Article
A MEK-independent role for CRAF in mitosis and tumor progression
Mielgo, Ainhoa, Seguin, Laetitia, Huang, Miller, Camargo, Maria Fernanda, Anand, Sudarshan, Franovic, Aleksandra, Weis, Sara M, Advani, Sunil J, Murphy, Eric A, Cheresh, David A
Published in Nature medicine (01.12.2011)
Published in Nature medicine (01.12.2011)
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Journal Article
Formation of endothelial lumens requires a coordinated PKCε-, Src-, Pak- and Raf-kinase-dependent signaling cascade downstream of Cdc42 activation
Koh, Wonshill, Sachidanandam, Kamakshi, Stratman, Amber N, Sacharidou, Anastasia, Mayo, Anne M, Murphy, Eric A, Cheresh, David A, Davis, George E
Published in Journal of cell science (01.06.2009)
Published in Journal of cell science (01.06.2009)
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Journal Article
FGFR 키나제 억제제를 이용하는 암의 치료
KOBAYASHI KEN, MARTIN ERIC S, MURPHY ERIC A, VASSAR ANGIE, FRANOVIC ALEKSANDRA, TYHONAS JOHN, COX JASON M, TIMPLE NOELITO, WILLIAMS RICHARD THOMAS, KANIA ROBERT, MILLER NICHOL
Year of Publication 26.07.2024
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Year of Publication 26.07.2024
Patent
CDK12/13 억제제에 의한 암 치료
ARNOLD LEE D, MARTIN ERIC, MURPHY ERIC A, GARDINER ELISABETH, TYHONAS JOHN, TIMPLE NOELITO, KANOUNI TOUFIKE
Year of Publication 05.09.2022
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Year of Publication 05.09.2022
Patent
섬유아세포 성장 인자 수용체 키나아제의 억제제
ARNOLD LEE D, MURPHY ERIC A, KALDOR STEPHEN W, TYHONAS JOHN, COX JASON M, KANIA ROBERT, KANOUNI TOUFIKE
Year of Publication 10.03.2023
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Year of Publication 10.03.2023
Patent
사이클린 의존성 키나제의 억제제
ARNOLD LEE D, MURPHY ERIC A, KALDOR STEPHEN W, TYHONAS JOHN, KANOUNI TOUFIKE
Year of Publication 13.04.2021
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Year of Publication 13.04.2021
Patent
Compaction of DNA in an anionic micelle environment followed by assembly into phosphatidylcholine liposomes
Murphy, E A, Waring, A J, Haynes, S M, Longmuir, K J
Published in Nucleic acids research (01.08.2000)
Published in Nucleic acids research (01.08.2000)
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Journal Article
Abstract LB173: Discovery of ALTA-2618, the first allosteric, mutant-selective targeted therapy for AKT1 E17K driven cancers
Murphy, Eric A., Bartberger, Michael D., Ibanez, Maureen, Smith, Troy T., Alvarez, Nicole, Timple, Noel, Zhu, Xuefeng, Fan, Kevin, Yu, Kevin
Published in Cancer research (Chicago, Ill.) (05.04.2024)
Published in Cancer research (Chicago, Ill.) (05.04.2024)
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Journal Article