Notch Inhibition in Cancer: Challenges and Opportunities
Fabbro, Doriano, Bauer, Michael, Murone, Maximilien, Lehal, Rajwinder
Published in Chimia (01.10.2020)
Published in Chimia (01.10.2020)
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Journal Article
Pharmacological Sirt6 inhibition improves glucose tolerance in a type 2 diabetes mouse model
Sociali, Giovanna, Magnone, Mirko, Ravera, Silvia, Damonte, Patrizia, Vigliarolo, Tiziana, Von Holtey, Maria, Vellone, Valerio G, Millo, Enrico, Caffa, Irene, Cea, Michele, Parenti, Marco Daniele, Del Rio, Alberto, Murone, Maximilien, Mostoslavsky, Raul, Grozio, Alessia, Nencioni, Alessio, Bruzzone, Santina
Published in The FASEB journal (01.07.2017)
Published in The FASEB journal (01.07.2017)
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Journal Article
Sirt6 inhibition delays the onset of experimental autoimmune encephalomyelitis by reducing dendritic cell migration
Ferrara, Giovanni, Benzi, Andrea, Sturla, Laura, Marubbi, Daniela, Frumento, Davide, Spinelli, Sonia, Abbotto, Elena, Ivaldi, Federico, von Holtey, Maria, Murone, Maximilien, Nencioni, Alessio, Uccelli, Antonio, Bruzzone, Santina
Published in Journal of neuroinflammation (31.07.2020)
Published in Journal of neuroinflammation (31.07.2020)
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Journal Article
Effect of Inhibition of the Lysophosphatidic Acid Receptor 1 on Metastasis and Metastatic Dormancy in Breast Cancer
MARSHALL, Jean-Claude A, COLLINS, Joshua W, MURONE, Maximilien, STEEG, Patricia S, NAKAYAMA, Joji, HORAK, Christine E, LIEWEHR, David J, STEINBERG, Seth M, ALBAUGH, Mary, VIDAL-VANACLOCHA, Fernando, PALMIERI, Diane, BARBIER, Maryse
Published in JNCI : Journal of the National Cancer Institute (05.09.2012)
Published in JNCI : Journal of the National Cancer Institute (05.09.2012)
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Journal Article
The Multi-kinase Inhibitor Debio 0617B Reduces Maintenance and Self-renewal of Primary Human AML CD34 + Stem/Progenitor Cells
Murone, Maximilien, Radpour, Ramin, Attinger, Antoine, Chessex, Anne Vaslin, Huguenin, Anne-Laure, Schürch, Christian M, Banz, Yara, Sengupta, Saumitra, Aguet, Michel, Rigotti, Stefania, Bachhav, Yogeshwar, Massière, Frédéric, Ramachandra, Murali, McAllister, Andres, Riether, Carsten
Published in Molecular cancer therapeutics (01.08.2017)
Published in Molecular cancer therapeutics (01.08.2017)
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Journal Article
Activating Smoothened mutations in sporadic basal-cell carcinoma
Jr, Ervin H. Epstein, de Sauvage, Frederic J, Xie, Jingwu, Murone, Maximilien, Luoh, Shiuh-Ming, Ryan, Anne, Gu, Qimin, Zhang, Chaohui, Bonifas, Jeannette M, Lam, Ching-Wan, Hynes, Mary, Goddard, Audrey, Rosenthal, Arnon
Published in Nature (London) (01.01.1998)
Published in Nature (London) (01.01.1998)
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Journal Article
Characterization of the human suppressor of fused, a negative regulator of the zinc-finger transcription factor Gli
Stone, D M, Murone, M, Luoh, S, Ye, W, Armanini, M P, Gurney, A, Phillips, H, Brush, J, Goddard, A, de Sauvage, F J, Rosenthal, A
Published in Journal of cell science (01.12.1999)
Published in Journal of cell science (01.12.1999)
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Journal Article
Gli regulation by the opposing activities of Fused and Suppressor of Fused
de Sauvage, Frederic J, Murone, Maximilien, Luoh, Shiuh-Ming, Stone, Donna, Li, Wenlu, Gurney, Austin, Armanini, Mark, Grey, Christa, Rosenthal, Arnon
Published in Nature cell biology (01.05.2000)
Published in Nature cell biology (01.05.2000)
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Journal Article
Hematopoietic Deficiencies in c‐mpl and TPO Knockout Mice
Murone, Maximilien, Carpenter, David A., de Sauvage, Frederic J.
Published in Stem cells (Dayton, Ohio) (01.01.1998)
Published in Stem cells (Dayton, Ohio) (01.01.1998)
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Journal Article
Abstract 5799: Characterization and profiling of CB-103, a novel small-molecule protein-protein interaction inhibitor targeting the NOTCH transcription complex
Lehal, Rajwinder, Urech, Charlotte, Vigolo, Michele, Murone, Maximilien, Radtke, Freddy
Published in Cancer research (Chicago, Ill.) (01.07.2018)
Published in Cancer research (Chicago, Ill.) (01.07.2018)
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Journal Article
Abstract 2695: Direct targeting of NOTCH transcription complex by a novel small molecule CB-103 circumvents dose-limiting toxicities associated with pan-NOTCH inhibitors
Lehal, Rajwinder, Zaric, Jelena, Vigolo, Michele, Urech, Charlotte, Murone, Maximilien, Radtke, Freddy
Published in Cancer research (Chicago, Ill.) (01.07.2019)
Published in Cancer research (Chicago, Ill.) (01.07.2019)
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Journal Article
In vitro anti‐lymphoma activity of the first‐in‐class pan‐NOTCH transcription inhibitor CB‐103
Spriano, Filippo, Tarantelli, Chiara, Arribas, Alberto J., Gaudio, Eugenio, Cascione, Luciano, Aresu, Luca, Rinaldi, Andrea, Zucca, Emanuele, Rossi, Davide, Stathis, Anastasios, Murone, Maximilien, Radtke, Freddy, Lehal, Rajwinder, Bertoni, Francesco
Published in British journal of haematology (01.03.2023)
Published in British journal of haematology (01.03.2023)
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Journal Article
Gene expression patterns in adenoid cystic carcinoma with and without diffuse NOTCH1 intracellular domain (NICD1) immunohistochemistry staining
Patel, Karan, Manzo, Massimiliano, Hapuarachi, Brindley, Rack, Samuel, Jermann, Philip, Feeney, Laura, Heathcote, Emily, Betts, Guy, Aster, Jon C., Murone, Maximilien, Bobadilla, Maria, Lehal, Rajwinder, Vogl, Florian D., Harrington, Kevin, Metcalf, Robert
Published in Oral oncology (01.11.2023)
Published in Oral oncology (01.11.2023)
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Journal Article
SIRT6 inhibitors with salicylate-like structure show immunosuppressive and chemosensitizing effects
Damonte, Patrizia, Sociali, Giovanna, Parenti, Marco Daniele, Soncini, Debora, Bauer, Inga, Boero, Silvia, Grozio, Alessia, Holtey, Maria von, Piacente, Francesco, Becherini, Pamela, Sanguineti, Roberta, Salis, Annalisa, Damonte, Gianluca, Cea, Michele, Murone, Maximilien, Poggi, Alessandro, Nencioni, Alessio, Del Rio, Alberto, Bruzzone, Santina
Published in Bioorganic & medicinal chemistry (15.10.2017)
Published in Bioorganic & medicinal chemistry (15.10.2017)
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Journal Article
Abstract 1163: Non clinical pharmacology, pharmacokinetics and safety profiling of CB-103: A novel first-in-class small molecule inhibitor of the NOTCH pathway
Lehal, Rajwinder, Frismantas, Viktoras, Urech, Charlotte, Murone, Maximilien, Weber, Dirk, Bauer, Michael, Bourquin, Jean-Pierre, Radtke, Freddy
Published in Cancer research (Chicago, Ill.) (01.07.2017)
Published in Cancer research (Chicago, Ill.) (01.07.2017)
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Journal Article
Targeting lysophosphatidic acid receptor type 1 with Debio 0719 inhibits spontaneous metastasis dissemination of breast cancer cells independently of cell proliferation and angiogenesis
DAVID, MARION, RIBEIRO, JOHNNY, DESCOTES, FRANÇOISE, SERRE, CLAIRE-MARIE, BARBIER, MARYSE, MURONE, MAXIMILIEN, CLÉZARDIN, PHILIPPE, PEYRUCHAUD, OLIVIER
Published in International journal of oncology (01.04.2012)
Published in International journal of oncology (01.04.2012)
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Journal Article
Wnt/Wingless Signaling Requires BCL9/Legless-Mediated Recruitment of Pygopus to the Nuclear β-Catenin-TCF Complex
Kramps, Thomas, Peter, Oliver, Brunner, Erich, Nellen, Denise, Froesch, Barbara, Chatterjee, Sandipan, Murone, Maximilien, Züllig, Stephanie, Basler, Konrad
Published in Cell (05.04.2002)
Published in Cell (05.04.2002)
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Journal Article
Abstract B061: Targeting lymphomas with the novel first-in-class pan-NOTCH transcription inhibitor CB-103
Spriano, Filippo, Tarantelli, Chiara, Arribas, Alberto, Gaudio, Eugenio, Cascione, Luciano, Aresu, Luca, Zucca, Emanuele, Rossi, Davide, Stathis, Anastasios, Murone, Maximilien, Weber, Dirk, Lehal, Rajwinder, Radtke, Freddy, Bertoni, Francesco
Published in Molecular cancer therapeutics (01.01.2018)
Published in Molecular cancer therapeutics (01.01.2018)
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Journal Article
Debio 0617B Inhibits Growth of STAT3-Driven Solid Tumors through Combined Inhibition of JAK, SRC, and Class III/V Receptor Tyrosine Kinases
Murone, Maximilien, Vaslin Chessex, Anne, Attinger, Antoine, Ramachandra, Raghuveer, Shetty, Shankar J, Daginakatte, Girish, Sengupta, Saumitra, Marappan, Sivapriya, Dhodheri, Samiulla, Rigotti, Stefania, Bachhav, Yogeshwar, Brienza, Silvano, Traxler, Peter, Lang, Marc, Aguet, Michel, Zoete, Vincent, Michielin, Olivier, Nicholas, Courtney, Johnson, Faye M, Ramachandra, Murali, McAllister, Andres
Published in Molecular cancer therapeutics (01.10.2016)
Published in Molecular cancer therapeutics (01.10.2016)
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Journal Article
Sonic hedgehog signaling by the Patched–Smoothened receptor complex
Murone, Maximilien, Rosenthal, Arnon, de Sauvage, Frederic J.
Published in Current biology (28.01.1999)
Published in Current biology (28.01.1999)
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