Identification of a Small Compound Targeting PKM2-Regulated Signaling Using 2D Gel Electrophoresis-Based Proteome-wide CETSA
Nagasawa, Ikuko, Muroi, Makoto, Kawatani, Makoto, Ohishi, Tomokazu, Ohba, Shun-ichi, Kawada, Manabu, Osada, Hiroyuki
Published in Cell chemical biology (20.02.2020)
Published in Cell chemical biology (20.02.2020)
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Proteomic profiling of small-molecule inhibitors reveals dispensability of MTH1 for cancer cell survival
Kawamura, Tatsuro, Kawatani, Makoto, Muroi, Makoto, Kondoh, Yasumitsu, Futamura, Yushi, Aono, Harumi, Tanaka, Miho, Honda, Kaori, Osada, Hiroyuki
Published in Scientific reports (23.05.2016)
Published in Scientific reports (23.05.2016)
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Journal Article
Cesium tolerance is enhanced by a chemical which binds to BETA-GLUCOSIDASE 23 in Arabidopsis thaliana
Moon, Ju Yeon, Adams, Eri, Miyazaki, Takae, Kondoh, Yasumitsu, Muroi, Makoto, Watanabe, Nobumoto, Osada, Hiroyuki, Shin, Ryoung
Published in Scientific reports (26.10.2021)
Published in Scientific reports (26.10.2021)
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Journal Article
A small-molecule ligand of valosin-containing protein/p97 inhibits cancer cell–accelerated fibroblast migration
Suvarna, Kruthi, Honda, Kaori, Muroi, Makoto, Kondoh, Yasumitsu, Osada, Hiroyuki, Watanabe, Nobumoto
Published in The Journal of biological chemistry (01.03.2019)
Published in The Journal of biological chemistry (01.03.2019)
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Journal Article
Cucurbitacin B induces neurogenesis in PC12 cells and protects memory in APP/PS1 mice
Li, Jing, Sun, Kaiyue, Muroi, Makoto, Gao, Lijuan, Chang, Young‐Tae, Osada, Hiroyuki, Xiang, Lan, Qi, Jianhua
Published in Journal of cellular and molecular medicine (01.09.2019)
Published in Journal of cellular and molecular medicine (01.09.2019)
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Methyl 3‑((6-Methoxy-1,4-dihydroindeno[1,2‑c]pyrazol-3-yl)amino)benzoate (GN39482) as a Tubulin Polymerization Inhibitor Identified by MorphoBase and ChemProteoBase Profiling Methods
Minegishi, Hidemitsu, Futamura, Yushi, Fukashiro, Shinji, Muroi, Makoto, Kawatani, Makoto, Osada, Hiroyuki, Nakamura, Hiroyuki
Published in Journal of medicinal chemistry (28.05.2015)
Published in Journal of medicinal chemistry (28.05.2015)
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Journal Article
Phenotypic Identification of a Novel Autophagy Inhibitor Chemotype Targeting Lipid Kinase VPS34
Robke, Lucas, Laraia, Luca, Carnero Corrales, Marjorie A., Konstantinidis, Georgios, Muroi, Makoto, Richters, André, Winzker, Michael, Engbring, Tobias, Tomassi, Stefano, Watanabe, Nobumoto, Osada, Hiroyuki, Rauh, Daniel, Waldmann, Herbert, Wu, Yao‐Wen, Engel, Julian
Published in Angewandte Chemie International Edition (03.07.2017)
Published in Angewandte Chemie International Edition (03.07.2017)
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Discovery of small-molecule modulator of heterotrimeric Gi-protein by integrated phenotypic profiling and chemical proteomics
Kawamura, Tatsuro, Futamura, Yushi, Shang, Erchang, Muroi, Makoto, Janning, Petra, Ueno, Masayoshi, Wilke, Julian, Takeda, Shigeki, Kondoh, Yasumitsu, Ziegler, Slava, Watanabe, Nobumoto, Waldmann, Herbert, Osada, Hiroyuki
Published in Bioscience, biotechnology, and biochemistry (01.12.2020)
Published in Bioscience, biotechnology, and biochemistry (01.12.2020)
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Journal Article
Allantopyrone A interferes with the degradation of hypoxia-inducible factor 1α protein by reducing proteasome activity in human fibrosarcoma HT-1080 cells
Okuda, Chiharu, Ueda, Yuto, Muroi, Makoto, Sanada, Emiko, Osada, Hiroyuki, Shiono, Yoshihito, Kimura, Ken-ichi, Takeda, Kenji, Kawaguchi, Koichiro, Kataoka, Takao
Published in Journal of antibiotics (01.06.2023)
Published in Journal of antibiotics (01.06.2023)
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Journal Article
A novel inhibitor of tumorspheres reveals the activation of the serine biosynthetic pathway upon mitochondrial inhibition
Subedi, Amit, Muroi, Makoto, Futamura, Yushi, Kawamura, Tatsuro, Aono, Harumi, Nishi, Mayuko, Ryo, Akihide, Watanabe, Nobumoto, Osada, Hiroyuki
Published in FEBS letters (01.04.2019)
Published in FEBS letters (01.04.2019)
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Journal Article
identification of an osteoclastogenesis inhibitor through the inhibition of glyoxalase I
Kawatani, Makoto, Okumura, Hideo, Honda, Kaori, Kanoh, Naoki, Muroi, Makoto, Dohmae, Naoshi, Takami, Masamichi, Kitagawa, Mitsuhiro, Futamura, Yushi, Imoto, Masaya, Osada, Hiroyuki
Published in Proceedings of the National Academy of Sciences - PNAS (19.08.2008)
Published in Proceedings of the National Academy of Sciences - PNAS (19.08.2008)
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Journal Article
Xanthohumol Impairs Autophagosome Maturation through Direct Inhibition of Valosin-Containing Protein
Sasazawa, Yukiko, Kanagaki, Shuhei, Tashiro, Etsu, Nogawa, Toshihiko, Muroi, Makoto, Kondoh, Yasumitsu, Osada, Hiroyuki, Imoto, Masaya
Published in ACS chemical biology (18.05.2012)
Published in ACS chemical biology (18.05.2012)
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Journal Article
Inhibition of mitochondrial complex I by the novel compound FSL0260 enhances high salinity-stress tolerance in Arabidopsis thaliana
Sako, Kaori, Futamura, Yushi, Shimizu, Takeshi, Matsui, Akihiro, Hirano, Hiroyuki, Kondoh, Yasumitsu, Muroi, Makoto, Aono, Harumi, Tanaka, Maho, Honda, Kaori, Shimizu, Kenshirou, Kawatani, Makoto, Nakano, Takeshi, Osada, Hiroyuki, Noguchi, Ko, Seki, Motoaki
Published in Scientific reports (26.05.2020)
Published in Scientific reports (26.05.2020)
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Journal Article
Proteomics accelerating the identification of the target molecule of bioactive small molecules
Wierzba, Konstanty, Muroi, Makoto, Osada, Hiroyuki
Published in Current opinion in chemical biology (01.02.2011)
Published in Current opinion in chemical biology (01.02.2011)
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