The complexity of a monogenic neurodegenerative disease: More than two decades of therapeutic driven research into Niemann-Pick type C disease
Hammond, Natalie, Munkacsi, Andrew B., Sturley, Stephen L.
Published in Biochimica et biophysica acta. Molecular and cell biology of lipids (01.08.2019)
Published in Biochimica et biophysica acta. Molecular and cell biology of lipids (01.08.2019)
Get full text
Journal Article
Potential COVID-19 therapeutics from a rare disease: weaponizing lipid dysregulation to combat viral infectivity
Sturley, Stephen L., Rajakumar, Tamayanthi, Hammond, Natalie, Higaki, Katsumi, Márka, Zsuzsa, Márka, Szabolcs, Munkacsi, Andrew B.
Published in Journal of lipid research (01.07.2020)
Published in Journal of lipid research (01.07.2020)
Get full text
Journal Article
Bioactivity-Guided Metabolite Profiling of Feijoa (Acca sellowiana) Cultivars Identifies 4‑Cyclopentene-1,3-dione as a Potent Antifungal Inhibitor of Chitin Synthesis
Mokhtari, Mona, Jackson, Michael D, Brown, Alistair S, Ackerley, David F, Ritson, Nigel J, Keyzers, Robert A, Munkacsi, Andrew B
Published in Journal of agricultural and food chemistry (06.06.2018)
Published in Journal of agricultural and food chemistry (06.06.2018)
Get full text
Journal Article
Chemical genomic analysis reveals the interplay between iron chelation, zinc homeostasis, and retromer function in the bioactivity of an ethanol adduct of the feijoa fruit–derived ellagitannin vescalagin
Mokhtari, Mona, Amiri, Pegah, Miller, Darach, Gresham, David, Bloor, Stephen J, Munkacsi, Andrew B
Published in G3 : genes - genomes - genetics (08.07.2024)
Published in G3 : genes - genomes - genetics (08.07.2024)
Get full text
Journal Article
Identification and characterization of protein interactions with the major Niemann–Pick type C disease protein in yeast reveals pathways of therapeutic potential
Hammond, Natalie, Snider, Jamie, Stagljar, Igor, Mitchell, Kevin, Lagutin, Kirill, Jessulat, Matthew, Babu, Mohan, Teesdale-Spittle, Paul H, Sheridan, Jeffrey P, Sturley, Stephen L, Munkacsi, Andrew B
Published in Genetics (Austin) (31.08.2023)
Published in Genetics (Austin) (31.08.2023)
Get full text
Journal Article
Phosphoinositide and redox dysregulation by the anticancer methylthioadenosine phosphorylase transition state inhibitor
Salita, Timothy, Rustam, Yepy H., Hofferek, Vinzenz, Jackson, Michael, Tollestrup, Isaac, Sheridan, Jeffrey P., Schramm, Vern L., Evans, Gary B., Reid, Gavin E., Munkacsi, Andrew B.
Published in Biochimica et biophysica acta. Molecular and cell biology of lipids (01.09.2023)
Published in Biochimica et biophysica acta. Molecular and cell biology of lipids (01.09.2023)
Get full text
Journal Article
Phenotypic Screening for Small Molecules that Protect β‑Cells from Glucolipotoxicity
Small, Jonnell C., Joblin-Mills, Aidan, Carbone, Kaycee, Kost-Alimova, Maria, Ayukawa, Kumiko, Khodier, Carol, Dancik, Vlado, Clemons, Paul A., Munkacsi, Andrew B., Wagner, Bridget K.
Published in ACS chemical biology (20.05.2022)
Published in ACS chemical biology (20.05.2022)
Get full text
Journal Article
Functional genomics and metabolomics advance the ethnobotany of the Samoan traditional medicine “matalafi”
Molimau-Samasoni, Seeseei, Woolner, Victoria Helen, Foliga, Su’emalo Talie, Robichon, Katharina, Patel, Vimal, Andreassend, Sarah K., Sheridan, Jeffrey P., Kawa, Tama Te, Gresham, David, Miller, Darach, Sinclair, Daniel J., La Flamme, Anne C., Melnik, Alexey V., Aron, Allegra, Dorrestein, Pieter C., Atkinson, Paul H., Keyzers, Robert A., Munkacsi, Andrew B.
Published in Proceedings of the National Academy of Sciences - PNAS (09.11.2021)
Published in Proceedings of the National Academy of Sciences - PNAS (09.11.2021)
Get full text
Journal Article
An “Exacerbate-reverse” Strategy in Yeast Identifies Histone Deacetylase Inhibition as a Correction for Cholesterol and Sphingolipid Transport Defects in Human Niemann-Pick Type C Disease
Munkacsi, Andrew B., Chen, Fannie W., Brinkman, Matthew A., Higaki, Katsumi, Gutiérrez, Giselle Domínguez, Chaudhari, Jagruti, Layer, Jacob V., Tong, Amy, Bard, Martin, Boone, Charles, Ioannou, Yiannis A., Sturley, Stephen L.
Published in The Journal of biological chemistry (08.07.2011)
Published in The Journal of biological chemistry (08.07.2011)
Get full text
Journal Article
Antifungal Activity of Disalt of Epipyrone A from Epicoccum nigrum Likely via Disrupted Fatty Acid Elongation and Sphingolipid Biosynthesis
Lee, Alex J, Hammond, Joseph, Sheridan, Jeffrey, Swift, Simon, Munkacsi, Andrew B, Villas-Boas, Silas G
Published in Journal of fungi (Basel) (01.09.2024)
Published in Journal of fungi (Basel) (01.09.2024)
Get full text
Journal Article
Multi‐omic analysis reveals genes and proteins integral to bioactivity of Echinochrome A isolated from the waste stream of the sea urchin industry in Aotearoa New Zealand
Hammond, Joseph, Das, Isabella M., Paenga, Ruihana, Caddie, Manu, Skinner, Damian, Sheridan, Jeffrey P., Miller, Matthew R., Munkacsi, Andrew B.
Published in Food science & nutrition (01.07.2024)
Published in Food science & nutrition (01.07.2024)
Get full text
Journal Article
Identification and Bioactivity of 3-epi-Xestoaminol C Isolated from the New Zealand Brown Alga Xiphophora chondrophylla
Dasyam, Nathaniel, Munkacsi, Andrew B, Fadzilah, Nazmi H, Senanayake, Dinindu S, O’Toole, Ronan F, Keyzers, Robert A
Published in Journal of natural products (Washington, D.C.) (27.06.2014)
Published in Journal of natural products (Washington, D.C.) (27.06.2014)
Get full text
Journal Article
A functional, genome-wide evaluation of liposensitive yeast identifies the "ARE2 required for viability" (ARV1) gene product as a major component of eukaryotic fatty acid resistance
Ruggles, Kelly V, Garbarino, Jeanne, Liu, Ying, Moon, James, Schneider, Kerry, Henneberry, Annette, Billheimer, Jeff, Millar, John S, Marchadier, Dawn, Valasek, Mark A, Joblin-Mills, Aidan, Gulati, Sonia, Munkacsi, Andrew B, Repa, Joyce J, Rader, Dan, Sturley, Stephen L
Published in The Journal of biological chemistry (14.02.2014)
Published in The Journal of biological chemistry (14.02.2014)
Get full text
Journal Article
Polyhalogenated Indoles from the Red Alga Rhodophyllis membranacea: The First Isolation of Bromo-Chloro-Iodo Secondary Metabolites
Woolner, Victoria H, Jones, Cori M, Field, Jessica J, Fadzilah, Nazmi H, Munkacsi, Andrew B, Miller, John H, Keyzers, Robert A, Northcote, Peter T
Published in Journal of natural products (Washington, D.C.) (25.03.2016)
Published in Journal of natural products (Washington, D.C.) (25.03.2016)
Get full text
Journal Article
Sterols and sphingolipids: Dynamic duo or partners in crime?
Gulati, Sonia, Liu, Ying, Munkacsi, Andrew B., Wilcox, Lisa, Sturley, Stephen L.
Published in Progress in lipid research (01.10.2010)
Published in Progress in lipid research (01.10.2010)
Get full text
Journal Article