Characterization of intermediate steps in amyloid beta (Aβ) production under near-native conditions
Olsson, Fredrik, Schmidt, Staffan, Althoff, Veit, Munter, Lisa M, Jin, Shaobo, Rosqvist, Susanne, Lendahl, Urban, Multhaup, Gerd, Lundkvist, Johan
Published in The Journal of biological chemistry (17.01.2014)
Published in The Journal of biological chemistry (17.01.2014)
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Journal Article
The proton-pump inhibitor lansoprazole enhances amyloid beta production
Badiola, Nahuai, Alcalde, Victor, Pujol, Albert, Münter, Lisa-Marie, Multhaup, Gerd, Lleó, Alberto, Coma, Mireia, Soler-López, Montserrat, Aloy, Patrick
Published in PloS one (08.03.2013)
Published in PloS one (08.03.2013)
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Journal Article
GxxxG motifs within the amyloid precursor protein transmembrane sequence are critical for the etiology of Aβ42
Munter, Lisa-Marie, Voigt, Philipp, Harmeier, Anja, Kaden, Daniela, Gottschalk, Kay E, Weise, Christoph, Pipkorn, Rüdiger, Schaefer, Michael, Langosch, Dieter, Multhaup, Gerd
Published in The EMBO journal (21.03.2007)
Published in The EMBO journal (21.03.2007)
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Journal Article
Amyloid beta 42 peptide (Aβ42)-lowering compounds directly bind to Aβ and interfere with amyloid precursor protein (APP) transmembrane dimerization
Richter, Luise, Munter, Lisa-Marie, Ness, Julia, Hildebrand, Peter W, Dasari, Muralidhar, Unterreitmeier, Stephanie, Bulic, Bruno, Beyermann, Michael, Gust, Ronald, Reif, Bernd, Weggen, Sascha, Langosch, Dieter, Multhaup, Gerd
Published in Proceedings of the National Academy of Sciences - PNAS (17.08.2010)
Published in Proceedings of the National Academy of Sciences - PNAS (17.08.2010)
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Journal Article
APP dimer formation is initiated in the endoplasmic reticulum and differs between APP isoforms
Isbert, Simone, Wagner, Katja, Eggert, Simone, Schweitzer, Andrea, Multhaup, Gerd, Weggen, Sascha, Kins, Stefan, Pietrzik, Claus U.
Published in Cellular and molecular life sciences : CMLS (01.04.2012)
Published in Cellular and molecular life sciences : CMLS (01.04.2012)
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Journal Article
Dietary Cu Stabilizes Brain Superoxide Dismutase 1 Activity and Reduces Amyloid Aβ Production in APP23 Transgenic Mice
Bayer, Thomas A., Schäfer, Stephanie, Simons, Andreas, Kemmling, André, Kamer, Thomas, Tepest, Ralf, Eckert, Anne, Schüssel, Katrin, Eikenberg, Oliver, Sturchler-Pierrat, Christine, Abramowski, Dorothee, Staufenbiel, Matthias, Multhaup, Gerd
Published in Proceedings of the National Academy of Sciences - PNAS (25.11.2003)
Published in Proceedings of the National Academy of Sciences - PNAS (25.11.2003)
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Journal Article
Pyroglutamate Abeta pathology in APP/PS1KI mice, sporadic and familial Alzheimer’s disease cases
Wirths, Oliver, Bethge, Tobias, Marcello, Andrea, Harmeier, Anja, Jawhar, Sadim, Lucassen, Paul J., Multhaup, Gerd, Brody, David L., Esparza, Thomas, Ingelsson, Martin, Kalimo, Hannu, Lannfelt, Lars, Bayer, Thomas A.
Published in Journal of Neural Transmission (01.01.2010)
Published in Journal of Neural Transmission (01.01.2010)
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Journal Article
Clioquinol Mediates Copper Uptake and Counteracts Copper Efflux Activities of the Amyloid Precursor Protein of Alzheimer's Disease
Treiber, Carina, Simons, Andreas, Strauss, Markus, Hafner, Mathias, Cappai, Roberto, Bayer, Thomas A, Multhaup, Gerd
Published in The Journal of biological chemistry (10.12.2004)
Published in The Journal of biological chemistry (10.12.2004)
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Journal Article
A Family Knockout of All Four Drosophila Metallothioneins Reveals a Central Role in Copper Homeostasis and Detoxification
Egli, Dieter, Yepiskoposyan, Hasmik, Selvaraj, Anand, Balamurugan, Kuppusamy, Rajaram, Rama, Simons, Andreas, Multhaup, Gerd, Mettler, Simone, Vardanyan, Alla, Georgiev, Oleg, Schaffner, Walter
Published in Molecular and Cellular Biology (01.03.2006)
Published in Molecular and Cellular Biology (01.03.2006)
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Journal Article
Hippocampal Neuron Loss Exceeds Amyloid Plaque Load in a Transgenic Mouse Model of Alzheimer's Disease
Schmitz, Christoph, Rutten, Bart P.F., Pielen, Andrea, Schäfer, Stephanie, Wirths, Oliver, Tremp, Günter, Czech, Christian, Blanchard, Veronique, Multhaup, Gerd, Rezaie, Payam, Korr, Hubert, Steinbusch, Harry W.M., Pradier, Laurent, Bayer, Thomas A.
Published in The American journal of pathology (01.04.2004)
Published in The American journal of pathology (01.04.2004)
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Journal Article
Axonopathy in an APP/PS1 transgenic mouse model of Alzheimer's disease
Wirths, Oliver, Weis, Joachim, Szczygielski, Jacek, Multhaup, Gerd, Bayer, Thomas A
Published in Acta neuropathologica (01.04.2006)
Published in Acta neuropathologica (01.04.2006)
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Journal Article
Homodimerization of Amyloid Precursor Protein and Its Implication in the Amyloidogenic Pathway of Alzheimer's Disease
Scheuermann, Stefan, Hambsch, Boris, Hesse, Lars, Stumm, Joachim, Schmidt, Carsten, Beher, Dirk, Bayer, Thomas A., Beyreuther, Konrad, Multhaup, Gerd
Published in The Journal of biological chemistry (07.09.2001)
Published in The Journal of biological chemistry (07.09.2001)
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Journal Article
The Amyloid Precursor Protein of Alzheimer's Disease in the Reduction of Copper(II) to Copper(I)
Multhaup, Gerd, Schlicksupp, Andrea, Hesse, Lars, Beher, Dirk, Ruppert, Thomas, Masters, Colin L., Beyreuther, Konrad
Published in Science (American Association for the Advancement of Science) (08.03.1996)
Published in Science (American Association for the Advancement of Science) (08.03.1996)
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Profile of cholesterol-related sterols in aged amyloid precursor protein transgenic mouse brain
Lütjohann, Dieter, Brzezinka, Andreas, Barth, Esther, Abramowski, Dorothee, Staufenbiel, Matthias, von Bergmann, Klaus, Beyreuther, Konrad, Multhaup, Gerd, Bayer, Thomas A
Published in Journal of lipid research (01.07.2002)
Published in Journal of lipid research (01.07.2002)
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Journal Article
Copper levels are increased in the cerebral cortex and liver of APP and APLP2 knockout mice
White, Anthony R, Reyes, Rosario, Mercer, Julian F.B, Camakaris, James, Zheng, Hui, Bush, Ashley I, Multhaup, Gerd, Beyreuther, Konrad, Masters, Colin L, Cappai, Roberto
Published in Brain research (25.09.1999)
Published in Brain research (25.09.1999)
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Journal Article
Human BACE Forms Dimers and Colocalizes with APP
Schmechel, Ariane, Strauss, Markus, Schlicksupp, Andrea, Pipkorn, Rüdiger, Haass, Christian, Bayer, Thomas A., Multhaup, Gerd
Published in The Journal of biological chemistry (17.09.2004)
Published in The Journal of biological chemistry (17.09.2004)
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Journal Article
The Alzheimer's Disease Amyloid Precursor Protein Modulates Copper-Induced Toxicity and Oxidative Stress in Primary Neuronal Cultures
White, Anthony R, Multhaup, Gerd, Maher, Fran, Bellingham, Shayne, Camakaris, James, Zheng, Hui, Bush, Ashley I, Beyreuther, Konrad, Masters, Colin L, Cappai, Roberto
Published in The Journal of neuroscience (01.11.1999)
Published in The Journal of neuroscience (01.11.1999)
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