Bispecific Estrogen Receptor α Degraders Incorporating Novel Binders Identified Using DNA-Encoded Chemical Library Screening
Disch, Jeremy S, Duffy, Jennifer M, Lee, Esther C. Y, Gikunju, Diana, Chan, Betty, Levin, Benjamin, Monteiro, Michael I, Talcott, Sarah A, Lau, Anthony C, Zhou, Fei, Kozhushnyan, Anton, Westlund, Neil E, Mullins, Patrick B, Yu, Yan, von Rechenberg, Moritz, Zhang, Junyi, Arnautova, Yelena A, Liu, Yanbin, Zhang, Ying, McRiner, Andrew J, Keefe, Anthony D, Kohlmann, Anna, Clark, Matthew A, Cuozzo, John W, Huguet, Christelle, Arora, Shilpi
Published in Journal of medicinal chemistry (22.04.2021)
Published in Journal of medicinal chemistry (22.04.2021)
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Discovery of Clinical Candidate PF-06648671: A Potent γ‑Secretase Modulator for the Treatment of Alzheimer’s Disease
Pettersson, Martin, Johnson, Douglas S., Humphrey, John M., am Ende, Christopher W., Butler, Todd W., Dorff, Peter H., Efremov, Ivan V., Evrard, Edelweiss, Green, Michael E., Helal, Christopher J., Kauffman, Gregory W., Mullins, Patrick B., Navaratnam, Thayalan, O’Donnell, Christopher J., O’Sullivan, Theresa J., Patel, Nandini C., Stepan, Antonia F., Stiff, Cory M., Subramanyam, Chakrapani, Trapa, Patrick, Tran, Tuan P., Vetelino, Beth Cooper, Yang, Eddie, Xie, Longfei, Pustilnik, Leslie R., Steyn, Stefanus J., Wood, Kathleen M., Bales, Kelly R., Hajos-Korcsok, Eva, Verhoest, Patrick R.
Published in Journal of medicinal chemistry (27.06.2024)
Published in Journal of medicinal chemistry (27.06.2024)
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A New and Useful Method for the Macrocyclization of Linear Peptides
Londregan, Allyn T, Farley, Kathleen A, Limberakis, Chris, Mullins, Patrick B, Piotrowski, David W
Published in Organic letters (01.06.2012)
Published in Organic letters (01.06.2012)
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Design, Synthesis, and Pharmacological Evaluation of a Novel Series of Pyridopyrazine-1,6-dione γ‑Secretase Modulators
Pettersson, Martin, Johnson, Douglas S, Subramanyam, Chakrapani, Bales, Kelly R, am Ende, Christopher W, Fish, Benjamin A, Green, Michael E, Kauffman, Gregory W, Mullins, Patrick B, Navaratnam, Thayalan, Sakya, Subas M, Stiff, Cory M, Tran, Tuan P, Xie, Longfei, Zhang, Liming, Pustilnik, Leslie R, Vetelino, Beth C, Wood, Kathleen M, Pozdnyakov, Nikolay, Verhoest, Patrick R, O’Donnell, Christopher J
Published in Journal of medicinal chemistry (13.02.2014)
Published in Journal of medicinal chemistry (13.02.2014)
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Design and synthesis of dihydrobenzofuran amides as orally bioavailable, centrally active γ-secretase modulators
Pettersson, Martin, Johnson, Douglas S., Subramanyam, Chakrapani, Bales, Kelly R., am Ende, Christopher W., Fish, Benjamin A., Green, Michael E., Kauffman, Gregory W., Lira, Ricardo, Mullins, Patrick B., Navaratnam, Thayalan, Sakya, Subas M., Stiff, Cory M., Tran, Tuan P., Vetelino, Beth C., Xie, Longfei, Zhang, Liming, Pustilnik, Leslie R., Wood, Kathleen M., O’Donnell, Christopher J.
Published in Bioorganic & medicinal chemistry letters (15.04.2012)
Published in Bioorganic & medicinal chemistry letters (15.04.2012)
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Journal Article
Design of Pyridopyrazine-1,6-dione γ‑Secretase Modulators that Align Potency, MDR Efflux Ratio, and Metabolic Stability
Pettersson, Martin, Johnson, Douglas S, Humphrey, John M, Butler, Todd W, am Ende, Christopher W, Fish, Benjamin A, Green, Michael E, Kauffman, Gregory W, Mullins, Patrick B, O’Donnell, Christopher J, Stepan, Antonia F, Stiff, Cory M, Subramanyam, Chakrapani, Tran, Tuan P, Vetelino, Beth Cooper, Yang, Eddie, Xie, Longfei, Bales, Kelly R, Pustilnik, Leslie R, Steyn, Stefanus J, Wood, Kathleen M, Verhoest, Patrick R
Published in ACS medicinal chemistry letters (14.05.2015)
Published in ACS medicinal chemistry letters (14.05.2015)
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Journal Article
Design of potent inhibitors of human β-secretase. Part 1
Freskos, John N., Fobian, Yvette M., Benson, Timothy E., Bienkowski, Michael J., Brown, David L., Emmons, Thomas L., Heintz, Robert, Laborde, Alice, McDonald, Joseph J., Mischke, Brent V., Molyneaux, John M., Moon, Joseph B., Mullins, Patrick B., Bryan Prince, D., Paddock, Donna J., Tomasselli, Alfredo G., Winterrowd, Gregory
Published in Bioorganic & medicinal chemistry letters (2007)
Published in Bioorganic & medicinal chemistry letters (2007)
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Design of potent inhibitors of human β-secretase. Part 2
Freskos, John N., Fobian, Yvette M., Benson, Timothy E., Moon, Joseph B., Bienkowski, Michael J., Brown, David L., Emmons, Thomas L., Heintz, Robert, Laborde, Alice, McDonald, Joseph J., Mischke, Brent V., Molyneaux, John M., Mullins, Patrick B., Bryan Prince, D., Paddock, Donna J., Tomasselli, Alfredo G., Winterrowd, Greg
Published in Bioorganic & medicinal chemistry letters (2007)
Published in Bioorganic & medicinal chemistry letters (2007)
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Journal Article
Bispecific Estrogen Receptor a Degraders Incorporating Novel Binders Identified Using DNA-Encoded Chemical Library Screening
Disch, Jeremy S., Duffy, Jennifer M., Lee, Esther C. Y., Gikunju, Diana, Chan, Betty, Levin, Benjamin, Monteiro, Michael, Talcott, Sarah A., Lau, Anthony C., Zhou, Fei, Kozhushnyan, Anton, Westlund, Neil E., Mullins, Patrick B., Yu, Yan, von Rechenberg, Moritz, Zhang, Junyi, Arnautova, Yelena A., Liu, Yanbin, Zhang, Ying, McRiner, Andrew J., Keefe, Anthony D., Kohlmann, Anna, Clark, Matthew A., Cuozzo, John W., Huguet, Christelle, Arora, Shilpi
Published in Journal of medicinal chemistry (22.04.2021)
Published in Journal of medicinal chemistry (22.04.2021)
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Journal Article
Abstract 5346: Discovery of new targeted protein degraders using DNA-encoded chemistry
Keefe, Anthony D., Disch, Jeremy S., Duffy, Jennifer, Lee, Esther C., Gikunju, Diana, Chan, Betty, Levin, Benjamin D., Monteiro, Michael I., Talcott, Sarah A., Lau, Anthony, Zhou, Fei, Kozhushnyan, Anton, Westlund, Neil E., Mullins, Patrick B., Yu, Yan, von Rechenberg, Moritz, Zhang, Junyi, Arnautova, Yelena, Liu, Yanbin, Zhang, Ying, McRiner, Andrew J., Kohlmann, Anna, Clark, Matthew A., Cuozzo, John W., Huguet, Christelle, Arora, Shilpi
Published in Cancer research (Chicago, Ill.) (04.04.2023)
Published in Cancer research (Chicago, Ill.) (04.04.2023)
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Journal Article
Design and synthesis of dihydrobenzofuran amides as orally bioavailable, centrally active I3-secretase modulators
Pettersson, Martin, Johnson, Douglas S, Subramanyam, Chakrapani, Bales, Kelly R, am Ende, Christopher W, Fish, Benjamin A, Green, Michael E, Kauffman, Gregory W, Lira, Ricardo, Mullins, Patrick B, Navaratnam, Thayalan, Sakya, Subas M, Stiff, Cory M, Tran, Tuan P, Vetelino, Beth C, Xie, Longfei, Zhang, Liming, Pustilnik, Leslie R, Wood, Kathleen M, OaDonnell, Christopher J
Published in Bioorganic & medicinal chemistry letters (15.04.2012)
Published in Bioorganic & medicinal chemistry letters (15.04.2012)
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Journal Article
Synthesis and identification of conformationally constrained selective MMP inhibitors
Freskos, John N., McDonald, Joseph J., Mischke, Brent V., Mullins, Patrick B., Shieh, Huey-Sheng, Stegeman, Roderick A., Stevens, Anna M.
Published in Bioorganic & medicinal chemistry letters (05.07.1999)
Published in Bioorganic & medicinal chemistry letters (05.07.1999)
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AROMATIC SULFONE HYDROXAMIC ACID METALLOPROTEASE INHIBITOR
CAROL P HOWARD, DEBORAH A. MISCHKE, THERESA R FLETCHER, GUNNAR J. HANSON, THOMAS E. BARTA, LOUIS J BEDELL, JOSEPH G RICO, NATHAN W STEHLE, MADELEINE H LI, JOHN N. FRESKOS, DANIEL P. GETMAN, DANIEL P. BECKER, PATRICK B MULLINS, SUSAN L. HOCKERMAN, JOSEPH J. MCDONALD, CLARA I. VILLAMIL, JEFFREY N CARROLL, GARY A. DECRESCENZO, STEPHEN A. KOLODZIEJ, TERRI L. BOEHM
Year of Publication 30.04.2010
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Year of Publication 30.04.2010
Patent
PIPERIDINYL-AND PIPERAZINYL-SULFONYLMETHYL HYDROXAMIC ACIDS AND THEIR USE AS PROTEASE INHIBITORS
BROWN, DAVID, L, KASSAB, DARREN, J, MULLINS, PATRICK, B, GRAPPERHAUS, MARGARET, L, MASSA, MARK, A, MCDONALD, JOSEPH, J, SCHMIDT, MICHELLE, A, RICO, JOSEPH, G
Year of Publication 16.08.2006
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Year of Publication 16.08.2006
Patent
PIPERIDINYL-AND PIPERAZINYL-SULFONYLMETHYL HYDROXAMIC ACIDS AND THEIR USE AS PROTEASE INHIBITORS
BROWN, DAVID, L, KASSAB, DARREN, J, MULLINS, PATRICK, B, GRAPPERHAUS, MARGARET, L, MASSA, MARK, A, MCDONALD, JOSEPH, J, SCHMIDT, MICHELLE, A, RICO, JOSEPH, G
Year of Publication 07.07.2005
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Year of Publication 07.07.2005
Patent
PIPERIDINYL-AND PIPERAZINYL-SULFONYLMETHYL HYDROXAMIC ACIDS AND THEIR USE AS PROTEASE INHIBITORS
BROWN, DAVID, L, KASSAB, DARREN, J, MULLINS, PATRICK, B, GRAPPERHAUS, MARGARET, L, MASSA, MARK, A, MCDONALD, JOSEPH, J, SCHMIDT, MICHELLE, A, RICO, JOSEPH, G
Year of Publication 12.05.2005
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Year of Publication 12.05.2005
Patent