Lenalidomide and CC-4047 inhibit the proliferation of malignant B cells while expanding normal CD34+ progenitor cells
VERHELLE, Dominique, CORRAL, Laura G, LOPEZ-GIRONA, Antonia, MUTTER, George W, BRADY, Helen A, CHAN, Kyle W. H, WONG, Kevin, MUELLER, Jessica H, MOUTOUH-DE PARSEVAL, Laure, JENSEN-PERGAKES, Kristen, SCHAFER, Peter H, CHEN, Roger, GLEZER, Emilia, FERGUSON, Gregory D
Published in Cancer research (Chicago, Ill.) (15.01.2007)
Published in Cancer research (Chicago, Ill.) (15.01.2007)
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The anti-cancer drug lenalidomide inhibits angiogenesis and metastasis via multiple inhibitory effects on endothelial cell function in normoxic and hypoxic conditions
Lu, Ling, Payvandi, Faribourz, Wu, Lei, Zhang, Ling-Hua, Hariri, Robert J, Man, Hon-Wah, Chen, Roger S., Muller, George W., Hughes, Christopher C.W., Stirling, David I., Schafer, Peter H., Bartlett, J. Blake
Published in Microvascular research (01.03.2009)
Published in Microvascular research (01.03.2009)
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Isosteric analogs of lenalidomide and pomalidomide: Synthesis and biological activity
Ruchelman, Alexander L., Man, Hon-Wah, Zhang, Weihong, Chen, Roger, Capone, Lori, Kang, Jian, Parton, Anastasia, Corral, Laura, Schafer, Peter H., Babusis, Darius, Moghaddam, Mehran F., Tang, Yang, Shirley, Michael A., Muller, George W.
Published in Bioorganic & medicinal chemistry letters (01.01.2013)
Published in Bioorganic & medicinal chemistry letters (01.01.2013)
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Thalidomide and Lenalidomide Extend Survival in a Transgenic Mouse Model of Amyotrophic Lateral Sclerosis
Kiaei, Mahmoud, Petri, Susanne, Kipiani, Khatuna, Gardian, Gabrielle, Choi, Dong-Kug, Chen, Junyu, Calingasan, Noel Y, Schafer, Peter, Muller, George W, Stewart, Charles, Hensley, Kenneth, Beal, M. Flint
Published in The Journal of neuroscience (01.03.2006)
Published in The Journal of neuroscience (01.03.2006)
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Thalidomide and immunomodulatory derivatives augment natural killer cell cytotoxicity in multiple myeloma
Davies, Faith E., Raje, Noopur, Hideshima, Teru, Lentzsch, Suzanne, Young, Gloria, Tai, Yu-Tzu, Lin, Boris, Podar, Klaus, Gupta, Deepak, Chauhan, Dharminder, Treon, Steven P., Richardson, Paul G., Schlossman, Robert L., Morgan, Gareth J., Muller, George W., Stirling, David I., Anderson, Kenneth C.
Published in Blood (01.07.2001)
Published in Blood (01.07.2001)
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1,1-Diarylalkenes as anticancer agents: Dual inhibitors of tubulin polymerization and phosphodiesterase 4
Ruchelman, Alexander L., Man, Hon-Wah, Chen, Roger, Liu, Wei, Lu, Ling, Cedzik, Dorota, Zhang, Ling, Leisten, Jim, Collette, Alice, Narla, Rama Krishna, Raymon, Heather K., Muller, George W.
Published in Bioorganic & medicinal chemistry (01.11.2011)
Published in Bioorganic & medicinal chemistry (01.11.2011)
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Enhancement of Cytokine Production and AP-1 Transcriptional Activity in T Cells by Thalidomide-Related Immunomodulatory Drugs
Schafer, Peter H, Gandhi, Anita K, Loveland, Michelle A, Chen, Roger S, Man, Hon-Wah, Schnetkamp, Paul P M, Wolbring, Gregor, Govinda, Sowmya, Corral, Laura G, Payvandi, Faribourz, Muller, George W, Stirling, David I
Published in The Journal of pharmacology and experimental therapeutics (01.06.2003)
Published in The Journal of pharmacology and experimental therapeutics (01.06.2003)
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CC-5079: A Small Molecule with MKP1, Antiangiogenic, and Antitumor Activity
Vu, Huan N., M.D, Miller, Walter J., D.O, O'Connor, Sarah A., B.S, He, Mei, M.S, Schafer, Peter H., Ph.D, Payvandi, Faribourz, Ph.D, Muller, George W., Ph.D, Stirling, David I, Libutti, Steven K., M.D
Published in The Journal of surgical research (01.11.2010)
Published in The Journal of surgical research (01.11.2010)
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Combination therapy targeting the tumor microenvironment is effective in a model of human ocular melanoma
Mangiameli, David P, Blansfield, Joseph A, Kachala, Stephan, Lorang, Dominique, Schafer, Peter H, Muller, George W, Stirling, David I, Libutti, Steven K
Published in Journal of translational medicine (18.07.2007)
Published in Journal of translational medicine (18.07.2007)
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Discovery of (S)-N-{2-[1-(3-Ethoxy-4-methoxyphenyl)-2-methanesulfonylethyl]-1,3-dioxo-2,3-dihydro-1H-isoindol-4-yl}acetamide (Apremilast), a Potent and Orally Active Phosphodiesterase 4 and Tumor Necrosis Factor-α Inhibitor
Man, Hon-Wah, Schafer, Peter, Wong, Lu Min, Patterson, Rebecca T, Corral, Laura G, Raymon, Heather, Blease, Kate, Leisten, Jim, Shirley, Michael A, Tang, Yang, Babusis, Darius M, Chen, Roger, Stirling, Dave, Muller, George W
Published in Journal of medicinal chemistry (26.03.2009)
Published in Journal of medicinal chemistry (26.03.2009)
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Pomalidomide and Lenalidomide Induce p21WAF-1 Expression in Both Lymphoma and Multiple Myeloma through a LSD1-Mediated Epigenetic Mechanism
ESCOUBET-LOZACH, Laure, LIN, I-Lin, JENSEN-PERGAKES, Kristen, BRADY, Helen A, GANDHI, Anita K, SCHAFER, Peter H, MULLER, George W, WORLAND, Peter J, CHAN, Kyle W. H, VERHELLE, Dominique
Published in Cancer research (Chicago, Ill.) (15.09.2009)
Published in Cancer research (Chicago, Ill.) (15.09.2009)
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Discovery of (S)-N-{2-[1-(3-Ethoxy-4-methoxyphenyl)-2-methanesulfonylethyl]-1,3-dioxo-2,3-dihydro-1H-isoindol-4-yl}acetamide (Apremilast), a Potent and Orally Active Phosphodiesterase 4 and Tumor Necrosis Factor-a Inhibitor
MAN, Hon-Wah, SCHAFER, Peter, BABUSIS, Darius M, CHEN, Roger, STIRLING, Dave, MULLER, George W, LU MIN WONG, PATTERSON, Rebecca T, CORRAL, Laura G, RAYMON, Heather, BLEASE, Kate, LEISTEN, Jim, SHIRLEY, Michael A, YANG TANG
Published in Journal of medicinal chemistry (26.03.2009)
Published in Journal of medicinal chemistry (26.03.2009)
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A novel technique for quantifying changes in vascular density, endothelial cell proliferation and protein expression in response to modulators of angiogenesis using the chick chorioallantoic membrane (CAM) assay
Miller, Walter J, Kayton, Mark L, Patton, Angela, O'Connor, Sarah, He, Mei, Vu, Huan, Baibakov, Galina, Lorang, Dominique, Knezevic, Vladimir, Kohn, Elise, Alexander, H Richard, Stirling, David, Payvandi, Faribourz, Muller, George W, Libutti, Steven K
Published in Journal of translational medicine (30.01.2004)
Published in Journal of translational medicine (30.01.2004)
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Chiral inversion of the second generation IMiD™ CC-4047 (ACTIMID™) in human plasma and phosphate-buffered saline
Teo, Steve K., Chen, Yong, Muller, George W., Chen, Roger S., D. Thomas, Steve, Stirling, David I., Chandula, Reddy S.
Published in Chirality (New York, N.Y.) (2003)
Published in Chirality (New York, N.Y.) (2003)
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Protective Antitumor Immunity Induced by a Costimulatory Thalidomide Analog in Conjunction with Whole Tumor Cell Vaccination Is Mediated by Increased Th1-Type Immunity
Dredge, Keith, Marriott, J. Blake, Todryk, Stephen M, Muller, George W, Chen, Roger, Stirling, David I, Dalgleish, Angus G
Published in The Journal of immunology (1950) (15.05.2002)
Published in The Journal of immunology (1950) (15.05.2002)
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The synthetic compound CC-5079 is a potent inhibitor of tubulin polymerization and tumor necrosis factor-α production with antitumor activity
ZHANG, Ling-Hua, LEI WU, BARTLETT, J. Blake, SCHAFER, Peter H, PAWANDI, Faribourz, RAYMON, Heather K, CHEN, Roger S, CORRAL, Laura, SHIRLEY, Michael A, NARLA, Rama Krishna, GAMEZ, Jim, MULLER, George W, STIRLING, David I
Published in Cancer research (Chicago, Ill.) (15.01.2006)
Published in Cancer research (Chicago, Ill.) (15.01.2006)
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Effect of 3-fluorothalidomide and 3-methylthalidomide enantiomers on tumor necrosis factor production and antitumor responses to the antivascular agent 5,6-dimethylxanthenone-4-acetic acid (DMXAA)
Chung, Francisco, Palmer, Brian D, Muller, George W, Man, Hon-Wah, Kestell, Phillip, Baguley, Bruce C, Ching, Lai-Ming
Published in Oncology research (2003)
Published in Oncology research (2003)
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Antiproliferative effects of CC-8062 and CC-8075 in pancreatic cancer cells
Mouratidis, Petros X E, Colston, Kay W, Bartlett, Jake Blake, Muller, George W, Man, Hon-Wah, Stirling, David, Dalgleish, Angus G
Published in Pancreas (01.01.2009)
Published in Pancreas (01.01.2009)
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α-Fluoro-substituted thalidomide analogues
MAN, Hon-Wah, CORRAL, Laura G, STIRLING, David I, MULLER, George W
Published in Bioorganic & medicinal chemistry letters (20.10.2003)
Published in Bioorganic & medicinal chemistry letters (20.10.2003)
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