Combining BH3-mimetics to target both BCL-2 and MCL1 has potent activity in pre-clinical models of acute myeloid leukemia
Moujalled, Donia M., Pomilio, Giovanna, Ghiurau, Corina, Ivey, Adam, Salmon, Jessica, Rijal, Sewa, Macraild, Sarah, Zhang, Lan, Teh, Tse-Chieh, Tiong, Ing-Soo, Lan, Ping, Chanrion, Maia, Claperon, Audrey, Rocchetti, Francesca, Zichi, Adrien, Kraus-Berthier, Laurence, Wang, Youzhen, Halilovic, Ensar, Morris, Erick, Colland, Frédéric, Segal, David, Huang, David, Roberts, Andrew W., Maragno, Ana Leticia, Lessene, Guillaume, Geneste, Olivier, Wei, Andrew H.
Published in Leukemia (01.04.2019)
Published in Leukemia (01.04.2019)
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Mitochondrial apoptosis is dispensable for NLRP3 inflammasome activation but non-apoptotic caspase-8 is required for inflammasome priming
Allam, Ramanjaneyulu, Lawlor, Kate E, Yu, Eric Chi-Wang, Mildenhall, Alison L, Moujalled, Donia M, Lewis, Rowena S, Ke, Francine, Mason, Kylie D, White, Michael J, Stacey, Katryn J, Strasser, Andreas, O'Reilly, Lorraine A, Alexander, Warren, Kile, Benjamin T, Vaux, David L, Vince, James E
Published in EMBO reports (01.09.2014)
Published in EMBO reports (01.09.2014)
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Journal Article
Acquired mutations in BAX confer resistance to BH3-mimetic therapy in acute myeloid leukemia
Moujalled, Donia M., Brown, Fiona C., Chua, Chong Chyn, Dengler, Michael A., Pomilio, Giovanna, Anstee, Natasha S., Litalien, Veronique, Thompson, Ella, Morley, Thomas, MacRaild, Sarah, Tiong, Ing S., Morris, Rhiannon, Dun, Karen, Zordan, Adrian, Shah, Jaynish, Banquet, Sebastien, Halilovic, Ensar, Morris, Erick, Herold, Marco J., Lessene, Guillaume, Adams, Jerry M., Huang, David C. S., Roberts, Andrew W., Blombery, Piers, Wei, Andrew H.
Published in Blood (09.02.2023)
Published in Blood (09.02.2023)
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Journal Article
TDP-43 mutations causing amyotrophic lateral sclerosis are associated with altered expression of RNA-binding protein hnRNP K and affect the Nrf2 antioxidant pathway
Moujalled, Diane, Grubman, Alexandra, Acevedo, Karla, Yang, Shu, Ke, Yazi D, Moujalled, Donia M, Duncan, Clare, Caragounis, Aphrodite, Perera, Nirma D, Turner, Bradley J, Prudencio, Mercedes, Petrucelli, Leonard, Blair, Ian, Ittner, Lars M, Crouch, Peter J, Liddell, Jeffrey R, White, Anthony R
Published in Human molecular genetics (01.05.2017)
Published in Human molecular genetics (01.05.2017)
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Journal Article
Phosphorylation of hnRNP K by cyclin-dependent kinase 2 controls cytosolic accumulation of TDP-43
Moujalled, Diane, James, Janine L, Yang, Shu, Zhang, Katharine, Duncan, Clare, Moujalled, Donia M, Parker, Sarah J, Caragounis, Aphrodite, Lidgerwood, Grace, Turner, Bradley J, Atkin, Julie D, Grubman, Alexandra, Liddell, Jeffrey R, Proepper, Christian, Boeckers, Tobias M, Kanninen, Katja M, Blair, Ian, Crouch, Peter J, White, Anthony R
Published in Human molecular genetics (15.03.2015)
Published in Human molecular genetics (15.03.2015)
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Journal Article
The MCL1 inhibitor S63845 is tolerable and effective in diverse cancer models
Kotschy, András, Szlavik, Zoltán, Murray, James, Davidson, James, Maragno, Ana Leticia, Le Toumelin-Braizat, Gaëtane, Chanrion, Maïa, Kelly, Gemma L., Gong, Jia-Nan, Moujalled, Donia M., Bruno, Alain, Csekei, Márton, Paczal, Attila, Szabo, Zoltán B., Sipos, Szabolcs, Radics, Gábor, Proszenyak, Agnes, Balint, Balázs, Ondi, Levente, Blasko, Gábor, Robertson, Alan, Surgenor, Allan, Dokurno, Pawel, Chen, Ijen, Matassova, Natalia, Smith, Julia, Pedder, Christopher, Graham, Christopher, Studeny, Aurélie, Lysiak-Auvity, Gaëlle, Girard, Anne-Marie, Gravé, Fabienne, Segal, David, Riffkin, Chris D., Pomilio, Giovanna, Galbraith, Laura C. A., Aubrey, Brandon J., Brennan, Margs S., Herold, Marco J., Chang, Catherine, Guasconi, Ghislaine, Cauquil, Nicolas, Melchiore, Fabien, Guigal-Stephan, Nolwen, Lockhart, Brian, Colland, Frédéric, Hickman, John A., Roberts, Andrew W., Huang, David C. S., Wei, Andrew H., Strasser, Andreas, Lessene, Guillaume, Geneste, Olivier
Published in Nature (London) (27.10.2016)
Published in Nature (London) (27.10.2016)
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Journal Article
Cotargeting BCL-2 and MCL-1 in high-risk B-ALL
Moujalled, Donia M., Hanna, Diane T., Hediyeh-zadeh, Soroor, Pomilio, Giovanna, Brown, Lauren, Litalien, Veronique, Bartolo, Ray, Fleming, Shaun, Chanrion, Maïa, Banquet, Sébastien, Maragno, Ana-Leticia, Kraus-Berthier, Laurence, Schoumacher, Marie, Mullighan, Charles G., Georgiou, Angela, White, Christine A., Lessene, Guillaume, Huang, David C.S., Roberts, Andrew W., Geneste, Olivier, Rasmussen, Lorna, Davis, Melissa J., Ekert, Paul G., Wei, Andrew, Ng, Ashley P., Khaw, Seong L.
Published in Blood advances (23.06.2020)
Published in Blood advances (23.06.2020)
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In TNF-stimulated cells, RIPK1 promotes cell survival by stabilizing TRAF2 and cIAP1, which limits induction of non-canonical NF-κB and activation of caspase-8
Gentle, Ian E., Wong, W. Wei-Lynn, Evans, Joseph M., Bankovacki, Alexandra, Cook, Wendy D., Khan, Nufail R., Nachbur, Ulrich, Rickard, James, Anderton, Holly, Moulin, Maryline, Lluis, Josep Maria, Moujalled, Donia M., Silke, John, Vaux, David L.
Published in The Journal of biological chemistry (29.01.2016)
Published in The Journal of biological chemistry (29.01.2016)
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Journal Article
Clinical MDR1 inhibitors enhance Smac-mimetic bioavailability to kill murine LSCs and improve survival in AML models
Morrish, Emma, Copeland, Anthony, Moujalled, Donia M., Powell, Jason A., Silke, Natasha, Lin, Ann, Jarman, Kate E., Sandow, Jarrod J., Ebert, Gregor, Mackiewicz, Liana, Beach, Jessica A., Christie, Elizabeth L., Lewis, Alexander C., Pomilio, Giovanna, Fischer, Karla C., MacPherson, Laura, Bowtell, David D.L., Webb, Andrew I., Pellegrini, Marc, Dawson, Mark A., Pitson, Stuart M., Wei, Andrew H., Silke, John, Brumatti, Gabriela
Published in Blood advances (27.10.2020)
Published in Blood advances (27.10.2020)
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Journal Article
AMG 176, a Selective MCL1 Inhibitor, Is Effective in Hematologic Cancer Models Alone and in Combination with Established Therapies
Caenepeel, Sean, Brown, Sean P, Belmontes, Brian, Moody, Gordon, Keegan, Kathleen S, Chui, Danny, Whittington, Douglas A, Huang, Xin, Poppe, Leszek, Cheng, Alan C, Cardozo, Mario, Houze, Jonathan, Li, Yunxiao, Lucas, Brian, Paras, Nick A, Wang, Xianghong, Taygerly, Joshua P, Vimolratana, Marc, Zancanella, Manuel, Zhu, Liusheng, Cajulis, Elaina, Osgood, Tao, Sun, Jan, Damon, Leah, Egan, Regina K, Greninger, Patricia, McClanaghan, Joseph D, Gong, Jianan, Moujalled, Donia, Pomilio, Giovanna, Beltran, Pedro, Benes, Cyril H, Roberts, Andrew W, Huang, David C, Wei, Andrew, Canon, Jude, Coxon, Angela, Hughes, Paul E
Published in Cancer discovery (01.12.2018)
Published in Cancer discovery (01.12.2018)
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Journal Article
Intact TP-53 function is essential for sustaining durable responses to BH3-mimetic drugs in leukemias
Thijssen, Rachel, Diepstraten, Sarah T., Moujalled, Donia, Chew, Edward, Flensburg, Christoffer, Shi, Melissa X., Dengler, Michael A., Litalien, Veronique, MacRaild, Sarah, Chen, Maoshan, Anstee, Natasha S., Reljić, Boris, Gabriel, Sarah S., Djajawi, Tirta M., Riffkin, Chris D., Aubrey, Brandon J., Chang, Catherine, Tai, Lin, Xu, Zhen, Morley, Thomas, Pomilio, Giovanna, Bruedigam, Claudia, Kallies, Axel, Stroud, David A., Bajel, Ashish, Kluck, Ruth M., Lane, Steven W., Schoumacher, Marie, Banquet, Sébastien, Majewski, Ian J., Strasser, Andreas, Roberts, Andrew W., Huang, David C.S., Brown, Fiona C., Kelly, Gemma L., Wei, Andrew H.
Published in Blood (20.05.2021)
Published in Blood (20.05.2021)
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Journal Article
BAX Mutated Clonal Hematopoiesis Arises Following Treatment with the BCL2 Inhibitor Class of Therapeutics across a Range of Hematological and Non-Hematological Neoplasms
Tiong, Ing Soo, Nguyen, Tamia, Teh, Charis, Chua, Chong Chyn, Ftouni, Sarah, Lew, Thomas E, Brown, Fiona C., Moujalled, Donia, Muttiah, Christine, Gray, Daniel, Anderson, Mary Ann, Thompson, Philip A., Tam, Constantine S., Seymour, John F., Dawson, Sarah-Jane, Wei, Andrew H., Lindeman, Geoffrey, Blombery, Piers
Published in Blood (02.11.2023)
Published in Blood (02.11.2023)
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Journal Article
TAK1 is required for survival of mouse fibroblasts treated with TRAIL, and does so by NF-kappaB dependent induction of cFLIPL
Lluis, Josep Maria, Nachbur, Ulrich, Cook, Wendy Diane, Gentle, Ian Edward, Moujalled, Donia, Moulin, Maryline, Wong, Wendy Wei-Lynn, Khan, Nufail, Chau, Diep, Callus, Bernard Andrew, Vince, James Edward, Silke, John, Vaux, David Lawrence
Published in PloS one (08.01.2010)
Published in PloS one (08.01.2010)
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Journal Article
Abstract 342: S63845, a novel BH3 mimetic Mcl-1 inhibitor synergizes with midostaurin to induce potent apoptosis in acute myeloid leukemia cells carrying FLT3-ITD mutations
Skwarska, Anna, Zhang, Qi, Herbrich, Shelley M., Baran, Natalia, Halilovic, Ensar, Ruvolo, Peter, Ruvolo, Vivian, Morris, Erick, Wei, Andrew, Moujalled, Donia, Andreff, Michael, Konopleva, Marina
Published in Cancer research (Chicago, Ill.) (01.07.2019)
Published in Cancer research (Chicago, Ill.) (01.07.2019)
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Journal Article
Combination Therapy of FLT3 Tyrosine Kinase Inhibitors and BH3 Mimetics Targeting Antiapoptotic MCL-1 Synergistically Eliminates FLT3-ITD Acute Myeloid Leukemia Cells in Vitro and In Vivo
Skwarska, Anna, Moujalled, Donia M, Panis, Paul F, Patel, Shraddha, Zhang, Qi, Herbrich, Shelley, Kurvilla, Vinitha, Baran, Natalia, Pomilio, Giovanna, Halilovic, Ensar, Mistry, Prakash, Ruvolo, Vivian, Ruvolo, Peter P., Derréal, Alix, Banquet, Sebastien, Niemira, Magdalena, Kretowski, Adam, Daver, Naval, Andreeff, Michael, Wei, Andrew H., Konopleva, Marina
Published in Blood (23.11.2021)
Published in Blood (23.11.2021)
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Journal Article
In TNF-stimulated Cells, RIPK1 Promotes Cell Survival by Stabilizing TRAF2 and cIAP1, which Limits Induction of Non-canonical NF-κB and Activation of Caspase-8
Gentle, Ian E., Wong, W. Wei-Lynn, Evans, Joseph M., Bankovacki, Alexandra, Cook, Wendy D., Khan, Nufail R., Nachbur, Ulrich, Rickard, James, Anderton, Holly, Moulin, Maryline, Lluis, Josep Maria, Moujalled, Donia M., Silke, John, Vaux, David L.
Published in The Journal of biological chemistry (15.04.2011)
Published in The Journal of biological chemistry (15.04.2011)
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Journal Article
Acquired Mutations in BAX Confer Resistance to BH3 Mimetics in Acute Myeloid Leukemia
Moujalled, Donia M, Brown, Fiona C, Pomilio, Giovanna, Anstee, Natasha S, Litalien, Veronique, Thompson, Ella R, Morley, Thomas, MacRaild, Sarah, Chua, Chong C, Banquet, SéBastien, Chanrion, Maia, Maragno, Ana-Leticia, Schoumacher, Marie, Herold, Marco J, Lessene, Guillaume, Geneste, Olivier, Huang, David C.S., Roberts, Andrew W, Blombery, Piers, Wei, Andrew
Published in Blood (05.11.2020)
Published in Blood (05.11.2020)
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Journal Article
Combined BCL-2 and HDAC Targeting Has Potent and TP53 Independent Activity in AML
Salmon, Jessica M, Pomilio, Giovanna, Moujalled, Donia M, Macraild, Sarah, Teh, Charis E, Riajl, Sewa, Ivey, Adam, Teh, Tse-Chieh, Ekert, Paul G, Kraus-Berthier, Laurence, Kloos, Ioana, Schoumacher, Marie, Gray, Daniel, Wei, Andrew H
Published in Blood (29.11.2018)
Published in Blood (29.11.2018)
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Journal Article
Identification of Potent BH3-Mimetic Combinations Targeting Pro-Survival Pathways in Human B-Cell Acute Lymphoblastic Leukemia
Moujalled, Donia M, Hanna, Diane T, Pomilio, Giovanna, Litalien, Veronique, Fleming, Shaun, Chanrion, Marie, Maragno, Ana-Leticia, Kraus-Berthier, Laurence, Khaw, Seong Lin, Lessene, Guillaume, Huang, David, Roberts, Andrew W., Geneste, Olivier, Ekert, Paul G, Ng, Ashley P, Wei, Andrew H
Published in Blood (29.11.2018)
Published in Blood (29.11.2018)
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Journal Article
TARGETING MULTIDRUG RESISTANCE PROTEIN 1 (MDR1) POTENTIATES SMAC-MIMETIC THERAPY TO KILL LEUKEMIC STEM CELLS AND OVERCOME RESISTANCE IN ACUTE MYELOID LEUKEMIA
Morrish, Emma, Copeland, Anthony, Silke, Natasha, Beach, Jessica, Christie, Elizabeth, Sandow, Jarrod, Ebert, Gregor, Mackiewicz, Liana, Jarman, Kate, Moujalled, Donia, Pomilio, Giovanna, Fischer, Karla, Dawson, Mark, Bowtell, David, Pellegrini, Marc, Webb, Andrew, Wei, Andrew, Silke, John, Brumatti, Gabriela
Published in Experimental hematology (01.08.2019)
Published in Experimental hematology (01.08.2019)
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