Phase I study of OPB‐51602, an oral inhibitor of signal transducer and activator of transcription 3, in patients with relapsed/refractory hematological malignancies
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Extended cohort study of OPB51602, a novel inhibitor of STAT3/5 activation, in non-small cell lung carcinoma
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Abstract B56: A phase 1, open-label, dose escalation, nonrandomized study to assess the maximum tolerated dose, dose limiting toxicity, and pharmacokinetics of OPB-31121 in subjects with advanced solid tumors
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Published in Molecular cancer therapeutics (12.11.2011)
Published in Molecular cancer therapeutics (12.11.2011)
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HETEROCYCLIC COMPOUND AND PHARMACEUTICAL COMPOSITION THEREOF
SAKAMOTO MAKOTO, MIYAJIMA KEISUKE, MATSUYAMA HIRONORI, FUKUSHIMA TAE, YOSHIDA KENJI, HASHIMOTO NORIKAZU, KOJIMA YUTAKA, YASUMURA KOICHI, KODAMA TAKESHI, NAKAGAWA TAKASHI, OHI NAOTO, SUMIDA TAKUMI, IIDA MASATOSHI, FUJITA SHIGEKAZU, MOTOYAMA MASAAKI, KAN KEIZO, TABUSA FUJIO, SEKIGUCHI KAZUO, TAKASU HIDEKI, HARADA YASUO
Year of Publication 20.08.2010
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Year of Publication 20.08.2010
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Miyauchi, Shun, Imaoka, Takeshi, Okada, Tadashi, Motoyama, Masaaki, Kawaguchi, Teruhisa, Akiyama, Hitoshi, Odomi, Masaaki
Published in Japanese journal of pharmacology (1996)
Published in Japanese journal of pharmacology (1996)
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Expression of matrix metalloproteinase 2 (MMP-2), membrane-type 1 MMP and tissue inhibitor of metalloproteinase 2 and activation of proMMP-2 in pancreatic duct adenocarcinomas in hamsters treated with N-nitrosobis(2-oxopropyl)amine
Iki, Katsumichi, Tsutsumi, Masahiro, Kido, Akira, Sakitani, Hiroyuki, Takahama, Makoto, Yoshimoto, Masatoshi, Motoyama, Masaaki, Tatsumi, Kunihiko, Tsunoda, Tsukasa, Konishi, Yoichi
Published in Carcinogenesis (New York) (01.07.1999)
Published in Carcinogenesis (New York) (01.07.1999)
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Leukopenia-Inducing Effect of a Combination of a New 5-Fluorouracil (5-FU)-Derived Drug, BOF-A2 (Emitefur), with Other 5-FU-Derived Drugs or BV-araU (Sorivudine) in Rats
shun Miyauchi, Takeshi Imaoka, Tadashi Okada, Masaaki Motoyama, Teruhisa Kawaguchi, Hitoshi Akiyama, Masaaki Odomi
Published in Japanese Journal of Pharmacology (1996)
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Published in Japanese Journal of Pharmacology (1996)
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Inhibition of Spontaneous Rat Osteosarcoma Lung Metastasis by 3 S ‐[4‐(Nhydroxyamino)‐2 R ‐isobutylsuccinyl]amino‐1‐methoxy‐3,4‐dihydrocarbostyril, a Novel Matrix Metalloproteinase Inhibitor
Kido, Akira, Tsutsumi, Masahiro, Iki, Katsumichi, Motoyama, Masaaki, Takahama, Makoto, Tsujiuchi, Toshifumi, Morishita, Toru, Tatsumi, Kunihiko, Tamai, Susumu, Konishi, Yoichi
Published in Cancer science (01.03.1999)
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Published in Cancer science (01.03.1999)
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Effects of the Plasma Concentration of 5‐Fluorouracil and the Duration of Continuous Venous Infusion of 5‐Fluorouracil with an Inhibitor of 5‐Fluorouracil Degradation on Yoshida Sarcomas in Rats
Fujii, Setsuro, Shimamoto, Yuji, Ohshimo, Hideyuki, Imaoka, Takeshi, Motoyama, Masaaki, Fukushima, Masakazu, Shirasaka, Tetsuhiko
Published in Cancer science (01.02.1989)
Published in Cancer science (01.02.1989)
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Inhibition of Spontaneous Rat Osteosarcoma Lung Metastasis by 3S‐[4‐(Nhydroxyamino)‐2R‐isobutylsuccinyl]amino‐1‐methoxy‐3,4‐dihydrocarbostyril, a Novel Matrix Metalloproteinase Inhibitor
Kido, Akira, Tsutsumi, Masahiro, Iki, Katsumichi, Motoyama, Masaaki, Takahama, Makoto, Tsujiuchi, Toshifumi, Morishita, Toru, Tatsumi, Kunihiko, Tamai, Susumu, Konishi, Yoichi
Published in Japanese Journal of Cancer Research (01.03.1999)
Published in Japanese Journal of Cancer Research (01.03.1999)
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STAT3/5 ACTIVATION INHIBITOR
OKUNO, MITSUHIRO, HAYASHI, KAZUHIKO, OHI, NAOTO, YANAGIHARA, YASUO, AKAMATSU, SEIJI, YOSHIDA, KENJI, OHBUCHI, YUTAKA, OHNISHI, KENJI, WATANABE, TAKASHI, SEKIGUCHI, KAZUO, SUGIYAMA, KAZUHISA, MOTOYAMA, MASAAKI, KODAMA, TAKESHI, SUZUKI, TAKASHI, KIYONO, KUNIHIKO, SUMIDA, TAKUMI, TANAKA, HIDEO
Year of Publication 24.03.2015
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Year of Publication 24.03.2015
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MEDICINAL DRUG
KOJIMA, YUTAKA, TAKASU, HIDEKI, HIGUCHI, KUMI, KAN, KEIZO, NAKAGAWA, TAKASHI, MIYAJIMA, KEISUKE, YASUMURA, KOICHI, YAMADA, SATOSHI, OHNISHI, KENJI, OTSUJI, SHUN, MOTOYAMA, MASAAKI, KODAMA, TAKESHI, MATSUYAMA, HIRONORI, SUMIDA, TAKUMI, SAKAMOTO, MAKOTO
Year of Publication 20.01.2015
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Year of Publication 20.01.2015
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MEDICINAL DRUG
KOJIMA, YUTAKA, TAKASU, HIDEKI, HIGUCHI, KUMI, KAN, KEIZO, NAKAGAWA, TAKASHI, MIYAJIMA, KEISUKE, YASUMURA, KOICHI, YAMADA, SATOSHI, OHNISHI, KENJI, OTSUJI, SHUN, MOTOYAMA, MASAAKI, KODAMA, TAKESHI, MATSUYAMA, HIRONORI, SUMIDA, TAKUMI, SAKAMOTO, MAKOTO
Year of Publication 30.09.2014
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Year of Publication 30.09.2014
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MEDICINAL DRUG
SAKAMOTO MAKOTO, MIYAJIMA KEISUKE, YAMADA SATOSHI, MATSUYAMA HIRONORI, KOJIMA YUTAKA, YASUMURA KOICHI, HIGUCHI KUMI, KODAMA TAKESHI, OHNISHI KENJI, OTSUJI SHUN, NAKAGAWA TAKASHI, SUMIDA TAKUMI, MOTOYAMA MASAAKI, KAN KEIZO, TAKASU HIDEKI
Year of Publication 29.08.2014
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Year of Publication 29.08.2014
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STAT3/5 activation inhibitor
OKUNO, MITSUHIRO, HAYASHI, KAZUHIKO, OHI, NAOTO, YANAGIHARA, YASUO, AKAMATSU, SEIJI, YOSHIDA, KENJI, OHBUCHI, YUTAKA, OHNISHI, KENJI, WATANABE, TAKASHI, SEKIGUCHI, KAZUO, SUGIYAMA, KAZUHISA, MOTOYAMA, MASAAKI, KODAMA, TAKESHI, SUZUKI, TAKASHI, KIYONO, KUNIHIKO, SUMIDA, TAKUMI, TANAKA, HIDEO
Year of Publication 26.06.2014
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Year of Publication 26.06.2014
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MEDICINAL DRUG
KENJI OHNISHI, TAKUMI SUMIDA, YUTAKA KOJIMA, KEIZO KAN, HIDEKI TAKASU, SATOSHI YAMADA, MASAAKI MOTOYAMA, HIRONORI MATSUYAMA, SHUN OTSUJI, TAKESHI KODAMA, KUMI HIGUCHI, KEISUKE MIYAJIMA, TAKASHI NAKAGAWA, MAKOTO SAKAMOTO, KOICHI YASUMURA
Year of Publication 12.05.2014
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Year of Publication 12.05.2014
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LÆGEMIDDEL
KOJIMA, YUTAKA, TAKASU, HIDEKI, HIGUCHI, KUMI, KAN, KEIZO, NAKAGAWA, TAKASHI, MIYAJIMA, KEISUKE, YASUMURA, KOICHI, YAMADA, SATOSHI, OHNISHI, KENJI, OTSUJI, SHUN, MOTOYAMA, MASAAKI, KODAMA, TAKESHI, MATSUYAMA, HIRONORI, SUMIDA, TAKUMI, SAKAMOTO, MAKOTO
Year of Publication 12.05.2014
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Year of Publication 12.05.2014
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MEDICINAL DRUG
KOJIMA, YUTAKA, TAKASU, HIDEKI, HIGUCHI, KUMI, KAN, KEIZO, NAKAGAWA, TAKASHI, MIYAJIMA, KEISUKE, YASUMURA, KOICHI, YAMADA, SATOSHI, OHNISHI, KENJI, OTSUJI, SHUN, MOTOYAMA, MASAAKI, KODAMA, TAKESHI, MATSUYAMA, HIRONORI, SUMIDA, TAKUMI, SAKAMOTO, MAKOTO
Year of Publication 23.04.2014
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Year of Publication 23.04.2014
Patent
STAT3/5 ACTIVATION INHIBITOR
OKUNO, MITSUHIRO, HAYASHI, KAZUHIKO, OHI, NAOTO, YANAGIHARA, YASUO, AKAMATSU, SEIJI, YOSHIDA, KENJI, OHBUCHI, YUTAKA, OHNISHI, KENJI, WATANABE, TAKASHI, SEKIGUCHI, KAZUO, SUGIYAMA, KAZUHISA, MOTOYAMA, MASAAKI, KODAMA, TAKESHI, SUZUKI, TAKASHI, KIYONO, KUNIHIKO, SUMIDA, TAKUMI, TANAKA, HIDEO
Year of Publication 31.12.2013
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Year of Publication 31.12.2013
Patent