Predicting Total Drug Clearance and Volumes of Distribution Using the Machine Learning-Mediated Multimodal Method through the Imputation of Various Nonclinical Data
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Published in Journal of chemical information and modeling (12.09.2022)
Published in Journal of chemical information and modeling (12.09.2022)
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Prediction of Total Drug Clearance in Humans Using Animal Data: Proposal of a Multimodal Learning Method Based on Deep Learning
Iwata, Hiroaki, Matsuo, Tatsuru, Mamada, Hideaki, Motomura, Takahisa, Matsushita, Mayumi, Fujiwara, Takeshi, Kazuya, Maeda, Handa, Koichi
Published in Journal of pharmaceutical sciences (01.04.2021)
Published in Journal of pharmaceutical sciences (01.04.2021)
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Quinolone Carboxylic Acids as a Novel Monoketo Acid Class of Human Immunodeficiency Virus Type 1 Integrase Inhibitors
Sato, Motohide, Kawakami, Hiroshi, Motomura, Takahisa, Aramaki, Hisateru, Matsuda, Takashi, Yamashita, Masaki, Ito, Yoshiharu, Matsuzaki, Yuji, Yamataka, Kazunobu, Ikeda, Satoru, Shinkai, Hisashi
Published in Journal of medicinal chemistry (13.08.2009)
Published in Journal of medicinal chemistry (13.08.2009)
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Design and synthesis of novel fluorene derivatives as inhibitors of pyruvate dehydrogenase kinase
Inoue, Masafumi, Nagamori, Hironobu, Morita, Toru, Kobayashi, Satoru, Suzawa, Koichi, Kitao, Yuki, Saito, Tomoyuki, Kawahara, Iichiro, Orita, Takuya, Akai, Shota, Adachi, Tsuyoshi, Motomura, Takahisa
Published in Bioorganic & medicinal chemistry letters (01.09.2024)
Published in Bioorganic & medicinal chemistry letters (01.09.2024)
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Correction to "Optimization Efforts for Identification of Novel Highly Potent Keap1-Nrf2 Protein-Protein Interaction Inhibitors"
Otake, Kazuki, Hara, Yoshinori, Ubukata, Minoru, Inoue, Masafumi, Nagahashi, Noboru, Motoda, Dai, Ogawa, Naoki, Hantani, Yoshiji, Hantani, Rie, Adachi, Tsuyoshi, Nomura, Akihiro, Yamaguchi, Keishi, Maekawa, Mariko, Mamada, Hideaki, Motomura, Takahisa, Sato, Motohide, Harada, Kazuhito
Published in Journal of medicinal chemistry (12.09.2024)
Published in Journal of medicinal chemistry (12.09.2024)
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Optimization Efforts for Identification of Novel Highly Potent Keap1-Nrf2 Protein–Protein Interaction Inhibitors
Otake, Kazuki, Hara, Yoshinori, Ubukata, Minoru, Inoue, Masafumi, Nagahashi, Noboru, Motoda, Dai, Ogawa, Naoki, Hantani, Yoshiji, Hantani, Rie, Adachi, Tsuyoshi, Nomura, Akihiro, Yamaguchi, Keishi, Maekawa, Mariko, Mamada, Hideaki, Motomura, Takahisa, Sato, Motohide, Harada, Kazuhito
Published in Journal of medicinal chemistry (14.03.2024)
Published in Journal of medicinal chemistry (14.03.2024)
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Methyl and Fluorine Effects in Novel Orally Bioavailable Keap1–Nrf2 PPI Inhibitor
Otake, Kazuki, Ubukata, Minoru, Nagahashi, Noboru, Ogawa, Naoki, Hantani, Yoshiji, Hantani, Rie, Adachi, Tsuyoshi, Nomura, Akihiro, Yamaguchi, Keishi, Maekawa, Mariko, Mamada, Hideaki, Motomura, Takahisa, Sato, Motohide, Harada, Kazuhito
Published in ACS medicinal chemistry letters (11.05.2023)
Published in ACS medicinal chemistry letters (11.05.2023)
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Structure-based drug design of novel and highly potent pyruvate dehydrogenase kinase inhibitors
Bessho, Yuki, Akaki, Tatsuo, Hara, Yoshinori, Yamakawa, Maki, Obika, Shingo, Mori, Genki, Ubukata, Minoru, Yasue, Katsutaka, Nakane, Yoshitomi, Terasako, Yasuo, Orita, Takuya, Doi, Satoki, Iwanaga, Tomoko, Fujishima, Ayumi, Adachi, Tsuyoshi, Ueno, Hiroshi, Motomura, Takahisa
Published in Bioorganic & medicinal chemistry (15.12.2021)
Published in Bioorganic & medicinal chemistry (15.12.2021)
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Novel HIV-1 Integrase Inhibitors Derived from Quinolone Antibiotics
Sato, Motohide, Motomura, Takahisa, Aramaki, Hisateru, Matsuda, Takashi, Yamashita, Masaki, Ito, Yoshiharu, Kawakami, Hiroshi, Matsuzaki, Yuji, Watanabe, Wataru, Yamataka, Kazunobu, Ikeda, Satoru, Kodama, Eiichi, Matsuoka, Masao, Shinkai, Hisashi
Published in Journal of medicinal chemistry (09.03.2006)
Published in Journal of medicinal chemistry (09.03.2006)
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피라졸-아미드 화합물의 제조 방법
MATSUO TAKUYA, SUZAWA KOICHI, ITO HIROTSUGU, MOTOMURA TAKAHISA, TAKEICHI TSUBASA, INABA TAKASHI, ITO TAKAO, INOUE MASAFUMI, KAJIMOTO YASUYUKI, IKEMOTO YUKISHIGE, YAMASAKI TAKAHIRO, YAMAMOTO HIROSHI
Year of Publication 04.04.2019
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Year of Publication 04.04.2019
Patent
PRODUCTION METHOD FOR PYRAZOLE-AMIDE COMPOUND
INABA, Takashi, ITO, Takao, ITO, Hirotsugu, MATSUO, Takuya, KAJIMOTO, Yasuyuki, SUZAWA, Koichi, IKEMOTO, Yukishige, INOUE, Masafumi, MOTOMURA, Takahisa, YAMASAKI, Takahiro, TAKEICHI, Tsubasa, YAMAMOTO, Hiroshi
Year of Publication 01.02.2018
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Year of Publication 01.02.2018
Patent