Discovery of 7-arylsulfonyl-1,2,3,4, 4a,9a-hexahydro-benzo[4,5]furo[2,3-c]pyridines: Identification of a potent and selective 5-HT6 receptor antagonist showing activity in rat social recognition test
Tripathy, Rabindranath, McHugh, Robert J., Bacon, Edward R., Salvino, Joseph M., Morton, George C., Aimone, Lisa D., Huang, Zeck, Mathiasen, Joanne R., DiCamillo, Amy, Huffman, Mark J., McKenna, Beth A., Kopec, Karla, Lu, Lily D., Qian, Jie, Angeles, Thelma S., Connors, Thomas, Spais, Chrysanthe, Holskin, Beverly, Duzic, Emir, Schaffhauser, Hervé, Rossé, Gerard C.
Published in Bioorganic & medicinal chemistry letters (01.02.2012)
Published in Bioorganic & medicinal chemistry letters (01.02.2012)
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Journal Article
A selective small molecule agonist of the melanocortin-1 receptor inhibits lipopolysaccharide-induced cytokine accumulation and leukocyte infiltration in mice
Kang, Liya, McIntyre, Kim W., Gillooly, Kathleen M., Yang, Yifan, Haycock, John, Roberts, Stephen, Khanna, Ashish, Herpin, Timothy F., Yu, Guixue, Wu, Ximao, Morton, George C., Tuerdi, Huji, Koplowitz, Barry, Walker, Stephen G., Wardwell‐Swanson, Judy, Macor, John E., Lawrence, R. Michael, Carlson, Kenneth E.
Published in Journal of leukocyte biology (01.10.2006)
Published in Journal of leukocyte biology (01.10.2006)
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Journal Article
비알코올성 지방간염(NASH), 간 염증, 간세포 풍선화, 간 섬유증, 및 지방증의 치료에 사용하기 위한 (S)-2-아미노-6-헥산산 (APL)
MERALI SALIM, CHILDERS WAYNE E, BARRERO CARLOS, MORTON GEORGE C, RICO MARIO CESAR
Year of Publication 09.01.2023
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Year of Publication 09.01.2023
Patent
2-Arylbenzoxazoles as novel cholesteryl ester transfer protein inhibitors: Optimization via array synthesis
Harikrishnan, Lalgudi S., Kamau, Muthoni G., Herpin, Timothy F., Morton, George C., Liu, Yalei, Cooper, Christopher B., Salvati, Mark E., Qiao, Jennifer X., Wang, Tammy C., Adam, Leonard P., Taylor, David S., Chen, Alice Ye A., Yin, Xiaohong, Seethala, Ramakrishna, Peterson, Tara L., Nirschl, David S., Miller, Arthur V., Weigelt, Carolyn A., Appiah, Kingsley K., O’Connell, Jonathan C., Michael Lawrence, R.
Published in Bioorganic & medicinal chemistry (15.04.2008)
Published in Bioorganic & medicinal chemistry (15.04.2008)
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Journal Article
Novel brain penetrant benzofuropiperidine 5-HT6 receptor antagonists
Sundar, Babu G., Bailey, Thomas R., Dunn, Derek D., Bacon, Edward R., Salvino, Joseph M., Morton, George C., Aimone, Lisa D., Zeqi, Huang, Mathiasen, Joanne R., Dicamillo, Amy, Huffman, Mark J., McKenna, Beth A., Kopec, Karla, Lu, Lily D., Brown, Rebecca, Qian, Jie, Angeles, Thelma, Connors, Thomas, Spais, Chrysanthe, Holskin, Beverly, Galinis, Deborah, Duzic, Emir, Schaffhauser, Herve, Rosse, Gerard C.
Published in Bioorganic & medicinal chemistry letters (01.01.2012)
Published in Bioorganic & medicinal chemistry letters (01.01.2012)
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Journal Article
Discovery of Tyrosine-Based Potent and Selective Melanocortin-1 Receptor Small-Molecule Agonists with Anti-inflammatory Properties
Herpin, Timothy F, Yu, Guixue, Carlson, Kenneth E, Morton, George C, Wu, Ximao, Kang, Liya, Tuerdi, Huji, Khanna, Ashish, Tokarski, John S, Lawrence, R. Michael, Macor, John E
Published in Journal of medicinal chemistry (27.03.2003)
Published in Journal of medicinal chemistry (27.03.2003)
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Journal Article
Novel solid-phase synthesis of 1,5-benzothiazepine-4-one derivatives
Morton, George C, Salvino, Joseph M, Labaudinière, Richard F, Herpin, Timothy F
Published in Tetrahedron letters (22.04.2000)
Published in Tetrahedron letters (22.04.2000)
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Journal Article
Synthesis and diversity analysis of lead discovery piperazine-2-carboxamide libraries
Herpin, T F, Morton, G C, Dunn, A K, Fillon, C, Menard, P R, Tang, S Y, Salvino, J M, Labaudinière, R F
Published in Molecular diversity (01.01.1998)
Published in Molecular diversity (01.01.1998)
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Journal Article
Aminothiazole compounds and methods using same
Morton, George C, Childers, Wayne E, Zhang, Hanghang, Abou-Gharbia, Magid, Issa, Jean-Pierre J
Year of Publication 17.10.2023
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Year of Publication 17.10.2023
Patent
Compositions and methods for treatment of insulin resistance
Morton, George C, Barrero, Carlos A, Merali, Salim, Childers, Wayne E
Year of Publication 31.08.2023
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Year of Publication 31.08.2023
Patent
NOVEL BRIDGED BICYCLOALKYL-SUBSTITUTED AMINOTHIZOLES AND THEIR METHODS OF USE
ABOU-GHARBIA, Magid A, ISSA, Jean-Pierre J, ZHANG, Hanghang, MORTON, George C, CHILDERS, Wayne E
Year of Publication 02.08.2023
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Year of Publication 02.08.2023
Patent
(S)-2-AMINO-6-((3-AMINOPROPYL)AMINO)HEXANOIC ACID (APL) FOR USE IN THE TREATMENT OF NON-ALCOHOLIC STEATOHEPATITIS (NASH), LIVER INFLAMMATION, HEPATOCELLULAR BALLOONING, LIVER FIBROSIS AND STEATOSIS
RICO, Mario Cesar, MORTON, George C, MERALI, Salim, CHILDERS, Wayne E, BARRERO, Carlos
Year of Publication 08.06.2023
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Year of Publication 08.06.2023
Patent
Compositions and methods for treatment of insulin resistance
Morton, George C, Barrero, Carlos A, Merali, Salim, Childers, Wayne E
Year of Publication 07.03.2023
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Year of Publication 07.03.2023
Patent
(S)-2-AMINO-6-((3-AMINOPROPYL)AMINO)HEXANOIC ACID (APL) FOR USE IN THE TREATMENT OF NON-ALCOHOLIC STEATOHEPATITIS (NASH), LIVER INFLAMMATION, HEPATOCELLULAR BALLOONING, LIVER FIBROSIS AND STEATOSIS
MORTON, George, C, RICO, Mario Cesar, MERALI, Salim, CHILDERS, Wayne, E, BARRERO, Carlos
Year of Publication 01.03.2023
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Year of Publication 01.03.2023
Patent
NOVEL BRIDGED BICYCLOALKYL-SUBSTITUTED AMINOTHIZOLES AND THEIR METHODS OF USE
MORTON, George, C, ABOU-GHARBIA, Magid, A, ZHANG, Hanghang, ISSA, Jean-Pierre, J, CHILDERS, Wayne, E
Year of Publication 04.01.2023
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Year of Publication 04.01.2023
Patent
COMPOSITIONS AND METHODS FOR TREATMENT OF INSULIN RESISTANCE
MORTON, George, C, BARRERO, Carlos, A, MERALI, Salim, CHILDERS, Wayne, E
Year of Publication 29.12.2021
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Year of Publication 29.12.2021
Patent