Selective blockade of the orexin-2 receptor attenuates ethanol self-administration, place preference, and reinstatement
Shoblock, James R., Welty, Natalie, Aluisio, Leah, Fraser, Ian, Motley, S. Timothy, Morton, Kirsten, Palmer, James, Bonaventure, Pascal, Carruthers, Nicholas I., Lovenberg, Timothy W., Boggs, Jamin, Galici, Ruggero
Published in Psychopharmacologia (01.05.2011)
Published in Psychopharmacologia (01.05.2011)
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Synthesis and Pharmacological Characterization of Two Novel, Brain Penetrating P2X7 Antagonists
Letavic, Michael A, Lord, Brian, Bischoff, Francois, Hawryluk, Natalie A, Pieters, Serge, Rech, Jason C, Sales, Zachary, Velter, Adriana I, Ao, Hong, Bonaventure, Pascal, Contreras, Victor, Jiang, Xiaohui, Morton, Kirsten L, Scott, Brian, Wang, Qi, Wickenden, Alan D, Carruthers, Nicholas I, Bhattacharya, Anindya
Published in ACS medicinal chemistry letters (11.04.2013)
Published in ACS medicinal chemistry letters (11.04.2013)
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Novel Benzamide-Based Histamine H3 Receptor Antagonists: The Identification of Two Candidates for Clinical Development
Letavic, Michael A, Aluisio, Leah, Apodaca, Richard, Bajpai, Manoj, Barbier, Ann J, Bonneville, Anne, Bonaventure, Pascal, Carruthers, Nicholas I, Dugovic, Christine, Fraser, Ian C, Kramer, Michelle L, Lord, Brian, Lovenberg, Timothy W, Li, Lilian Y, Ly, Kiev S, Mcallister, Heather, Mani, Neelakandha S, Morton, Kirsten L, Ndifor, Anthony, Nepomuceno, S. Diane, Pandit, Chennagiri R, Sands, Steven B, Shah, Chandra R, Shelton, Jonathan E, Snook, Sandra S, Swanson, Devin M, Xiao, Wei
Published in ACS medicinal chemistry letters (09.04.2015)
Published in ACS medicinal chemistry letters (09.04.2015)
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Indole- and benzothiophene-based histamine H3 antagonists
SANTILLAN, Alejandro, MCCLURE, Kelly J, LOVENBERG, Timothy W, CARRUTHERS, Nicholas I, GRICE, Cheryl A, ALLISON, Brett D, LORD, Brian, BOGGS, Jamin D, MORTON, Kirsten L, EVERSON, Anita M, NEPOMUCENO, Diane, LETAVIC, Michael A, LEE-DUTRA, Alice
Published in Bioorganic & medicinal chemistry letters (01.11.2010)
Published in Bioorganic & medicinal chemistry letters (01.11.2010)
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Journal Article
Novel substituted pyrrolidines are high affinity histamine H3 receptor antagonists
STOCKING, Emily M, ALUISIO, Leah, LORD, Brian, LY, Kiev S, MORTON, Kirsten L, NEPOMUCENO, Diane, SHAH, Chandravadan R, SHELTON, Jonathan, SOYODE-JOHNSON, Akinola, LETAVIC, Michael A, ATACK, John R, BONAVENTURE, Pascal, CARRUTHERS, Nicholas I, DUGOVIC, Christine, EVERSON, Anita, FRASER, Ian, XIAOHUI JIANG, LEUNG, Perry
Published in Bioorganic & medicinal chemistry letters (01.05.2010)
Published in Bioorganic & medicinal chemistry letters (01.05.2010)
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Safety and pharmacokinetics of recombinant factor XIII in healthy volunteers: a randomized, placebo-controlled, double-blind, multi-dose study
Visich, Jennifer E, Zuckerman, Linda A, Butine, Michael D, Gunewardena, Kulasiri A, Wild, Richard, Morton, Kirsten M, Reynolds, Thomas C
Published in Thrombosis and haemostasis (01.10.2005)
Published in Thrombosis and haemostasis (01.10.2005)
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Pre-clinical characterization of aryloxypyridine amides as histamine H3 receptor antagonists: Identification of candidates for clinical development
Letavic, Michael A., Aluisio, Leah, Atack, John R., Bonaventure, Pascal, Carruthers, Nicholas I., Dugovic, Christine, Everson, Anita, Feinstein, Mark A., Fraser, Ian C., Hoey, Kenway, Jiang, Xiaohui, Keith, John M., Koudriakova, Tatiana, Leung, Perry, Lord, Brian, Lovenberg, Timothy W., Ly, Kiev S., Morton, Kirsten L., Timothy Motley, S., Nepomuceno, Diane, Rizzolio, Michele, Rynberg, Raymond, Sepassi, Kia, Shelton, Jonathan
Published in Bioorganic & medicinal chemistry letters (15.07.2010)
Published in Bioorganic & medicinal chemistry letters (15.07.2010)
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Journal Article
In vitro and in vivo characterization of JNJ-31020028 (N-(4-{4-[2-(diethylamino)-2-oxo-1-phenylethyl]piperazin-1-yl}-3-fluorophenyl)-2-pyridin-3-ylbenzamide), a selective brain penetrant small molecule antagonist of the neuropeptide Y Y2 receptor
Shoblock, James R., Welty, Natalie, Nepomuceno, Diane, Lord, Brian, Aluisio, Leah, Fraser, Ian, Motley, S. Timothy, Sutton, Steve W., Morton, Kirsten, Galici, Ruggero, Atack, John R., Dvorak, Lisa, Swanson, Devin M., Carruthers, Nicholas I., Dvorak, Curt, Lovenberg, Timothy W., Bonaventure, Pascal
Published in Psychopharmacology (01.02.2010)
Published in Psychopharmacology (01.02.2010)
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Synthesis and Pharmacological Characterization of Two Novel, Brain Penetrating P2X(7) Antagonists
Letavic, Michael A., Lord, Brian, Bischoff, Francois, Hawryluk, Natalie A., Pieters, Serge, Rech, Jason C., Sales, Zachary, Velter, Adriana I., Ao, Hong, Bonaventure, Pascal, Contreras, Victor, Jiang, Xiaohui, Morton, Kirsten L., Scott, Brian, Wang, Qi, Wickenden, Alan D., Carruthers, Nicholas I., Bhattacharya, Anindya
Published in ACS medicinal chemistry letters (01.04.2013)
Published in ACS medicinal chemistry letters (01.04.2013)
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Journal Article
Indole- and benzothiophene-based histamine H 3 antagonists
Santillan, Alejandro, McClure, Kelly J., Allison, Brett D., Lord, Brian, Boggs, Jamin D., Morton, Kirsten L., Everson, Anita M., Nepomuceno, Diane, Letavic, Michael A., Lee-Dutra, Alice, Lovenberg, Timothy W., Carruthers, Nicholas I., Grice, Cheryl A.
Published in Bioorganic & medicinal chemistry letters (01.11.2010)
Published in Bioorganic & medicinal chemistry letters (01.11.2010)
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Journal Article
Heterocyclic replacement of the central phenyl core of diamine-based histamine H 3 receptor antagonists
Swanson, Devin M., Shah, Chandra R., Lord, Brian, Morton, Kirsten, Dvorak, Lisa K., Mazur, Curt, Apodaca, Richard, Xiao, Wei, Boggs, Jamin D., Feinstein, Mark, Wilson, Sandy J., Barbier, Ann J., Bonaventure, Pascal, Lovenberg, Timothy W., Carruthers, Nicholas I.
Published in European journal of medicinal chemistry (01.11.2009)
Published in European journal of medicinal chemistry (01.11.2009)
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Journal Article
Heterocyclic replacement of the central phenyl core of diamine-based histamine H3 receptor antagonists
SWANSON, Devin M, SHAH, Chandra R, WILSON, Sandy J, BARBIER, Ann J, BONAVENTURE, Pascal, LOVENBERG, Timothy W, CARRUTHERS, Nicholas I, LORD, Brian, MORTON, Kirsten, DVORAK, Lisa K, MAZUR, Curt, APODACA, Richard, WEI XIAO, BOGGS, Jamin D, FEINSTEIN, Mark
Published in European journal of medicinal chemistry (01.11.2009)
Published in European journal of medicinal chemistry (01.11.2009)
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Journal Article
The discovery and synthesis of JNJ 31020028, a small molecule antagonist of the Neuropeptide Y Y sub(2) receptor
Swanson, Devin M, Wong, Victoria D, Jablonowski, Jill A, Shah, Chandra, Rudolph, Dale A, Dvorak, Curt A, Seierstad, Mark, Dvorak, Lisa K, Morton, Kirsten, Nepomuceno, Diane, Atack, John R, Bonaventure, Pascal, Lovenberg, Timothy W, Carruthers, Nicholas I
Published in Bioorganic & medicinal chemistry letters (15.09.2011)
Published in Bioorganic & medicinal chemistry letters (15.09.2011)
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Journal Article
Indole- and benzothiophene-based histamine H sub(3 antagonists)
Santillan, Alejandro, McClure, Kelly J, Allison, Brett D, Lord, Brian, Boggs, Jamin D, Morton, Kirsten L, Everson, Anita M, Nepomuceno, Diane, Letavic, Michael A, Lee-Dutra, Alice, Lovenberg, Timothy W, Carruthers, Nicholas I, Grice, Cheryl A
Published in Bioorganic & medicinal chemistry letters (01.11.2010)
Published in Bioorganic & medicinal chemistry letters (01.11.2010)
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Journal Article
The discovery and synthesis of JNJ 31020028, a small molecule antagonist of the Neuropeptide Y Y2 receptor
Swanson, Devin M., Wong, Victoria D., Jablonowski, Jill A., Shah, Chandra, Rudolph, Dale A., Dvorak, Curt A., Seierstad, Mark, Dvorak, Lisa K., Morton, Kirsten, Nepomuceno, Diane, Atack, John R., Bonaventure, Pascal, Lovenberg, Timothy W., Carruthers, Nicholas I.
Published in Bioorganic & medicinal chemistry letters (15.09.2011)
Published in Bioorganic & medicinal chemistry letters (15.09.2011)
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Journal Article
In vitro and in vivo characterization of JNJ-31020028 (N-(4-{4-[2-(diethylamino)-2-oxo-1-phenylethyl]piperaz in-1-yl}-3-fluorophenyl)-2-pyridin-3-ylbenzamide), a selective brain penetrant small molecule antagonist of the neuropeptide Y Y sub(2) receptor
Shoblock, James R, Welty, Natalie, Nepomuceno, Diane, Lord, Brian, Aluisio, Leah, Fraser, Ian, Motley, STimothy, Sutton, Steve W, Morton, Kirsten, Galici, Ruggero, Atack, John R, Dvorak, Lisa, Swanson, Devin M, Carruthers, Nicholas I, Dvorak, Curt, Lovenberg, Timothy W, Bonaventure, Pascal
Published in Psychopharmacology (01.02.2010)
Published in Psychopharmacology (01.02.2010)
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Journal Article
In vitro and in vivo characterization of JNJ-31020028 N-(4-{4-[2-(diethylamino)-2-oxo-1-phenylethyl]piperazin-1-yl}-3-fluorophenyl)-2-pyridin-3-ylbenzamide, a selective brain penetrant small molecule antagonist of the neuropeptide Y Y2 receptor
SHOBLOCK, James R, WELTY, Natalie, ATACK, John R, DVORAK, Lisa, SWANSON, Devin M, CARRUTHERS, Nicholas I, DVORAK, Curt, LOVENBERG, Timothy W, BONAVENTURE, Pascal, NEPOMUCENO, Diane, LORD, Brian, ALUISIO, Leah, FRASER, Ian, TIMOTHY MOTLEY, S, SUTTON, Steve W, MORTON, Kirsten, GALICI, Ruggero
Published in Psychopharmacologia (2010)
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Published in Psychopharmacologia (2010)
Journal Article
Novel substituted pyrrolidines are high affinity histamine H 3 receptor antagonists
Stocking, Emily M., Aluisio, Leah, Atack, John R., Bonaventure, Pascal, Carruthers, Nicholas I., Dugovic, Christine, Everson, Anita, Fraser, Ian, Jiang, Xiaohui, Leung, Perry, Lord, Brian, Ly, Kiev S., Morton, Kirsten L., Nepomuceno, Diane, Shah, Chandravadan R., Shelton, Jonathan, Soyode-Johnson, Akinola, Letavic, Michael A.
Published in Bioorganic & medicinal chemistry letters (01.05.2010)
Published in Bioorganic & medicinal chemistry letters (01.05.2010)
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Journal Article
Synthesis and Pharmacological Characterization of Two Novel, Brain Penetrating P2X 7 Antagonists
Letavic, Michael A., Lord, Brian, Bischoff, Francois, Hawryluk, Natalie A., Pieters, Serge, Rech, Jason C., Sales, Zachary, Velter, Adriana I., Ao, Hong, Bonaventure, Pascal, Contreras, Victor, Jiang, Xiaohui, Morton, Kirsten L., Scott, Brian, Wang, Qi, Wickenden, Alan D., Carruthers, Nicholas I., Bhattacharya, Anindya
Published in ACS medicinal chemistry letters (11.04.2013)
Published in ACS medicinal chemistry letters (11.04.2013)
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Journal Article
Pre-clinical characterization of aryloxypyridine amides as histamine H sub(3) receptor antagonists: Identification of candidates for clinical development
Letavic, Michael A, Aluisio, Leah, Atack, John R, Bonaventure, Pascal, Carruthers, Nicholas I, Dugovic, Christine, Everson, Anita, Feinstein, Mark A, Fraser, Ian C, Hoey, Kenway, Jiang, Xiaohui, Keith, John M, Koudriakova, Tatiana, Leung, Perry, Lord, Brian, Lovenberg, Timothy W, Ly, Kiev S, Morton, Kirsten L, Motley, STimothy, Nepomuceno, Diane, Rizzolio, Michele, Rynberg, Raymond, Sepassi, Kia, Shelton, Jonathan
Published in Bioorganic & medicinal chemistry letters (15.07.2010)
Published in Bioorganic & medicinal chemistry letters (15.07.2010)
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Journal Article