Targeting proteinase-activated receptors: therapeutic potential and challenges
Ramachandran, Rithwik, Noorbakhsh, Farshid, DeFea, Kathryn, Hollenberg, Morley D.
Published in Nature reviews. Drug discovery (01.01.2012)
Published in Nature reviews. Drug discovery (01.01.2012)
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Journal Article
Metformin: Is it a drug for all reasons and diseases?
Triggle, Chris R., Mohammed, Ibrahim, Bshesh, Khalifa, Marei, Isra, Ye, Kevin, Ding, Hong, MacDonald, Ross, Hollenberg, Morley D., Hill, Michael A.
Published in Metabolism, clinical and experimental (01.08.2022)
Published in Metabolism, clinical and experimental (01.08.2022)
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Journal Article
Metformin down-regulates TGF beta signal transduction and production of PAR2 N-terminus cleaving protease activity in an NR4a1 dependent manner in a PC3 prostate cancer cell line
Mihara, Koichiro, Saifeddine, Mahmoud, Hollenberg, Morley D
Published in The FASEB journal (01.05.2022)
Published in The FASEB journal (01.05.2022)
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Journal Article
Repurposing Metformin for Vascular Disease
Triggle, Chris R, Marei, Isra, Ye, Kevin, Ding, Hong, Anderson, Todd J, Hollenberg, Morley D, Hill, Michael A
Published in Current medicinal chemistry (01.01.2023)
Published in Current medicinal chemistry (01.01.2023)
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Journal Article
Neutrophil Elastase and Proteinase-3 Trigger G Protein-biased Signaling through Proteinase-activated Receptor-1 (PAR1)
Mihara, Koichiro, Ramachandran, Rithwik, Renaux, Bernard, Saifeddine, Mahmoud, Hollenberg, Morley D.
Published in The Journal of biological chemistry (15.11.2013)
Published in The Journal of biological chemistry (15.11.2013)
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Journal Article
Proteinases, Their Extracellular Targets, and Inflammatory Signaling
Ramachandran, Rithwik, Altier, Christophe, Oikonomopoulou, Katerina, Hollenberg, Morley D
Published in Pharmacological reviews (01.10.2016)
Published in Pharmacological reviews (01.10.2016)
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Journal Article
Proteinase-activated Receptor-2 Transactivation of Epidermal Growth Factor Receptor and Transforming Growth Factor-β Receptor Signaling Pathways Contributes to Renal Fibrosis
Chung, Hyunjae, Ramachandran, Rithwik, Hollenberg, Morley D., Muruve, Daniel A.
Published in The Journal of biological chemistry (27.12.2013)
Published in The Journal of biological chemistry (27.12.2013)
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Journal Article
Proteinases and their receptors in inflammatory arthritis: an overview
Oikonomopoulou, Katerina, Diamandis, Eleftherios P., Hollenberg, Morley D., Chandran, Vinod
Published in Nature reviews. Rheumatology (01.03.2018)
Published in Nature reviews. Rheumatology (01.03.2018)
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Journal Article
Proteinase-activated receptors (PARs) - focus on receptor-receptor-interactions and their physiological and pathophysiological impact
Gieseler, Frank, Ungefroren, Hendrik, Settmacher, Utz, Hollenberg, Morley D, Kaufmann, Roland
Published in Cell communication and signaling (11.11.2013)
Published in Cell communication and signaling (11.11.2013)
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Journal Article
Protease allergens as initiators–regulators of allergic inflammation
Soh, Wai Tuck, Zhang, Jihui, Hollenberg, Morley D., Vliagoftis, Harissios, Rothenberg, Marc E., Sokol, Caroline L., Robinson, Clive, Jacquet, Alain
Published in Allergy (Copenhagen) (01.05.2023)
Published in Allergy (Copenhagen) (01.05.2023)
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Journal Article
Hyperglycaemic impairment of PAR2-mediated vasodilation: Prevention by inhibition of aortic endothelial sodium-glucose-co-Transporter-2 and minimizing oxidative stress
El-Daly, Mahmoud, Pulakazhi Venu, Vivek Krishna, Saifeddine, Mahmoud, Mihara, Koichiro, Kang, Sean, Fedak, Paul W.M., Alston, Laurie A., Hirota, Simon A., Ding, Hong, Triggle, Chris R., Hollenberg, Morley D.
Published in Vascular pharmacology (01.10.2018)
Published in Vascular pharmacology (01.10.2018)
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Journal Article
Myopia-Inhibiting Concentrations of Muscarinic Receptor Antagonists Block Activation of Alpha2A-Adrenoceptors In Vitro
Carr, Brittany J, Mihara, Koichiro, Ramachandran, Rithwik, Saifeddine, Mahmoud, Nathanson, Neil M, Stell, William K, Hollenberg, Morley D
Published in Investigative ophthalmology & visual science (01.06.2018)
Published in Investigative ophthalmology & visual science (01.06.2018)
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Journal Article
Thrombin-Mediated Direct Activation of Proteinase-Activated Receptor-2: Another Target for Thrombin Signaling
Mihara, Koichiro, Ramachandran, Rithwik, Saifeddine, Mahmoud, Hansen, Kristina K, Renaux, Bernard, Polley, Danny, Gibson, Stacy, Vanderboor, Christina, Hollenberg, Morley D
Published in Molecular pharmacology (01.05.2016)
Published in Molecular pharmacology (01.05.2016)
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Journal Article