Discovery and structural characterization of peficitinib (ASP015K) as a novel and potent JAK inhibitor
Hamaguchi, Hisao, Amano, Yasushi, Moritomo, Ayako, Shirakami, Shohei, Nakajima, Yutaka, Nakai, Kazuo, Nomura, Naoko, Ito, Misato, Higashi, Yasuyuki, Inoue, Takayuki
Published in Bioorganic & medicinal chemistry (01.10.2018)
Published in Bioorganic & medicinal chemistry (01.10.2018)
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Journal Article
Analysis of fluoroquinolone-resistance using MIC determination and homology modelling of ParC of contemporary Mycoplasma genitalium strains
Hamasuna, Ryoichi, Hanzawa, Hiroyuki, Moritomo, Ayako, Matsumoto, Masahiro, Aono, Hisami, Tomisaki, Ikko, Akasaka, Takaaki, Fujimoto, Naohiro, Jensen, Jørgen Skov
Published in Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy (01.03.2022)
Published in Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy (01.03.2022)
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Journal Article
Synthesis and Evaluation of 1H-Pyrrolo[2,3-b]pyridine Derivatives as Novel Immunomodulators Targeting Janus Kinase 3
Nakajima, Yutaka, Tojo, Takashi, Morita, Masataka, Hatanaka, Keiko, Shirakami, Shohei, Tanaka, Akira, Sasaki, Hiroshi, Nakai, Kazuo, Mukoyoshi, Koichiro, Hamaguchi, Hisao, Takahashi, Fumie, Moritomo, Ayako, Higashi, Yasuyuki, Inoue, Takayuki
Published in Chemical & pharmaceutical bulletin (01.05.2015)
Published in Chemical & pharmaceutical bulletin (01.05.2015)
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Journal Article
Discovery and Biological Evaluation of Potent and Orally Active Human 11β-Hydroxysteroid Dehydrogenase Type 1 Inhibitors for the Treatment of Type 2 Diabetes Mellitus
Koike, Takanori, Shiraki, Ryota, Sasuga, Daisuke, Hosaka, Mitsuru, Kawano, Tomoaki, Fukudome, Hiroki, Kurosawa, Kazuo, Moritomo, Ayako, Mimasu, Shinya, Ishii, Hirofumi, Yoshimura, Seiji
Published in Chemical & pharmaceutical bulletin (01.08.2019)
Published in Chemical & pharmaceutical bulletin (01.08.2019)
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Journal Article
Synthesis and structure–activity relationships of new carbonyl guanidine derivatives as novel dual 5-HT2B and 5-HT7 receptor antagonists
Moritomo, Ayako, Yamada, Hiroyoshi, Watanabe, Toshihiro, Itahana, Hirotsune, Akuzawa, Shinobu, Okada, Minoru, Ohta, Mitsuaki
Published in Bioorganic & medicinal chemistry (15.12.2013)
Published in Bioorganic & medicinal chemistry (15.12.2013)
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Journal Article
Synthesis and structure–activity relationships of new carbonyl guanidine derivatives as novel dual 5-HT2B and 5-HT7 receptor antagonists. Part 2
Moritomo, Ayako, Yamada, Hiroyoshi, Watanabe, Toshihiro, Itahana, Hirotsune, Koga, Yuji, Akuzawa, Shinobu, Okada, Minoru
Published in Bioorganic & medicinal chemistry (01.08.2014)
Published in Bioorganic & medicinal chemistry (01.08.2014)
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Journal Article
Synthesis and pharmacological evaluation of optically pure, novel carbonyl guanidine derivatives as dual 5-HT2B and 5-HT7 receptor antagonists
Moritomo, Ayako, Yamada, Hiroyoshi, Matsuzawa-Nomura, Takaho, Watanabe, Toshihiro, Itahana, Hirotsune, Oku, Makoto, Akuzawa, Shinobu, Okada, Minoru
Published in Bioorganic & medicinal chemistry (01.11.2014)
Published in Bioorganic & medicinal chemistry (01.11.2014)
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Journal Article
Discovery and Biological Evaluation of Potent and Orally Active Human 11β-Hydroxysteroid Dehydrogenase Type 1 Inhibitors for the Treatment of Type 2 Diabetes Mellitus
Takanori Koike, Ryota Shiraki, Daisuke Sasuga, Mitsuru Hosaka, Tomoaki Kawano, Hiroki Fukudome, Kazuo Kurosawa, Ayako Moritomo, Shinya Mimasu, Hirofumi Ishii, Seiji Yoshimura
Published in Chemical and Pharmaceutical Bulletin (01.08.2019)
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Published in Chemical and Pharmaceutical Bulletin (01.08.2019)
Journal Article
Synthesis and structure–activity relationships of pyrazine-2-carboxamide derivatives as novel echinoderm microtubule-associated protein-like 4 (EML4)–anaplastic lymphoma kinase (ALK) inhibitors
Iikubo, Kazuhiko, Kurosawa, Kazuo, Matsuya, Takahiro, Kondoh, Yutaka, Kamikawa, Akio, Moritomo, Ayako, Iwai, Yoshinori, Tomiyama, Hiroshi, Shimada, Itsuro
Published in Bioorganic & medicinal chemistry (15.04.2019)
Published in Bioorganic & medicinal chemistry (15.04.2019)
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Journal Article
Synthesis and pharmacological evaluation of glycine amide derivatives as novel vascular adhesion protein-1 inhibitors without CYP3A4 and CYP2C19 inhibition
Yamaki, Susumu, Koga, Yuji, Nagashima, Akira, Kondo, Mitsuhiro, Shimada, Yoshiaki, Kadono, Keitaro, Moritomo, Ayako, Yoshihara, Kosei
Published in Bioorganic & medicinal chemistry (01.08.2017)
Published in Bioorganic & medicinal chemistry (01.08.2017)
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Journal Article
Discovery and biological evaluation of novel pyrazolopyridine derivatives as potent and orally available PI3Kδ inhibitors
Hamajima, Toshihiro, Takahashi, Fumie, Kato, Koji, Mukoyoshi, Koichiro, Yoshihara, Kousei, Yamaki, Susumu, Sugano, Yukihito, Moritomo, Ayako, Yamagami, Kaoru, Yokoo, Koji, Fukahori, Hidehiko
Published in Bioorganic & medicinal chemistry (15.05.2018)
Published in Bioorganic & medicinal chemistry (15.05.2018)
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Journal Article
Synthesis and structure activity relationships of glycine amide derivatives as novel Vascular Adhesion Protein-1 inhibitors
Yamaki, Susumu, Suzuki, Daisuke, Fujiyasu, Jiro, Neya, Masahiro, Nagashima, Akira, Kondo, Mitsuhiro, Akabane, Takafumi, Kadono, Keitaro, Moritomo, Ayako, Yoshihara, Kosei
Published in Bioorganic & medicinal chemistry (01.01.2017)
Published in Bioorganic & medicinal chemistry (01.01.2017)
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Journal Article
Optimization and in vivo evaluation of pyrazolopyridines as a potent and selective PI3Kδ inhibitor
Hamajima, Toshihiro, Takahashi, Fumie, Kato, Koji, Sugano, Yukihito, Yamaki, Susumu, Moritomo, Ayako, Kubo, Satoshi, Nakamura, Koji, Yamagami, Kaoru, Hamakawa, Nozomu, Yokoo, Koji, Fukahori, Hidehiko
Published in Bioorganic & medicinal chemistry (07.08.2018)
Published in Bioorganic & medicinal chemistry (07.08.2018)
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Journal Article
Optimization of 5,6,7,8-tetrahydropyrido[4,3-d]pyrimidines to generate a highly selective PI3Kδ inhibitor
Hamajima, Toshihiro, Takahashi, Fumie, Kato, Koji, Sugano, Yukihito, Yamaki, Susumu, Suzuki, Daisuke, Moritomo, Ayako, Kubo, Satoshi, Nakamura, Koji, Yamagami, Kaoru, Yokoo, Koji, Fukahori, Hidehiko
Published in Bioorganic & medicinal chemistry (15.03.2019)
Published in Bioorganic & medicinal chemistry (15.03.2019)
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Journal Article
Novel quinuclidinyl heteroarylcarbamate derivatives as muscarinic receptor antagonists
Nagashima, Shinya, Matsushima, Yuji, Hamaguchi, Hisao, Nagata, Hiroshi, Kontani, Toru, Moritomo, Ayako, Koshika, Tadatsura, Takeuchi, Makoto
Published in Bioorganic & medicinal chemistry (01.07.2014)
Published in Bioorganic & medicinal chemistry (01.07.2014)
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Journal Article
Discovery of 3,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridin-2(1H)-one derivatives as novel JAK inhibitors
Yamagishi, Hiroaki, Shirakami, Shohei, Nakajima, Yutaka, Tanaka, Akira, Takahashi, Fumie, Hamaguchi, Hisao, Hatanaka, Keiko, Moritomo, Ayako, Inami, Masamichi, Higashi, Yasuyuki, Inoue, Takayuki
Published in Bioorganic & medicinal chemistry (01.08.2015)
Published in Bioorganic & medicinal chemistry (01.08.2015)
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Journal Article
Design, synthesis, and evaluation of 4,6-diaminonicotinamide derivatives as novel and potent immunomodulators targeting JAK3
Nakajima, Yutaka, Aoyama, Naohiro, Takahashi, Fumie, Sasaki, Hiroshi, Hatanaka, Keiko, Moritomo, Ayako, Inami, Masamichi, Ito, Misato, Nakamura, Koji, Nakamori, Fumihiro, Inoue, Takayuki, Shirakami, Shohei
Published in Bioorganic & medicinal chemistry (01.10.2016)
Published in Bioorganic & medicinal chemistry (01.10.2016)
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Journal Article
Synthesis and SAR study of new thiazole derivatives as vascular adhesion protein-1 (VAP-1) inhibitors for the treatment of diabetic macular edema: Part 2
Inoue, Takayuki, Morita, Masataka, Tojo, Takashi, Nagashima, Akira, Moritomo, Ayako, Imai, Keisuke, Miyake, Hiroshi
Published in Bioorganic & medicinal chemistry (01.05.2013)
Published in Bioorganic & medicinal chemistry (01.05.2013)
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Journal Article
Synthesis and SAR study of new thiazole derivatives as vascular adhesion protein-1 (VAP-1) inhibitors for the treatment of diabetic macular edema
Inoue, Takayuki, Morita, Masataka, Tojo, Takashi, Yoshihara, Kousei, Nagashima, Akira, Moritomo, Ayako, Ohkubo, Mitsuru, Miyake, Hiroshi
Published in Bioorganic & medicinal chemistry (01.03.2013)
Published in Bioorganic & medicinal chemistry (01.03.2013)
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Journal Article