Discovery of Aficamten (CK-274), a Next-Generation Cardiac Myosin Inhibitor for the Treatment of Hypertrophic Cardiomyopathy
Chuang, Chihyuan, Collibee, Scott, Ashcraft, Luke, Wang, Wenyue, Vander Wal, Mark, Wang, Xiaolin, Hwee, Darren T, Wu, Yangsong, Wang, Jingying, Chin, Eva R, Cremin, Peadar, Zamora, Jeanelle, Hartman, James, Schaletzky, Julia, Wehri, Eddie, Robertson, Laura A, Malik, Fady I, Morgan, Bradley P
Published in Journal of medicinal chemistry (14.10.2021)
Published in Journal of medicinal chemistry (14.10.2021)
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Journal Article
Pharmacokinetics, Mass Balance, Tissue Distribution, Metabolism, and Excretion of [ 14 C]Aficamten Following Single Oral Dose Administration to Rats
Grillo, Mark P, Sukhun, Rajaa, Bashir, Mohammad, Ashcraft, Luke, Morgan, Bradley P
Published in Xenobiotica (07.08.2024)
Published in Xenobiotica (07.08.2024)
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In vitro and in vivo preclinical pharmacokinetic characterization of aficamten, a small molecule cardiac myosin inhibitor
Sukhun, Rajaa, Cremin, Peadar, Xu, Donghong, Zamora, Jeanelle, Cheung, Jennifer, Ashcraft, Luke, Grillo, Mark P, Morgan, Bradley P
Published in Xenobiotica (09.08.2024)
Published in Xenobiotica (09.08.2024)
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Journal Article
Discovery of GBT440, an Orally Bioavailable R‑State Stabilizer of Sickle Cell Hemoglobin
Metcalf, Brian, Chuang, Chihyuan, Dufu, Kobina, Patel, Mira P, Silva-Garcia, Abel, Johnson, Carl, Lu, Qing, Partridge, James R, Patskovska, Larysa, Patskovsky, Yury, Almo, Steven C, Jacobson, Matthew P, Hua, Lan, Xu, Qing, Gwaltney, Stephen L, Yee, Calvin, Harris, Jason, Morgan, Bradley P, James, Joyce, Xu, Donghong, Hutchaleelaha, Athiwat, Paulvannan, Kumar, Oksenberg, Donna, Li, Zhe
Published in ACS medicinal chemistry letters (09.03.2017)
Published in ACS medicinal chemistry letters (09.03.2017)
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Journal Article
Cardiac Troponin Activator CK-963 Increases Cardiac Contractility in Rats
Collibee, Scott E., Romero, Antonio, Muci, Alexander R., Hwee, Darren T., Chuang, Chihyuan, Hartman, James J., Motani, Alykhan S., Ashcraft, Luke, DeRosier, Andre, Grillo, Mark, Lu, Qing, Malik, Fady I., Morgan, Bradley P.
Published in Journal of medicinal chemistry (23.05.2024)
Published in Journal of medicinal chemistry (23.05.2024)
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Journal Article
Discovery of Nelutroctiv (CK-136), a Selective Cardiac Troponin Activator for the Treatment of Cardiovascular Diseases Associated with Reduced Cardiac Contractility
Romero, Antonio, Ashcraft, Luke, Chandra, Aroop, DiMassa, Vincent, Cremin, Peadar, Collibee, Scott E., Chuang, Chihyuan, Hartman, James, Hwee, Darren T., St. Jean, David, Malinowski, Justin, DeBenedetto, Mikkel, Moebius, David, Payette, Joshua, Vargas, Richard, Yeoman, John, Motani, Alykhan, Reagan, Jeffrey, Malik, Fady I., Morgan, Bradley P.
Published in Journal of medicinal chemistry (23.05.2024)
Published in Journal of medicinal chemistry (23.05.2024)
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Journal Article
Cardiac myosin activation part 1: From concept to clinic
Malik, Fady I, Morgan, Bradley P
Published in Journal of molecular and cellular cardiology (01.10.2011)
Published in Journal of molecular and cellular cardiology (01.10.2011)
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Journal Article
Cardiac myosin inhibitor, CK-586, minimally reduces systolic function and ameliorates obstruction in feline hypertrophic cardiomyopathy
Rivas, Victor N., Crofton, Amanda E., Jauregui, Carina E., Wouters, Jalena R., Yang, Betty S., Wittenburg, Luke A., Kaplan, Joanna L., Hwee, Darren T., Murphy, Anne N., Morgan, Bradley P., Malik, Fady I., Harris, Samantha P., Stern, Joshua A.
Published in Scientific reports (27.05.2024)
Published in Scientific reports (27.05.2024)
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Journal Article
Highly selective inhibition of myosin motors provides the basis of potential therapeutic application
Sirigu, Serena, Hartman, James J., Planelles-Herrero, Vicente José, Ropars, Virginie, Clancy, Sheila, Wang, Xi, Chuang, Grace, Qian, Xiangping, Lu, Pu-Ping, Barrett, Edward, Rudolph, Karin, Royer, Christopher, Morgan, Bradley P., Stura, Enrico A., Malik, Fady I., Houdusse, Anne M.
Published in Proceedings of the National Academy of Sciences - PNAS (22.11.2016)
Published in Proceedings of the National Academy of Sciences - PNAS (22.11.2016)
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Journal Article
Effects of Aficamten on cardiac contractility in a feline translational model of hypertrophic cardiomyopathy
Sharpe, Ashley N., Oldach, Maureen S., Rivas, Victor N., Kaplan, Joanna L., Walker, Ashley L., Kovacs, Samantha L., Hwee, Darren T., Cremin, Peadar, Morgan, Bradley P., Malik, Fady I., Harris, Samantha P., Stern, Joshua A.
Published in Scientific reports (02.01.2023)
Published in Scientific reports (02.01.2023)
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Journal Article
Discovery of Reldesemtiv, a Fast Skeletal Muscle Troponin Activator for the Treatment of Impaired Muscle Function
Collibee, Scott E, Bergnes, Gustave, Chuang, Chihyuan, Ashcraft, Luke, Gardina, Jeffrey, Garard, Marc, Jamison, Chris R, Lu, Kevin, Lu, Pu-Ping, Muci, Alexander, Romero, Antonio, Valkevich, Ellen, Wang, Wenyue, Warrington, Jeffrey, Yao, Bing, Durham, Nickie, Hartman, James, Marquez, Anna, Hinken, Aaron, Schaletzky, Julia, Xu, Donghong, Hwee, Darren T, Morgans, David, Malik, Fady I, Morgan, Bradley P
Published in Journal of medicinal chemistry (28.10.2021)
Published in Journal of medicinal chemistry (28.10.2021)
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Journal Article
Preclinical characterization of CK-4021586, a new class of cardiac myosin inhibitors for the treatment of hypertrophic cardiomyopathy
Sankar Sarkar, Saswata, Hartman, James J., Hwee, Darren T., Chuang, Chihyuan, Cremin, Peadar, deRosier, Andre, Edell, Samantha, Madhvani, Roshni, Wu, Yangsong, Yco, Lisette, Zamora, Jeanelle, Murphy, Anne, Morgan, Bradley P., Malik, Fady I.
Published in Biophysical journal (10.02.2023)
Published in Biophysical journal (10.02.2023)
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Journal Article
Pharmacokinetics of a single dose of Aficamten (CK‐274) on cardiac contractility in a A31P MYBPC3 hypertrophic cardiomyopathy cat model
Sharpe, Ashley N., Oldach, Maureen S., Kaplan, Joanna L., Rivas, Victor, Kovacs, Samantha L., Hwee, Darren T., Morgan, Bradley P., Malik, Fady I., Harris, Samantha P., Stern, Joshua A.
Published in Journal of veterinary pharmacology and therapeutics (01.01.2023)
Published in Journal of veterinary pharmacology and therapeutics (01.01.2023)
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Journal Article
Activation of fast skeletal muscle troponin as a potential therapeutic approach for treating neuromuscular diseases
Russell, Alan J, Hartman, James J, Hinken, Aaron C, Muci, Alexander R, Kawas, Raja, Driscoll, Lena, Godinez, Guillermo, Lee, Kenneth H, Marquez, David, Browne, William F, Chen, Michael M, Clarke, David, Collibee, Scott E, Garard, Marc, Hansen, Richard, Jia, Zhiheng, Lu, Pu-Ping, Rodriguez, Hector, Saikali, Khalil G, Schaletzky, Julia, Vijayakumar, Vipin, Albertus, Daniel L, Claflin, Dennis R, Morgans, David J, Morgan, Bradley P, Malik, Fady I
Published in Nature medicine (01.03.2012)
Published in Nature medicine (01.03.2012)
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Journal Article
Medical Malpractice Lawsuits Involving Pediatric Trainees
Bradley, Morgan T, Golan, Roei, Agudelo, Vanessa, Thomas, Nicholas D, Donches, Katherine
Published in Curēus (Palo Alto, CA) (01.08.2023)
Published in Curēus (Palo Alto, CA) (01.08.2023)
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Journal Article
Aficamten is a small-molecule cardiac myosin inhibitor designed to treat hypertrophic cardiomyopathy
Hartman, James J, Hwee, Darren T, Robert-Paganin, Julien, Chuang, Chihyuan, Chin, Eva R, Edell, Samantha, Lee, Ken H, Madhvani, Roshni, Paliwal, Preeti, Pernier, Julien, Sarkar, Saswata Sankar, Schaletzky, Julia, Schauer, Kristine, Taheri, Khanha D, Wang, Jingying, Wehri, Eddie, Wu, Yangsong, Houdusse, Anne, Morgan, Bradley P, Malik, Fady I
Published in Nature cardiovascular research (01.08.2024)
Published in Nature cardiovascular research (01.08.2024)
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Journal Article
Flat epithelial atypia with and without atypical ductal hyperplasia: to re-excise or not. Results of a 5-year prospective study
Uzoaru, Ikechukwu, Morgan, Bradley R., Liu, Zheng G., Bellafiore, Frank J., Gaudier, Farah S., Lo, Jeanne V., Pakzad, Kourosh
Published in Virchows Archiv : an international journal of pathology (01.10.2012)
Published in Virchows Archiv : an international journal of pathology (01.10.2012)
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Journal Article
Development of a Factory Process for Omecamtiv Mecarbil, a Novel Cardiac Myosin Activator
Caille, Seb, Allgeier, Alan M, Bernard, Charles, Correll, Tiffany L, Cosbie, Andrew, Crockett, Richard D, Cui, Sheng, Faul, Margaret M, Hansen, Karl B, Huggins, Seth, Langille, Neil, Mennen, Steven M, Morgan, Bradley P, Morrison, Henry, Muci, Alexander, Nagapudi, Karthik, Quasdorf, Kyle, Ranganathan, Krishnakumar, Roosen, Philipp, Shi, Xianqing, Thiel, Oliver R, Wang, Fang, Tvetan, Justin T, Woo, Jacqueline C. S, Wu, Steven, Walker, Shawn D
Published in Organic process research & development (16.08.2019)
Published in Organic process research & development (16.08.2019)
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Journal Article
Cardiac Myosin Activation: A Potential Therapeutic Approach for Systolic Heart Failure
Malik, Fady I., Hartman, James J., Elias, Kathleen A., Morgan, Bradley P., Rodriguez, Hector, Brejc, Katjuša, Anderson, Robert L., Sueoka, Sandra H., Lee, Kenneth H., Finer, Jeffrey T., Sakowicz, Roman, Baliga, Ramesh, Cox, David R., Garard, Marc, Godinez, Guillermo, Kawas, Raja, Kraynack, Erica, Lenzi, David, Lu, Pu Ping, Muci, Alexander, Niu, Congrong, Qian, Xiangping, Pierce, Daniel W., Pokrovskii, Maria, Suehiro, Ion, Sylvester, Sheila, Tochimoto, Todd, Valdez, Corey, Wang, Wenyue, Katori, Tatsuo, Kass, David A., Shen, You-Tang, Vatner, Stephen F., Morgans, David J.
Published in Science (American Association for the Advancement of Science) (18.03.2011)
Published in Science (American Association for the Advancement of Science) (18.03.2011)
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