MGCD0103, a novel isotype-selective histone deacetylase inhibitor, has broad spectrum antitumor activity in vitro and in vivo
Fournel, Marielle, Bonfils, Claire, Hou, Yu, Yan, Pu Theresa, Trachy-Bourget, Marie-Claude, Kalita, Ann, Liu, Jianhong, Lu, Ai-Hua, Zhou, Nancy Z, Robert, Marie-France, Gillespie, Jeffrey, Wang, James J, Ste-Croix, Hélène, Rahil, Jubrail, Lefebvre, Sylvain, Moradei, Oscar, Delorme, Daniel, Macleod, A Robert, Besterman, Jeffrey M, Li, Zuomei
Published in Molecular cancer therapeutics (01.04.2008)
Published in Molecular cancer therapeutics (01.04.2008)
Get full text
Journal Article
Novel Aminophenyl Benzamide-Type Histone Deacetylase Inhibitors with Enhanced Potency and Selectivity
Moradei, Oscar M, Mallais, Tammy C, Frechette, Sylvie, Paquin, Isabelle, Tessier, Pierre E, Leit, Silvana M, Fournel, Marielle, Bonfils, Claire, Trachy-Bourget, Marie-Claude, Liu, Jianhong, Yan, Theresa P, Lu, Ai-Hua, Rahil, Jubrail, Wang, James, Lefebvre, Sylvain, Li, Zuomei, Vaisburg, Arkadii F, Besterman, Jeffrey M
Published in Journal of medicinal chemistry (15.11.2007)
Published in Journal of medicinal chemistry (15.11.2007)
Get full text
Journal Article
Discovery of MK-8718, an HIV Protease Inhibitor Containing a Novel Morpholine Aspartate Binding Group
Bungard, Christopher J, Williams, Peter D, Ballard, Jeanine E, Bennett, David J, Beaulieu, Christian, Bahnck-Teets, Carolyn, Carroll, Steve S, Chang, Ronald K, Dubost, David C, Fay, John F, Diamond, Tracy L, Greshock, Thomas J, Hao, Li, Holloway, M. Katharine, Felock, Peter J, Gesell, Jennifer J, Su, Hua-Poo, Manikowski, Jesse J, McKay, Daniel J, Miller, Mike, Min, Xu, Molinaro, Carmela, Moradei, Oscar M, Nantermet, Philippe G, Nadeau, Christian, Sanchez, Rosa I, Satyanarayana, Tummanapalli, Shipe, William D, Singh, Sanjay K, Truong, Vouy Linh, Vijayasaradhi, Sivalenka, Wiscount, Catherine M, Vacca, Joseph P, Crane, Sheldon N, McCauley, John A
Published in ACS medicinal chemistry letters (14.07.2016)
Published in ACS medicinal chemistry letters (14.07.2016)
Get full text
Journal Article
Total Asymmetric Synthesis of the Putative Structure of the Cytotoxic Diterpenoid (−)-Sclerophytin A and of the Authentic Natural Sclerophytins A and B
Bernardelli, Patrick, Moradei, Oscar M, Friedrich, Dirk, Yang, Jiong, Gallou, Fabrice, Dyck, Brian P, Doskotch, Raymond W, Lange, Tim, Paquette, Leo A
Published in Journal of the American Chemical Society (19.09.2001)
Published in Journal of the American Chemical Society (19.09.2001)
Get full text
Journal Article
Identification of a CARM1 Inhibitor with Potent In Vitro and In Vivo Activity in Preclinical Models of Multiple Myeloma
Drew, Allison E., Moradei, Oscar, Jacques, Suzanne L., Rioux, Nathalie, Boriack-Sjodin, Ann P., Allain, Christina, Scott, Margaret Porter, Jin, Lei, Raimondi, Alejandra, Handler, Jessica L., Ott, Heidi M., Kruger, Ryan G., McCabe, Michael T., Sneeringer, Christopher, Riera, Thomas, Shapiro, Gideon, Waters, Nigel J., Mitchell, Lorna H., Duncan, Kenneth W., Moyer, Mikel P., Copeland, Robert A., Smith, Jesse, Chesworth, Richard, Ribich, Scott A.
Published in Scientific reports (21.12.2017)
Published in Scientific reports (21.12.2017)
Get full text
Journal Article
Aryl Pyrazoles as Potent Inhibitors of Arginine Methyltransferases: Identification of the First PRMT6 Tool Compound
Mitchell, Lorna H., Drew, Allison E., Ribich, Scott A., Rioux, Nathalie, Swinger, Kerren K., Jacques, Suzanne L., Lingaraj, Trupti, Boriack-Sjodin, P. Ann, Waters, Nigel J., Wigle, Tim J., Moradei, Oscar, Jin, Lei, Riera, Tom, Porter-Scott, Margaret, Moyer, Mikel P., Smith, Jesse J., Chesworth, Richard, Copeland, Robert A.
Published in ACS medicinal chemistry letters (11.06.2015)
Published in ACS medicinal chemistry letters (11.06.2015)
Get full text
Journal Article
Structural Insights into Ternary Complex Formation of Human CARM1 with Various Substrates
Boriack-Sjodin, P. Ann, Jin, Lei, Jacques, Suzanne L, Drew, Allison, Sneeringer, Chris, Scott, Margaret Porter, Moyer, Mikel P, Ribich, Scott, Moradei, Oscar, Copeland, Robert A
Published in ACS chemical biology (18.03.2016)
Published in ACS chemical biology (18.03.2016)
Get full text
Journal Article
Abstract 2437: Crystal structures of CARM1 bound to sinefungin and diverse peptide substrates
Boriack-Sjodin, Ann, Jin, Lei, Jacques, Suzanne L., Drew, Allison, Porter Scott, Margaret, Ribich, Scott, Moradei, Oscar
Published in Cancer research (Chicago, Ill.) (01.08.2015)
Published in Cancer research (Chicago, Ill.) (01.08.2015)
Get full text
Journal Article
Rapid occurrence of sugar tricyclic orthoesters by acid catalyzed intramolecular orthotransesterification
Get full text
Journal Article
Web Resource
Discovery of N-(2-Aminophenyl)-4-[(4-pyridin-3-ylpyrimidin-2-ylamino)methyl]benzamide (MGCD0103), an Orally Active Histone Deacetylase Inhibitor
Zhou, Nancy, Moradei, Oscar, Raeppel, Stephane, Leit, Silvana, Frechette, Sylvie, Gaudette, Frederic, Paquin, Isabelle, Bernstein, Naomy, Bouchain, Giliane, Vaisburg, Arkadii, Jin, Zhiyun, Gillespie, Jeff, Wang, James, Fournel, Marielle, Yan, Pu T, Trachy-Bourget, Marie-Claude, Kalita, Ann, Lu, Aihua, Rahil, Jubrail, MacLeod, A. Robert, Li, Zuomei, Besterman, Jeffrey M, Delorme, Daniel
Published in Journal of medicinal chemistry (24.07.2008)
Published in Journal of medicinal chemistry (24.07.2008)
Get full text
Journal Article
SMARCA2 길항제로서 유용한 피리딘-2-온 화합물
DUNCAN KENNETH WILLIAM, CAMPBELL JOHN EMMERSON, MUNCHHOF MICHAEL JOHN, MORADEI OSCAR, LAMPE JOHN W, HARVEY DARREN MARTIN
Year of Publication 08.04.2021
Get full text
Year of Publication 08.04.2021
Patent
CARM1 INHIBITORS AND USES THEREOF
CHESWORTH RICHARD, MORADEI OSCAR MIGUEL, SHAPIRO GIDEON, BABINE ROBERT E, JIN LEI
Year of Publication 11.01.2016
Get full text
Year of Publication 11.01.2016
Patent
INHIBITORS OF HISTONE DEACETYLASE
PAQUIN ISABELLE, FRECHETTE SYLVIE, ROY SIMON, VAISBURG ARKADII, MORADEI OSCAR, ISAKOVIC LUBO
Year of Publication 08.07.2015
Get full text
Year of Publication 08.07.2015
Patent
Design and synthesis of 4-[( s-triazin-2-ylamino)methyl]- N-(2-aminophenyl)-benzamides and their analogues as a novel class of histone deacetylase inhibitors
Paquin, Isabelle, Raeppel, Stéphane, Leit, Silvana, Gaudette, Frédéric, Zhou, Nancy, Moradei, Oscar, Saavedra, Oscar, Bernstein, Naomy, Raeppel, Franck, Bouchain, Giliane, Fréchette, Sylvie, Woo, Soon H., Vaisburg, Arkadii, Fournel, Marielle, Kalita, Ann, Robert, Marie-France, Lu, Aihua, Trachy-Bourget, Marie-Claude, Yan, Pu Theresa, Liu, Jianhong, Rahil, Jubrail, MacLeod, A. Robert, Besterman, Jeffrey M., Li, Zuomei, Delorme, Daniel
Published in Bioorganic & medicinal chemistry (01.02.2008)
Published in Bioorganic & medicinal chemistry (01.02.2008)
Get full text
Journal Article
Structurally Simple Trichostatin A-Like Straight Chain Hydroxamates as Potent Histone Deacetylase Inhibitors
Woo, Soon Hyung, Frechette, Sylvie, Khalil, Elie Abou, Bouchain, Giliane, Vaisburg, Arkadii, Bernstein, Naomy, Moradei, Oscar, Leit, Silvana, Allan, Martin, Fournel, Marielle, Trachy-Bourget, Marie-Claude, Li, Zuomei, Besterman, Jeffrey M, Delorme, Daniel
Published in Journal of medicinal chemistry (20.06.2002)
Published in Journal of medicinal chemistry (20.06.2002)
Get full text
Journal Article
Development of Potential Antitumor Agents. Synthesis and Biological Evaluation of a New Set of Sulfonamide Derivatives as Histone Deacetylase Inhibitors
Bouchain, Giliane, Leit, Silvana, Frechette, Sylvie, Khalil, Elie Abou, Lavoie, Rico, Moradei, Oscar, Woo, Soon Hyung, Fournel, Marielle, Yan, Pu T, Kalita, Ann, Trachy-Bourget, Marie-Claude, Beaulieu, Carole, Li, Zuomei, Robert, Marie-France, MacLeod, A. Robert, Besterman, Jeffrey M, Delorme, Daniel
Published in Journal of medicinal chemistry (27.02.2003)
Published in Journal of medicinal chemistry (27.02.2003)
Get full text
Journal Article
SAR and biological evaluation of analogues of a small molecule histone deacetylase inhibitor N-(2-aminophenyl)-4-((4-(pyridin-3-yl)pyrimidin-2-ylamino)methyl)benzamide ( MGCD0103)
Raeppel, Stéphane, Zhou, Nancy, Gaudette, Frédéric, Leit, Silvana, Paquin, Isabelle, Larouche, Guillaume, Moradei, Oscar, Fréchette, Sylvie, Isakovic, Ljubomir, Delorme, Daniel, Fournel, Marielle, Kalita, Ann, Lu, Aihua, Trachy-Bourget, Marie-Claude, Yan, Pu Theresa, Liu, Jianhong, Rahil, Jubrail, Wang, James, Besterman, Jeffrey M., Murakami, Koji, Li, Zuomei, Vaisburg, Arkadii
Published in Bioorganic & medicinal chemistry letters (01.02.2009)
Published in Bioorganic & medicinal chemistry letters (01.02.2009)
Get full text
Journal Article
Substituted N-(2-aminophenyl)-benzamides, ( E)- N-(2-aminophenyl)-acrylamides and their analogues: Novel classes of histone deacetylase inhibitors
Moradei, Oscar, Leit, Silvana, Zhou, Nancy, Fréchette, Sylvie, Paquin, Isabelle, Raeppel, Stéphane, Gaudette, Frédéric, Bouchain, Giliane, Woo, Soon H., Vaisburg, Arkadii, Fournel, Marielle, Kalita, Ann, Lu, Aihua, Trachy-Bourget, Marie-Claude, Yan, Pu T., Liu, Jianhong, Li, Zuomei, Rahil, Jubrail, MacLeod, A. Robert, Besterman, Jeffrey M., Delorme, Daniel
Published in Bioorganic & medicinal chemistry letters (01.08.2006)
Published in Bioorganic & medicinal chemistry letters (01.08.2006)
Get full text
Journal Article