St. John's Wort Induces Hepatic Drug Metabolism through Activation of the Pregnane X Receptor
Moore, Linda B., Goodwin, Bryan, Jones, Stacey A., Wisely, G. Bruce, Serabjit-Singh, Cosette J., Willson, Timothy M., Collins, Jon L., Kliewer, Steven A.
Published in Proceedings of the National Academy of Sciences - PNAS (20.06.2000)
Published in Proceedings of the National Academy of Sciences - PNAS (20.06.2000)
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Journal Article
Identification of a Novel Human Constitutive Androstane Receptor (CAR) Agonist and Its Use in the Identification of CAR Target Genes
Maglich, Jodi M., Parks, Derek J., Moore, Linda B., Collins, Jon L., Goodwin, Bryan, Billin, Andrew N., Stoltz, Catherine A., Kliewer, Steven A., Lambert, Millard H., Willson, Timothy M., Moore, John T.
Published in The Journal of biological chemistry (09.05.2003)
Published in The Journal of biological chemistry (09.05.2003)
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Journal Article
The Human Nuclear Xenobiotic Receptor PXR: Structural Determinants of Directed Promiscuity
Watkins, Ryan E., Wisely, G. Bruce, Moore, Linda B., Collins, Jon L., Lambert, Millard H., Williams, Shawn P., Willson, Timothy M., Kliewer, Steven A., Redinbo, Matthew R.
Published in Science (American Association for the Advancement of Science) (22.06.2001)
Published in Science (American Association for the Advancement of Science) (22.06.2001)
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Journal Article
Structural Disorder in the Complex of Human Pregnane X Receptor and the Macrolide Antibiotic Rifampicin
Chrencik, Jill E, Orans, Jillian, Moore, Linda B, Xue, Yu, Peng, Li, Collins, Jon L, Wisely, G. Bruce, Lambert, Millard H, Kliewer, Steven A, Redinbo, Matthew R
Published in Molecular endocrinology (Baltimore, Md.) (01.05.2005)
Published in Molecular endocrinology (Baltimore, Md.) (01.05.2005)
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Journal Article
The Phytoestrogen Coumestrol Is a Naturally Occurring Antagonist of the Human Pregnane X Receptor
Wang, Hongwei, Li, Hao, Moore, Linda B, Johnson, Michael D. L, Maglich, Jodi M, Goodwin, Bryan, Ittoop, Olivia R. R, Wisely, Bruce, Creech, Katrina, Parks, Derek J, Collins, Jon L, Willson, Timothy M, Kalpana, Ganjam V, Venkatesh, Madhukumar, Xie, Wen, Cho, Sool Y, Roboz, John, Redinbo, Matthew, Moore, John T, Mani, Sridhar
Published in Molecular endocrinology (Baltimore, Md.) (01.04.2008)
Published in Molecular endocrinology (Baltimore, Md.) (01.04.2008)
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Journal Article
Pregnane X Receptor (PXR), Constitutive Androstane Receptor (CAR), and Benzoate X Receptor (BXR) Define Three Pharmacologically Distinct Classes of Nuclear Receptors
Moore, Linda B, Maglich, Jodi M, McKee, David D, Wisely, Bruce, Willson, Timothy M, Kliewer, Steven A, Lambert, Millard H, Moore, John T
Published in Molecular endocrinology (Baltimore, Md.) (01.05.2002)
Published in Molecular endocrinology (Baltimore, Md.) (01.05.2002)
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Journal Article
Identification of a Nonsteroidal Liver X Receptor Agonist through Parallel Array Synthesis of Tertiary Amines
Collins, Jon L, Fivush, Adam M, Watson, Michael A, Galardi, Cristin M, Lewis, Michael C, Moore, Linda B, Parks, Derek J, Wilson, Joan G, Tippin, Tim K, Binz, Jane G, Plunket, Kelli D, Morgan, Daniel G, Beaudet, Elizabeth J, Whitney, Karl D, Kliewer, Steven A, Willson, Timothy M
Published in Journal of medicinal chemistry (09.05.2002)
Published in Journal of medicinal chemistry (09.05.2002)
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Journal Article
Identification of a Chemical Tool for the Orphan Nuclear Receptor FXR
Maloney, Patrick R, Parks, Derek J, Haffner, Curt D, Fivush, Adam M, Chandra, Gyan, Plunket, Kelli D, Creech, Katrina L, Moore, Linda B, Wilson, Joan G, Lewis, Michael C, Jones, Stacey A, Willson, Timothy M
Published in Journal of medicinal chemistry (10.08.2000)
Published in Journal of medicinal chemistry (10.08.2000)
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Journal Article
Functional and structural comparison of PXR and CAR
Moore, John T., Moore, Linda B., Maglich, Jodi M., Kliewer, Steve A.
Published in BBA - General Subjects (17.02.2003)
Published in BBA - General Subjects (17.02.2003)
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Book Review
Journal Article
Induction of Cytochrome P450 3A4 in Primary Human Hepatocytes and Activation of the Human Pregnane X Receptor by Tamoxifen and 4-Hydroxytamoxifen
DESAI, Pankaj B, NALLANI, Srikanth C, SANE, Rucha S, MOORE, Linda B, GOODWIN, Bryan J, BUCKLEY, Donna J, BUCKLEY, Arthur R
Published in Drug metabolism and disposition (01.05.2002)
Published in Drug metabolism and disposition (01.05.2002)
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Journal Article
Subtype Specific Effects of Peroxisome Proliferator-Activated Receptor Ligands on Corepressor Affinity
Stanley, Thomas B, Leesnitzer, Lisa M, Montana, Valerie G, Galardi, Cristin M, Lambert, Millard H, Holt, Jason A, Xu, H. Eric, Moore, Linda B, Blanchard, Steven G, Stimmel, Julie B
Published in Biochemistry (Easton) (12.08.2003)
Published in Biochemistry (Easton) (12.08.2003)
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Journal Article
Crystal Structure of the Pregnane X Receptor-Estradiol Complex Provides Insights into Endobiotic Recognition
Xue, Yu, Moore, Linda B, Orans, Jillian, Peng, Li, Bencharit, Sompop, Kliewer, Steven A, Redinbo, Matthew R
Published in Molecular endocrinology (Baltimore, Md.) (01.05.2007)
Published in Molecular endocrinology (Baltimore, Md.) (01.05.2007)
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Journal Article
2.1 Å Crystal Structure of Human PXR in Complex with the St. John's Wort Compound Hyperforin
Watkins, Ryan E, Maglich, Jodi M, Moore, Linda B, Wisely, G. Bruce, Noble, Schroeder M, Davis-Searles, Paula R, Lambert, Mill H, Kliewer, Steven A, Redinbo, Matthew R
Published in Biochemistry (Easton) (18.02.2003)
Published in Biochemistry (Easton) (18.02.2003)
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Journal Article
A Regulatory Cascade of the Nuclear Receptors FXR, SHP-1, and LRH-1 Represses Bile Acid Biosynthesis
Goodwin, Bryan, Jones, Stacey A., Price, Roger R., Watson, Michael A., McKee, David D., Moore, Linda B., Galardi, Cristin, Wilson, Joan G., Lewis, Michael C., Roth, Matthew E., Maloney, Patrick R., Willson, Timothy M., Kliewer, Steven A.
Published in Molecular cell (01.09.2000)
Published in Molecular cell (01.09.2000)
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Journal Article
Regulation of the Human CYP2B6 Gene by the Nuclear Pregnane X Receptor
Goodwin, B, Moore, L B, Stoltz, C M, McKee, D D, Kliewer, S A
Published in Molecular pharmacology (01.09.2001)
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Published in Molecular pharmacology (01.09.2001)
Journal Article
The Pregnane X Receptor: A Promiscuous Xenobiotic Receptor That Has Diverged during Evolution
Jones, Stacey A, Moore, Linda B, Shenk, Jennifer L, Wisely, G. Bruce, Hamilton, Geraldine A, McKee, David D, Tomkinson, Nicholas C. O, LeCluyse, Edward L, Lambert, Millard H, Willson, Timothy M, Kliewer, Steven A, Moore, John T
Published in Molecular endocrinology (Baltimore, Md.) (01.01.2000)
Published in Molecular endocrinology (Baltimore, Md.) (01.01.2000)
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Journal Article
Orphan Nuclear Receptors Constitutive Androstane Receptor and Pregnane X Receptor Share Xenobiotic and Steroid Ligands
Moore, Linda B., Parks, Derek J., Jones, Stacey A., Bledsoe, Randy K., Consler, Thomas G., Stimmel, Julie B., Goodwin, Bryan, Liddle, Christopher, Blanchard, Steven G., Willson, Timothy M., Collins, Jon L., Kliewer, Steven A.
Published in The Journal of biological chemistry (19.05.2000)
Published in The Journal of biological chemistry (19.05.2000)
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Journal Article
Structural Determinants of Ligand Binding Selectivity between the Peroxisome Proliferator-Activated Receptors
Xu, H. Eric, Lambert, Millard H., Montana, Valerie G., Plunket, Kelli D., Moore, Linda B., Collins, Jon L., Oplinger, Jeffery A., Kliewer, Steven A., Gampe, Robert T., McKee, David D., Moore, John T., Willson, Timothy M.
Published in Proceedings of the National Academy of Sciences - PNAS (20.11.2001)
Published in Proceedings of the National Academy of Sciences - PNAS (20.11.2001)
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Journal Article
Activation of the Nuclear Receptor LXR by Oxysterols Defines a New Hormone Response Pathway
Lehmann, Jürgen M., Kliewer, Steven A., Moore, Linda B., Smith-Oliver, Tracey A., Oliver, Beverly B., Su, Jui-Lan, Sundseth, Scott S., Winegar, Deborah A., Blanchard, Daniel E., Spencer, Thomas A., Willson, Timothy M.
Published in The Journal of biological chemistry (07.02.1997)
Published in The Journal of biological chemistry (07.02.1997)
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Journal Article
A New Series of Estrogen Receptor Modulators That Display Selectivity for Estrogen Receptor β
Henke, Brad R, Consler, Thomas G, Go, Ning, Hale, Ron L, Hohman, Dana R, Jones, Stacey A, Lu, Amy T, Moore, Linda B, Moore, John T, Orband-Miller, Lisa A, Robinett, R. Graham, Shearin, Jean, Spearing, Paul K, Stewart, Eugene L, Turnbull, Philip S, Weaver, Susan L, Williams, Shawn P, Wisely, G. Bruce, Lambert, Millard H
Published in Journal of medicinal chemistry (05.12.2002)
Published in Journal of medicinal chemistry (05.12.2002)
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Journal Article