Niclosamide: Beyond an antihelminthic drug
Chen, Wei, Mook, Robert A., Premont, Richard T., Wang, Jiangbo
Published in Cellular signalling (01.01.2018)
Published in Cellular signalling (01.01.2018)
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Journal Article
Niclosamide-induced Wnt signaling inhibition in colorectal cancer is mediated by autophagy
Wang, Jiangbo, Ren, Xiu-Rong, Piao, Hailan, Zhao, Shengli, Osada, Takuya, Premont, Richard T, Mook, Jr, Robert A, Morse, Michael A, Lyerly, Herbert Kim, Chen, Wei
Published in Biochemical journal (08.02.2019)
Published in Biochemical journal (08.02.2019)
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Journal Article
Structure–activity studies of Wnt/β-catenin inhibition in the Niclosamide chemotype: Identification of derivatives with improved drug exposure
Mook, Robert A., Wang, Jiangbo, Ren, Xiu-Rong, Chen, Minyong, Spasojevic, Ivan, Barak, Larry S., Lyerly, H. Kim, Chen, Wei
Published in Bioorganic & medicinal chemistry (01.09.2015)
Published in Bioorganic & medicinal chemistry (01.09.2015)
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Journal Article
In vitro biological activity of a novel small-molecule inhibitor of polo-like kinase 1
Lansing, Timothy J, McConnell, Randy T, Duckett, Derek R, Spehar, Glenn M, Knick, Victoria B, Hassler, Daniel F, Noro, Nobuhiro, Furuta, Masaaki, Emmitte, Kyle A, Gilmer, Tona M, Mook, Jr, Robert A, Cheung, Mui
Published in Molecular cancer therapeutics (01.02.2007)
Published in Molecular cancer therapeutics (01.02.2007)
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Journal Article
Perhexiline promotes HER3 ablation through receptor internalization and inhibits tumor growth
Ren, Xiu-Rong, Wang, Jiangbo, Osada, Takuya, Mook, Jr, Robert A, Morse, Michael A, Barak, Larry S, Lyerly, Herbert Kim, Chen, Wei
Published in Breast cancer research : BCR (15.02.2015)
Published in Breast cancer research : BCR (15.02.2015)
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Journal Article
Niclosamide-conjugated polypeptide nanoparticles inhibit Wnt signaling and colon cancer growth
Bhattacharyya, Jayanta, Ren, Xiu-Rong, Mook, Robert A, Wang, Jiangbo, Spasojevic, Ivan, Premont, Richard T, Li, Xinghai, Chilkoti, Ashutosh, Chen, Wei
Published in Nanoscale (31.08.2017)
Published in Nanoscale (31.08.2017)
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Journal Article
Identification of DK419, a potent inhibitor of Wnt/β-catenin signaling and colorectal cancer growth
Wang, Jiangbo, Mook, Robert A., Ren, Xiu-rong, Zhang, Qingfu, Jing, Genevieve, Lu, Min, Spasojevic, Ivan, Lyerly, H. Kim, Hsu, David, Chen, Wei
Published in Bioorganic & medicinal chemistry (01.11.2018)
Published in Bioorganic & medicinal chemistry (01.11.2018)
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Journal Article
Discovery of Manassantin A Protein Targets Using Large-Scale Protein Folding and Stability Measurements
Geer Wallace, M. Ariel, Kwon, Do-Yeon, Weitzel, Douglas H, Lee, Chen-Ting, Stephenson, Tesia N, Chi, Jen-Tsan, Mook, Robert A, Dewhirst, Mark W, Hong, Jiyong, Fitzgerald, Michael C
Published in Journal of proteome research (05.08.2016)
Published in Journal of proteome research (05.08.2016)
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Journal Article
Discovery of Dabrafenib: A Selective Inhibitor of Raf Kinases with Antitumor Activity against B‑Raf-Driven Tumors
Rheault, Tara R., Stellwagen, John C., Adjabeng, George M., Hornberger, Keith R., Petrov, Kimberly G., Waterson, Alex G., Dickerson, Scott H., Mook, Robert A., Laquerre, Sylvie G., King, Alastair J., Rossanese, Olivia W., Arnone, Marc R., Smitheman, Kimberly N., Kane-Carson, Laurie S., Han, Chao, Moorthy, Ganesh S., Moss, Katherine G., Uehling, David E.
Published in ACS medicinal chemistry letters (14.03.2013)
Published in ACS medicinal chemistry letters (14.03.2013)
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Journal Article
Small molecule dual-inhibitors of TRPV4 and TRPA1 for attenuation of inflammation and pain
Kanju, Patrick, Chen, Yong, Lee, Whasil, Yeo, Michele, Lee, Suk Hee, Romac, Joelle, Shahid, Rafiq, Fan, Ping, Gooden, David M., Simon, Sidney A., Spasojevic, Ivan, Mook, Robert A., Liddle, Rodger A., Guilak, Farshid, Liedtke, Wolfgang B.
Published in Scientific reports (01.06.2016)
Published in Scientific reports (01.06.2016)
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Journal Article
Discovery of 5-[[4-[(2,3-Dimethyl-2H-indazol-6-yl)methylamino]-2-pyrimidinyl]amino]-2-methyl-benzenesulfonamide (Pazopanib), a Novel and Potent Vascular Endothelial Growth Factor Receptor Inhibitor
Harris, Philip A, Boloor, Amogh, Cheung, Mui, Kumar, Rakesh, Crosby, Renae M, Davis-Ward, Ronda G, Epperly, Andrea H, Hinkle, Kevin W, Hunter, Robert N, Johnson, Jennifer H, Knick, Victoria B, Laudeman, Christopher P, Luttrell, Deirdre K, Mook, Robert A, Nolte, Robert T, Rudolph, Sharon K, Szewczyk, Jerzy R, Truesdale, Anne T, Veal, James M, Wang, Liping, Stafford, Jeffrey A
Published in Journal of medicinal chemistry (14.08.2008)
Published in Journal of medicinal chemistry (14.08.2008)
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Journal Article
Benzimidazole inhibitors from the Niclosamide chemotype inhibit Wnt/β-catenin signaling with selectivity over effects on ATP homeostasis
Mook, Robert A., Ren, Xiu-Rong, Wang, Jiangbo, Piao, Hailan, Barak, Larry S., Lyerly, H. Kim, Chen, Wei
Published in Bioorganic & medicinal chemistry (15.03.2017)
Published in Bioorganic & medicinal chemistry (15.03.2017)
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Journal Article
Small molecule modulators of Wnt/β-catenin signaling
Mook, Robert A., Chen, Minyong, Lu, Jiuyi, Barak, Larry S., Lyerly, H. Kim, Chen, Wei
Published in Bioorganic & medicinal chemistry letters (01.04.2013)
Published in Bioorganic & medicinal chemistry letters (01.04.2013)
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Journal Article
Optimization and SAR for dual ErbB-1/ErbB-2 tyrosine kinase inhibition in the 6-furanylquinazoline series
Petrov, Kimberly G., Zhang, Yue-Mei, Carter, Malcolm, Cockerill, G. Stuart, Dickerson, Scott, Gauthier, Cassandra A., Guo, Yu, Mook, Robert A., Rusnak, David W., Walker, Ann L., Wood, Edgar R., Lackey, Karen E.
Published in Bioorganic & medicinal chemistry letters (01.09.2006)
Published in Bioorganic & medicinal chemistry letters (01.09.2006)
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Journal Article
Synthesis and Biological Evaluation of Manassantin Analogues for Hypoxia-Inducible Factor 1α Inhibition
Kwon, Do-Yeon, Lee, Hye Eun, Weitzel, Douglas H., Park, Kyunghye, Lee, Sun Hee, Lee, Chen-Ting, Stephenson, Tesia N., Park, Hyeri, Fitzgerald, Michael C., Chi, Jen-Tsan, Mook, Robert A., Dewhirst, Mark W., Lee, You Mie, Hong, Jiyong
Published in Journal of medicinal chemistry (08.10.2015)
Published in Journal of medicinal chemistry (08.10.2015)
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Journal Article
Identification of a novel Smoothened antagonist that potently suppresses Hedgehog signaling
Wang, Jiangbo, Mook, Robert A., Lu, Jiuyi, Gooden, David M., Ribeiro, Anthony, Guo, Anchen, Barak, Larry S., Kim Lyerly, H., Chen, Wei
Published in Bioorganic & medicinal chemistry (15.11.2012)
Published in Bioorganic & medicinal chemistry (15.11.2012)
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Journal Article
The insecticide synergist piperonyl butoxide inhibits hedgehog signaling: assessing chemical risks
Wang, Jiangbo, Lu, Jiuyi, Mook, Jr, Robert A, Zhang, Min, Zhao, Shengli, Barak, Larry S, Freedman, Jonathan H, Lyerly, H Kim, Chen, Wei
Published in Toxicological sciences (01.08.2012)
Published in Toxicological sciences (01.08.2012)
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Journal Article
Optimization of 4,6-bis-anilino-1H-pyrrolo[2,3-d]pyrimidine IGF-1R tyrosine kinase inhibitors towards JNK selectivity
Chamberlain, Stanley D, Redman, Anikó M, Wilson, Joseph W, Deanda, Felix, Shotwell, J Brad, Gerding, Roseanne, Lei, Huangshu, Yang, Bin, Stevens, Kirk L, Hassell, Anne M, Shewchuk, Lisa M, Leesnitzer, M Anthony, Smith, Jeffery L, Sabbatini, Peter, Atkins, Charity, Groy, Arthur, Rowand, Jason L, Kumar, Rakesh, Mook, Jr, Robert A, Moorthy, Ganesh, Patnaik, Samarjit
Published in Bioorganic & medicinal chemistry letters (15.01.2009)
Published in Bioorganic & medicinal chemistry letters (15.01.2009)
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Journal Article
Design of potent thiophene inhibitors of polo-like kinase 1 with improved solubility and reduced protein binding
EMMITTE, Kyle A, ADJEBANG, George M, JACKSON, Jeffrey R, KUNTZ, Kevin W, LANSING, Timothy J, MOOK, Robert A, NAILOR, Kristen E, POBANZ, Mark A, SMITH, Stephon C, SUNG, Chiu-Mei, CHEUNG, Mui, WEBB ANDREWS, C, BADIANG ALBERTI, Jennifer G, BAMBAL, Ramesh, CHAMBERLAIN, Stanley D, DAVIS-WARD, Ronda G, DICKSON, Hamilton D, HASSLER, Daniel F, HORNBERGER, Keith R
Published in Bioorganic & medicinal chemistry letters (15.03.2009)
Published in Bioorganic & medicinal chemistry letters (15.03.2009)
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