Current nonclinical testing paradigm enables safe entry to First-In-Human clinical trials: The IQ consortium nonclinical to clinical translational database
Monticello, Thomas M., Jones, Thomas W., Dambach, Donna M., Potter, David M., Bolt, Michael W., Liu, Maggie, Keller, Douglas A., Hart, Timothy K., Kadambi, Vivek J.
Published in Toxicology and applied pharmacology (01.11.2017)
Published in Toxicology and applied pharmacology (01.11.2017)
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Journal Article
Inhibition of both sclerostin and DKK1 results in novel skull findings in the rat and non-human primate that is not observed with inhibition of sclerostin alone
Bienvenu, Jean Guy, Chouinard, Luc, Felx, Melanie, Boyce, Rogely Waite, Monticello, Thomas M
Published in Bone (New York, N.Y.) (01.02.2024)
Published in Bone (New York, N.Y.) (01.02.2024)
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Journal Article
Do longer duration nonclinical toxicology studies provide predictive clinical safety value? The IQ consortium longer duration nonclinical to clinical translational database
Monticello, Thomas M., Potter, David M., Huang, Qihong, Hart, Timothy K., Shuey, Dana, Troth, Sean, Vergis, James M., Tassew, Nardos, Glascott, Peter
Published in Toxicology and applied pharmacology (01.11.2024)
Published in Toxicology and applied pharmacology (01.11.2024)
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Journal Article
Nonclinical safety evaluation of erenumab, a CGRP receptor inhibitor for the prevention of migraine
Bussiere, Jeanine L., Davies, Rhian, Dean, Charles, Xu, Cen, Kim, Kyung Hoon, Vargas, Hugo M., Chellman, Gary J., Balasubramanian, Ganesh, Rubio-Beltran, Eloisa, MaassenVanDenBrink, Antoinette, Monticello, Thomas M.
Published in Regulatory toxicology and pharmacology (01.08.2019)
Published in Regulatory toxicology and pharmacology (01.08.2019)
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Journal Article
Phosphatidylinositol 3-Kinase δ Inhibitor-Induced Immunomodulation and Secondary Opportunistic Infection in the Cynomolgus Monkey ( Macaca fascicularis )
Werner, Jonathan A, Ishida, Katsu, Wisler, John, Karbowski, Christine, Kalanzi, Jackson, Bussiere, Jeanine, Monticello, Thomas M
Published in Toxicologic pathology (01.12.2020)
Published in Toxicologic pathology (01.12.2020)
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Journal Article
Characterization of false positive, contaminant-driven mutagenicity in impurities associated with the sotorasib drug substance
Coppi, Aldo, Davies, Rhian, Wegesser, Teresa, Ishida, Katsu, Karmel, Jamie, Han, Jun, Aiello, Frankie, Xie, Yong, Corbett, Michael T., Parsons, Andrew T., Monticello, Thomas M., Minocherhomji, Sheroy
Published in Regulatory toxicology and pharmacology (01.06.2022)
Published in Regulatory toxicology and pharmacology (01.06.2022)
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Journal Article
Mercapturate pathway metabolites of sotorasib, a covalent inhibitor of KRASG12C, are associated with renal toxicity in the Sprague Dawley rat
Werner, Jonathan A., Davies, Rhian, Wahlstrom, Jan, Dahal, Upendra P., Jiang, Min, Stauber, Jonathan, David, Benjamin, Siska, William, Thomas, Barbara, Ishida, Katsu, Humphreys, W. Griffith, Lipford, J. Russell, Monticello, Thomas M.
Published in Toxicology and applied pharmacology (15.07.2021)
Published in Toxicology and applied pharmacology (15.07.2021)
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Journal Article
Phosphatidylinositol 3-Kinase δ-Specific Inhibitor-Induced Changes in the Ovary and Testis in the Sprague Dawley Rat and Cynomolgus Monkey
Ishida, Katsu, Werner, Jonathan A, Lafleur, Marc, Wisler, John, Wannberg, Sharon, Kalanzi, Jackson, Bussiere, Jeanine L, Monticello, Thomas M
Published in International journal of toxicology (01.07.2021)
Published in International journal of toxicology (01.07.2021)
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Journal Article
Best practices for reporting pathology interpretations within GLP toxicology studies
Morton, Daniel, Kemp, Ramon K, Francke-Carroll, Sabine, Jensen, Karl, McCartney, Jeffrey, Monticello, Thomas M, Perry, Richard, Pulido, Olga, Roome, Nigel, Schafer, Ken, Sellers, Rani, Snyder, Paul W
Published in Toxicologic pathology (01.10.2006)
Published in Toxicologic pathology (01.10.2006)
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Journal Article
Correlation of regional and nonlinear formaldehyde-induced nasal cancer with proliferating populations of cells
MONTICELLO, T. M, SWENBERG, J. A, GROSS, E. A, LEININGER, J. R, KIMBELL, J. S, SEILKOP, S, STARR, T. B, GIBSON, J. E, MORGAN, K. T
Published in Cancer research (Chicago, Ill.) (01.03.1996)
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Published in Cancer research (Chicago, Ill.) (01.03.1996)
Journal Article
Vasopeptidase inhibition with omapatrilat improves cardiac geometry and survival in cardiomyopathic hamsters more than does ACE inhibition with captopril
Trippodo, N C, Fox, M, Monticello, T M, Panchal, B C, Asaad, M M
Published in Journal of cardiovascular pharmacology (01.12.1999)
Published in Journal of cardiovascular pharmacology (01.12.1999)
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Journal Article
Utilization of electron probe microanalysis in gadolinium-treated mice
Wasserman, A J, Monticello, T M, Feldman, R S, Gitlitz, P H, Durham, S K
Published in Toxicologic pathology (01.09.1996)
Published in Toxicologic pathology (01.09.1996)
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Journal Article
Novel fluoro-substituted camptothecins : in vivo antitumor activity, reduced gastrointestinal toxicity and pharmacokinetic characterization
ROSE, William C, MARATHE, Punit H, JANG, Graham R, MONTICELLO, Thomas M, BALASUBRAMANIAN, Balu N, LONG, Byron, FAIRCHILD, Craig R, WALL, Monroe E, WANI, Mansukh C
Published in Cancer chemotherapy and pharmacology (01.07.2006)
Published in Cancer chemotherapy and pharmacology (01.07.2006)
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Journal Article
Comparison of acute hepatocellular proliferating cell nuclear antigen labeling indices and growth fractions, p34cdc2 kinases, and serum enzymes in carbon tetrachloride-treated rats
Monticello, T M, Barton, D, Ma, X, Babish, J G, Durham, S K
Published in Toxicologic pathology (01.07.1995)
Published in Toxicologic pathology (01.07.1995)
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