Discovery of Trifluoromethyl Glycol Carbamates as Potent and Selective Covalent Monoacylglycerol Lipase (MAGL) Inhibitors for Treatment of Neuroinflammation
McAllister, Laura A, Butler, Christopher R, Mente, Scot, O’Neil, Steven V, Fonseca, Kari R, Piro, Justin R, Cianfrogna, Julie A, Foley, Timothy L, Gilbert, Adam M, Harris, Anthony R, Helal, Christopher J, Johnson, Douglas S, Montgomery, Justin I, Nason, Deane M, Noell, Stephen, Pandit, Jayvardhan, Rogers, Bruce N, Samad, Tarek A, Shaffer, Christopher L, da Silva, Rafael G, Uccello, Daniel P, Webb, Damien, Brodney, Michael A
Published in Journal of medicinal chemistry (12.04.2018)
Published in Journal of medicinal chemistry (12.04.2018)
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Journal Article
LpxC inhibitors as new antibacterial agents and tools for studying regulation of lipid A biosynthesis in Gram-negative pathogens
Tomaras, Andrew P, McPherson, Craig J, Kuhn, Michael, Carifa, Arlene, Mullins, Lisa, George, David, Desbonnet, Charlene, Eidem, Tess M, Montgomery, Justin I, Brown, Matthew F, Reilly, Usa, Miller, Alita A, O'Donnell, John P
Published in mBio (30.09.2014)
Published in mBio (30.09.2014)
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Journal Article
Toward the assembly and characterization of an encoded library hit confirmation platform: Bead-Assisted Ligand Isolation Mass Spectrometry (BALI-MS)
Ratnayake, Anokha S., Flanagan, Mark E., Foley, Timothy L., Hultgren, Scott L., Bellenger, Justin, Montgomery, Justin I., Lall, Manjinder S., Liu, Bo, Ryder, Tim, Kölmel, Dominik K., Shavnya, Andre, Feng, Xidong, Lefker, Bruce, Byrnes, Laura J., Sahasrabudhe, Parag V., Farley, Kathleen A., Chen, Shi, Wan, Jinqiao
Published in Bioorganic & medicinal chemistry (01.07.2021)
Published in Bioorganic & medicinal chemistry (01.07.2021)
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Journal Article
Inhibition of LpxC protects mice from resistant Acinetobacter baumannii by modulating inflammation and enhancing phagocytosis
Lin, Lin, Tan, Brandon, Pantapalangkoor, Paul, Ho, Tiffany, Baquir, Beverlie, Tomaras, Andrew, Montgomery, Justin I, Reilly, Usa, Barbacci, Elsa G, Hujer, Kristine, Bonomo, Robert A, Fernandez, Lucia, Hancock, Robert E W, Adams, Mark D, French, Samuel W, Buslon, Virgil S, Spellberg, Brad
Published in mBio (2012)
Published in mBio (2012)
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Selecting Approaches for Hit Identification and Increasing Options by Building the Efficient Discovery of Actionable Chemical Matter from DNA-Encoded Libraries
Foley, Timothy L., Burchett, Woodrow, Chen, Qiuxia, Flanagan, Mark E., Kapinos, Brendon, Li, Xianyang, Montgomery, Justin I., Ratnayake, Anokha S., Zhu, Hongyao, Peakman, Marie-Claire
Published in SLAS discovery (01.02.2021)
Published in SLAS discovery (01.02.2021)
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Journal Article
Snapshots and ensembles of BTK and cIAP1 protein degrader ternary complexes
Schiemer, James, Horst, Reto, Meng, Yilin, Montgomery, Justin I., Xu, Yingrong, Feng, Xidong, Borzilleri, Kris, Uccello, Daniel P., Leverett, Carolyn, Brown, Stephen, Che, Ye, Brown, Matthew F., Hayward, Matthew M., Gilbert, Adam M., Noe, Mark C., Calabrese, Matthew F.
Published in Nature chemical biology (01.02.2021)
Published in Nature chemical biology (01.02.2021)
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Journal Article
Snapshots and ensembles of BTK and cIAP1 protein degrader ternary complexes
Schiemer, James, Horst, Reto, Meng, Yilin, Montgomery, Justin I, Xu, Yingrong, Feng, Xidong, Borzilleri, Kris, Uccello, Daniel P, Leverett, Carolyn, Brown, Stephen, Che, Ye, Brown, Matthew F, Hayward, Matthew M, Gilbert, Adam M, Noe, Mark C, Calabrese, Matthew F
Published in Nature chemical biology (01.02.2021)
Published in Nature chemical biology (01.02.2021)
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Journal Article
A Solution Phase Platform to Characterize Chemical Reaction Compatibility with DNA-Encoded Chemical Library Synthesis
Ratnayake, Anokha S, Flanagan, Mark E, Foley, Timothy L, Smith, Justin D, Johnson, Jillian G, Bellenger, Justin, Montgomery, Justin I, Paegel, Brian M
Published in ACS combinatorial science (14.10.2019)
Published in ACS combinatorial science (14.10.2019)
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Journal Article
A chemical probe to modulate human GID4 Pro/N-degron interactions
Owens, Dominic D G, Maitland, Matthew E R, Khalili Yazdi, Aliakbar, Song, Xiaosheng, Reber, Viviane, Schwalm, Martin P, Machado, Raquel A C, Bauer, Nicolas, Wang, Xu, Szewczyk, Magdalena M, Dong, Cheng, Dong, Aiping, Loppnau, Peter, Calabrese, Matthew F, Dowling, Matthew S, Lee, Jisun, Montgomery, Justin I, O'Connell, Thomas N, Subramanyam, Chakrapani, Wang, Feng, Adamson, Ella C, Schapira, Matthieu, Gstaiger, Matthias, Knapp, Stefan, Vedadi, Masoud, Min, Jinrong, Lajoie, Gilles A, Barsyte-Lovejoy, Dalia, Owen, Dafydd R, Schild-Poulter, Caroline, Arrowsmith, Cheryl H
Published in Nature chemical biology (21.05.2024)
Published in Nature chemical biology (21.05.2024)
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Journal Article
Chemical tools for the Gid4 subunit of the human E3 ligase C-terminal to LisH (CTLH) degradation complex
Yazdi, Aliakbar Khalili, Perveen, Sumera, Dong, Cheng, Song, Xiaosheng, Dong, Aiping, Szewczyk, Magdalena M, Calabrese, Matthew F, Casimiro-Garcia, Agustin, Chakrapani, Subramanyam, Dowling, Matthew S, Ficici, Emel, Lee, Jisun, Montgomery, Justin I, O'Connell, Thomas N, Skrzypek, Grzegorz J, Tran, Tuan P, Troutman, Matthew D, Wang, Feng, Young, Jennifer A, Min, Jinrong, Barsyte-Lovejoy, Dalia, Brown, Peter J, Santhakumar, Vijayaratnam, Arrowsmith, Cheryl H, Vedadi, Masoud, Owen, Dafydd R
Published in MedChemComm (20.03.2024)
Published in MedChemComm (20.03.2024)
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Journal Article
Pyridone Methylsulfone Hydroxamate LpxC Inhibitors for the Treatment of Serious Gram-Negative Infections
Montgomery, Justin I, Brown, Matthew F, Reilly, Usa, Price, Loren M, Abramite, Joseph A, Arcari, Joel, Barham, Rose, Che, Ye, Chen, Jinshan Michael, Chung, Seung Won, Collantes, Elizabeth M, Desbonnet, Charlene, Doroski, Matthew, Doty, Jonathan, Engtrakul, Juntyma J, Harris, Thomas M, Huband, Michael, Knafels, John D, Leach, Karen L, Liu, Shenping, Marfat, Anthony, McAllister, Laura, McElroy, Eric, Menard, Carol A, Mitton-Fry, Mark, Mullins, Lisa, Noe, Mark C, O’Donnell, John, Oliver, Robert, Penzien, Joseph, Plummer, Mark, Shanmugasundaram, Veerabahu, Thoma, Christy, Tomaras, Andrew P, Uccello, Daniel P, Vaz, Alfin, Wishka, Donn G
Published in Journal of medicinal chemistry (23.02.2012)
Published in Journal of medicinal chemistry (23.02.2012)
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Journal Article
Optimization of a Dicarboxylic Series for in Vivo Inhibition of Citrate Transport by the Solute Carrier 13 (SLC13) Family
Huard, Kim, Gosset, James R, Montgomery, Justin I, Gilbert, Adam, Hayward, Matthew M, Magee, Thomas V, Cabral, Shawn, Uccello, Daniel P, Bahnck, Kevin, Brown, Janice, Purkal, Julie, Gorgoglione, Matthew, Lanba, Adhiraj, Futatsugi, Kentaro, Herr, Michael, Genung, Nathan E, Aspnes, Gary, Polivkova, Jana, Garcia-Irizarry, Carmen N, Li, Qifang, Canterbury, Daniel, Niosi, Mark, Vera, Nicholas B, Li, Zhenhong, Khunte, Bhagyashree, Siderewicz, Jaclyn, Rolph, Timothy, Erion, Derek M
Published in Journal of medicinal chemistry (11.02.2016)
Published in Journal of medicinal chemistry (11.02.2016)
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Journal Article
Potent Inhibitors of LpxC for the Treatment of Gram-Negative Infections
Brown, Matthew F, Reilly, Usa, Abramite, Joseph A, Arcari, Joel T, Oliver, Robert, Barham, Rose A, Che, Ye, Chen, Jinshan Michael, Collantes, Elizabeth M, Chung, Seung Won, Desbonnet, Charlene, Doty, Jonathan, Doroski, Matthew, Engtrakul, Juntyma J, Harris, Thomas M, Huband, Michael, Knafels, John D, Leach, Karen L, Liu, Shenping, Marfat, Anthony, Marra, Andrea, McElroy, Eric, Melnick, Michael, Menard, Carol A, Montgomery, Justin I, Mullins, Lisa, Noe, Mark. C, O’Donnell, John, Penzien, Joseph, Plummer, Mark S, Price, Loren M, Shanmugasundaram, Veerabahu, Thoma, Christy, Uccello, Daniel P, Warmus, Joseph S, Wishka, Donn G
Published in Journal of medicinal chemistry (26.01.2012)
Published in Journal of medicinal chemistry (26.01.2012)
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Journal Article
Trimethylaluminium-Facilitated Direct Amidation of Carboxylic Acids
Chung, SeungWon, Uccello, Daniel P., Choi, Huiwon, Montgomery, Justin I., Chen, Jinshan
Published in Synlett (01.09.2011)
Published in Synlett (01.09.2011)
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Journal Article
Heterocyclic methylsulfone hydroxamic acid LpxC inhibitors as Gram-negative antibacterial agents
McAllister, Laura A., Montgomery, Justin I., Abramite, Joseph A., Reilly, Usa, Brown, Matthew F., Chen, Jinshan M., Barham, Rose A., Che, Ye, Chung, Seung Won, Menard, Carol A., Mitton-Fry, Mark, Mullins, Lisa M., Noe, Mark C., O’Donnell, John P., Oliver, Robert M., Penzien, Joseph B., Plummer, Mark, Price, Loren M., Shanmugasundaram, Veerabahu, Tomaras, Andrew P., Uccello, Daniel P.
Published in Bioorganic & medicinal chemistry letters (15.11.2012)
Published in Bioorganic & medicinal chemistry letters (15.11.2012)
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Journal Article
Synthesis, X-ray Crystallography, and Computational Analysis of 1-Azafenestranes
Denmark, Scott E, Montgomery, Justin I, Kramps, Laurenz A
Published in Journal of the American Chemical Society (06.09.2006)
Published in Journal of the American Chemical Society (06.09.2006)
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Journal Article
Discovery and characterization of a novel class of pyrazolopyrimidinedione tRNA synthesis inhibitors
Montgomery, Justin I., Smith, James F., Tomaras, Andrew P., Zaniewski, Richard, McPherson, Craig J., McAllister, Laura A., Hartman-Neumann, Sandra, Arcari, Joel T., Lescoe, Marykay, Gutierrez, Jemy, Yuan, Ying, Limberakis, Chris, Miller, Alita A.
Published in Journal of antibiotics (01.06.2015)
Published in Journal of antibiotics (01.06.2015)
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