Amino acid levels determine metabolism and CYP450 function of hepatocytes and hepatoma cell lines
Boon, Ruben, Kumar, Manoj, Tricot, Tine, Elia, Ilaria, Ordovas, Laura, Jacobs, Frank, One, Jennifer, De Smedt, Jonathan, Eelen, Guy, Bird, Matthew, Roelandt, Philip, Doglioni, Ginevra, Vriens, Kim, Rossi, Matteo, Vazquez, Marta Aguirre, Vanwelden, Thomas, Chesnais, François, El Taghdouini, Adil, Najimi, Mustapha, Sokal, Etienne, Cassiman, David, Snoeys, Jan, Monshouwer, Mario, Hu, Wei-Shou, Lange, Christian, Carmeliet, Peter, Fendt, Sarah-Maria, Verfaillie, Catherine M
Published in Nature communications (13.03.2020)
Published in Nature communications (13.03.2020)
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Journal Article
Pharmacokinetic Drug–Drug Interaction of Apalutamide, Part 2: Investigating Interaction Potential Using a Physiologically Based Pharmacokinetic Model
Van den Bergh, An, Snoeys, Jan, De Zwart, Loeckie, Ward, Peter, Lopez-Gitlitz, Angela, Ouellet, Daniele, Monshouwer, Mario, Chien, Caly
Published in Clinical pharmacokinetics (01.09.2020)
Published in Clinical pharmacokinetics (01.09.2020)
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Journal Article
Unbound Drug Concentration in Brain Homogenate and Cerebral Spinal Fluid at Steady State as a Surrogate for Unbound Concentration in Brain Interstitial Fluid
XINGRONG LIU, VAN NATTA, Kristine, YEO, Helen, VILENSKI, Olga, WELLER, Paul E, WORBOYS, Philip D, MONSHOUWER, Mario
Published in Drug metabolism and disposition (01.04.2009)
Published in Drug metabolism and disposition (01.04.2009)
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Journal Article
Effects of Co-Culture Media on Hepatic Differentiation of hiPSC with or without HUVEC Co-Culture
Freyer, Nora, Greuel, Selina, Knöspel, Fanny, Strahl, Nadja, Amini, Leila, Jacobs, Frank, Monshouwer, Mario, Zeilinger, Katrin
Published in International journal of molecular sciences (07.08.2017)
Published in International journal of molecular sciences (07.08.2017)
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Journal Article
Unlocking the Mechanisms of Cutaneous Adverse Drug Reactions: Activation of the Phosphatidylinositol 3-Kinase/Protein Kinase B Pathway by EGFR Inhibitors Triggers Keratinocyte Differentiation and Polarization of Epidermal Immune Responses
Ondet, Thomas, Roux, Pierre-François, Monshouwer, Mario, Stamatas, Georgios N.
Published in JID innovations (01.06.2021)
Published in JID innovations (01.06.2021)
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Journal Article
In Vitro Model for Hepatotoxicity Studies Based on Primary Human Hepatocyte Cultivation in a Perfused 3D Bioreactor System
Knöspel, Fanny, Jacobs, Frank, Freyer, Nora, Damm, Georg, De Bondt, An, van den Wyngaert, Ilse, Snoeys, Jan, Monshouwer, Mario, Richter, Marco, Strahl, Nadja, Seehofer, Daniel, Zeilinger, Katrin
Published in International journal of molecular sciences (16.04.2016)
Published in International journal of molecular sciences (16.04.2016)
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Prediction of the drug–drug interaction potential of the α1‐acid glycoprotein bound, CYP3A4/CYP2C9 metabolized oncology drug, erdafitinib
De Zwart, Loeckie, Snoeys, Jan, Jacobs, Frank, Li, Lilian Y., Poggesi, Italo, Verboven, Peter, Goris, Ivo, Scheers, Ellen, Wynant, Inneke, Monshouwer, Mario, Mamidi, Rao N. V. S.
Published in CPT: pharmacometrics and systems pharmacology (01.09.2021)
Published in CPT: pharmacometrics and systems pharmacology (01.09.2021)
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In silico identification of potential cholestasis-inducing agents via modeling of Na(+)-dependent taurocholate cotransporting polypeptide substrate specificity
Greupink, Rick, Nabuurs, Sander B, Zarzycka, Barbara, Verweij, Vivienne, Monshouwer, Mario, Huisman, Maarten T, Russel, Frans G M
Published in Toxicological sciences (01.09.2012)
Published in Toxicological sciences (01.09.2012)
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Journal Article
In Silico and in vitro Pharmacogenetic Analysis in Mice
Guo, Yingying, Lu, Peng, Farrell, Erin, Zhang, Xun, Weller, Paul, Monshouwer, Mario, Wang, Jianmei, Liao, Guochun, Zhang, Zhaomei, Hu, Steven, Allard, John, Shafer, Steve, Usuka, Jonathan, Peltz, Gary
Published in Proceedings of the National Academy of Sciences - PNAS (06.11.2007)
Published in Proceedings of the National Academy of Sciences - PNAS (06.11.2007)
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An in vivo and in vitro comparison of CYP induction in rat liver and intestine using slices and quantitative RT-PCR
Martignoni, Marcella, de Kanter, Ruben, Grossi, Pietro, Mahnke, Axel, Saturno, Grazia, Monshouwer, Mario
Published in Chemico-biological interactions (30.12.2004)
Published in Chemico-biological interactions (30.12.2004)
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Journal Article
Substrate specific metabolism by polymorphic cytochrome P450 2D6 alleles
Bogni, Alessia, Monshouwer, Mario, Moscone, Anna, Hidestrand, Mats, Ingelman-Sundberg, Magnus, Hartung, Thomas, Coecke, Sandra
Published in Toxicology in vitro (01.08.2005)
Published in Toxicology in vitro (01.08.2005)
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