Small-Molecule Inhibitors of the Interaction between the E3 Ligase VHL and HIF1α
Buckley, Dennis L., Gustafson, Jeffrey L., Van Molle, Inge, Roth, Anke G., Tae, Hyun Seop, Gareiss, Peter C., Jorgensen, William L., Ciulli, Alessio, Crews, Craig M.
Published in Angewandte Chemie International Edition (12.11.2012)
Published in Angewandte Chemie International Edition (12.11.2012)
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Journal Article
Hypocrates is a genetically encoded fluorescent biosensor for (pseudo)hypohalous acids and their derivatives
Kostyuk, Alexander I., Tossounian, Maria-Armineh, Panova, Anastasiya S., Thauvin, Marion, Raevskii, Roman I., Ezeriņa, Daria, Wahni, Khadija, Van Molle, Inge, Sergeeva, Anastasia D., Vertommen, Didier, Gorokhovatsky, Andrey Yu, Baranov, Mikhail S., Vriz, Sophie, Messens, Joris, Bilan, Dmitry S., Belousov, Vsevolod V.
Published in Nature communications (10.01.2022)
Published in Nature communications (10.01.2022)
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Journal Article
Secreted amyloid-β precursor protein functions as a GABABR1a ligand to modulate synaptic transmission
Rice, Heather C, de Malmazet Daniel, Schreurs An, Frere, Samuel, Van Molle Inge, Volkov, Alexander N, Creemers Eline, Vertkin Irena, Nys, Julie, Ranaivoson, Fanomezana M, Comoletti Davide, Savas, Jeffrey N, Han, Remaut, Balschun Detlef, Wierda, Keimpe D, Slutsky Inna, Farrow, Karl, De Strooper Bart, de Wit Joris
Published in Science (American Association for the Advancement of Science) (11.01.2019)
Published in Science (American Association for the Advancement of Science) (11.01.2019)
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Journal Article
Sulfenome mining in Arabidopsis thaliana
Waszczak, Cezary, Akter, Salma, Eeckhout, Dominique, Persiau, Geert, Wahni, Khadija, Bodra, Nandita, Van Molle, Inge, De Smet, Barbara, Vertommen, Didier, Gevaert, Kris, De Jaeger, Geert, Van Montagu, Marc, Messens, Joris, Van Breusegem, Frank
Published in Proceedings of the National Academy of Sciences - PNAS (05.08.2014)
Published in Proceedings of the National Academy of Sciences - PNAS (05.08.2014)
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Journal Article
Redox‐regulated methionine oxidation of Arabidopsis thaliana glutathione transferase Phi9 induces H‐site flexibility
Tossounian, Maria‐Armineh, Wahni, Khadija, Van Molle, Inge, Vertommen, Didier, Astolfi Rosado, Leonardo, Messens, Joris
Published in Protein science (01.01.2019)
Published in Protein science (01.01.2019)
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Journal Article
Q586B2 is a crucial virulence factor during the early stages of Trypanosoma brucei infection that is conserved amongst trypanosomatids
Stijlemans, Benoit, De Baetselier, Patrick, Van Molle, Inge, Lecordier, Laurence, Hendrickx, Erika, Romão, Ema, Vincke, Cécile, Baetens, Wendy, Schoonooghe, Steve, Hassanzadeh-Ghassabeh, Gholamreza, Korf, Hannelie, Wallays, Marie, Pinto Torres, Joar E., Perez-Morga, David, Brys, Lea, Campetella, Oscar, Leguizamón, María S., Claes, Mathieu, Hendrickx, Sarah, Mabille, Dorien, Caljon, Guy, Remaut, Han, Roelants, Kim, Magez, Stefan, Van Ginderachter, Jo A., De Trez, Carl
Published in Nature communications (27.02.2024)
Published in Nature communications (27.02.2024)
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Journal Article
Structure of the Prx6‐subfamily 1‐Cys peroxiredoxin from Sulfolobus islandicus
Stroobants, Sander, Van Molle, Inge, Saidi, Queen, Jonckheere, Karl, Maes, Dominique, Peeters, Eveline
Published in Acta crystallographica. Section F, Structural biology communications (01.06.2019)
Published in Acta crystallographica. Section F, Structural biology communications (01.06.2019)
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Journal Article
Dissecting Fragment-Based Lead Discovery at the von Hippel-Lindau Protein:Hypoxia Inducible Factor 1α Protein-Protein Interface
Van Molle, Inge, Thomann, Andreas, Buckley, Dennis L., So, Ernest C., Lang, Steffen, Crews, Craig M., Ciulli, Alessio
Published in Chemistry & biology (26.10.2012)
Published in Chemistry & biology (26.10.2012)
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Journal Article
Selective Engagement of FcγRIV by a M2e-Specific Single Domain Antibody Construct Protects Against Influenza A Virus Infection
De Vlieger, Dorien, Hoffmann, Katja, Van Molle, Inge, Nerinckx, Wim, Van Hoecke, Lien, Ballegeer, Marlies, Creytens, Sarah, Remaut, Han, Hengel, Hartmut, Schepens, Bert, Saelens, Xavier
Published in Frontiers in immunology (12.12.2019)
Published in Frontiers in immunology (12.12.2019)
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Journal Article
The active site architecture in peroxiredoxins: a case study on Mycobacterium tuberculosis AhpE
Pedre, Brandán, van Bergen, Laura A H, Palló, Anna, Rosado, Leonardo A, Dufe, Veronica Tamu, Molle, Inge Van, Wahni, Khadija, Erdogan, Huriye, Alonso, Mercedes, Proft, Frank De, Messens, Joris
Published in Chemical communications (Cambridge, England) (01.01.2016)
Published in Chemical communications (Cambridge, England) (01.01.2016)
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Journal Article
Chaperoning Anfinsen: the steric foldases
Pauwels, Kris, Van Molle, Inge, Tommassen, Jan, Van Gelder, Patrick
Published in Molecular microbiology (01.05.2007)
Published in Molecular microbiology (01.05.2007)
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Journal Article
Chloroplasts Assemble the Major Subunit FaeG of Escherichia coli F4 (K88) Fimbriae to Strand-swapped Dimers
Van Molle, Inge, Joensuu, Jussi J., Buts, Lieven, Panjikar, Santosh, Kotiaho, Mirkka, Bouckaert, Julie, Wyns, Lode, Niklander-Teeri, Viola, De Greve, Henri
Published in Journal of molecular biology (04.05.2007)
Published in Journal of molecular biology (04.05.2007)
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Journal Article
How Thioredoxin can Reduce a Buried Disulphide Bond
Messens, Joris, Molle, Inge Van, Vanhaesebrouck, Peter, Limbourg, Maya, Belle, Karolien Van, Wahni, Khadija, Martins, José C, Loris, Remy, Wyns, Lode
Published in Journal of molecular biology (04.06.2004)
Published in Journal of molecular biology (04.06.2004)
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Journal Article
E3 Compounds and Methods for the Enhanced Degradation of Targeted Proteins and Other Polypeptides by an E3 Ubiquitin Ligase
SMITH IAN EDWARD DAVID, MOLLE INGE VAN, BUCKLEY DENNIS, CAMPOS SEBASTIEN ANDRE, ROTH ANKE G, TAE HYUN SEOP, GAREISS PETER C, MIAH AFJAL HUSSAIN, MICHEL JULIEN, HARLING JOHN DAVID, LE JOELLE, JORGENSEN WILLIAM, HOYER DENTIN WADE, CREWS CRAIG M, GUSTAFSON JEFFREY, CIULLI ALESSIO
Year of Publication 26.06.2024
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Year of Publication 26.06.2024
Patent
Structure-Guided Design and Optimization of Small Molecules Targeting the Protein–Protein Interaction between the von Hippel–Lindau (VHL) E3 Ubiquitin Ligase and the Hypoxia Inducible Factor (HIF) Alpha Subunit with in Vitro Nanomolar Affinities
Galdeano, Carles, Gadd, Morgan S, Soares, Pedro, Scaffidi, Salvatore, Van Molle, Inge, Birced, Ipek, Hewitt, Sarah, Dias, David M, Ciulli, Alessio
Published in Journal of medicinal chemistry (23.10.2014)
Published in Journal of medicinal chemistry (23.10.2014)
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Journal Article
E3 Compounds and Methods for the Enhanced Degradation of Targeted Proteins and Other Polypeptides by an E3 Ubiquitin Ligase
SMITH IAN EDWARD DAVID, MOLLE INGE VAN, BUCKLEY DENNIS, CAMPOS SEBASTIEN ANDRE, ROTH ANKE G, TAE HYUN SEOP, GAREISS PETER C, MIAH AFJAL HUSSAIN, MICHEL JULIEN, HARLING JOHN DAVID, LE JOELLE, JORGENSEN WILLIAM, HOYER DENTIN WADE, CREWS CRAIG M, GUSTAFSON JEFFREY, CIULLI ALESSIO
Year of Publication 14.09.2022
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Year of Publication 14.09.2022
Patent
Targeting the von Hippel–Lindau E3 Ubiquitin Ligase Using Small Molecules To Disrupt the VHL/HIF-1α Interaction
Buckley, Dennis L, Van Molle, Inge, Gareiss, Peter C, Tae, Hyun Seop, Michel, Julien, Noblin, Devin J, Jorgensen, William L, Ciulli, Alessio, Crews, Craig M
Published in Journal of the American Chemical Society (14.03.2012)
Published in Journal of the American Chemical Society (14.03.2012)
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Journal Article
Small-Molecule Inhibitors of the Interaction between the E3 Ligase VHL and HIF1a
Buckley, Dennis L., Gustafson, Jeffrey L., Van Molle, Inge, Roth, Anke G., Tae, Hyun Seop, Gareiss, Peter C., Jorgensen, William L., Ciulli, Alessio, Crews, Craig M.
Published in Angewandte Chemie International Edition (01.01.2012)
Published in Angewandte Chemie International Edition (01.01.2012)
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Journal Article
E3 Compounds and Methods for the Enhanced Degradation of Targeted Proteins and Other Polypeptides by an E3 Ubiquitin Ligase
SMITH IAN EDWARD DAVID, MOLLE INGE VAN, BUCKLEY DENNIS, CAMPOS SEBASTIEN ANDRE, ROTH ANKE G, TAE HYUN SEOP, GAREISS PETER C, MIAH AFJAL HUSSAIN, MICHEL JULIEN, HARLING JOHN DAVID, LE JOELLE, JORGENSEN WILLIAM, HOYER DENTIN WADE, CREWS CRAIG M, GUSTAFSON JEFFREY, CIULLI ALESSIO
Year of Publication 04.06.2020
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Year of Publication 04.06.2020
Patent