Safety of lemborexant versus placebo and zolpidem: effects on auditory awakening threshold, postural stability, and cognitive performance in healthy older participants in the middle of the night and upon morning awakening
Murphy, Patricia, Kumar, Dinesh, Zammit, Gary, Rosenberg, Russell, Moline, Margaret
Published in Journal of clinical sleep medicine (15.05.2020)
Published in Journal of clinical sleep medicine (15.05.2020)
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Lemborexant, A Dual Orexin Receptor Antagonist (DORA) for the Treatment of Insomnia Disorder: Results From a Bayesian, Adaptive, Randomized, Double-Blind, Placebo-Controlled Study
Murphy, Patricia, Moline, Margaret, Mayleben, David, Rosenberg, Russell, Zammit, Gary, Pinner, Kate, Dhadda, Shobha, Hong, Quan, Giorgi, Luigi, Satlin, Andrew
Published in Journal of clinical sleep medicine (15.11.2017)
Published in Journal of clinical sleep medicine (15.11.2017)
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Donepezil in Parkinson's disease dementia: A randomized, double-blind efficacy and safety study
Dubois, Bruno, Tolosa, Eduardo, Katzenschlager, Regina, Emre, Murat, Lees, Andrew J., Schumann, Günther, Pourcher, Emmanuelle, Gray, Julian, Thomas, Gail, Swartz, Jina, Hsu, Timothy, Moline, Margaret L.
Published in Movement disorders (01.09.2012)
Published in Movement disorders (01.09.2012)
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Effectiveness and tolerability of high-dose (23 mg/d) versus standard-dose (10 mg/d) donepezil in moderate to severe Alzheimer's disease: A 24-week, randomized, double-blind study
Farlow, Martin R., MD, Salloway, Stephen, MD, MS, Tariot, Pierre N., MD, Yardley, Jane, PhD, Moline, Margaret L., PhD, Wang, Qin, PhD, Brand-Schieber, Elimor, PhD, Zou, Heng, MS, Hsu, Timothy, MD, Satlin, Andrew, MD
Published in Clinical therapeutics (01.07.2010)
Published in Clinical therapeutics (01.07.2010)
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The ADAS-cog in Alzheimer's disease clinical trials: psychometric evaluation of the sum and its parts
Cano, Stefan J, Posner, Holly B, Moline, Margaret L, Hurt, Stephen W, Swartz, Jina, Hsu, Tim, Hobart, Jeremy C
Published in Journal of neurology, neurosurgery and psychiatry (01.12.2010)
Published in Journal of neurology, neurosurgery and psychiatry (01.12.2010)
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Cost-effectiveness analysis of lemborexant for treating insomnia in Japan: a model-based projection, incorporating the risk of falls, motor vehicle collisions, and workplace accidents
Ikeda, Shunya, Azuma, Mie Kasai, Fujimoto, Kenichi, Shibahara, Hidetoshi, Inoue, Sachie, Moline, Margaret, Ishii, Mika, Mishima, Kazuo
Published in Psychological medicine (01.10.2022)
Published in Psychological medicine (01.10.2022)
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Pharmacokinetics, Pharmacodynamics, and Safety of the Dual Orexin Receptor Antagonist Lemborexant: Findings From Single‐Dose and Multiple‐Ascending‐Dose Phase 1 Studies in Healthy Adults
Landry, Ishani, Nakai, Kenya, Ferry, Jim, Aluri, Jagadeesh, Hall, Nancy, Lalovic, Bojan, Moline, Margaret L.
Published in Clinical pharmacology in drug development (01.02.2021)
Published in Clinical pharmacology in drug development (01.02.2021)
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Gender differences in pharmacokinetics and pharmacodynamics of zolpidem following sublingual administration
Greenblatt, David J, Harmatz, Jerold S, Singh, Nikhilesh N, Steinberg, Frank, Roth, Thomas, Moline, Margaret L, Harris, Stephen C, Kapil, Ram P
Published in Journal of clinical pharmacology (01.03.2014)
Published in Journal of clinical pharmacology (01.03.2014)
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Effect of discontinuation of lemborexant following long‐term treatment of insomnia disorder: Secondary analysis of a randomized clinical trial
Takaesu, Yoshikazu, Suzuki, Masahiro, Moline, Margaret, Pinner, Kate, Inabe, Kanako, Nishi, Yurie, Kuriyama, Kenichi
Published in Clinical and translational science (01.04.2023)
Published in Clinical and translational science (01.04.2023)
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The Association between Insomnia and Insomnia Treatment Side Effects on Health Status, Work Productivity, and Healthcare Resource Use
DiBonaventura, Marco, Richard, Lance, Kumar, Maya, Forsythe, Anna, Flores, Natalia M, Moline, Margaret
Published in PloS one (01.10.2015)
Published in PloS one (01.10.2015)
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Sleep, Sleep Disorders, and Mild Traumatic Brain Injury. What We Know and What We Need to Know: Findings from a National Working Group
Wickwire, Emerson M., Williams, Scott G., Roth, Thomas, Capaldi, Vincent F., Jaffe, Michael, Moline, Margaret, Motamedi, Gholam K., Morgan, Gregory W., Mysliwiec, Vincent, Germain, Anne, Pazdan, Renee M., Ferziger, Reuven, Balkin, Thomas J., MacDonald, Margaret E., Macek, Thomas A., Yochelson, Michael R., Scharf, Steven M., Lettieri, Christopher J.
Published in Neurotherapeutics (01.04.2016)
Published in Neurotherapeutics (01.04.2016)
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On-the-road driving performance the morning after bedtime administration of lemborexant in healthy adult and elderly volunteers
Vermeeren, Annemiek, Jongen, Stefan, Murphy, Patricia, Moline, Margaret, Filippov, Gleb, Pinner, Kate, Perdomo, Carlos, Landry, Ishani, Majid, Oneeb, Van Oers, Anita C M, Van Leeuwen, Cees J, Ramaekers, Johannes G, Vuurman, Eric F P M
Published in Sleep (New York, N.Y.) (01.04.2019)
Published in Sleep (New York, N.Y.) (01.04.2019)
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Evidence‐based insomnia treatment strategy using novel orexin antagonists: A review
Kishi, Taro, Nishida, Maika, Koebis, Michinori, Taninaga, Takehiro, Muramoto, Kenzo, Kubota, Naoki, Moline, Margaret, Sakuma, Kenji, Okuya, Makoto, Nomura, Ikuo, Iwata, Nakao
Published in Neuropsychopharmacology reports (01.12.2021)
Published in Neuropsychopharmacology reports (01.12.2021)
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Donepezil in patients with subcortical vascular cognitive impairment: a randomised double-blind trial in CADASIL
Dichgans, Martin, MD, Markus, Hugh S, FRCP, Salloway, Stephen, MD, Verkkoniemi, Auli, MD, Moline, Margaret, PhD, Wang, Qin, PhD, Posner, Holly, MD, Chabriat, Hugues S, MD
Published in Lancet neurology (01.04.2008)
Published in Lancet neurology (01.04.2008)
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Efficacy of Lemborexant in Adults ≥ 65 Years of Age with Insomnia Disorder
Arnold, Valerie, Ancoli-Israel, Sonia, Dang-Vu, Thien Thanh, Mishima, Kazuo, Pinner, Kate, Malhotra, Manoj, Moline, Margaret
Published in Neurology and therapy (01.08.2024)
Published in Neurology and therapy (01.08.2024)
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Transitioning insomnia patients from zolpidem to lemborexant: A multicenter, open-label study evaluating a next-dose transition approach to insomnia pharmacotherapy
Ahmad, Maha, Kelly, James, Montano, C. Brendan, Kumar, Dinesh, Perdomo, Carlos, Malhotra, Manoj, Amchin, Jess, Moline, Margaret
Published in Sleep medicine. X (01.12.2024)
Published in Sleep medicine. X (01.12.2024)
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Comparison of Pharmacokinetic Profiles of Zolpidem Buffered Sublingual Tablet and Zolpidem Oral Immediate-Release Tablet: Results from a Single-Center, Single-Dose, Randomized, Open-Label Crossover Study in Healthy Adults
Greenblatt, David J., MD, Harmatz, Jerold S., AB, Roth, Thomas, PhD, Singh, Nikhilesh N., PhD, Moline, Margaret L., PhD, Harris, Stephen C., MD, Kapil, Ram P., PhD
Published in Clinical therapeutics (01.05.2013)
Published in Clinical therapeutics (01.05.2013)
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Concentration-Response Modeling of ECG Data From Early-Phase Clinical Studies as an Alternative Clinical and Regulatory Approach to Assessing QT Risk - Experience From the Development Program of Lemborexant
Murphy, Patricia J, Yasuda, Sanae, Nakai, Kenya, Yoshinaga, Takashi, Hall, Nancy, Zhou, Meijian, Aluri, Jagadeesh, Rege, Bhaskar, Moline, Margaret, Ferry, Jim, Darpo, Borje
Published in Journal of clinical pharmacology (01.01.2017)
Published in Journal of clinical pharmacology (01.01.2017)
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Journal Article
Safety and tolerability of donepezil 23 mg in moderate to severe Alzheimer's disease
Farlow, Martin, Veloso, Felix, Moline, Margaret, Yardley, Jane, Brand-Schieber, Elimor, Bibbiani, Francesco, Zou, Heng, Hsu, Timothy, Satlin, Andrew
Published in BMC neurology (25.05.2011)
Published in BMC neurology (25.05.2011)
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Re-examining the factor structure of the Insomnia Severity Index (ISI) and defining the meaningful within-individual change (MWIC) for subjects with insomnia disorder in two phase III clinical trials of the efficacy of lemborexant
Lenderking, William R., Savva, Yulia, Atkinson, Mark J., Campbell, Renee, Chabot, Isabelle, Moline, Margaret, Meier, Genevieve, Morin, Charles M.
Published in Journal of patient-reported outcomes (29.06.2024)
Published in Journal of patient-reported outcomes (29.06.2024)
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