Tumor-targeted 4-1BB agonists for combination with T cell bispecific antibodies as off-the-shelf therapy
Claus, Christina, Ferrara, Claudia, Xu, Wei, Sam, Johannes, Lang, Sabine, Uhlenbrock, Franziska, Albrecht, Rosmarie, Herter, Sylvia, Schlenker, Ramona, Hüsser, Tamara, Diggelmann, Sarah, Challier, John, Mössner, Ekkehard, Hosse, Ralf J, Hofer, Thomas, Brünker, Peter, Joseph, Catherine, Benz, Jörg, Ringler, Philippe, Stahlberg, Henning, Lauer, Matthias, Perro, Mario, Chen, Stanford, Küttel, Christine, Bhavani Mohan, Preethi L, Nicolini, Valeria, Birk, Martina Carola, Ongaro, Amandine, Prince, Christophe, Gianotti, Reto, Dugan, Gregory, Whitlow, Christopher T, Solingapuram Sai, Kiran Kumar, Caudell, David L, Burgos-Rodriguez, Armando G, Cline, J Mark, Hettich, Michael, Ceppi, Maurizio, Giusti, Anna Maria, Crameri, Flavio, Driessen, Wouter, Morcos, Peter N, Freimoser-Grundschober, Anne, Levitsky, Victor, Amann, Maria, Grau-Richards, Sandra, von Hirschheydt, Thomas, Tournaviti, Stella, Mølhøj, Michael, Fauti, Tanja, Heinzelmann-Schwarz, Viola, Teichgräber, Volker, Colombetti, Sara, Bacac, Marina, Zippelius, Alfred, Klein, Christian, Umaña, Pablo
Published in Science translational medicine (12.06.2019)
Published in Science translational medicine (12.06.2019)
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Identification of potential sites for tryptophan oxidation in recombinant antibodies using tert-butylhydroperoxide and quantitative LC-MS
Hensel, Miriam, Steurer, Rebecca, Fichtl, Juergen, Elger, Carsten, Wedekind, Frank, Petzold, Andreas, Schlothauer, Tilman, Molhoj, Michael, Reusch, Dietmar, Bulau, Patrick
Published in PloS one (03.03.2011)
Published in PloS one (03.03.2011)
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From proof of concept to the routine use of an automated and robust multi-dimensional liquid chromatography mass spectrometry workflow applied for the charge variant characterization of therapeutic antibodies
Goyon, Alexandre, Dai, Lu, Chen, Tao, Wei, Bingchuan, Yang, Feng, Andersen, Nisana, Kopf, Robert, Leiss, Michael, Mølhøj, Michael, Guillarme, Davy, Stella, Cinzia
Published in Journal of Chromatography A (29.03.2020)
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Structure-based prediction of asparagine and aspartate degradation sites in antibody variable regions
Sydow, Jasmin F, Lipsmeier, Florian, Larraillet, Vincent, Hilger, Maximiliane, Mautz, Bjoern, Mølhøj, Michael, Kuentzer, Jan, Klostermann, Stefan, Schoch, Juergen, Voelger, Hans R, Regula, Joerg T, Cramer, Patrick, Papadimitriou, Apollon, Kettenberger, Hubert
Published in PloS one (24.06.2014)
Published in PloS one (24.06.2014)
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Applying mini-bore HPAEC-MS/MS for the characterization and quantification of Fc N-glycans from heterogeneously glycosylated IgGs
Maier, Maria, Reusch, Dietmar, Bruggink, Cees, Bulau, Patrick, Wuhrer, Manfred, Mølhøj, Michael
Published in Journal of chromatography. B, Analytical technologies in the biomedical and life sciences (15.10.2016)
Published in Journal of chromatography. B, Analytical technologies in the biomedical and life sciences (15.10.2016)
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Inter-laboratory study to evaluate the performance of automated online characterization of antibody charge variants by multi-dimensional LC-MS/MS
Camperi, Julien, Grunert, Ingrid, Heinrich, Katrin, Winter, Martin, Özipek, Saban, Hoelterhoff, Sina, Weindl, Thomas, Mayr, Kilian, Bulau, Patrick, Meier, Monika, Mølhøj, Michael, Leiss, Michael, Guillarme, Davy, Bathke, Anja, Stella, Cinzia
Published in Talanta (Oxford) (01.11.2021)
Published in Talanta (Oxford) (01.11.2021)
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Simultaneous assessment of Asp isomerization and Asn deamidation in recombinant antibodies by LC-MS following incubation at elevated temperatures
Diepold, Katharina, Bomans, Katrin, Wiedmann, Michael, Zimmermann, Boris, Petzold, Andreas, Schlothauer, Tilman, Mueller, Robert, Moritz, Bernd, Stracke, Jan Olaf, Mølhøj, Michael, Reusch, Dietmar, Bulau, Patrick
Published in PloS one (17.01.2012)
Published in PloS one (17.01.2012)
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Variable heavy-variable light domain and Fab-arm CrossMabs with charged residue exchanges to enforce correct light chain assembly
Regula, Joerg Thomas, Imhof-Jung, Sabine, Mølhøj, Michael, Benz, Joerg, Ehler, Andreas, Bujotzek, Alexander, Schaefer, Wolfgang, Klein, Christian
Published in Protein engineering, design and selection (01.07.2018)
Published in Protein engineering, design and selection (01.07.2018)
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Assessment of chemical modifications of sites in the CDRs of recombinant antibodies: Susceptibility vs. functionality of critical quality attributes
Haberger, Markus, Bomans, Katrin, Diepold, Katharina, Hook, Michaela, Gassner, Jana, Schlothauer, Tilman, Zwick, Adrian, Spick, Christian, Kepert, Jochen Felix, Hienz, Brigitte, Wiedmann, Michael, Beck, Hermann, Metzger, Philipp, Mølhøj, Michael, Knoblich, Constanze, Grauschopf, Ulla, Reusch, Dietmar, Bulau, Patrick
Published in mAbs (01.03.2014)
Published in mAbs (01.03.2014)
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A highly stable polyethylene glycol-conjugated human single-chain antibody neutralizing granulocyte-macrophage colony stimulating factor at low nanomolar concentration
Krinner, Eva-Maria, Hepp, Julia, Hoffmann, Patrick, Bruckmaier, Sandra, Petersen, Laetitia, Petsch, Silke, Parr, Larissa, Schuster, Ioana, Mangold, Susanne, Lorenczewski, Grit, Lutterbüse, Petra, Buziol, Stefan, Hochheim, Inessa, Volkland, Jörg, Mølhøj, Michael, Sriskandarajah, Mirnalini, Strasser, Markus, Itin, Christian, Wolf, Andreas, Basu, Amartya, Yang, Karen, Filpula, David, Sørensen, Poul, Kufer, Peter, Baeuerle, Patrick, Raum, Tobias
Published in Protein engineering, design and selection (01.10.2006)
Published in Protein engineering, design and selection (01.10.2006)
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Identification and monitoring of host cell proteins by mass spectrometry combined with high performance immunochemistry testing
Bomans, Katrin, Lang, Antje, Roedl, Veronika, Adolf, Lisa, Kyriosoglou, Kyrillos, Diepold, Katharina, Eberl, Gabriele, Mølhøj, Michael, Strauss, Ulrike, Schmalz, Christian, Vogel, Rudolf, Reusch, Dietmar, Wegele, Harald, Wiedmann, Michael, Bulau, Patrick
Published in PloS one (27.11.2013)
Published in PloS one (27.11.2013)
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Detection of a phosphorylated glycine-serine linker in an IgG-based fusion protein
Tyshchuk, Oksana, Völger, Hans Rainer, Ferrara, Claudia, Bulau, Patrick, Koll, Hans, Mølhøj, Michael
Published in mAbs (01.01.2017)
Published in mAbs (01.01.2017)
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GingisKHAN™ protease cleavage allows a high-throughput antibody to Fab conversion enabling direct functional assessment during lead identification of human monoclonal and bispecific IgG1 antibodies
Moelleken, Jörg, Endesfelder, Manuel, Gassner, Christian, Lingke, Sabine, Tomaschek, Simone, Tyshchuk, Oksana, Lorenz, Stefan, Reiff, Ulrike, Mølhøj, Michael
Published in mAbs (03.10.2017)
Published in mAbs (03.10.2017)
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Characterization and prediction of positional 4-hydroxyproline and sulfotyrosine, two post-translational modifications that can occur at substantial levels in CHO cells-expressed biotherapeutics
Tyshchuk, Oksana, Gstöttner, Christoph, Funk, Dennis, Nicolardi, Simone, Frost, Stefan, Klostermann, Stefan, Becker, Tim, Jolkver, Elena, Schumacher, Felix, Koller, Claudia Ferrara, Völger, Hans Rainer, Wuhrer, Manfred, Bulau, Patrick, Mølhøj, Michael
Published in mAbs (03.10.2019)
Published in mAbs (03.10.2019)
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Heavy and light chain pairing of bivalent quadroma and knobs-into-holes antibodies analyzed by UHR-ESI-QTOF mass spectrometry
Schaefer, Wolfgang, Völger, Hans R, Lorenz, Stefan, Imhof-Jung, Sabine, Regula, Jörg T, Klein, Christian, Mølhøj, Michael
Published in mAbs (01.01.2016)
Published in mAbs (01.01.2016)
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DuoMab: a novel CrossMab-based IgG-derived antibody format for enhanced antibody-dependent cell-mediated cytotoxicity
Sustmann, Claudio, Dickopf, Steffen, Regula, Jörg T, Kettenberger, Hubert, Mølhøj, Michael, Gassner, Christian, Weininger, Diana, Fenn, Sebastian, Manigold, Tobias, Kling, Lothar, Künkele, Klaus-Peter, Schwaiger, Manfred, Bossenmaier, Birgit, Griese, Julia J, Hopfner, Karl-Peter, Graff-Meyer, Alexandra, Stahlberg, Henning, Ringler, Philippe, Lauer, Matthias E, Brinkmann, Ulrich, Schaefer, Wolfgang, Klein, Christian
Published in mAbs (17.11.2019)
Published in mAbs (17.11.2019)
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CD19-/CD3-bispecific antibody of the BiTE class is far superior to tandem diabody with respect to redirected tumor cell lysis
Mølhøj, Michael, Crommer, Sandrine, Brischwein, Klaus, Rau, Doris, Sriskandarajah, Mirnaalini, Hoffmann, Patrick, Kufer, Peter, Hofmeister, Robert, Baeuerle, Patrick A.
Published in Molecular immunology (01.03.2007)
Published in Molecular immunology (01.03.2007)
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The Biosynthesis of L-Arabinose in Plants: Molecular Cloning and Characterization of a Golgi-Localized UDP-D-Xylose 4-Epimerase Encoded by the MUR4 Gene of Arabidopsis
Burget, Emilie G., Verma, Rajeev, Mølhøj, Michael, Reiter, Wolf-Dieter
Published in The Plant cell (01.02.2003)
Published in The Plant cell (01.02.2003)
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The biosynthesis of the branched‐chain sugar d‐apiose in plants: functional cloning and characterization of a UDP‐d‐apiose/UDP‐d‐xylose synthase from Arabidopsis
Mølhøj, Michael, Verma, Rajeev, Reiter, Wolf‐Dieter
Published in The Plant journal : for cell and molecular biology (01.09.2003)
Published in The Plant journal : for cell and molecular biology (01.09.2003)
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