Discovery of (R)‑8-(6-Methyl-4-oxo-1,4,5,6-tetrahydropyrrolo[3,4‑b]pyrrol-2-yl)-3-(1-methylcyclopropyl)-2-((1-methylcyclopropyl)amino)quinazolin-4(3H)‑one, a Potent and Selective Pim-1/2 Kinase Inhibitor for Hematological Malignancies
Wang, Hui-Ling, Andrews, Kristin L, Booker, Shon K, Canon, Jude, Cee, Victor J, Chavez, Frank, Chen, Yuping, Eastwood, Heather, Guerrero, Nadia, Herberich, Brad, Hickman, Dean, Lanman, Brian A, Laszlo, Jimmy, Lee, Matthew R, Lipford, J. Russell, Mattson, Bethany, Mohr, Christopher, Nguyen, Yen, Norman, Mark H, Pettus, Liping H, Powers, David, Reed, Anthony B, Rex, Karen, Sastri, Christine, Tamayo, Nuria, Wang, Paul, Winston, Jeffrey T, Wu, Bin, Wu, Qiong, Wu, Tian, Wurz, Ryan P, Xu, Yang, Zhou, Yihong, Tasker, Andrew S
Published in Journal of medicinal chemistry (14.02.2019)
Published in Journal of medicinal chemistry (14.02.2019)
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Long-term results of endosseous implants as retention elements of orbital epitheses, reconstruction techniques, and aftercare after radical tumor resection
Baum, Sven H, Klein, Matthias, Mohr, Christopher, Weischer, Thomas
Published in The International journal of oral and maxillofacial implants (01.05.2019)
Published in The International journal of oral and maxillofacial implants (01.05.2019)
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Abstract CT057: Phase I trial to evaluate the feasibility and safety of an individualized peptide vaccine of unmodified cancer antigens: PepIVAC-01
Haen, Sebastian, Löffler, Markus W., Kohlbacher, Oliver, Nahnsen, Sven, Mohr, Christopher, Stieglbaueren, Monika, Hrstic, Patricia, Buonaguro, Luigi, Martus, Peter, Häntschel, Maik, Gouttefangeas, Cécile, Beckert, Stefan, Königsrainer, Alfred, Stevanovic, Stefan, Kanz, Lothar, Rammensee, Hans-Georg
Published in Cancer research (Chicago, Ill.) (01.07.2018)
Published in Cancer research (Chicago, Ill.) (01.07.2018)
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Long‐term follow‐up and health‐related quality of life among cancer survivors with stage IEA orbital‐type lymphoma after external photon‐beam radiotherapy: Results from a longitudinal study
Hoffmann, Christian, Rating, Philipp, Bechrakis, Nikolaos, Eckstein, Anja, Sokolenko, Ekaterina, Jabbarli, Leyla, Westekemper, Henrike, Mohr, Christopher, Schmeling, Claus, Huettmann, Andreas, Tresckow, Julia, Göricke, Sophia, Deuschl, Cornelius, Johansson, Patricia, Poettgen, Christoph, Gauler, Thomas, Guberina, Nika, Moliavi, Sourour, Stuschke, Martin, Guberina, Maja
Published in Hematological oncology (01.12.2022)
Published in Hematological oncology (01.12.2022)
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Unfolded Protein Response in Cancer: IRE1α Inhibition by Selective Kinase Ligands Does Not Impair Tumor Cell Viability
Harrington, Paul E, Biswas, Kaustav, Malwitz, David, Tasker, Andrew S, Mohr, Christopher, Andrews, Kristin L, Dellamaggiore, Ken, Kendall, Richard, Beckmann, Holger, Jaeckel, Peter, Materna-Reichelt, Silvia, Allen, Jennifer R, Lipford, J. Russell
Published in ACS medicinal chemistry letters (08.01.2015)
Published in ACS medicinal chemistry letters (08.01.2015)
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Abstract 4455: Discovery of AMG 510, a first-in-human covalent inhibitor of KRASG12C for the treatment of solid tumors
Lanman, Brian A., Chen, Jian Jeffrey, Liu, Longbin, Lopez, Patricia, Pickrell, Alexander J., Reed, Anthony B., Wang, Hui-Ling, Achanta, Pragathi, Canon, Jude, Erlanson, Daniel A., Fucini, Raymond V., Jeong, Joon Won, Mohr, Christopher, Saiki, Anne Y., Cee, Victor J., Lipford, J. Russell, Rex, Karen, Volak, Laurie P.
Published in Cancer research (Chicago, Ill.) (01.07.2019)
Published in Cancer research (Chicago, Ill.) (01.07.2019)
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Journal Article
Discovery and Optimization of Quinazolinone-pyrrolopyrrolones as Potent and Orally Bioavailable Pan-Pim Kinase Inhibitors
Pettus, Liping H, Andrews, Kristin L, Booker, Shon K, Chen, Jie, Cee, Victor J, Chavez, Frank, Chen, Yuping, Eastwood, Heather, Guerrero, Nadia, Herberich, Bradley, Hickman, Dean, Lanman, Brian A, Laszlo, Jimmy, Lee, Matthew R, Lipford, J. Russell, Mattson, Bethany, Mohr, Christopher, Nguyen, Yen, Norman, Mark H, Powers, David, Reed, Anthony B, Rex, Karen, Sastri, Christine, Tamayo, Nuria, Wang, Paul, Winston, Jeffrey T, Wu, Bin, Wu, Tian, Wurz, Ryan P, Xu, Yang, Zhou, Yihong, Tasker, Andrew S, Wang, Hui-Ling
Published in Journal of medicinal chemistry (14.07.2016)
Published in Journal of medicinal chemistry (14.07.2016)
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Journal Article
The discovery of novel 3-(pyrazin-2-yl)-1H-indazoles as potent pan-Pim kinase inhibitors
Wang, Hui-Ling, Cee, Victor J., Chavez, Frank, Lanman, Brian A., Reed, Anthony B., Wu, Bin, Guerrero, Nadia, Lipford, J. Russell, Sastri, Christine, Winston, Jeff, Andrews, Kristin L., Huang, Xin, Lee, Matthew R., Mohr, Christopher, Xu, Yang, Zhou, Yihong, Tasker, Andrew S.
Published in Bioorganic & medicinal chemistry letters (15.02.2015)
Published in Bioorganic & medicinal chemistry letters (15.02.2015)
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Journal Article
Discovery of imidazopyridazines as potent Pim-1/2 kinase inhibitors
Wurz, Ryan P., Sastri, Christine, D’Amico, Derin C., Herberich, Brad, Jackson, Claire L.M., Pettus, Liping H., Tasker, Andrew S., Wu, Bin, Guerrero, Nadia, Lipford, J. Russell, Winston, Jeffrey T., Yang, Yajing, Wang, Paul, Nguyen, Yen, Andrews, Kristin L., Huang, Xin, Lee, Matthew R., Mohr, Christopher, Zhang, J.D., Reid, Darren L., Xu, Yang, Zhou, Yihong, Wang, Hui-Ling
Published in Bioorganic & medicinal chemistry letters (15.11.2016)
Published in Bioorganic & medicinal chemistry letters (15.11.2016)
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Journal Article
Discovery of 5-(1H-indol-5-yl)-1,3,4-thiadiazol-2-amines as potent PIM inhibitors
Wu, Bin, Wang, Hui-Ling, Cee, Victor J., Lanman, Brian A., Nixey, Thomas, Pettus, Liping, Reed, Anthony B., Wurz, Ryan P., Guerrero, Nadia, Sastri, Christine, Winston, Jeff, Lipford, J. Russell, Lee, Matthew R., Mohr, Christopher, Andrews, Kristin L., Tasker, Andrew S.
Published in Bioorganic & medicinal chemistry letters (15.02.2015)
Published in Bioorganic & medicinal chemistry letters (15.02.2015)
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Journal Article
Discovery of a Covalent Inhibitor of KRAS G12C (AMG 510) for the Treatment of Solid Tumors
Lanman, Brian A, Allen, Jennifer R, Allen, John G, Amegadzie, Albert K, Ashton, Kate S, Booker, Shon K, Chen, Jian Jeffrey, Chen, Ning, Frohn, Michael J, Goodman, Guy, Kopecky, David J, Liu, Longbin, Lopez, Patricia, Low, Jonathan D, Ma, Vu, Minatti, Ana E, Nguyen, Thomas T, Nishimura, Nobuko, Pickrell, Alexander J, Reed, Anthony B, Shin, Youngsook, Siegmund, Aaron C, Tamayo, Nuria A, Tegley, Christopher M, Walton, Mary C, Wang, Hui-Ling, Wurz, Ryan P, Xue, May, Yang, Kevin C, Achanta, Pragathi, Bartberger, Michael D, Canon, Jude, Hollis, L Steven, McCarter, John D, Mohr, Christopher, Rex, Karen, Saiki, Anne Y, San Miguel, Tisha, Volak, Laurie P, Wang, Kevin H, Whittington, Douglas A, Zech, Stephan G, Lipford, J Russell, Cee, Victor J
Published in Journal of medicinal chemistry (09.01.2020)
Published in Journal of medicinal chemistry (09.01.2020)
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Abstract 516: Discovery and preclinical characterization of AMG 650, a first-in-class inhibitor of kinesin KIF18A motor protein with potent activity against chromosomally unstable cancers
Belmontes, Brian, Moriguchi, Jodi, Chung, Grace, Sun, Jan, Ninniri, Maria Stefania S., Hanestad, Kelly, Chen, Kui, McCarter, John D., Dahal, Upendra P., Ghimire-Rijal, Sudipa, Hao, Yue, Mohr, Christopher P., Yu, Xinchao, Rees, Matthew G., Ronan, Melissa, Roth, Jennifer, Minocherhomji, Sheroy, Allen, Jennifer R., Bourbeau, Matthew P., Hughes, Paul E., Tamayo, Nuria A, Payton, Marc N.
Published in Cancer research (Chicago, Ill.) (04.04.2023)
Published in Cancer research (Chicago, Ill.) (04.04.2023)
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Journal Article
The discovery and optimization of aminooxadiazoles as potent Pim kinase inhibitors
Wurz, Ryan P., Pettus, Liping H., Jackson, Claire, Wu, Bin, Wang, Hui-Ling, Herberich, Brad, Cee, Victor, Lanman, Brian A., Reed, Anthony B., Chavez, Frank, Nixey, Thomas, Laszlo, Jimmy, Wang, Paul, Nguyen, Yen, Sastri, Christine, Guerrero, Nadia, Winston, Jeff, Lipford, J. Russell, Lee, Matthew R., Andrews, Kristin L., Mohr, Christopher, Xu, Yang, Zhou, Yihong, Reid, Darren L., Tasker, Andrew S.
Published in Bioorganic & medicinal chemistry letters (15.02.2015)
Published in Bioorganic & medicinal chemistry letters (15.02.2015)
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Abstract 1991: Characterization of the exome, transcriptome, and immunopeptidome to map alterations in primary and recurrent glioblastoma
Dubbelaar, Marissa L., Freudenmann, Lena K., Scheid, Jonas, Velz, Julia, Medici, Gioele, Kapolou, Konstantina, Mohme, Malte, Bichmann, Leon, Gauder, Marie, Czemmel, Stefan, Mohr, Christopher, Kowalewski, Daniel J., Westphal, Manfred, Lamszus, Katrin, Regli, Luca, Weller, Michael, Rammensee, Hans-Georg, Salih, Helmut, Neidert, Marian C., Walz, Juliane S.
Published in Cancer research (Chicago, Ill.) (15.06.2022)
Published in Cancer research (Chicago, Ill.) (15.06.2022)
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Journal Article
Discovery and Optimization of Macrocyclic Quinoxaline-pyrrolo-dihydropiperidinones as Potent Pinn-1/2 Kinase Inhibitors
Cee, Victor J., Chavez, Frank, Herberich, Bradley, Lanman, Brian A., Pettus, Liping H., Reed, Anthony B., Wu, Bin, Wurz, Ryan P., Andrews, Kristin L., Chen, Jie, Hickman, Dean, Laszlo, Jimmy, Lee, Matthew R., Guerrero, Nadia, Mattson, Bethany K., Yen Nguyen, Mohr, Christopher, Rex, Karen, Sastri, Christine E., Wang, Paul, Wu, Qiong, Wu, Tian, Xu, Yang, Zhou, Yihong, Winston, Jeffrey T., Lipford, J. Russell, Tasker, Andrew S., Wang, Hui-Ling
Published in ACS medicinal chemistry letters (01.04.2016)
Published in ACS medicinal chemistry letters (01.04.2016)
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Journal Article
The current state of facial prosthetics – A multicenter analysis
Thiele, Oliver C, Brom, Jörn, Dunsche, Anton, Ehrenfeld, Michael, Federspil, Philippe, Frerich, Bernhard, Hölzle, Frank, Klein, Martin, Kreppel, Matthias, Kübler, Alexander C, Kübler, Norbert R, Kunkel, Martin, Kuttenberger, Johannes, Lauer, Günter, Mayer, Boris, Mohr, Christopher, Neff, Andreas, Rasse, Michael, Reich, Rudolf H, Reinert, Siegmar, Rothamel, Daniel, Sader, Robert, Schliephake, Henning, Schmelzeisen, Rainer, Schramm, Alexander, Sieg, Peter, Terheyden, Hendrik, Wiltfang, Jörg, Ziegler, Christoph M, Mischkowski, Robert A, Zöller, Joachim E
Published in Journal of cranio-maxillo-facial surgery (01.09.2015)
Published in Journal of cranio-maxillo-facial surgery (01.09.2015)
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Erratum to “Personalized peptide vaccine-induced immune response associated with long-term survival of a metastatic cholangiocarcinoma patient”
Löffler, Markus W, Chandran, P. Anoop, Laske, Karoline, Schroeder, Christopher, Bonzheim, Irina, Walzer, Mathias, Hilke, Franz J, Trautwein, Nico, Kowalewski, Daniel J, Schuster, Heiko, Günder, Marc, Carcamo Yañez, Viviana A, Mohr, Christopher, Sturm, Marc, Nguyen, Huu-Phuc, Riess, Olaf, Bauer, Peter, Nahnsen, Sven, Nadalin, Silvio, Zieker, Derek, Glatzle, Jörg, Thiel, Karolin, Schneiderhan-Marra, Nicole, Clasen, Stephan, Bösmüller, Hans, Fend, Falko, Kohlbacher, Oliver, Gouttefangeas, Cécile, Stevanović, Stefan, Königsrainer, Alfred, Rammensee, Hans-Georg
Published in Journal of hepatology (01.01.2017)
Published in Journal of hepatology (01.01.2017)
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