Targeting enhancer switching overcomes non-genetic drug resistance in acute myeloid leukaemia
Bell, Charles C., Fennell, Katie A., Chan, Yih-Chih, Rambow, Florian, Yeung, Miriam M., Vassiliadis, Dane, Lara, Luis, Yeh, Paul, Martelotto, Luciano G., Rogiers, Aljosja, Kremer, Brandon E., Barbash, Olena, Mohammad, Helai P., Johanson, Timothy M., Burr, Marian L., Dhar, Arindam, Karpinich, Natalie, Tian, Luyi, Tyler, Dean S., MacPherson, Laura, Shi, Junwei, Pinnawala, Nathan, Yew Fong, Chun, Papenfuss, Anthony T., Grimmond, Sean M., Dawson, Sarah-Jane, Allan, Rhys S., Kruger, Ryan G., Vakoc, Christopher R., Goode, David L., Naik, Shalin H., Gilan, Omer, Lam, Enid Y. N., Marine, Jean-Christophe, Prinjha, Rab K., Dawson, Mark A.
Published in Nature communications (20.06.2019)
Published in Nature communications (20.06.2019)
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Lsd1 as a therapeutic target in Gfi1-activated medulloblastoma
Lee, Catherine, Rudneva, Vasilisa A., Erkek, Serap, Zapatka, Marc, Chau, Lianne Q., Tacheva-Grigorova, Silvia K., Garancher, Alexandra, Rusert, Jessica M., Aksoy, Ozlem, Lea, Robin, Mohammad, Helai P., Wang, Jianxun, Weiss, William A., Grimes, H. Leighton, Pfister, Stefan M., Northcott, Paul A., Wechsler-Reya, Robert J.
Published in Nature communications (18.01.2019)
Published in Nature communications (18.01.2019)
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Journal Article
Targeting Histone Methylation in Cancer
McCabe, Michael T, Mohammad, Helai P, Barbash, Olena, Kruger, Ryan G
Published in The cancer journal (Sudbury, Mass.) (01.09.2017)
Published in The cancer journal (Sudbury, Mass.) (01.09.2017)
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Journal Article
Lysine specific demethylase 1 inactivation enhances differentiation and promotes cytotoxic response when combined with all- trans retinoic acid in acute myeloid leukemia across subtypes
Smitheman, Kimberly N, Severson, Tesa M, Rajapurkar, Satyajit R, McCabe, Michael T, Karpinich, Natalie, Foley, James, Pappalardi, Melissa B, Hughes, Ashley, Halsey, Wendy, Thomas, Elizabeth, Traini, Christopher, Federowicz, Kelly E, Laraio, Jenny, Mobegi, Fredrick, Ferron-Brady, Geraldine, Prinjha, Rabinder K, Carpenter, Christopher L, Kruger, Ryan G, Wessels, Lodewyk, Mohammad, Helai P
Published in Haematologica (Roma) (01.06.2019)
Published in Haematologica (Roma) (01.06.2019)
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Structure-Based Design of a Novel SMYD3 Inhibitor that Bridges the SAM-and MEKK2-Binding Pockets
Van Aller, Glenn S., Graves, Alan P., Elkins, Patricia A., Bonnette, William G., McDevitt, Patrick J., Zappacosta, Francesca, Annan, Roland S., Dean, Tony W., Su, Dai-Shi, Carpenter, Christopher L., Mohammad, Helai P., Kruger, Ryan G.
Published in Structure (London) (03.05.2016)
Published in Structure (London) (03.05.2016)
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Identification of hnRNP-A1 as a pharmacodynamic biomarker of type I PRMT inhibition in blood and tumor tissues
Noto, Paul B., Sikorski, Timothy W., Zappacosta, Francesca, Wagner, Craig D., Montes de Oca, Rocio, Szapacs, Matthew E., Annan, Roland S., Liu, Yan, McHugh, Charles F., Mohammad, Helai P., Piccoli, Steven P., Creasy, Caretha L.
Published in Scientific reports (17.12.2020)
Published in Scientific reports (17.12.2020)
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Rational Targeting of Cooperating Layers of the Epigenome Yields Enhanced Therapeutic Efficacy against AML
Duy, Cihangir, Teater, Matt, Garrett-Bakelman, Francine E, Lee, Tak C, Meydan, Cem, Glass, Jacob L, Li, Meng, Hellmuth, Johannes C, Mohammad, Helai P, Smitheman, Kimberly N, Shih, Alan H, Abdel-Wahab, Omar, Tallman, Martin S, Guzman, Monica L, Muench, David, Grimes, H Leighton, Roboz, Gail J, Kruger, Ryan G, Creasy, Caretha L, Paietta, Elisabeth M, Levine, Ross L, Carroll, Martin, Melnick, Ari M
Published in Cancer discovery (01.07.2019)
Published in Cancer discovery (01.07.2019)
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Acute myeloid leukemia is characterized by Wnt pathway inhibitor promoter hypermethylation
Griffiths, Elizabeth A., Gore, Steven D., Hooker, Craig, McDevitt, Michael A., Karp, Judith E., Smith, B. Douglas, Mohammad, Helai P., Ye, Ying, Herman, James G., Carraway, Hetty E.
Published in Leukemia & lymphoma (01.09.2010)
Published in Leukemia & lymphoma (01.09.2010)
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Journal Article
Epigenetic differences in cytogenetically normal versus abnormal acute myeloid leukemia
Griffiths, Elizabeth A., Gore, Steven D., Hooker, Craig M., Mohammad, Helai P., McDevitt, Michael A., Smith, B. Douglas, Karp, Judith E., Herman, James G., Carraway, Hetty E.
Published in Epigenetics (01.10.2010)
Published in Epigenetics (01.10.2010)
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Journal Article
A DNA Hypomethylation Signature Predicts Antitumor Activity of LSD1 Inhibitors in SCLC
Mohammad, Helai P., Smitheman, Kimberly N., Kamat, Chandrashekhar D., Soong, David, Federowicz, Kelly E., Van Aller, Glenn S., Schneck, Jess L., Carson, Jeffrey D., Liu, Yan, Butticello, Michael, Bonnette, William G., Gorman, Shelby A., Degenhardt, Yan, Bai, Yuchen, McCabe, Michael T., Pappalardi, Melissa B., Kasparec, Jiri, Tian, Xinrong, McNulty, Kenneth C., Rouse, Meagan, McDevitt, Patrick, Ho, Thau, Crouthamel, Michelle, Hart, Timothy K., Concha, Nestor O., McHugh, Charles F., Miller, William H., Dhanak, Dashyant, Tummino, Peter J., Carpenter, Christopher L., Johnson, Neil W., Hann, Christine L., Kruger, Ryan G.
Published in Cancer cell (13.07.2015)
Published in Cancer cell (13.07.2015)
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In Memoriam: John H. Nilson, PhD (1950–2023)
Keri, Ruth A, Jorgensen, Joan S, Mohammad, Helai P, Hunzicker-Dunn, Mary
Published in Endocrinology (Philadelphia) (23.12.2023)
Published in Endocrinology (Philadelphia) (23.12.2023)
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Journal Article
Histone demethylase LSD1 is required for germinal center formation and BCL6-driven lymphomagenesis
Hatzi, Katerina, Geng, Huimin, Doane, Ashley S., Meydan, Cem, LaRiviere, Reed, Cardenas, Mariano, Duy, Cihangir, Shen, Hao, Vidal, Maria Nieves Calvo, Baslan, Timour, Mohammad, Helai P., Kruger, Ryan G., Shaknovich, Rita, Haberman, Ann M., Inghirami, Giorgio, Lowe, Scott W., Melnick, Ari M.
Published in Nature immunology (01.01.2019)
Published in Nature immunology (01.01.2019)
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LSD1 inhibition exerts its antileukemic effect by recommissioning PU.1- and C/EBPα-dependent enhancers in AML
Cusan, Monica, Cai, Sheng F., Mohammad, Helai P., Krivtsov, Andrei, Chramiec, Alan, Loizou, Evangelia, Witkin, Matthew D., Smitheman, Kimberly N., Tenen, Daniel G., Ye, Min, Will, Britta, Steidl, Ulrich, Kruger, Ryan G., Levine, Ross L., Rienhoff, Hugh Y., Koche, Richard P., Armstrong, Scott A.
Published in Blood (12.04.2018)
Published in Blood (12.04.2018)
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Phase I, Open-Label, Dose-Escalation Study of the Safety, Pharmacokinetics, Pharmacodynamics, and Efficacy of GSK2879552 in Relapsed/Refractory SCLC
Bauer, Todd M., Besse, Benjamin, Martinez-Marti, Alex, Trigo, Jose Manuel, Moreno, Victor, Garrido, Pilar, Ferron-Brady, Geraldine, Wu, Yuehui, Park, Jennifer, Collingwood, Therese, Kruger, Ryan G., Mohammad, Helai P., Ballas, Marc S., Dhar, Arindam, Govindan, Ramaswamy
Published in Journal of thoracic oncology (01.10.2019)
Published in Journal of thoracic oncology (01.10.2019)
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Alterations of immune response of Non-Small Cell Lung Cancer with Azacytidine
Wrangle, John, Wang, Wei, Koch, Alexander, Easwaran, Hariharan, Mohammad, Helai P, Vendetti, Frank, Vancriekinge, Wim, Demeyer, Timothy, Du, Zhengzong, Parsana, Princy, Rodgers, Kristen, Yen, Ray-Whay, Zahnow, Cynthia A, Taube, Janis M, Brahmer, Julie R, Tykodi, Scott S, Easton, Keith, Carvajal, Richard D, Jones, Peter A, Laird, Peter W, Weisenberger, Daniel J, Tsai, Salina, Juergens, Rosalyn A, Topalian, Suzanne L, Rudin, Charles M, Brock, Malcolm V, Pardoll, Drew, Baylin, Stephen B
Published in Oncotarget (01.11.2013)
Published in Oncotarget (01.11.2013)
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Journal Article
DNMT1 modulates gene expression without its catalytic activity partially through its interactions with histone-modifying enzymes
Clements, Eriko G, Mohammad, Helai P, Leadem, Benjamin R, Easwaran, Hariharan, Cai, Yi, Van Neste, Leander, Baylin, Stephen B
Published in Nucleic acids research (01.05.2012)
Published in Nucleic acids research (01.05.2012)
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