METHODOLOGY TO ACCESS TETRAHYDRODIPYRIDOIMIDAZOLE DERIVATIVES
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Published in Heterocycles (01.09.2012)
Published in Heterocycles (01.09.2012)
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Discovery and Optimization of Novel Antagonists to the Human Neurokinin‑3 Receptor for the Treatment of Sex-Hormone Disorders (Part I)
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Published in Journal of medicinal chemistry (09.04.2015)
Published in Journal of medicinal chemistry (09.04.2015)
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N-Thiazolylamide-based free fatty-acid 2 receptor agonists: Discovery, lead optimization and demonstration of off-target effect in a diabetes model
Hoveyda, Hamid R., Fraser, Graeme L., Zoute, Ludivine, Dutheuil, Guillaume, Schils, Didier, Brantis, Cyrille, Lapin, Alexey, Parcq, Julien, Guitard, Sandra, Lenoir, François, Bousmaqui, Mohamed El, Rorive, Sarah, Hospied, Sandrine, Blanc, Sébastien, Bernard, Jérôme, Ooms, Frédéric, McNelis, Joanne C., Olefsky, Jerrold M.
Published in Bioorganic & medicinal chemistry (01.10.2018)
Published in Bioorganic & medicinal chemistry (01.10.2018)
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Optimization of Novel Antagonists to the Neurokinin‑3 Receptor for the Treatment of Sex-Hormone Disorders (Part II)
Hoveyda, Hamid R, Fraser, Graeme L, Dutheuil, Guillaume, El Bousmaqui, Mohamed, Korac, Julien, Lenoir, François, Lapin, Alexey, Noël, Sophie
Published in ACS medicinal chemistry letters (09.07.2015)
Published in ACS medicinal chemistry letters (09.07.2015)
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Chiral N-acyl-5,6,7(8-substituted)-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazines as selective NK-3 receptor antagonists, pharmaceutical composition, methods for use in NK-3 receptor mediated disorders and chiral synthesis thereof
Roy, Marie-Odile, El Bousmaqui, Mohamed, Batt, Frederic, Fraser, Graeme Lovat, Hoveyda, Hamid R, Dutheuil, Guillaume
Year of Publication 09.03.2021
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Year of Publication 09.03.2021
Patent
NOVEL CHIRAL N-ACYL-5,6,7(8-SUBSTITUTED)-TETRAHYDRO-[1,2,4]TRIAZOLO[4,3-A]PYRAZINES AS SELECTIVE NK-3 RECEPTOR ANTAGONISTS, PHARMACEUTICAL COMPOSITION, METHODS FOR USE IN NK-3 RECEPTOR MEDIATED DISORDERS AND CHIRAL SYNTHESIS THEREOF
Roy, Marie-Odile, Batt, Frederic, Fraser, Graeme Lovat, Hoveyda, Hamid R, Dutheuil, Guillaume, Bousmaqui, Mohamed El
Year of Publication 10.09.2020
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Year of Publication 10.09.2020
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Chiral N-acyl-5,6,7(8-substituted)-tetrahydro-[1,2,4]triazolo[4,3-A]pyrazines as selective NK-3 receptor antagonists, pharmaceutical composition, methods for use in NK-3 receptor mediated disorders and chiral synthesis thereof
Roy, Marie-Odile, Batt, Frederic, Fraser, Graeme Lovat, Hoveyda, Hamid R, Dutheuil, Guillaume, Bousmaqui, Mohamed El
Year of Publication 16.06.2020
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Year of Publication 16.06.2020
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NOVEL CHIRAL N-ACYL-5,6,7(8-SUBSTITUTED)-TETRAHYDRO-[1,2,4]TRIAZOLO[4,3-A]PYRAZINES AS SELECTIVE NK-3 RECEPTOR ANTAGONISTS, PHARMACEUTICAL COMPOSITION, METHODS FOR USE IN NK-3 RECEPTOR MEDIATED DISORDERS AND CHIRAL SYNTHESIS THEREOF
Roy, Marie-Odile, Batt, Frederic, Fraser, Graeme Lovat, Hoveyda, Hamid R, Dutheuil, Guillaume, Bousmaqui, Mohamed El
Year of Publication 24.01.2019
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Year of Publication 24.01.2019
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Novel chiral N-acyl-5,6,7,(8-substituted)-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazines as selective NK-3 receptor antagonists, pharmaceutical composition, methods for use in NK-3 receptor mediated disorders and chiral synthesis thereof
Roy, Marie-Odile, Fraser, Graeme, Hoveyda, Hamid, El Bousmaqui, Mohamed, Batt, Frederic, Dutheuil, Guillaume
Year of Publication 19.07.2018
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Year of Publication 19.07.2018
Patent
Novel chiral N-acyl-5,6,7,(8-substituted)-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazines as selective NK-3 receptor antagonists, pharmaceutical composition, methods for use in NK-3 receptor mediated disorders and chiral synthesis thereof
Roy, Marie-Odile, Fraser, Graeme, Hoveyda, Hamid, El Bousmaqui, Mohamed, Batt, Frederic, Dutheuil, Guillaume
Year of Publication 06.07.2017
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Year of Publication 06.07.2017
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NOVEL CHIRAL N-ACYL-5,6,7,(8-SUBSTITUTED)-TETRAHYDRO-[1,2,4]TRIAZOLO[4,3-a]PYRAZINES AS SELECTIVE NK-3 RECEPTOR ANTAGONISTS, PHARMACEUTICAL COMPOSITION, METHODS FOR USE IN NK-3 RECEPTOR MEDIATED DISORDERS AND CHIRAL SYNTHESIS THEREOF
Hoveyda Hamid, Fraser Graeme, Bousmaqui Mohamed El, Batt Frédéric, Dutheuil Guillaume, Roy Marie-Odile
Year of Publication 02.02.2017
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Year of Publication 02.02.2017
Patent
Chiral N-acyl-5,6,7(8-substituted)-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazines as selective NK-3 receptor antagonists, pharmaceutical composition, methods for use in NK-3 receptor mediated disorders and chiral synthesis thereof
Batt Frederic, El Bousmaqui Mohamed, Fraser Graeme L, Dutheuil Guillaume, Hoveyda Hamid R, Roy Marie-Odile
Year of Publication 25.10.2016
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Year of Publication 25.10.2016
Patent
NOVEL CHIRAL N-ACYL-5,6,7,(8-SUBSTITUTED)-TETRAHYDRO-[1,2,4]TRIAZOLO[4,3-a]PYRAZINES AS SELECTIVE NK-3 RECEPTOR ANTAGONISTS, PHARMACEUTICAL COMPOSITION, METHODS FOR USE IN NK-3 RECEPTOR MEDIATED DISORDERS AND CHIRAL SYNTHESIS THEREOF
Roy, Marie-Odile, Fraser, Graeme, El Bousmaqui, Mohamed, Dutheuil, Guillaume, Hoveyeda, Hamid, Batt, Frédéric
Year of Publication 15.07.2016
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Year of Publication 15.07.2016
Patent
ChemInform Abstract: Methodology to Access Tetrahydrodipyridoimidazole Derivatives
El Bousmaqui, Mohamed, Donnier-Marechal, Marion, Larchanche, Paul-Emmanuel, Melnyk, Patricia, Carato, Pascal
Published in ChemInform (08.01.2013)
Published in ChemInform (08.01.2013)
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CHIRAL N-ACYL-5,6,7,(8-SUBSTITUTED)-TETRAHYDRO-[1,2,4]TRIAZOLO[4,3-A]PYRAZINES AS SELECTIVE NK-3 RECEPTOR ANTAGONISTS, PHARMACEUTICAL COMPOSITION, METHODS FOR USE IN NK-3 RECEPTOR MEDIATED DISORDERS AND CHIRAL SYNTHESIS THEREOF
HOVEYDA, HAMID, ROY, MARIE-ODILE, EL BOUSMAQUI, MOHAMED, DUTHEUIL, GUILLAUME, FRASER, GRAEME, BATT, FREDERIC
Year of Publication 11.06.2019
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Year of Publication 11.06.2019
Patent
N-acil-5,6,7, (8-substituído) - tetraidro-[1,2,4] triazolo [4,3 -a] pirazinas quirais inovadoras como antagonistas de receptor de nk-3 seletivos, composição farmacêutica, métodos para usar em distúrbios mediados por receptor de nk-3 e síntese quiral dos mesmos
DUTHEUIL GUILLAUME, BATT FRÉDÉRIC, ROY MARIE-ODILE, FRASER GRAEME, MOHAMED EL BOUSMAQUI, HOVEYDA HAMID
Year of Publication 17.05.2022
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Year of Publication 17.05.2022
Patent
NOVEL CHIRAL N-ACYL-5,6,7,(8-SUBSTITUTED)-TETRAHYDRO-[1,2,4]TRIAZOLO[4,3-A]PYRAZINES AS SELECTIVE NK-3 RECEPTOR ANTAGONISTS, PHARMACEUTICAL COMPOSITION, AND METHODS FOR USE IN NK-3 RECEPTOR MEDIATED DISORDERS
DUTHEUIL, Guillaume, EL BOUSMAQUI, Mohamed, ROY, Marie-Odile, HOVEYEDA, Hamid, FRASER, Graeme, BATT, Frederic
Year of Publication 30.01.2017
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Year of Publication 30.01.2017
Patent
NOVEL CHIRAL N-ACYL-5,6,7,(8-SUBSTITUTED)-TETRAHYDRO-(1,2,4)TRIAZOLO(4,3-A)PYRAZINES AS SELECTIVE NK-3 RECEPTOR ANTAGONISTS, PHARMACEUTICAL COMPOSITION, AND METHODS FOR USE IN NK-3 RECEPTOR MEDIATED DISORDERS
ROY Marie-Odile, FRASER Graeme, EL BOUSMAQUI Mohamed, BATT Frederic, HOVEYEDA Hamid, DUTHEUIL Guillaume
Year of Publication 31.08.2016
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Year of Publication 31.08.2016
Patent
NOVEL CHIRAL N-ACYL-5,6,7,(8-SUBSTITUTED)-TETRAHYDRO-[1,2,4]TRIAZOLO[4,3-A]PYRAZINES AS SELECTIVE NK-3 RECEPTOR ANTAGONISTS, PHARMACEUTICAL COMPOSITION, AND METHODS FOR USE IN NK-3 RECEPTOR MEDIATED DISORDERS
BATT, FRÉDÉRIC, ROY, MARIE-ODILE, EL BOUSMAQUI, MOHAMED, DUTHEUIL, GUILLAUME, FRASER, GRAEME, HOVEYEDA, HAMID
Year of Publication 31.08.2016
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Year of Publication 31.08.2016
Patent
NOVEL CHIRAL N-ACYL-5,6,7,(8-SUBSTITUTED)-TETRAHYDRO-[1,2,4]TRIAZOLO[4,3-A]PYRAZINES AS SELECTIVE NK-3 RECEPTOR ANTAGONISTS, PHARMACEUTICAL COMPOSITION, AND METHODS FOR USE IN NK-3 RECEPTOR MEDIATED DISORDERS
BATT, FRÉDÉRIC, ROY, MARIE-ODILE, EL BOUSMAQUI, MOHAMED, DUTHEUIL, GUILLAUME, FRASER, GRAEME, HOVEYEDA, HAMID
Year of Publication 24.08.2016
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Year of Publication 24.08.2016
Patent