Small-molecule WNK inhibition regulates cardiovascular and renal function
Yamada, Ken, Park, Hyi-Man, Rigel, Dean F, DiPetrillo, Keith, Whalen, Erin J, Anisowicz, Anthony, Beil, Michael, Berstler, James, Brocklehurst, Cara Emily, Burdick, Debra A, Caplan, Shari L, Capparelli, Michael P, Chen, Guanjing, Chen, Wei, Dale, Bethany, Deng, Lin, Fu, Fumin, Hamamatsu, Norio, Harasaki, Kouki, Herr, Tracey, Hoffmann, Peter, Hu, Qi-Ying, Huang, Waan-Jeng, Idamakanti, Neeraja, Imase, Hidetomo, Iwaki, Yuki, Jain, Monish, Jeyaseelan, Jey, Kato, Mitsunori, Kaushik, Virendar K, Kohls, Darcy, Kunjathoor, Vidya, LaSala, Daniel, Lee, Jongchan, Liu, Jing, Luo, Yang, Ma, Fupeng, Mo, Ruowei, Mowbray, Sarah, Mogi, Muneto, Ossola, Flavio, Pandey, Pramod, Patel, Sejal J, Raghavan, Swetha, Salem, Bahaa, Shanado, Yuka H, Trakshel, Gary M, Turner, Gordon, Wakai, Hiromichi, Wang, Chunhua, Weldon, Stephen, Wielicki, Jennifer B, Xie, Xiaoling, Xu, Lingfei, Yagi, Yukiko I, Yasoshima, Kayo, Yin, Jianning, Yowe, David, Zhang, Ji-Hu, Zheng, Gang, Monovich, Lauren
Published in Nature chemical biology (01.11.2016)
Published in Nature chemical biology (01.11.2016)
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Photocyclic behavior of rhodopsin induced by an atypical isomerization mechanism
Gulati, Sahil, Jastrzebska, Beata, Banerjee, Surajit, Placeres, Ángel L., Miszta, Przemyslaw, Gao, Songqi, Gunderson, Karl, Tochtrop, Gregory P., Filipek, Sławomir, Katayama, Kota, Kiser, Philip D., Mogi, Muneto, Stewart, Phoebe L., Palczewski, Krzysztof
Published in Proceedings of the National Academy of Sciences - PNAS (28.03.2017)
Published in Proceedings of the National Academy of Sciences - PNAS (28.03.2017)
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Discovery and Characterization of Allosteric WNK Kinase Inhibitors
Yamada, Ken, Zhang, Ji-Hu, Xie, Xiaoling, Reinhardt, Juergen, Xie, Amy Qiongshu, LaSala, Daniel, Kohls, Darcy, Yowe, David, Burdick, Debra, Yoshisue, Hajime, Wakai, Hiromichi, Schmidt, Isabel, Gunawan, Jason, Yasoshima, Kayo, Yue, Q. Kimberley, Kato, Mitsunori, Mogi, Muneto, Idamakanti, Neeraja, Kreder, Natasha, Drueckes, Peter, Pandey, Pramod, Kawanami, Toshio, Huang, Waanjeng, Yagi, Yukiko I, Deng, Zhan, Park, Hyi-Man
Published in ACS chemical biology (16.12.2016)
Published in ACS chemical biology (16.12.2016)
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Application of Imaging Mass Spectrometry to Assess Ocular Drug Transit
Grove, Kerri J., Kansara, Viral, Prentiss, Melissa, Long, Debby, Mogi, Muneto, Kim, Sean, Rudewicz, Patrick J.
Published in SLAS discovery (01.12.2017)
Published in SLAS discovery (01.12.2017)
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Lack of involvement of CEP adducts in TLR activation and in angiogenesis
Gounarides, John, Cobb, Jennifer S, Zhou, Jing, Cook, Frank, Yang, Xuemei, Yin, Hong, Meredith, Erik, Rao, Chang, Huang, Qian, Xu, YongYao, Anderson, Karen, De Erkenez, Andrea, Liao, Sha-Mei, Crowley, Maura, Buchanan, Natasha, Poor, Stephen, Qiu, Yubin, Fassbender, Elizabeth, Shen, Siyuan, Woolfenden, Amber, Jensen, Amy, Cepeda, Rosemarie, Etemad-Gilbertson, Bijan, Giza, Shelby, Mogi, Muneto, Jaffee, Bruce, Azarian, Sassan
Published in PloS one (24.10.2014)
Published in PloS one (24.10.2014)
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Small-molecule factor B inhibitor for the treatment of complement-mediated diseases
Schubart, Anna, Anderson, Karen, Mainolfi, Nello, Sellner, Holger, Ehara, Takeru, Adams, Christopher M., Sweeney, Aengus Mac, Liao, Sha-Mei, Crowley, Maura, Littlewood-Evans, Amanda, Sarret, Sophie, Wieczorek, Grazyna, Perrot, Ludovic, Dubost, Valérie, Flandre, Thierry, Zhang, Yuzhou, Smith, Richard J. H., Risitano, Antonio M., Karki, Rajeshri G., Zhang, Chun, Valeur, Eric, Sirockin, Finton, Gerhartz, Bernd, Erbel, Paulus, Hughes, Nicola, Smith, Thomas M., Cumin, Frederic, Argikar, Upendra A., Haraldsson, Börje, Mogi, Muneto, Sedrani, Richard, Wiesmann, Christian, Jaffee, Bruce, Maibaum, Jürgen, Flohr, Stefanie, Harrison, Richard, Eder, Jörg
Published in Proceedings of the National Academy of Sciences - PNAS (16.04.2019)
Published in Proceedings of the National Academy of Sciences - PNAS (16.04.2019)
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Structure of neprilysin in complex with the active metabolite of sacubitril
Schiering, Nikolaus, D’Arcy, Allan, Villard, Frederic, Ramage, Paul, Logel, Claude, Cumin, Frederic, Ksander, Gary M., Wiesmann, Christian, Karki, Rajeshri G., Mogi, Muneto
Published in Scientific reports (15.06.2016)
Published in Scientific reports (15.06.2016)
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Complement factor B is critical for sub-RPE deposit accumulation in a model of Doyne honeycomb retinal dystrophy with features of age-related macular degeneration
Crowley, Maura A, Garland, Donita L, Sellner, Holger, Banks, Angela, Fan, Lin, Rejtar, Tomas, Buchanan, Natasha, Delgado, Omar, Xu, Yong Yao, Jose, Sandra, Adams, Christopher M, Mogi, Muneto, Wang, Karen, Bigelow, Chad E, Poor, Stephen, Anderson, Karen, Jaffee, Bruce D, Prasanna, Ganesh, Grosskreutz, Cynthia, Fernandez-Godino, Rosario, Pierce, Eric A, Dryja, Thaddeus P, Liao, Sha-Mei
Published in Human molecular genetics (06.01.2023)
Published in Human molecular genetics (06.01.2023)
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Discovery of 4-((2S,4S)-4-Ethoxy-1-((5-methoxy-7-methyl-1H-indol-4-yl)methyl)piperidin-2-yl)benzoic Acid (LNP023), a Factor B Inhibitor Specifically Designed To Be Applicable to Treating a Diverse Array of Complement Mediated Diseases
Mainolfi, Nello, Ehara, Takeru, Karki, Rajeshri G., Anderson, Karen, Mac Sweeney, Aengus, Liao, Sha-Mei, Argikar, Upendra A., Jendza, Keith, Zhang, Chun, Powers, James, Klosowski, Daniel W., Crowley, Maura, Kawanami, Toshio, Ding, Jian, April, Myriam, Forster, Cornelia, Serrano-Wu, Michael, Capparelli, Michael, Ramqaj, Rrezarta, Solovay, Catherine, Cumin, Frederic, Smith, Thomas M., Ferrara, Luciana, Lee, Wendy, Long, Debby, Prentiss, Melissa, De Erkenez, Andrea, Yang, Louis, Liu, Fang, Sellner, Holger, Sirockin, Finton, Valeur, Eric, Erbel, Paulus, Ostermeier, Daniela, Ramage, Paul, Gerhartz, Bernd, Schubart, Anna, Flohr, Stefanie, Gradoux, Nathalie, Feifel, Roland, Vogg, Barbara, Wiesmann, Christian, Maibaum, Juergen, Eder, Joerg, Sedrani, Richard, Harrison, Richard A., Mogi, Muneto, Jaffee, Bruce D., Adams, Christopher M.
Published in Journal of medicinal chemistry (11.06.2020)
Published in Journal of medicinal chemistry (11.06.2020)
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Complex binding pathways determine the regeneration of mammalian green cone opsin with a locked retinal analogue
Alexander, Nathan S., Katayama, Kota, Sun, Wenyu, Salom, David, Gulati, Sahil, Zhang, Jianye, Mogi, Muneto, Palczewski, Krzysztof, Jastrzebska, Beata
Published in The Journal of biological chemistry (30.06.2017)
Published in The Journal of biological chemistry (30.06.2017)
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A Novel Selective Soluble Guanylate Cyclase Activator, MGV354, Lowers Intraocular Pressure in Preclinical Models, Following Topical Ocular Dosing
Prasanna, Ganesh, Ferrara, Luciana, Adams, Christopher, Ehara, Takeru, Li, Byron, Yang, Louis, Xiang, Chuanxi, Ng, Christopher Thow Hing, Kim, Sean, Towler, Christopher, Topley, Todd, McAllister, Cale, Ghosh, Malay, Newton, Ronald, Stacy, Rebecca, Rice, Dennis S, Mogi, Muneto
Published in Investigative ophthalmology & visual science (01.04.2018)
Published in Investigative ophthalmology & visual science (01.04.2018)
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Understanding metabolism related differences in ocular efficacy of MGV354
Dumouchel, Jennifer L., Argikar, Upendra A., Adams, Christopher M., Prasanna, Ganesh, Ehara, Takeru, Kim, Sean, Breen, Chris, Mogi, Muneto
Published in Xenobiotica (02.01.2021)
Published in Xenobiotica (02.01.2021)
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안구 표면 통증의 치료 방법
MOGI MUNETO, MEDLEY QUINTUS, MONTECCHI PALMER MICHELA, STASI KALLIOPI
Year of Publication 28.10.2021
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Year of Publication 28.10.2021
Patent
A small-molecule inhibitor of C5 complement protein
Jendza, Keith, Kato, Mitsunori, Salcius, Michael, Srinivas, Honnappa, De Erkenez, Andrea, Nguyen, Anh, McLaughlin, Doug, Be, Celine, Wiesmann, Christian, Murphy, Jason, Bolduc, Philippe, Mogi, Muneto, Duca, Jose, Namil, Abdel, Capparelli, Michael, Darsigny, Veronique, Meredith, Erik, Tichkule, Ritesh, Ferrara, Luciana, Heyder, Jessica, Liu, Fang, Horton, Patricia A., Romanowski, Michael J., Schirle, Markus, Mainolfi, Nello, Anderson, Karen, Michaud, Gregory A.
Published in Nature chemical biology (01.07.2019)
Published in Nature chemical biology (01.07.2019)
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A Randomized, Controlled Phase I/II Study to Evaluate the Safety and Efficacy of MGV354 for Ocular Hypertension or Glaucoma
Stacy, Rebecca, Huttner, Kenneth, Watts, Jen, Peace, James, Wirta, David, Walters, Tom, Sall, Kenneth, Seaman, John, Ni, Xiao, Prasanna, Ganesh, Mogi, Muneto, Adams, Christopher, Yan, Jing-He, Wald, Michael, He, Yunsheng, Newton, Ronald, Kolega, Randall, Grosskreutz, Cynthia
Published in American journal of ophthalmology (01.08.2018)
Published in American journal of ophthalmology (01.08.2018)
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Design, Synthesis, and Preclinical Characterization of Selective Factor D Inhibitors Targeting the Alternative Complement Pathway
Karki, Rajeshri G, Powers, James, Mainolfi, Nello, Anderson, Karen, Belanger, David B, Liu, Donglei, Ji, Nan, Jendza, Keith, Gelin, Christine F, Mac Sweeney, Aengus, Solovay, Catherine, Delgado, Omar, Crowley, Maura, Liao, Sha-Mei, Argikar, Upendra A, Flohr, Stefanie, La Bonte, Laura R, Lorthiois, Edwige L, Vulpetti, Anna, Brown, Ann, Long, Debby, Prentiss, Melissa, Gradoux, Nathalie, de Erkenez, Andrea, Cumin, Frederic, Adams, Christopher, Jaffee, Bruce, Mogi, Muneto
Published in Journal of medicinal chemistry (09.05.2019)
Published in Journal of medicinal chemistry (09.05.2019)
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Discovery of a Novel Piperidine-Based Inhibitor of Cholesteryl Ester Transfer Protein (CETP) That Retains Activity in Hypertriglyceridemic Plasma
Yamada, Ken, Brousseau, Margaret, Honma, Wataru, Iimura, Akiko, Imase, Hidetomo, Iwaki, Yuki, Kawanami, Toshio, LaSala, Daniel, Liang, Guiqing, Mitani, Hironobu, Nonomura, Kazuhiko, Ohmori, Osamu, Pan, Meihui, Rigel, Dean F, Umemura, Ichiro, Yasoshima, Kayo, Zhu, Guoming, Mogi, Muneto
Published in Journal of medicinal chemistry (26.10.2017)
Published in Journal of medicinal chemistry (26.10.2017)
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The Discovery of (S)-1-(6-(34(4-(1-(Cyclopropanecarbonyl)piperidin-4-y1)-2-methylphenypamino)-2,3-dihydro-1H-inden-4-yl)pyridin-2-yl)-5-methyl-1H-pyrazole-4-carboxylic Acid, a Soluble Guanylate Cyclase Activator Specifically Designed for Topical Ocular Delivery as a Therapy for Glaucoma
Ehara, Takeru, Adams, Christopher M., Bevan, Doug, Ji, Nan, Meredith, Erik L., Belanger, David B., Powers, James, Kato, Mitsunori, Solovay, Catherine, Liu, Donglei, Capparelli, Michael, Bolduc, Philippe, Grob, Jonathan E., Daniels, Matthew H., Ferrara, Luciana, Yang, Louis, Li, Byron, Towler, Christopher S., Stacy, Rebecca C., Prasanna, Ganesh, Mogi, Muneto
Published in Journal of medicinal chemistry (22.03.2018)
Published in Journal of medicinal chemistry (22.03.2018)
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