Phenotypic screening in cancer drug discovery — past, present and future
Moffat, John G., Rudolph, Joachim, Bailey, David
Published in Nature reviews. Drug discovery (01.08.2014)
Published in Nature reviews. Drug discovery (01.08.2014)
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Journal Article
Opportunities and challenges in phenotypic drug discovery: an industry perspective
Moffat, John G., Vincent, Fabien, Lee, Jonathan A., Eder, Jörg, Prunotto, Marco
Published in Nature reviews. Drug discovery (01.08.2017)
Published in Nature reviews. Drug discovery (01.08.2017)
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Journal Article
Scalar–tensor–vector–gravity and NGC-1277
Moffat, John W, Toth, Viktor T
Published in Monthly notices of the Royal Astronomical Society (01.01.2024)
Published in Monthly notices of the Royal Astronomical Society (01.01.2024)
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Journal Article
Widespread potential for growth-factor-driven resistance to anticancer kinase inhibitors
Wilson, Timothy R., Fridlyand, Jane, Yan, Yibing, Penuel, Elicia, Burton, Luciana, Chan, Emily, Peng, Jing, Lin, Eva, Wang, Yulei, Sosman, Jeff, Ribas, Antoni, Li, Jiang, Moffat, John, Sutherlin, Daniel P., Koeppen, Hartmut, Merchant, Mark, Neve, Richard, Settleman, Jeff
Published in Nature (London) (26.07.2012)
Published in Nature (London) (26.07.2012)
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Formation and growth of the first supermassive black holes in MOG
Zhoolideh Haghighi, Mohammad H., Moffat, John
Published in The European physical journal. C, Particles and fields (07.03.2024)
Published in The European physical journal. C, Particles and fields (07.03.2024)
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Journal Article
Metabolite profiling stratifies pancreatic ductal adenocarcinomas into subtypes with distinct sensitivities to metabolic inhibitors
Daemen, Anneleen, Peterson, David, Sahu, Nisebita, McCord, Ron, Du, Xiangnan, Liu, Bonnie, Kowanetz, Katarzyna, Hong, Rebecca, Moffat, John, Gao, Min, Boudreau, Aaron, Mroue, Rana, Corson, Laura, O’Brien, Thomas, Qing, Jing, Sampath, Deepak, Merchant, Mark, Yauch, Robert, Manning, Gerard, Settleman, Jeffrey, Hatzivassiliou, Georgia, Evangelista, Marie
Published in Proceedings of the National Academy of Sciences - PNAS (11.08.2015)
Published in Proceedings of the National Academy of Sciences - PNAS (11.08.2015)
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Phosphoproteome Profiling of the Receptor Tyrosine Kinase MuSK Identifies Tyrosine Phosphorylation of Rab GTPases
Budayeva, Hanna G., Sengupta-Ghosh, Arundhati, Phu, Lilian, Moffat, John G., Ayalon, Gai, Kirkpatrick, Donald S.
Published in Molecular & cellular proteomics (01.04.2022)
Published in Molecular & cellular proteomics (01.04.2022)
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Journal Article
ERK mutations and amplification confer resistance to ERK-inhibitor therapy
Jaiswal, Bijay S, Durinck, Steffen, Stawiski, Eric, Yin, Jianping, Wang, Weiru, Lin, Eva, Moffat, John G, Martin, Scott, Modrusan, Zora, Seshagiri, Somasekar
Published in Clinical cancer research (15.08.2018)
Published in Clinical cancer research (15.08.2018)
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Ser1292 autophosphorylation is an indicator of LRRK2 kinase activity and contributes to the cellular effects of PD mutations
Sheng, Zejuan, Zhang, Shuo, Bustos, Daisy, Kleinheinz, Tracy, Le Pichon, Claire E, Dominguez, Sara L, Solanoy, Hilda O, Drummond, Jason, Zhang, Xiaolin, Ding, Xiao, Cai, Fang, Song, Qinghua, Li, Xianting, Yue, Zhenyu, van der Brug, Marcel P, Burdick, Daniel J, Gunzner-Toste, Janet, Chen, Huifen, Liu, Xingrong, Estrada, Anthony A, Sweeney, Zachary K, Scearce-Levie, Kimberly, Moffat, John G, Kirkpatrick, Donald S, Zhu, Haitao
Published in Science translational medicine (12.12.2012)
Published in Science translational medicine (12.12.2012)
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Conformation selection by ATP-competitive inhibitors and allosteric communication in ERK2
Anderson, Jake W, Vaisar, David, Jones, David N, Pegram, Laurel M, Vigers, Guy P, Chen, Huifen, Moffat, John G, Ahn, Natalie G
Published in eLife (27.03.2024)
Published in eLife (27.03.2024)
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