Required Immunoproteasome Subunit Inhibition Profile for Anti-Inflammatory Efficacy and Clinical Candidate KZR-616 ((2S,3R)‑N‑((S)‑3-(Cyclopent-1-en-1-yl)-1-((R)‑2-methyloxiran-2-yl)-1-oxopropan-2-yl)-3-hydroxy-3-(4-methoxyphenyl)-2-((S)‑2-(2-morpholinoacetamido)propanamido)propenamide)
Johnson, Henry W. B, Lowe, Eric, Anderl, Janet L, Fan, Andrea, Muchamuel, Tony, Bowers, Simeon, Moebius, David C, Kirk, Christopher, McMinn, Dustin L
Published in Journal of medicinal chemistry (27.12.2018)
Published in Journal of medicinal chemistry (27.12.2018)
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Journal Article
Enantioselective Total Synthesis of Hyperforin
Sparling, Brian A, Moebius, David C, Shair, Matthew D
Published in Journal of the American Chemical Society (16.01.2013)
Published in Journal of the American Chemical Society (16.01.2013)
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Journal Article
Total Synthesis of (−)-Nemorosone and (+)-Secohyperforin
Sparling, Brian A, Tucker, James K, Moebius, David C, Shair, Matthew D
Published in Organic letters (17.07.2015)
Published in Organic letters (17.07.2015)
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Discovery of Highly Selective Inhibitors of the Immunoproteasome Low Molecular Mass Polypeptide 2 (LMP2) Subunit
Johnson, Henry W. B, Anderl, Janet L, Bradley, Erin K, Bui, John, Jones, Jeffrey, Arastu-Kapur, Shirin, Kelly, Lisa M, Lowe, Eric, Moebius, David C, Muchamuel, Tony, Kirk, Christopher, Wang, Zhengping, McMinn, Dustin
Published in ACS medicinal chemistry letters (13.04.2017)
Published in ACS medicinal chemistry letters (13.04.2017)
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Journal Article
Enantioselective Synthesis of Cyclic Amides and Amines through Mo-Catalyzed Asymmetric Ring-Closing Metathesis
Sattely, Elizabeth S, Cortez, G. Alexander, Moebius, David C, Schrock, Richard R, Hoveyda, Amir H
Published in Journal of the American Chemical Society (15.06.2005)
Published in Journal of the American Chemical Society (15.06.2005)
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Journal Article
Catalytic and Regioselective Ring Expansion of Arylcyclobutanones with Trimethylsilyldiazomethane. Ligand-Dependent Entry to β-Ketosilane or Enolsilane Adducts
Dabrowski, Jennifer A, Moebius, David C, Wommack, Andrew J, Kornahrens, Anne F, Kingsbury, Jason S
Published in Organic letters (20.08.2010)
Published in Organic letters (20.08.2010)
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Journal Article
Required Immunoproteasome Subunit Inhibition Profile for Anti-Inflammatory Efficacy and Clinical Candidate KZR-616 ((2S,3R)-N-((S)-3-(Cyclopent-1-en-1-yl)-((R)-2-methyloxiran-2-yl)-1-oxopropan-2-yl)-3-hydroxy-3-(4-methoxyphenyl)-2-((S)-2-(2-morpholinoacetamido)propanamido)propenannide)
Johnson, Henry W. B., Lowe, Eric, Anderl, Janet L., Fan, Andrea, Muchamuel, Tony, Bowers, Simeon, Moebius, David C., Kirk, Christopher, McMinn, Dustin L.
Published in Journal of medicinal chemistry (27.12.2018)
Published in Journal of medicinal chemistry (27.12.2018)
Get full text
Journal Article