Search Results - "MIZUMA TAKASHI" :: K.UTB vyhledávací portál | TBU Library Retrieval Portal

Assessment of Presystemic and Systemic Intestinal Availability of Orally Administered Drugs Using In Vitro and In Vivo Data in Humans: Intestinal Sulfation Metabolism Impacts Presystemic Availability Much More Than Systemic Availability of Salbutamol, SULT1A3 Substrate

Assessment of Presystemic and Systemic Intestinal Availability of Orally Administered Drugs Using In Vitro and In Vivo Data in Humans: Intestinal Sulfation Metabolism Impacts Presystemic Availability Much More Than Systemic Availability of Salbutamol, SULT1A3 Substrate

by Mizuma, Takashi
Published in Journal of pharmaceutical sciences (01.12.2008)

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Journal Article

Intestinal glucuronidation metabolism may have a greater impact on oral bioavailability than hepatic glucuronidation metabolism in humans: A study with raloxifene, substrate for UGT1A1, 1A8, 1A9, and 1A10

Intestinal glucuronidation metabolism may have a greater impact on oral bioavailability than hepatic glucuronidation metabolism in humans: A study with raloxifene, substrate for UGT1A1, 1A8, 1A9, and 1A10

by Mizuma, Takashi
Published in International journal of pharmaceutics (13.08.2009)

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Journal Article

Kinetic Impact of Presystemic Intestinal Metabolism on Drug Absorption: Experiment and Data Analysis for the Prediction of In Vivo Absorption from In Vitro Data

Kinetic Impact of Presystemic Intestinal Metabolism on Drug Absorption: Experiment and Data Analysis for the Prediction of In Vivo Absorption from In Vitro Data

by Mizuma, Takashi
Published in DRUG METABOLISM AND PHARMACOKINETICS (2002)

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Journal Article

Dietary polyphenols (−)-epicatechin and chrysin inhibit intestinal glucuronidation metabolism to increase drug absorption

Dietary polyphenols (−)-epicatechin and chrysin inhibit intestinal glucuronidation metabolism to increase drug absorption

by Mizuma, Takashi, Awazu, Shoji
Published in Journal of pharmaceutical sciences (01.09.2004)

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Journal Article

Concentration-Dependent Atypical Intestinal Absorption of Cyclic Phenylalanylserine: Small Intestine Acts as an Interface between the Body and Ingested Compounds

Concentration-Dependent Atypical Intestinal Absorption of Cyclic Phenylalanylserine: Small Intestine Acts as an Interface between the Body and Ingested Compounds

by Mizuma, Takashi, Narasaka, Takuo, Awazu, Shoji
Published in Biological & Pharmaceutical Bulletin (01.11.2003)

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Journal Article

Does the well-stirred model assess the intestinal first-pass effect well?

Does the well-stirred model assess the intestinal first-pass effect well?

by Mizuma, Takashi, Tsuji, Akira, Hayashi, Masahiro
Published in Journal of pharmacy and pharmacology (01.12.2004)

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Journal Article

Factors Affecting Glucuronidation Activity in Caco-2 Cells

Factors Affecting Glucuronidation Activity in Caco-2 Cells

by Mizuma, Takashi, Momota, Ryoichi, Haga, Makoto, Hayashi, Masahiro
Published in DRUG METABOLISM AND PHARMACOKINETICS (2004)

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Journal Article

神経保護作用を有する柑橘類由来3, 5, 6, 7, 8, 3’, 4’-ヘプタメトキシフラボンのヒト血清アルブミンへの結合

神経保護作用を有する柑橘類由来3, 5, 6, 7, 8, 3’, 4’-ヘプタメトキシフラボンのヒト血清アルブミンへの結合

by 垣内, 綾乃, 伊藤, 志穏, 奥山, 聡, 古川, 美子, 水間, 俊
Published in Chem-Bio Informatics Journal (2017)

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Journal Article

Kinetic assessment of luminal degradation of orally effective prodrugs for rational drug development

Kinetic assessment of luminal degradation of orally effective prodrugs for rational drug development

by Mizuma, Takashi
Published in Journal of pharmaceutical sciences (01.02.2010)

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Journal Article

STORAGE BED

STORAGE BED

by MIZUMA TAKASHI
Year of Publication 03.08.2017

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Patent

Intestinal transport and metabolism of glucose-conjugated kyotorphin and cyclic kyotorphin: metabolic degradation is crucial to intestinal absorption of peptide drugs

Intestinal transport and metabolism of glucose-conjugated kyotorphin and cyclic kyotorphin: metabolic degradation is crucial to intestinal absorption of peptide drugs

by Mizuma, Takashi, Koyanagi, Akihiro, Awazu, Shoji
Published in Biochimica et biophysica acta (01.06.2000)

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Journal Article

Uptake of cyclic dipeptide by PEPT1 in Caco-2 cells: phenolic hydroxyl group of substrate enhances affinity for PEPT1

Uptake of cyclic dipeptide by PEPT1 in Caco-2 cells: phenolic hydroxyl group of substrate enhances affinity for PEPT1

by Mizuma, Takashi, Narasaka, Takuo, Awazu, Shoji
Published in Journal of pharmacy and pharmacology (01.09.2002)

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Journal Article

Predictability of the covalent binding of acidic drugs in man

Predictability of the covalent binding of acidic drugs in man

by Benet, Leslie Z., Spahn-Langguth, Hildegard, Iwakawa, Seigo, Volland, Christine, Mizuma, Takashi, Mayer, Sascha, Mutschler, Ernst, Lin, Emil T.
Published in Life sciences (1973) (1993)

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Journal Article

Inhibitory effect of phloridzin and phloretin on glucuronidation of p-nitrophenol, acetaminophen and 1-naphthol: kinetic demonstration of the influence of glucuronidation metabolism on intestinal absorption in rats

Inhibitory effect of phloridzin and phloretin on glucuronidation of p-nitrophenol, acetaminophen and 1-naphthol: kinetic demonstration of the influence of glucuronidation metabolism on intestinal absorption in rats

by Mizuma, Takashi, Awazu, Shoji
Published in Biochimica et biophysica acta (23.10.1998)

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Journal Article

Intestinal active absorption of sugar-conjugated compounds by glucose transport system: implication of improvement of poorly absorbable drugs

Intestinal active absorption of sugar-conjugated compounds by glucose transport system: implication of improvement of poorly absorbable drugs

by Mizuma, T, Ohta, K, Hayashi, M, Awazu, S
Published in Biochemical pharmacology (08.05.1992)

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Journal Article

生体膜バリアーを克服する有用な経口プロドラッグをデザインするための薬物動態速度論的戦略：膜透過性プロドラッグであるための速度論的分類と基準の提案

生体膜バリアーを克服する有用な経口プロドラッグをデザインするための薬物動態速度論的戦略：膜透過性プロドラッグであるための速度論的分類と基準の提案

by 水間, 俊
Published in Chem-Bio Informatics Journal (2008)

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Journal Article

管腔内分解と生体膜バリアーを克服する有効な経口プロドラッグ開発のための統合的薬物動態速度論評価と戦略

管腔内分解と生体膜バリアーを克服する有効な経口プロドラッグ開発のための統合的薬物動態速度論評価と戦略

by 水間, 俊
Published in Chem-Bio Informatics Journal (2008)

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Journal Article

Improvement of Intestinal Absorption of Leucine Enkephalin by Sugar Coupling and Peptidase Inhibitors

Improvement of Intestinal Absorption of Leucine Enkephalin by Sugar Coupling and Peptidase Inhibitors

by Mizuma, Takashi, Ohta, Kunihiro, Koyanagi, Akihiro, Awazu, Shoji
Published in Journal of pharmaceutical sciences (01.08.1996)

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Journal Article

Intestinal absorption of stable cyclic dipeptides by the oligopeptide transporter in rat

Intestinal absorption of stable cyclic dipeptides by the oligopeptide transporter in rat

by Mizuma, T, Masubuchi, S, Awazu, S
Published in Journal of pharmacy and pharmacology (01.02.1998)

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Journal Article

Intestinal transport and metabolism of analgesic dipeptide, kyotorphin: rate-limiting factor in intestinal absorption of peptide as drug

Intestinal transport and metabolism of analgesic dipeptide, kyotorphin: rate-limiting factor in intestinal absorption of peptide as drug

by Mizuma, Takashi, Koyanagi, Akihiro, Awazu, Shoji
Published in Biochimica et biophysica acta (17.04.1997)

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Journal Article

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